Seminar: Approaches to predict small RNA targets in bacteria
By Hakim Tafer, University of Leipzig, Germany. At 15:00 University of Copenhagen, LIFE, Grønnegårdsvej 3 (bld 1-61) 2nd floor, A211
Registration is not necessary. Refreshments will be served.
Small regulatory RNAs (sRNAs) in eukaryotes and bacteria play an important role in the regulation of gene expression. They act at the post-transcriptional regulators by base pairing with target mRNAs. Numerous sRNAs have already been identified, but the number of experimentally verified targets is considerably lower. Because experimental verification of putative interactions is a costly and tedious task, in-silico predictions are necessary for functional annotation of those novel sRNAs. Yet, the computational identification of these targets appears to be challenging because frequently the partial and incomplete sequence complementarity is difficult to evaluate. This talk will review available tools to predict putative ncRNA targets in bacteria and will then concentrate on two approaches developed in our group, RNAup and RNAplex.