FTP project DFF-4005-00443

AniGen: Animal genomes as model for human health

This project is granted by the Danish Council for Independent Research (Technology and Production Sciences, FTP).

Overview

News


2014-09-01: The AniGen project initiated.

2015-04-01: Oana Palasca started her PhD in the AniGen project.

2015-06-23: Workshop: Mammalian Genes, Genomes, Transcriptomes and Networks. Read more

2016-05-15: Nadezhda Doncheva started her Postdoc in the AniGen Project

Brief project overview and ongoing results


Animal models play an important role in developing treatments for human diseases. A main issue in using animal models for human diseases is whether the model genes and pathways are comparable to those of human. Even though many (coding as well as non-coding) genes between human and model animals such as mouse, pig and monkey are highly similar, they might be regulated differently. In spite of numerous databases and resources characterizing genes, there is currently no resource where the model genes are characterized with respect to the behavior of their human counterpart. In this project, such a repository will be made and the characterization will include gene sequence, gene structure (protein or non-coding RNA), expression level, (post-)transcriptional regulatory elements and pathways. The resource will point to which animal models are suitable for specific human genes, pathways and diseases, and the applicability of the resource will be tested both in academia and in industry. Project will be addressed through three work packages consituting the main elements organized i a pipeline. Once Animal data "components" have been compiled, the idea is that a limited number of human data components, e.g. genes of interest can be used to query the compilation, consisting of multiple databases. The different steps are largely dealt with in the indicated work packages.  
The overall structure of the project.

Participants


The key staff in this project is:

Nadezhda Doncheva
Postdoc
doncheva@rth.dk TBA
Oana Palasca
PhD student
jmx@rth.dk TBA
Jan Gorodkin (Project responsible)
Prof, Principal Investigator
gorodkin@rth.dk
Home page
+45 353 33578
Lars Juhl Jensen
Prof, Principal Investigator
Lars.Juhl.Jensen@cpr.ku.dk
Home page
+45 353 25025
Thomas Litman
Dr., Principal Investigator
thomas.litman@leo-pharma.com +45 4185 1753
Flemming Pociot
Prof, Principal Investigator
flemming.pociot.01@regionh.dk +45 38685339
+45 3045 6313

Events


Publications, webservers and software


The project holds part in the following papers (website, software, data repositories indicated)