Seminar: From structural bioinformatics to engineering of new enzymes
2012-06-06: by Janusz Bujnicki, Laboratory of Bioinformatics and Protein Engineering, International Institute of Molecular and Cell Biology, Warsaw, Poland on June 6th at 14.00-15.00 in auditorium A1-01.14, Nordre sti 2, 1st floor, University of Copenhagen, LIFE, Frederiksberg.
Registration is not necessary, refreshment will be served.
The work of my group is focused on theoretical and experimental studies of sequence-structure-function relationships in proteins and nucleic acids. Currently, our theoretical research involves the development and application of computer software for the analysis of proteins and RNA, in the area of structural bioinformatics (e.g. molecular modeling) and systems biology (e.g. interaction networks, biochemical pathways). Our experimental research is focused on the elucidation of sequence-structure-function relationships in proteins and nucleic acids and their complexes, using methods of biophysics, biochemistry, molecular biology, and cell biology. The major aim is a practical synthetic biology, i.e. the design and engineering of systems and molecules with new functions. In this talk, I will focus on the combination of protein engineering with theoretical modelling of protein-nucleic acid interactions. I will show how theoretical predictions can guide experiments toward engineering of enzymes with new, useful features.