Seminar: tRNA Nucleotidyltransferases: Reactions, Substrates, Evolution

2014-02-25: by Mario Moerl, Institute of Biochemistry, University of Leipzig. The Seminar will take place on February 25th, 14.15-15.00pm at University of Copen­hagen, SUND/LIFE, Dyrelægevej 36, Orangeriet, Frederiks­berg C.

Registration is not necessary. Refreshments will be served.


tRNA nucleotidyltransferases catalyse addition and maintenance of the nucleotide triplet C-C-A at the 3'-end of tRNAs. As this sequence represents the position for aminoacylation, it is highly conserved in all kingdoms of life. Instead of an external nucleic acid as a template for sequence-specific nucleotide addition, these enzymes use a set of amino acid residues to select the proper nucleotide for incorporation. In my presentation, I will discuss evolution, functionality and substrate specificity of these unusual RNA polymerases.