Seminar: microRNA and Diabetes
By Romano Regazzi, University of Lausanne, Switzerland at 10:00, Hagedorn Research Institute, NLE1.18, Niels Steensensvej 1, 2800 Gentofte
Registration is not necessary.
Pancreatic beta-cells exposed to proinflammatory cytokines display alterations in gene expression resulting in defective insulin secretion and apoptosis. MicroRNAs are small noncoding RNAs emerging as key regulators of gene expression. We have evaluated the contribution of microRNAs to cytokine-mediated beta-cell cytotoxicity and identified miR-21, miR-34a, and miR-146a as novel players in beta-cell failure elicited in vitro and in vivo by proinflammatory cytokines, notably during the development of peri-insulitis that precedes overt diabetes in non-obese diabetic (NOD) mice.