FTP project DFF-4005-00443
AniGen: Animal genomes as model for human health
This project is granted by the Danish Council for Independent Research (Technology and Production Sciences, FTP).
Overview
- News
- Brief project overview and ongoing results
- Participants
- Events
- Publications, webservers and software
News
2014-09-01: The AniGen project initiated.
2015-04-01: Oana Palasca started her PhD in the AniGen project.
2015-06-23: Workshop: Mammalian Genes, Genomes, Transcriptomes and Networks. Read more
2016-05-15: Nadezhda Doncheva started her Postdoc in the AniGen Project
Brief project overview and ongoing results
Animal models play an important role in developing treatments for human diseases. A main issue in using animal models for human diseases is whether the model genes and pathways are comparable to those of human. Even though many (coding as well as non-coding) genes between human and model animals such as mouse, pig and monkey are highly similar, they might be regulated differently. In spite of numerous databases and resources characterizing genes, there is currently no resource where the model genes are characterized with respect to the behavior of their human counterpart. In this project, such a repository will be made and the characterization will include gene sequence, gene structure (protein or non-coding RNA), expression level, (post-)transcriptional regulatory elements and pathways. The resource will point to which animal models are suitable for specific human genes, pathways and diseases, and the applicability of the resource will be tested both in academia and in industry. Project will be addressed through three work packages consituting the main elements organized i a pipeline. Once Animal data "components" have been compiled, the idea is that a limited number of human data components, e.g. genes of interest can be used to query the compilation, consisting of multiple databases. The different steps are largely dealt with in the indicated work packages. | ![]() The overall structure of the project. |
Participants
The key staff in this project is:
Nadezhda Doncheva Postdoc |
doncheva@rth.dk | TBA |
Oana Palasca PhD student |
jmx@rth.dk | TBA |
Jan Gorodkin (Project responsible) Prof, Principal Investigator |
gorodkin@rth.dk Home page |
+45 353 33578 |
Lars Juhl Jensen Prof, Principal Investigator |
Lars.Juhl.Jensen@cpr.ku.dk Home page |
+45 353 25025 |
Thomas Litman Dr., Principal Investigator |
thomas.litman@leo-pharma.com | +45 4185 1753 |
Flemming Pociot Prof, Principal Investigator |
flemming.pociot.01@regionh.dk | +45 38685339 +45 3045 6313 |
Events
Publications, webservers and software
The project holds part in the following papers (website, software, data repositories indicated)