SRPDB Bibliography

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Weiche, B., Burk, J., Angelini, S., Schiltz, E., Thumfart, J. O., and Koch, H. G. (2008)
A Cleavable N-Terminal Membrane Anchor is Involved in Membrane Binding of the Escherichia coli SRP Receptor.
J Mol Biol 377, 761-73

van Nues, R. W., Leung, E., McDonald, J. C., Dantuluru, I., and Brown, J. D. (2008)
Roles for Srp72p in assembly, nuclear export and function of the signal recognition particle. RNA Biol 5, [Epub ahead of print]

Hernandez Torres, J., Maldonado, M. A., and Chomilier, J. (2007)
Tandem duplications of a degenerated GTP-binding domain at the origin of GTPase receptors Toc159 and thylakoidal SRP.
Biochem Biophys Res Commun 364, 325-331

Siu, F. Y., Spanggord, R. J., and Doudna, J. A. (2007)
SRP RNA provides the physiologically essential GTPase activation function in cotranslational protein targeting.
RNA 13, 240-250

Yin, J., Iakhiaeva, E., Menichelli, E., and Zwieb, C. (2007)
Identification of the RNA binding regions of SRP68/72 and SRP72 by systematic mutagenesis of human SRP RNA.
RNA Biol 4, 154-159

Yurist, S., Dahan, I., and Eichler, J. (2007)
SRP19 is a dispensable component of the signal recognition particle in Archaea.
J Bacteriol 189, 276-279

Singh, J., Dani, H. M., Sharma, R., and Steinberg, P. (2006)
Inhibition of the biosynthesis of SRP polypeptides and secretory proteins by aflatoxin B(1) can disrupt protein targeting.
Cell Biochem Funct 24, 507-510

Focia, P. J., Gawronski-Salerno, J., Coon, J. S. t., and Freymann, D. M. (2006)
Structure of a GDP:AlF4 complex of the SRP GTPases Ffh and FtsY, and identification of a peripheral nucleotide interaction site.
J Mol Biol 360, 631-643

Romisch, K., Miller, F. W., Dobberstein, B., and High, S. (2006)
Human autoantibodies against the 54 kDa protein of the signal recognition particle block function at multiple stages,
Arthritis Res Ther 8, R39

Raine, A., Lovmar, M., Wikberg, J., and Ehrenberg, M. (2006)
Trigger factor binding to ribosomes with nascent peptide chains of varying lengths and sequences,
J Biol Chem [Epub ahead of print]

Steiner, D., Forrer, P., Stumpp, M. T., and Pluckthun, A. (2006)
Signal sequences directing cotranslational translocation expand the range of proteins amenable to phage display,
Nat Biotechnol 24, 823-831

Bloois, E. V., Haan, G. J., Gier, J. W., Oudega, B., and Luirink, J. (2006)
Distinct requirements for translocation of the N-tail and C-tail of the Escherichia coli inner membrane protein CYOA,
J Biol Chem 281, 10002-10009

Onafuwa-Nuga, A. A., Telesnitsky, A., and King, S. R. (2006)
7SL RNA, but not the 54-kd signal recognition particle protein, is an abundant component of both infectious HIV-1 and minimal virus-like particles,
RNA 12, 542-546

Eisner, G., Moser, M., Schafer, U., Beck, K., and Muller, M. (2006)
Alternate recruitment of signal recognition particle and trigger factor to the signal sequence of a growing nascent polypeptide,
J Biol Chem 281, 7172-7179

Halic, M., Gartmann, M., Schlenker, O., Mielke, T., Pool, M. R., Sinning, I., and Beckmann, R. (2006)
Signal recognition particle receptor exposes the ribosomal translocon binding site,
Science 12, 467-468

Hasler, J., and Strub, K. (2006)
Alu RNP and Alu RNA regulate translation initiation in vitro,
Nucleic Acids Res 34, 2374-2385

Zanen, G., Antelmann, H., Meima, R., Jongbloed, J. D., Kolkman, M., Hecker, M., van Dijl, J. M., and Quax, W. J. (2006)
Proteomic dissection of potential signal recognition particle dependence in protein secretion by Bacillus subtilis,
Proteomics 6, 3636-3648

Klenell, M., Morita, S., Tiemblo-Olmo, M., Muhlenbock, P., Karpinski, S., and Karpinska, B. (2005)
Involvement of the chloroplast signal recognition particle cpSRP43 in acclimation to conditions promoting photooxidative stress in Arabidopsis,
Plant Cell Physiol 46, 118-129

Kuruma, Y., Nishiyama, K. I., Shimizu, Y., Muller, M., and Ueda, T. (2005)
Development of a Minimal Cell-Free Translation System for the Synthesis of Presecretory and Integral Membrane Proteins,
Biotechnol Prog 21, 1243-1251

Spanggord, R. J., Siu, F., Ke, A., and Doudna, J. A. (2005)
RNA-mediated interaction between the peptide-binding and GTPase domains of the signal recognition particle,
Nat Struct Mol Biol 12, 1116-1122

Schaaf, A., Tintelnot, S., Baur, A., Reski, R., Gorr, G., and Decker, E. L. (2005)
Use of endogenous signal sequences for transient production and efficient secretion by moss (Physcomitrella patens) cells,
BMC Biotechnol 5, 30

Schlunzen, F., Wilson, D. N., Tian, P., Harms, J. M., McInnes, S. J., Hansen, H. A., Albrecht, R., Buerger, J., Wilbanks, S. M., and Fucini, P. (2005)
The Binding Mode of the Trigger Factor on the Ribosome: Implications for Protein Folding and SRP Interaction,
Structure (Camb) 13, 1685-1694

Halic, M., Becker, T., Frank, J., Spahn, C. M., and Beckmann, R. (2005)
Localization and dynamic behavior of ribosomal protein L30e,
Nat Struct Mol Biol 12, 467-468

Lustig, Y., Goldshmidt, H., Uliel, S., and Michaeli, S. (2005)
The Trypanosoma brucei signal recognition particle lacks the Alu-domain-binding proteins: purification and functional analysis of its binding proteins by RNAi,
J Cell Sci 118, 4551-4562

Hasona, A., Crowley, P. J., Levesque, C. M., Mair, R. W., Cvitkovitch, D. G., Bleiweis, A. S., and Brady, L. J. (2005)
Streptococcal viability and diminished stress tolerance in mutants lacking the signal recognition particle pathway or YidC2,
Proc Natl Acad Sci U S A 102, 17466-17471

Deitermann, S., Sprie, G. S., and Koch, H. G. (2005)
A dual function for SecA in the assembly of single-spanning membrane proteins in Escherichia coli,
J Biol Chem 280, 39077-39085

Buskiewicz, I., Peske, F., Wieden, H. J., Gryczynski, I., Rodnina, M. V., and Wintermeyer, W. (2005)
Conformations of the Signal Recognition Particle Protein Ffh from Escherichia coli as Determined by FRET,
J Mol Biol 351, 417-430

Buskiewicz, I., Kubarenko, A., Peske, F., Rodnina, M. V., and Wintermeyer, W. (2005)
Domain rearrangement of SRP protein Ffh upon binding 4.5S RNA and the SRP receptor FtsY,
RNA 11, 947-957

Chou, Y. T., and Gierasch, L. M. (2005)
The conformation of a signal peptide bound by Escherichia coli preprotein translocase SecA,
J Biol Chem 280, 32753-32760

Shan, S. O., and Walter, P. (2005)
Molecular Crosstalk between the Nucleotide Specificity Determinant of the SRP GTPase and the SRP Receptor,
Biochemistry 44, 6214-6222

Iakhiaeva, E., Yin, J., and Zwieb, C. (2005)
Identification of an RNA-binding Domain in Human SRP72,
J Mol Biol 345, 659-666

Shan, S. O., and Walter, P. (2005)
Co-translational protein targeting by the signal recognition particle,
FEBS Lett 579, 921-926

Singh, J., Singh, S., Dani, H. M., Sharma, R., and Steinberg, P. (2005)
Interactions of aflatoxin B1 with SRP components can disrupt protein targeting,
Cell Biochem Funct 23, 9-13

Sommerville, J., Brumwell, C. L., Politz, J. C., and Pederson, T. (2005)
Signal recognition particle assembly in relation to the function of amplified nucleoli of Xenopus oocytes,
J Cell Sci 118, 1299-1307

Hainzl, T., Huang, S., and Sauer-Eriksson, A. E. (2005)
Structural insights into SRP RNA: An induced fit mechanism for SRP assembly,
RNA 11, 1043-1050

Halic, M., and Beckmann, R. (2005)
The signal recognition particle and its interactions during protein targeting,
Curr Opin Struct Biol 15, 116-125

Houben, E. N., Zarivach, R., Oudega, B., and Luirink, J. (2005)
Early encounters of a nascent membrane protein: specificity and timing of contacts inside and outside the ribosome,
J Cell Biol

Huber, D., Boyd, D., Xia, Y., Olma, M. H., Gerstein, M., and Beckwith, J. (2005)
Use of Thioredoxin as a Reporter To Identify a Subset of Escherichia coli Signal Sequences That Promote Signal Recognition Particle-Dependent Translocation,
J Bacteriol 187, 2983-2991

Zwieb, C., Van Nues, R. W., Rosenblad, M. A., Brown, J. D., and Samuelsson, T. (2005)
A nomenclature for all signal recognition particle RNAs,
RNA 11, 7-13

Focia, P. J., Shepotinovskaya, I. V., Seidler, J. A., and Freymann, D. M. (2004)
Heterodimeric GTPase core of the SRP targeting complex,
Science 303, 373-377

Focia, P. J., Alam, H., Lu, T., Ramirez, U. D., and Freymann, D. M. (2004)
Novel protein and Mg2+ configurations in the Mg2+GDP complex of the SRP GTPase ffh,
Proteins 54, 222-230

Ferbitz, L., Maier, T., Patzelt, H., Bukau, B., Deuerling, E., and Ban, N. (2004)
Trigger factor in complex with the ribosome forms a molecular cradle for nascent proteins,
Nature 431, 590-596

Egea, P. F., Shan, S. O., Napetschnig, J., Savage, D. F., Walter, P., and Stroud, R. M. (2004)
Substrate twinning activates the signal recognition particle and its receptor,
Nature 427, 215-221

Abell, B. M., Pool, M. R., Schlenker, O., Sinning, I., and High, S. (2004)
Signal recognition particle mediates post-translational targeting in eukaryotes,
Embo J 23, 2755-2764

White, S. H., and von Heijne, G. (2004)
The machinery of membrane protein assembly,
Curr Opin Struct Biol 14, 397-404

Wild, K., Halic, M., Sinning, I., and Beckmann, R. (2004)
SRP meets the ribosome,
Nat Struct Mol Biol 11, 1049-1053

Wild, K., Rosendal, K. R., and Sinning, I. (2004)
A structural step into the SRP cycle,
Mol Microbiol 53, 357-363

Moll, R. G. (2004)
The archaeal signal recognition particle: steps toward membrane binding,
J Bioenerg Biomembr 36, 47-53

Chu, F., Shan, S. O., Moustakas, D. T., Alber, F., Egea, P. F., Stroud, R. M., Walter, P., and Burlingame, A. L. (2004)
Unraveling the interface of signal recognition particle and its receptor by using chemical cross-linking and tandem mass spectrometry,
Proc Natl Acad Sci U S A 101, 16454-16459

Yi, L., Celebi, N., Chen, M., and Dalbey, R. E. (2004)
Sec/SRP requirements and energetics of membrane insertion of subunits a, b, and c of the Escherichia coli F1F0 ATP synthase,
J Biol Chem 279, 39260-39267

Terzi, L., Pool, M. R., Dobberstein, B., and Strub, K. (2004)
Signal recognition particle Alu domain occupies a defined site at the ribosomal subunit interface upon signal sequence recognition,
Biochemistry 43, 107-117

Yin, J., Huang, Q., Pakhomova, O. P., Hinck, A. P., and Zwieb, C. (2004)
The conserved adenosine in helix 6 of signal recognition particle RNA initiates SRP assembly,
Archaea 1, 269–276

Luirink, J., and Sinning, I. (2004)
SRP-mediated protein targeting: structure and function revisited,
Biochim Biophys Acta 1694, 17-35

Tyson, G. W., Chapman, J., Hugenholtz, P., Allen, E. E., Ram, R. J., Richardson, P. M., Solovyev, V. V., Rubin, E. M., Rokhsar, D. S., and Banfield, J. F. (2004)
Community structure and metabolism through reconstruction of microbial genomes from the environment,
Nature

Dobberstein, B., and Sinning, I. (2004)
Structural biology. Surprising news from the PCC,
Science 303, 320-322

Van Nues, R. W., and Brown, J. D. (2004)
Saccharomyces SRP RNA secondary structures: A conserved S-domain and extended Alu-domain,
RNA 10, 75-89

Doudna, J. A., and Batey, R. T. (2004)
Structural Insights into the Signal Recognition Particle,
Annu Rev Biochem 73, 539-557

Yin, J., Yang, C. H., and Zwieb, C. (2004)
Two strategically placed base pairs in helix 8 of mammalian signal recognition particle RNA are crucial for the SPR19-dependent binding of protein SRP54,
Rna 10, 574-580

Halic, M., Becker, T., Pool, M. R., Spahn, C. M., Grassucci, R. A., Frank, J., and Beckmann, R. (2004)
Structure of the signal recognition particle interacting with the elongation-arrested ribosome,
Nature 427, 808-814

Horwich, A. (2004)
Cell biology: sight at the end of the tunnel,
Nature 431, 520-522

Huck, L., Scherrer, A., Terzi, L., Johnson, A. E., Bernstein, H. D., Cusack, S., Weichenrieder, O., and Strub, K. (2004)
Conserved tertiary base pairing ensures proper RNA folding and efficient assembly of the signal recognition particle Alu domain,
Nucleic Acids Res 32, 4915-4924

Rosenblad, M. A., Zwieb, C., and Samuelsson, T. (2004)
Identification and comparative analysis of components from the signal recognition particle in protozoa and fungi,
BMC Genomics 5, 5

Rosendal, K. R., Sinning, I., and Wild, K. (2004)
Crystallization of the crenarchaeal SRP core,
Acta Crystallogr Section D Biol Crystallogr 60, 140-143

Sagar, M. B., Lucast, L., and Doudna, J. A. (2004)
Conserved but nonessential interaction of SRP RNA with translation factor EF-G,
Rna 10, 772-778

Buskiewicz, I., Deuerling, E., Gu, S. Q., Jockel, J., Rodnina, M. V., Bukau, B., and Wintermeyer, W. (2004)
Trigger factor binds to ribosome-signal-recognition particle (SRP) complexes and is excluded by binding of the SRP receptor,
Proc Natl Acad Sci U S A 101, 7902-7906

Shepotinovskaya, I. V., Focia, P. J., and Freymann, D. M. (2003)
Crystallization of the GMPPCP complex of the NG domains of Thermus aquaticus Ffh and FtsY,
Acta Crystallogr D Biol Crystallogr 59, 1834-1837

Rosenblad, M. A., Gorodkin, J., Knudsen, B., Zwieb, C., and Samuelsson, T. (2003)
SRPDB: Signal Recognition Particle Database,
Nucleic Acids Res 31, 363-364

Rosendal, K. R., Wild, K., Montoya, G., and Sinning, I. (2003)
Crystal structure of the complete core of archaeal signal recognition particle and implications for interdomain communication,
Proc Natl Acad Sci U S A 100, 14701-14706

San Miguel, M., Marrington, R., Rodger, P. M., Rodger, A., and Robinson, C. (2003)
An Escherichia coli twin-arginine signal peptide switches between helical and unstructured conformations depending on the hydrophobicity of the environment,
Eur J Biochem 270, 3345-3352

Sauer-Eriksson, A. E., and Hainzl, T. (2003)
S-domain assembly of the signal recognition particle,
Curr Opin Struct Biol 13, 64-70

Koch, H. G., Moser, M., and Muller, M. (2003)
Signal recognition particle-dependent protein targeting, universal to all kingdoms of life,
Rev Physiol Biochem Pharmacol 146, 55-94

Beha, D., Deitermann, S., Muller, M., and Koch, H. G. (2003)
Export of beta-lactamase is independent of the signal recognition particle,
J Biol Chem 278, 22161-22167

Mandon, E. C., Jiang, Y., and Gilmore, R. (2003)
Dual recognition of the ribosome and the signal recognition particle by the SRP receptor during protein targeting to the endoplasmic reticulum,
J Cell Biol 162, 575-585

Schwartz, T., and Blobel, G. (2003)
Structural basis for the function of the beta subunit of the eukaryotic signal recognition particle receptor,
Cell 112, 793-803

Frasz, C., and Arvidson, C. G. (2003)
Role for both DNA and RNA in GTP Hydrolysis by the Neisseria gonorrhoeae Signal Recognition Particle Receptor,
J Bacteriol 185, 801-808

Moll, R. G. (2003)
Protein-protein, protein-RNA and protein-lipid interactions of signal-recognition particle components in the hyperthermoacidophilic archaeon Acidianus ambivalens,
Biochem J 374, 247-254

Lerner, R. S., Seiser, R. M., Zheng, T., Lager, P. J., Reedy, M. C., Keene, J. D., and Nicchitta, C. V. (2003)
Partitioning and translation of mRNAs encoding soluble proteins on membrane-bound ribosomes,
Rna 9, 1123-1137

Peterson, J. H., Woolhead, C. A., and Bernstein, H. D. (2003)
Basic amino acids in a distinct subset of signal peptides promote interaction with the signal recognition particle,
J Biol Chem 278, 46155-46162

Gu, S. Q., Peske, F., Wieden, H. J., Rodnina, M. V., and Wintermeyer, W. (2003)
The signal recognition particle binds to protein L23 at the peptide exit of the Escherichia coli ribosome,
Rna 9, 566-573

Cochrane, J. C., Batey, R. T., and Strobel, S. A. (2003)
Quantitation of free energy profiles in RNA-ligand interactions by nucleotide analog interference mapping,
Rna 9, 1282-1289

Li, Y., Cole, K., and altman, S. (2003)
The effect of a single, temperature-sensitive mutation on global gene expression in Escherichia coli,
Rna 9, 518-532

Zwieb, C. (2003)
Signal recognition particle-mediated protein targeting,
Recent Res Develop Mol Biol 1, 205-224

Liu, L., Ben-Shlomo, H., Xu, Y. X., Stern, M. Z., Goncharov, I., Zhang, Y., and Michaeli, S. (2003)
The trypanosomatid signal recognition particle consists of two RNA molecules, a 7SL RNA homologue and a novel tRNA-like molecule,
J Biol Chem 278, 18271-18280

Tyedmers, J., Lerner, M., Wiedmann, M., Volkmer, J., and Zimmermann, R. (2003)
Polypeptide-binding proteins mediate completion of co-translational protein translocation into the mammalian endoplasmic reticulum,
EMBO Rep 4, 505-510

Shepotinovskaya, I. V., and Freymann, D. M. (2002)
Conformational change of the N-domain on formation of the complex between the GTPase domains of Thermus aquaticus Ffh and FtsY,
Biochim Biophys Acta 1597,107-114

Liu, L., Liang, X. H., Uliel, S., Unger, R., Ullu, E., and Michaeli, S. (2002)
RNA interference of signal peptide-binding protein SRP54 elicits deleterious effects and protein sorting defects in trypanosomes,
J Biol Chem 277, 47348-47357

Tozik, I., Huang, Q., Zwieb, C., and Eichler, J. (2002)
Reconstitution of the signal recognition particle of the halophilic archaeon Haloferax volcanii,
Nucleic Acids Res 30, 4166-4175

Batey, R. T., and Doudna, J. A. (2002)
Structural and energetic analysis of metal ions essential to SRP signal recognition domain assembly,
Biochemistry 41, 11703-11710

Avdeeva, O. N., Myasnikov, A. G., Sergiev, P. V., Bogdanov, A. A., Brimacombe, R., and Dontsova, O. A. (2002)
Construction of the 'minimal' SRP that interacts with the translating ribosome but not with specific membrane receptors in Escherichia coli,
FEBS Lett 514, 70-73

Oubridge, C., Kuglstatter, A., Jovine, L., and Nagai, K. (2002)
Crystal structure of SRP19 in complex with the S domain of SRP RNA and its implication for the assembly of the signal recognition particle,
Mol Cell 9, 1251-1261

Pakhomova, O. N., Deep, S., Huang, Q., Zwieb, C., and Hinck, A. P. (2002)
Solution structure of protein SRP19 of Archaeoglobus fulgidus signal recognition particle,
J Mol Biol 317, 145-158

Wild, K., Weichenrieder, O., Strub, K., Sinning, I., and Cusack, S. (2002)
Towards the structure of the mammalian signal recognition particle,
Curr Opin Struct Biol 12, 72-81

Hainzl, T., Huang, S., and Sauer-Eriksson, A. E. (2002)
Structure of the SRP19 RNA complex and implications for signal recognition particle assembly,
Nature 417, 767-771

Herskovits, A. A., Shimoni, E., Minsky, A., and Bibi, E. (2002)
Accumulation of endoplasmic membranes and novel membrane-bound ribosome-signal recognition particle receptor complexes in Escherichia coli,
J Cell Biol 159, 403-410

Politz, J. C., Lewandowski, L. B., and Pederson, T. (2002)
Signal recognition particle RNA localization within the nucleolus differs from the classical sites of ribosome synthesis,
J Cell Biol 159, 411-418

Pool, M. R., Stumm, J., Fulga, T. A., Sinning, I., and Dobberstein, B. (2002)
Distinct modes of signal recognition particle interaction with the ribosome,
Science 297, 1345-1348

Kuglstatter, A., Oubridge, C., and Nagai, K. (2002)
Induced structural changes of 7SL RNA during the assembly of human signal recognition particle,
Nat Struct Biol 9, 740-744

Ramirez, U. D., Minasov, G., Focia, P. J., Stroud, R. M., Walter, P., Kuhn, P., and Freymann, D. M. (2002)
Structural basis for mobility in the 1.1 A crystal structure of the NG domain of Thermus aquaticus Ffh,
J Mol Biol 320, 783-799

Regalia, M., Rosenblad, M. A., and Samuelsson, T. (2002)
Prediction of signal recognition particle RNA genes,
Nucleic Acids Res 30, 3368-3377

Caetano-Anolles, G. (2002)
Evolved RNA secondary structure and the rooting of the universal tree of life,
J Mol Evol 54, 333-345

Rinke-Appel, J., Osswald, M., von Knoblauch, K., Mueller, F., Brimacombe, R., Sergiev, P., Avdeeva, O., Bogdanov, A., and Dontsova, O. (2002)
Crosslinking of 4.5S RNA to the Escherichia coli ribosome in the presence or absence of the protein Ffh,
RNA 8, 612-625

Brunelli, C. A., O'Connor, M., and Dahlberg, A. E. (2002)
Decreased requirement for 4.5S RNA in 16S and 23S rRNA mutants of Escherichia coli,
FEBS Lett 514, 44-48

Padmanabhan, S., and Freymann, D. M. (2001)
The conformation of bound GMPPNP suggests a mechanism for gating the active site of the SRP GTPase,
Structure 9, 859-867

Dean, K. A., von Ahsen, O., Gorlich, D., and Fried, H. M. (2001)
Signal recognition particle protein 19 is imported into the nucleus by importin 8 (RanBP8) and transportin,
J Cell Sci 114, 3479-3485

Perumal, K., Sinha, K., Henning, D., and Reddy, R. (2001)
Purification, characterization, and cloning of the cDNA of human signal recognition particle RNA 3'-adenylating enzyme,
J Biol Chem 276, 21791-21796

Yang, C. H., and Zwieb, C. (2001)
Swapping of functional domains using a chimeric monster deletion mutagenesis strategy,
Biotechniques 31, 724-728

Grosshans, H., Deinert, K., Hurt, E., and Simos, G. (2001)
Biogenesis of the signal recognition particle (SRP) involves import of SRP proteins into the nucleolus, assembly with the SRP-RNA, and Xpo1p-mediated export,
J Cell Biol 153, 745-762

Yin, J., Yang, C. H., and Zwieb, C. (2001)
Assembly of human signal recognition particle (SRP): overlap of regions required for binding of protein SRP54 and assembly control,
RNA 7, 1389-1396

Herskovits, A. A., Seluanov, A., Rajsbaum, R., ten Hagen-Jongman, C. M., Henrichs, T., Bochkareva, E. S., Phillips, G. J., Probst, F. J., Nakae, T., Ehrmann, M., Luirink, J., and Bibi, E. (2001)
Evidence for coupling of membrane targeting and function of the signal recognition particle (SRP) receptor FtsY,
EMBO Rep 2, 1040-1046

Beckmann, R., Spahn, C. M., Eswar, N., Helmers, J., Penczek, P. A., Sali, A., Frank, J., and Blobel, G. (2001)
Architecture of the protein-conducting channel associated with the translating 80S ribosome,
Cell 107, 361-372

Jagath, J. R., Matassova, N. B., de Leeuw, E., Warnecke, J. M., Lentzen, G., Rodnina, M. V., Luirink, J., and Wintermeyer, W. (2001)
Important role of the tetraloop region of 4.5S RNA in SRP binding to its receptor FtsY,
RNA 7, 293-301

Maeshima, H., Okuno, E., Aimi, T., Morinaga, T., and Itoh, T. (2001)
An archaeal protein homologous to mammalian SRP54 and bacterial Ffh recognizes a highly conserved region of SRP RNA,
FEBS Lett 507, 336-340

Keenan, R. J., Freymann, D. M., Stroud, R. M., and Walter, P. (2001)
The Signal Recognition Particle,
Annu Rev Biochem 70, 755-775

Driessen, A. J., Manting, E. H., and van der Does, C. (2001)
The structural basis of protein targeting and translocation in bacteria,
Nat Struct Biol 8, 492-498

Bhuiyan, S. H., Pakhomova, O. N., Hinck, A. P., and Zwieb, C. (2001)
Complexes with truncated RNAs from the large domain of Archaeoglobus fulgidus signal recognition particle,
FEMS Microbiol Lett 198, 105-110

Ring, G., and Eichler, J. (2001)
Characterization of inverted membrane vesicles from the halophilic archaeon Haloferax volcanii,
J Membr Biol 183, 195-204

Rose, M. A., and Weeks, K. M. (2001)
Visualizing induced fit in early assembly of the human signal recognition particle,
Nat Struct Biol 8, 515-520.

Fulga, T. A., Sinning, I., Dobberstein, B., and Pool, M. R. (2001)
SRbeta coordinates signal sequence release from SRP with ribosome binding to the translocon,
Embo J 20, 2338-2347

Gorodkin, J., Knudsen, B., Zwieb, C., and Samuelsson, T. (2001)
SRPDB (Signal Recognition Particle Database),
Nucleic Acids Research 1, 169-170

Pakhomova, O. N., Cui, Y., Zwieb, C., and Hinck, A. P. (2001)
Sequence-specific 1H, 13C and 15N signal assignments and secondary structure of archaeoglobusfulgidus SRP19,
J Biomol NMR 20, 187-188

Wild, K., Sinning, I., and Cusack, S. (2001)
Crystal structure of an early protein-RNA assembly complex of the signal recognition particle,
Science 294, 598-601

Peluso, P., Shan, S. O., Nock, S., Herschlag, D., and Walter, P. (2001)
Role of SRP RNA in the GTPase cycles of Ffh and FtsY,
Biochemistry 40, 15224-15233

Peluso, P., Herschlag, D., Nock, S., Freymann, D. M., Johnson, A. E., and Walter, P. (2000)
Role of 4.5S RNA in assembly of the bacterial signal recognition particle with its receptor,
Science 288, 1640-1643

Neumann-Haefelin, C., Schafer, U., Muller, M., and Koch, H. G. (2000)
SRP-dependent co-translational targeting and SecA-dependent translocation analyzed as individual steps in the export of a bacterial protein,
Embo J 19, 6419-626.

Legate, K. R., Falcone, D., and Andrews, D. W. (2000)
Nucleotide-dependent binding of the GTPase domain of the signal recognition particle receptor beta-subunit to the alpha-subunit,
J Biol Chem 275, 27439-27446

Mason, N., Ciufo, L. F., and Brown, J. D. (2000)
Elongation arrest is a physiologically important function of signal recognition particle,
EMBO J 19, 4164-4174.

Batey, R. T., Rambo, R. P., Lucast, L., Rha, B., and Doudna, J. A. (2000)
Crystal structure of the ribonucleoprotein core of the signal recognition particle,
Science 287, 1232-1239

Politz, J. C., Yarovoi, S., Kilroy, S. M., Gowda, K., Zwieb, C., and Pederson, T. (2000)
Signal Recognition Particle Components in the Nucleolus,
Proc Natl Acad Sci U S A 97, 55-60

Bhuiyan, S. H., Gowda, K., Hotokezaka, H., and Zwieb, C. (2000)
Assembly of archaeal signal recognition particle from recombinant components,
Nucleic Acids Research 28, 1365-1373

Rupert, P. B., and Ferre-D'amare A, R. (2000)
SRPrises in RNA-protein recognition,
Structure Fold Des 8, R99-104

Chin, C. N., and von Heijne, G. (2000)
Charge pair interactions in a model transmembrane helix in the ER membrane,
J Mol Biol 303, 1-5

Herskovits, A. A., and Bibi, E. (2000)
Association of Escherichia coli ribosomes with the inner membrane requires the signal recognition particle receptor but is independent of the signal recognition particle,
Proc Natl Acad Sci U S A 97, 4621-4626.

Herskovits, A. A., Bochkareva, E. S., and Bibi, E. (2000)
New prospects in studying the bacterial signal recognition particle pathway,
Mol Microbiol 38, 927-939

Montoya, G., Kaat, K., Moll, R., Schafer, G., and Sinning, I. (2000)
The crystal structure of the conserved GTPase of SRP54 from the archaeon Acidianus ambivalens and its comparison with related structures suggests a model for the SRP-SRP receptor complex,
Structure Fold Des 8, 515-525

Jovine, L., Hainzl, T., Oubridge, C., Scott, W. G., Li, J., Sixma, T. K., Wonacott, A., Skarzynski, T., and Nagai, K. (2000)
Crystal structure of the ffh and EF-G binding sites in the conserved domain IV of Escherichia coli 4.5S RNA,
Structure Fold Des 8, 527-540

Eichler, J. (2000)
Archaeal protein translocation,
Eur J Biochem 267, 3402-3412.

Walter, P., Keenan, R., and Schmitz, U. (2000)
Perspectives: structural biology. SRP--where the RNA and membrane worlds meet,
Science 287, 1212-123.

Zwieb, C., and Samuelsson, T. (2000)
SRPDB (Signal Recognition Particle Database),
Nucleic Acids Research 28, 171-172

Diener, J. L., and Wilson, C. (2000)
Role of SRP19 in assembly of the archaeoglobus fulgidus signal recognition particle,
Biochemistry 39, 12862-12874

Jovine, L., Hainzl, T., Oubridge, C., and Nagai, K. (2000)
Crystallization and preliminary X-ray analysis of the conserved domain IV of Escherichia coli 4.5S RNA. erratum,
Acta Crystallogr D Biol Crystallogr 56, 1512

Weichenrieder, O., Wild, K., Strub, K., and Cusack, S. (2000)
Structure and assembly of the Alu domain of the mammalian signal recognition particle,
Nature 408, 167-73.

Suzuma, S., Hayashi, K., Nakamura, K., and Yamane, K. (1999)
Analysis of Escherichia coli 4.5S RNA binding affinity to Ffh and EF-G,
FEMS Microbiol Lett 180, 271-277

Bacher, G., Pool, M., and Dobberstein, B. (1999)
The ribosome regulates the GTPase of the beta-subunit of the signal recognition particle receptor,
J Cell Biol 146, 723-730

Freymann, D. M., Keenan, R. J., Stroud, R. M., and Walter, P. (1999)
Functional changes in the structure of the SRP GTPase on binding GDP and Mg2+GDP,
Nat Struct Biol 6, 793-801

Nakamura, K., Yahagi, S., Yamazaki, T., and Yamane, K. (1999)
Bacillus subtilis histone-like protein, HBsu, is an integral component of a SRP-like particle that can bind the Alu domain of small cytoplasmic RNA,
J Biol Chem 274, 13569-13576

Amin, P., Sy, D. A., Pilgrim, M. L., Parry, D. H., Nussaume, L., and Hoffman, N. E. (1999)
Arabidopsis mutants lacking the 43- and 54-kilodalton subunits of the chloroplast signal recognition particle have distinct phenotypes [In Process Citation],
Plant Physiol 121, 61-70

Moll, R., Schmidtke, S., and Schafer, G. (1999)
Domain structure, GTP-hydrolyzing activity and 7S RNA binding of Acidianus ambivalens ffh-homologous protein suggest an SRP-like complex in archaea,
Eur J Biochem 259, 441-448

Clemons, W. M., Jr., Gowda, K., Black, S. D., Zwieb, C., and Ramakrishnan, V. (1999)
Crystal Structure of the Conserved Subdomain of Human Protein SRP54M at 2.1 Å Resolution: Evidence for the Mechanism of Signal Peptide Binding,
J Mol Biol 292, 697-705

Sinha, K., Perumal, K., Chen, Y., and Reddy, R. (1999)
Post-transcriptional adenylation of signal recognition particle RNA is carried out by an enzyme different from mRNA Poly(A) polymerase [In Process Citation],
J Biol Chem 274, 30826-30831

Newitt, J. A., Ulbrandt, N. D., and Bernstein, H. D. (1999)
The structure of multiple polypeptide domains determines the signal recognition particle targeting requirement of Escherichia coli inner membrane proteins,
J Bacteriol 181, 4561-4567

Stirling, C. J. (1999)
Protein targeting to the endoplasmic reticulum in yeast. 1997 Fleming Lecture,
Microbiology 145, 991-998

Cristobal, S., Scotti, P., Luirink, J., von Heijne, G., and de Gier, J. W. (1999)
The signal recognition particle-targeting pathway does not necessarily deliver proteins to the sec-translocase in Escherichia coli,
J Biol Chem 274, 20068-20070

Dalbey, R. E., and Robinson, C. (1999)
Protein translocation into and across the bacterial plasma membrane and the plant thylakoid membrane,
Trends Biochem Sci 24, 17-22

Strub, K., Fornallaz, M., and Bui, N. (1999)
The Alu domain homolog of the yeast signal recognition particle consists of an Srp14p homodimer and a yeast-specific RNA structure,
RNA 5, 1333-1347

Tu, C. J., Schuenemann, D., and Hoffman, N. E. (1999)
Chloroplast FtsY, chloroplast signal recognition particle, and GTP are required to reconstitute the soluble phase of light-harvesting chlorophyll protein transport into thylakoid membranes,
J Biol Chem 274, 27219-27224

Nielsen, H., Brunak, S., and von Heijne, G. (1999)
Machine learning approaches for the prediction of signal peptides and other protein sorting signals,
Protein Eng 12, 3-9.

Marley, J. J., Phenix, K. V., Irwin, C. R., Thompson, J., Robinson, P. A., and Linden, G. J. (1999)
Signal recognition particle receptor (SRPR) is downregulated in a rat model of cyclosporin A-induced gingival overgrowth,
J Periodontal Res 34, 188-196

Gowda, K., Clemons, W. M., Jr., Zwieb, C., and Black, S. D. (1999)
Expression, purification, and crystallography of the conserved methionine-rich domain of human signal recognition particle 54 kDa protein,
Protein Sci 8, 1144-1151

Wild, K., Weichenrieder, O., Leonard, G. A., and Cusack, S. (1999)
The 2 A structure of helix 6 of the human signal recognition particle RNA,
Structure Fold Des 7, 1345-1352.

Arvidson, C. G., Powers, T., Walter, P., and So, M. (1999)
Neisseria gonorrhoeae PilA is an FtsY homolog,
J Bacteriol 181, 731-739

Blatch, G. L., and Lassle, M. (1999)
The tetratricopeptide repeat: a structural motif mediating protein-protein interactions,
Bioessays 21, 932-939

Boisrame, A., Beckerich, J. M., and Gaillardin, C. (1999)
A mutation in the secretion pathway of the yeast Yarrowia lipolytica that displays synthetic lethality in combination with a mutation affecting the signal recognition particle,
Mol Gen Genet 261, 601-609

Brinkmann, H., and Philippe, H. (1999)
Archaea sister group of Bacteria? Indications from tree reconstruction artifacts in ancient phylogenies,
Mol Biol Evol 16, 817-825

Samuelsson, T., and Zwieb, N. (1999)
The Signal Recognition Particle Database (SRPDB),
Nucleic Acids Research 27, 169-170

Bui, N., and Strub, K. (1999)
New insights into signal recognition and elongation arrest activities of the signal recognition particle,
Biol Chem 380, 135-145

Schmitz, U., Behrens, S., Freymann, D. M., Keenan, R. J., Lukavsky, P., Walter, P., and James, T. L. (1999)
Structure of the phylogenetically most conserved domain of SRP RNA,
RNA 5, 1419-1429

Schmitz, U., James, T. L., Lukavsky, P., and Walter, P. (1999)
Structure of the most conserved internal loop in SRP RNA,
Nat Struct Biol 6, 634-638.

Scotti, P. A., Valent, Q. A., Manting, E. H., Urbanus, M. L., Driessen, A. J., Oudega, B., and Luirink, J. (1999)
SecA is not required for signal recognition particle-mediated targeting and initial membrane insertion of a nascent inner membrane protein,
J Biol Chem 274, 29883-29888

Valent, Q. A., Scotti, P. A., High, S., de Gier, J. W., von Heijne, G., Lentzen, G., Wintermeyer, W., Oudega, B., and Luirink, J. (1998)
The Escherichia coli SRP and SecB targeting pathways converge at the translocon,
Embo J 17, 2504-212.

von Heijne, G. (1998)
Life and death of a signal peptide,
Nature 396, 111, 113

Larsen, N., Samuelsson, T., and Zwieb, N. (1998)
The Signal Recognition Particle Database (SRPDB),
Nucleic Acids Research 26, 179-180

Gowda, K., Black, S. D., Moeller, I., Sakakibara, Y., Liu, M.-C., and Zwieb, C. (1998)
Protein SRP54 of human signal recognition particle: cloning, expression, and comparative analysis of functional sites,
Gene 207, 197-207

Gribaldo, S., and Cammarano, P. (1998)
The root of the universal tree of life inferred from anciently duplicated genes encoding components of the protein-targeting machinery,
J Mol Evol 47, 508-516

Plath, K., Mothes, W., Wilkinson, B. M., Stirling, C. J., and Rapoport, T. A. (1998)
Signal sequence recognition in posttranslational protein transport across the yeast ER membrane,
Cell 94, 795-807

Matoba, S., and Ogrydziak, D. M. (1998)
Another factor besides hydrophobicity can affect signal peptide interaction with signal recognition particle,
J Biol Chem 273, 18841-18847

Beckerich, J. M., Boisrame-Baudevin, A., and Gaillardin, C. (1998)
Yarrowia lipolytica: a model organism for protein secretion studies,
Int Microbiol 1, 123-130

Jacobson, M. R., and Pederson, T. (1998)
Localization of signal recognition particle RNA in the nucleolus of mammalian cells,
Proc Natl Acad Sci U S A 95, 7981-7986

Keenan, R. J., Freymann, D. M., Walter, P., and Stroud, R. M. (1998)
Crystal structure of the signal sequence binding subunit of the signal recognition particle,
Cell 94, 181-191

Schuenemann, D., Gupta, S., Persello-Cartieaux, F., Klimyuk, V. V., Jones, J. D. G., Nussaume, L., and Hoffman, N. E. (1998)
A novel signal recognition particle targets light-harvesting proteins to the thylakoid membranes,
Proc Natl Acad Sci U S A 95, 10312-10316

Chen, Y., Sinha, K., Perumal, K., Gu, J., and Reddy, R. (1998)
Accurate 3' end processing and adenylation of human signal recognition particle RNA and alu RNA in vitro,
J Biol Chem 273, 35023-35031

Ulbrandt, N. D., Newitt, J. A., and Bernstein, H. D. (1997)
The E. coli signal recognition particle is required for the insertion of a subset of inner membrane proteins,
Cell 88, 187-196

Millman, J. S., and Andrews, D. W. (1997)
Switching the model: a concerted mechanism for GTPases in protein targeting,
Cell 89, 673-676

Freymann, D. M., Keenan, R. J., Stroud, R. M., and Walter, P. (1997)
Structure of the conserved GTPase domain of the signal recognition particle,
Nature 385, 361-364

Weichenrieder, O., Kapp, U., Cusack, S., and Strub, K. (1997)
Identification of a minimal Alu RNA folding domain that specifically binds SRP9/14,
RNA 3, 1262-174.

Moll, R., Schmidtke, S., Petersen, A., and Schafer, G. (1997)
The signal recognition particle receptor alpha subunit of the hyperthermophilic archaeon Acidianus ambivalens exhibits an intrinsic GTP-hydrolyzing activity,
Biochim Biophys Acta 1335, 218-230

Gowda, K., and Zwieb, C. (1997)
Determinants of a protein-induced RNA switch in the large domain of signal recognition particle identified by systematic site-directed mutagenesis,
Nucleic Acids Research 25, 2835-2840

Wilkinson, B. M., Regnacq, M., and Stirling, C. J. (1997)
Protein translocation across the membrane of the endoplasmic reticulum,
Journal of Membrane Biology 155, 189-197

Winzeler, E., Wheeler, R., and Shapiro, L. (1997)
Transcriptional analysis of the Caulobacter 4.5 S RNA ffs gene and the physiological basis of an ffs mutant with a Ts phenotype,
J Mol Biol 272, 665-676

Gowda, K., Chittenden, K., and Zwieb, C. (1997)
Binding site of the M-domain of human protein SRP 54 determined by systematic site directed mutagenesis of signal recognition particle RNA,
Nucleic Acids Research 25, 388-394

Montoya, G., Svennssom, C., Luirink, J., and Sinning, I. (1997)
Crystal structure of the NG domain from the signal-recognition particle receptor FtsY,
Nature 385, 365-368

Zelazny, A., Seluanov, A., Cooper, A., and Bibi, E. (1997)
The NG domain of the prokaryotic signal recognition particle receptor, FtsY, is fully functional when fused to an unrelated integral membrane polypeptide,
Proc Natl Acad Sci U S A 94, 6025-6029

Zheng, N., and Gierasch, L. M. (1997)
Domain interactions in E. coli SRP: stabilization of M domain by RNA is required for effective signal sequence modulation of NG domain,
Mol Cell 1, 79-87

Henry, K. A., Zwieb, C., and Fried, H. M. (1997)
Purification and biochemical characterization of the 19-kDa Signal Recognition Particle RNA-binding protein expressed as a hexahistidine-tagged polypeptide in Escherichia coli,
Protein Expression and Purification 9, 15-26

Zwieb, C., Gowda, K., Larsen, N. and Müller, F. (1997) Comparative modeling of the three-dimensional structure of signal recognition particle RNA ACS Symposium Series, in 682 (Leontis, N. B. S. L., J. Jr, Ed.) pp 405-413, American Chemical Society, Washington, DC.
Moser, C., Mol, O., Goody, R. S., and Sinning, I. (1997)
The signal recognition particle receptor of Escherichia coli (FtsY) has a nucleotide exchange factor built into the GTPase domain,
Proc Natl Acad Sci U S A 94, 11339-1144.

Lai, C., and Langley, C. H. (1997)
A homologue of the 19 kDa signal recognition particle protein locus in Drosophila melanogaster,
Gene 203, 59-63

Nielsen, H., Engelbrecht, J., Brunak, S., and von Heijne, G. (1997)
A neural network method for identification of prokaryotic and eukaryotic signal peptides and prediction of their cleavage sites,
Int J Neural Syst 8, 581-99.

Pohlschroder, M., Prinz, W. A., Hartmann, E., and Beckwith, J. (1997)
Protein translocation in the three domains of life: variations on a theme,
Cell 91, 563-56.

Chittenden, K., Gowda, K., Black, S. D., and Zwieb, C. (1997)
Interaction of rice and human SRP19 polypeptides with signal recognition particle RNA,
Plant Mol Biol 34, 507-515

Beckmann, R., Bubeck, D., Grassucci, R., Penczek, P., Verschoor, A., Blobel, G., and Frank, J. (1997)
Alignment of conduits for the nascent polypeptide chain in the ribosome-Sec61 complex,
Science 278, 2123-2126

Ben-Shlomo, H., Levitan, A., Beja, O., and Michaeli, S. (1997)
The trypanosomatid Leptomonas collosoma 7SL RNA gene. Analysis of elements controlling its expression,
Nucleic Acids Res 25, 4977-4984

Birse, D. E., Kapp, U., Strub, K., Cusack, S., and Aberg, A. (1997)
The crystal structure of the signal recognition particle Alu RNA binding heterodimer, SRP9/14,
Embo J 16, 3757-3766

Black, S. D., Gowda, K., Chittenden, K., Walker, K. P., 3rd, and Zwieb, C. (1997)
Identification of an RNA-binding-loop in the N-terminal region of signal-recognition-particle protein SRP19,
Eur J Biochem 245, 564-572

Ronimus, R. S., and Musgrave, D. R. (1997)
Identification of a gene in the euryarchaeal Thermococcus species AN1 encoding a protein homologous to the alpha subunit of the eukaryal signal recognition particle (SRP) receptor,
Biochim Biophys Acta 1351, 1-8

Chang, D. Y., Newitt, J. A., Hsu, K., Bernstein, H. D., and Maraia, R. J. (1997)
A highly conserved nucleotide in the Alu domain of SRP RNA mediates translation arrest through high affinity binding to SRP9/14,
Nucleic Acids Res 25, 1117-1122

Nielsen, H., Engelbrecht, J., Brunak, S., and von Heijne, G. (1997)
Identification of prokaryotic and eukaryotic signal peptides and prediction of their cleavage sites,
Protein Eng 10, 1-6.

Moll, R., Schmidtke, S., and Schaefer, G. (1996)
A putative signal recognition particle receptor alpha subunit (SR alpha) homologue is expressed in the hyperthermophilic crenarchaeon Sulfolobus acidocaldarius,
FEMS Microbiol Lett 137, 51-56

Ng, D. T., Brown, J. D., and Walter, P. (1996)
Signal sequences specify the targeting route to the endoplasmic reticulum membrane,
Journal of Cell Biology 134, 269-278

Andrews, D. W., and Johnson, A. E. (1996)
The translocon: more than a hole in the ER membrane?,
Trends Biochem Sci 21, 365-369

Nielsen, H., Engelbrecht, J., von Heijne, G., and Brunak, S. (1996)
Defining a similarity threshold for a functional protein sequence pattern: the signal peptide cleavage site,
Proteins 24, 165-77.

Bacher, G., Lutcke, H., Jungnickel, B., Rapoport, T. A., and Dobberstein, B. (1996)
Regulation by the ribosome of the GTPase of the signal-recognition particle during protein targeting,
Nature 381, 248-251

Packer, J. C., and Howe, C. J. (1996)
The cyanobacterial genome contains a single copy of the ffh gene encoding a homologue of the 54 kDa subunit of signal recognition particle,
Plant Molecular Biology 30, 659-665

Patel, S., and Austen, B. M. (1996)
Substitution of fifty four homologue (Ffh) in Escherichia coli with the mammalian 54-kDa protein of signal-recognition particle,
European Journal of Biochemistry 238, 760-768

Belin, D., Bost, S., Vassalli, J. D., and Strub, K. (1996)
A two-step recognition of signal sequences determines the translocation efficiency of proteins,
EMBO Journal 15, 468-478

Powers, T., and Walter, P. (1996)
Protein targeting. The ribosome talks back [news; comment],
Nature 381, 191-192

Birse, D. E., Doublie, S., Kapp, U., Strub, K., Cusack, S., and Aberg, A. (1996)
Crystallization and preliminary crystallographic analysis of the signal recognition particle SRPphi14-9 fusion protein,
FEBS Letters 384, 215-218

Riedel, L., Volger, U., Luckinger, R., Putz, A., Sanger, H. L., and Wassenegger, M. (1996)
Molecular analysis of the gene family of the signal recognition particle (SRP) RNA of tomato,
Plant Molecular Biology 31, 113-125

Schmitz, U., Freymann, D. M., James, T. L., Keenan, R. J., Vinayak, R., and Walter, P. (1996)
NMR studies of the most conserved RNA domain of the mammalian signal recognition particle (SRP),
RNA 2, 1213-127.

Shibata, T., Fujii, Y., Nakamura, Y., Nakamura, K., and Yamane, K. (1996)
Identification of protein synthesis elongation factor G as a 4.5 S RNA-binding protein in Escherichia coli,
Journal of Biological Chemistry 271, 13162-13168

de Gier, J. W., Mansournia, P., Valent, Q. A., Phillips, G. J., Luirink, J., and von Heijne, G. (1996)
Assembly of a cytoplasmic membrane protein in Escherichia coli is dependent on the signal recognition particle,
FEBS Lett 399, 307-309

Larsen, N., and Zwieb, C. (1996)
The signal recognition particle database (SRPDB),
Nucleic acids research 24, 80-81

Lentzen, G., Moine, H., Ehresmann, C., Ehresmann, B., and Wintermeyer, W. (1996)
Structure of 4.5S RNA in the signal recognition particle of Escherichia coli as studied by enzymatic and chemical probing,
RNA 2, 244-253

Levine, R. L., Mosoni, L., Berlett, B., and Stadtman, E. R. (1996)
Methionine residues as endogenous antioxidants in proteins,
Procedings of the National Academy of Sciences U.S.A. 93, 15036-15040

Voigt, S., Jungnickel, B., Hartmann, E., and Rapoport, T. A. (1996)
Signal sequence-dependent function of the TRAM protein during early phases of protein transport across the endoplasmic reticulum membrane,
Journal of Cell Biology 134, 25-35

Doublie, S., Kapp, U., Aberg, A., Brown, K., Strub, K., and Cusack, S. (1996)
Crystallization and preliminary X-ray analysis of the 9 kDa protein of the mouse signal recognition particle and the selenomethionyl-SRP9,
FEBS Letters 384, 219-221

Young, J. C., and Andrews, D. W. (1996)
The signal recognition particle receptor alpha subunit assembles co-translationally on the endoplasmic reticulum membrane during an mRNA-encoded translation pause in vitro,
EMBO Journal 15, 172-181

Zheng, N., and Gierasch, L. M. (1996)
Signal sequences: the same yet different,
Cell 86, 849-852

Zwieb, C., Müller, F., and Larsen, N. (1996)
Comparative analysis of tertiary structure elements in signal recognition particle RNA,
Folding & Design 1, 315-324

Kurita, K., Honda, K., Suzuma, S., Takamatsu, H., Nakamura, K., and Yamane, K. (1996)
Identification of a region of Bacillus subtilis Ffh, a homologue of mammalian SRP54 protein, that is essential for binding to small cytoplasmic RNA,
Journal of Biological Chemistry 271, 13140-13146

Miller, J. D., Tajima, S., Lauffer, L., and Walter, P. (1995)
The beta subunit of the signal recognition particle receptor is a transmembrane GTPase that anchors the alpha subunit, a peripheral membrane GTPase, to the endoplasmic reticulum membrane,
Journal of Cell Biology 128, 273-282

Walker, P. K., Black, S. D., and Zwieb, C. (1995)
Cooperative assembly of signal recognition particle RNA with protein SRP19,
Biochemistry 34, 11989-11997

Watson, B. S., Hazlett, T. L., Eccleston, J. F., Davis, C., Jameson, D. M., and Johnson, A. E. (1995)
Macromolecular arrangement in the aminoacyl-tRNA.elongation factor Tu.GTP ternary complex. A fluorescence energy transfer study,
Biochemistry 34, 7904-7912

Wickner, W. (1995)
The nascent-polypeptide-associated complex: having a "NAC" for fidelity in translocation [comment],
Proc Natl Acad Sci U S A 92, 9433-9434

Young, J. C., Ursini, J., Legate, K. R., Miller, J. D., Walter, P., and Andrews, D. W. (1995)
An amino-terminal domain containing hydrophobic and hydrophilic sequences binds the signal recognition particle receptor alpha subunit to the beta subunit on the endoplasmic reticulum membrane,
Journal of Biological Chemistry 270, 15650-15657

Kusters, R., Lentzen, G., Eppens, E., van Geel, A., van der Weijden, C. C., Wintermeyer, W., and Luirink, J. (1995)
The functioning of the SRP receptor FtsY in protein-targeting in E. coli is correlated with its ability to bind and hydrolyse GTP,
FEBS Letters 372, 253-258

Nakamura, K., Hashizume, E., Shibata, T., Nakamura, Y., Mala, S., and Yamane, K. (1995)
Small cytoplasmic RNA (scRNA) gene from Clostridium perfringens can replace the gene for the Bacillus subtilis scRNA in both growth and sporulation,
Microbiology 141, 2965-2975

Lauring, B., Kreibich, G., and Wiedmann, M. (1995)
The intrinsic ability of ribosomes to bind to endoplasmic reticulum membranes is regulated by signal recognition particle and nascent-polypeptide-associated complex [see comments],
Proc Natl Acad Sci U S A 92, 9435-9439

Lauring, B., Sakai, H., Kreibich, G., and Wiedmann, M. (1995)
Nascent polypeptide-associated complex protein prevents mistargeting of nascent chains to the endoplasmic reticulum [published erratum appears in Proc Natl Acad Sci U S A 1995 Aug 15;92(17):8088],
Proc Natl Acad Sci U S A 92, 5411-5415

Li, X., Henry, R., Yuan, J., Cline, K., and Hoffman, N. E. (1995)
A chloroplast homologue of the signal recognition particle subunit SRP54 is involved in the posttranslational integration of a protein into thylakoid membranes,
Proceedings of the National Academy of Sciences of U.S.A 92, 3789-3793

Lyko, F., Martoglio, B., Jungnickel, B., Rapoport, T. A., and Dobberstein, B. (1995)
Signal sequence processing in rough microsomes,
Journal of Biological Chemistry 270, 19873-19878

Lütcke, H. (1995)
Signal recognition particle (SRP), a ubiquitous initiator of protein translocation,
Eur J Biochem 228, 531-550

Macfarlane, J., and Muller, M. (1995)
The functional integration of a polytopic membrane protein of Escherichia coli is dependent on the bacterial signal-recognition particle,
European Journal of Biochemistry 233, 766-771

McNair, A., Zemzoumi, K., Lutcke, H., Guillerm, C., Boitelle, A., Capron, A., and Dissous, C. (1995)
Cloning of a signal-recognition-particle subunit of Schistosoma mansoni,
Parasitology Research 81, 175-177

Ogg, S. C., and Walter, P. (1995)
SRP samples nascent chains for the presence of signal sequences by interacting with ribosomes at a discrete step during translation elongation,
Cell 81, 1075-1084

Persson, B. C., Bylund, G. O., Berg, D. E., and Wikstrom, P. M. (1995)
Functional analysis of the ffh-trmD region of the Escherichia coli chromosome by using reverse genetics,
J Bacteriol 177, 5554-5560

Powers, T., and Walter, P. (1995)
Reciprocal stimulation of GTP hydrolysis by two directly interacting GTPases,
Science 269, 1422-1424

Riedel, L., Putz, A., Hauser, M. T., Luckinger, R., Wassenegger, M., and Sanger, H. L. (1995)
Characterization of the signal recognition particle (SRP) RNA population of tomato (Lycopersicon esculentum),
Plant Mol Biol 27, 669-680

Samuelsson, T., Olsson, M., Wikstrom, P. M., and Johansson, B. R. (1995)
The GTPase activity of the Escherichia coli Ffh protein is important for normal growth,
Biochimica et Biophysica Acta 1267, 83-91

Brown, J. D., Hann, B. C., Medzihradszky, K. F., Niwa, M., Burlingame, A. L., and Walter, P. (1994)
Subunits of the Saccharomyces cerevisiae signal recognition particle required for its functional expression,
EMBO J 13, 4390-4400

Chittenden, K., Black, S. D., and Zwieb, C. (1994)
Systematic site-directed mutagenesis of protein SRP19: identification of the residues essential for binding to signal recognition particle RNA,
Journal of Biological Chemistry 269, 20497-20502

Choquet, C. G., Patel, G. B., Beveridge, T. J., and Sprott, G. D. (1994)
Stability of pressure-extruded liposomes made from archaeobacterial ether lipids,
Appl Microbiol Biotechnol 42, 375-84.

Chu, B., Lindstrom, J. T., and Belanger, F. C. (1994)
Arabidopsis thaliana expresses three divergent Srp54 genes,
Plant Physiol 106, 1157-1162

Crowley, K. S., Liao, S., Worrell, V. E., Reinhart, G. D., and Johnson, A. E. (1994)
Secretory proteins move through the endoplasmic reticulum membrane via an aqueous, gated pore,
Cell 78, 461-471

Czarnota, G. J., Andrews, D. W., Farrow, N. A., and Ottensmeyer, F. P. (1994)
A structure for the signal sequence binding protein SRP54: 3D reconstruction from STEM images of single molecules,
Journal of Structural Biology 113, 35-46

Dobberstein, B. (1994)
Protein transport. On the beaten pathway [news; comment],
Nature 367, 599-600

Althoff, S. M., Stevens, S. W., and Wise, J. A. (1994)
The SRP54 GTPase is essential for protein export in the fission yeast Schizosaccharomyces pombe,
Molecular & Cellular Biology 14, 7839-7854

Althoff, S., Selinger, D., and Wise, J. A. (1994)
Molecular evolution of SRP cycle components: functional implications,
Nucleic Acids Res 22, 1933-1947

He, X. P., Bataille, N., and Fried, H. M. (1994)
Nuclear export of signal recognition particle RNA is a facilitated process that involves the Alu sequence domain,
Journal of Cell Science 107, 903-912

Jensen, C. G., and Pedersen, S. (1994)
Concentrations of 4.5S RNA and Ffh protein in Escherichia coli: the stability of Ffh protein is dependent on the concentration of 4.5S RNA,
Journal of Bacteriology 176, 7148-7154

Jensen, C. G., Brown, S., and Pedersen, S. (1994)
Effect of 4.5S RNA depletion on Escherichia coli protein synthesis and secretion,
Journal of Bacteriology 176, 2502-2506

Jones, J. D., and Gierasch, L. M. (1994)
Effect of charged residue substitutions on the membrane-interactive properties of signal sequences of the Escherichia coli LamB protein,
Biophys J 67, 1534-1545

Jung, C., and Zimmermann, R. (1994)
The relationship between size of a presecretory protein and extent of signal-recognition-particle-mediated arrest of its translation,
Biochemical & Biophysical Research Communications 205, 603-611

Lentzen, G., Dobberstein, B., and Wintermeyer, W. (1994)
Formation of SRP-like particles induces a conformational change in E.coli 4.5S RNA,
FEBS Letters 348, 233-238

Luirink, J., and Dobberstein, B. (1994)
Mammalian and Escherichia coli signal recognition particles. [Review],
Molecular Microbiology 11, 9-13

Luirink, J., ten Hagen-Jongman, C. M., van der Weijden, C. C., Oudega, B., High, S., Dobberstein, B., and Kusters, R. (1994)
An alternative protein targeting pathway in Escherichia coli: studies on the role of FtsY,
EMBO Journal 13, 2289-2296

Miller, J. D., Bernstein, H. D., and Walter, P. (1994)
Interaction of E. coli Ffh/4.5S ribonucleoprotein and FtsY mimics that of mammalian signal recognition particle and its receptor [see comments],
Nature 367, 657-659

Walter, P., and Johnson, A. E. (1994)
Signal sequence recognition and protein targeting to the endoplasmic reticulum membrane. [Review],
Annual Review of Cell Biology 10, 87-119

Ng, D. T., and Walter, P. (1994)
Protein translocation across the endoplasmic reticulum. [Review],
Current Opinion in Cell Biology 6, 510-516

Wickner, W. T. (1994)
How ATP drives proteins across membranes [comment],
Science 266, 1197-1198

Wiedmann, B., Sakai, H., Davis, T. A., and Wiedmann, M. (1994)
A protein complex required for signal-sequence-specific sorting and translocation,
Nature 370, 434-440

Wolin, S. L. (1994)
From the elephant to E. coli: SRP-dependent protein targeting. [Review],
Cell 77, 787-790

Zwieb, C. (1994)
Site-directed mutagenesis of signal recognition particle RNA: identification of the nucleotides in helix 8 required for interaction with protein SRP19,
European Journal of Biochemistry 222, 885-890

Nishiguchi, M., Honda, K., Amikura, R., Nakamura, K., and Yamane, K. (1994)
Structural requirements of Bacillus subtilis small cytoplasmic RNA for cell growth, sporulation, and extracellular enzyme production,
Journal of Bacteriology 176, 157-165

Zwieb, C., and Larsen, N. (1994)
The signal recognition particle database (SRPDB),
Nucleic acids research 22, 3483-3487

Nakamura, K., Nishiguchi, M., Honda, K., and Yamane, K. (1994)
The Bacillus subtilis SRP54 homologue, Ffh, has an intrinsic GTPase activity and forms a ribonucleoprotein complex with small cytoplasmic RNA in vivo,
Biochemical & Biophysical Research Communications 199, 1394-1399

Nakamura, K., Nishiguchi, M., Minemura, M., Honda, K., and Yamane, K. (1994)
Small cytoplasmic RNA of Bacillus brevis: transcriptional and phylogenetic analysis,
Microbiology 140, 493-498

Patel, S., and Austen, B. (1994)
The structure of the signal-binding domain of the 54 kDa subunit of signal recognition particle and its role in membrane insertion,
Biochemical Society Transactions 22, 1030-1033

Quentin, Y. (1994)
Emergence of master sequences in families of retroposons derived from 7sl RNA. [Review],
Genetica 93, 203-215

Rapiejko, P. J., and Gilmore, R. (1994)
Signal sequence recognition and targeting of ribosomes to the endoplasmic reticulum by the signal recognition particle do not require GTP,
Molecular Biology of the Cell 5, 887-897

Schlenstedt, G., Zimmermann, M., and Zimmermann, R. (1994)
A stably folded presecretory protein associates with and upon unfolding translocates across the membrane of mammalian microsomes,
FEBS Letters 340, 139-144

Selinger, D., Brennwald, P., althoff, S., Reich, C., Hann, B., Walter, P., and Wise, J. A. (1994)
Genetic and biochemical analysis of the fission yeast
ribonucleoprotein particle containing a homolog of Srp54p,
Nucleic Acids Research 22, 2557-2567

Lindstrom, J. T., Chu, B., and Belanger, F. C. (1993)
Isolation and characterization of an Arabidopsis thaliana gene for the 54 kDa subunit of the signal recognition particle,
Plant Molecular Biology 23, 1265-1272

Wolin, S. L., and Walter, P. (1993)
Discrete nascent chain lengths are required for the insertion of presecretory proteins into microsomal membranes,
Journal of Cell Biology 121, 1211-1219

Zopf, D., Bernstein, H. D., and Walter, P. (1993)
GTPase domain of the 54-kD subunit of the mammalian signal recognition particle is required for protein translocation but not for signal sequence binding,
Journal of Cell Biology 120, 1113-1121

Honda, K., Nakamura, K., Nishiguchi, M., and Yamane, K. (1993)
Cloning and characterization of a Bacillus subtilis gene encoding a homolog of the 54-kilodalton subunit of mammalian signal recognition particle and Escherichia coli Ffh,
Journal of Bacteriology 175, 4885-4894

Johnson, A. E. (1993)
Protein translocation across the ER membrane: a fluorescent light at the end of the tunnel. [Review],
Trends in Biochemical Sciences 18, 456-458

Larsen, N., and Zwieb, C. (1993)
The signal recognition particle database (SRPDB),
Nucleic Acids Res 21, 3019-3020

Lütcke, H., Prehn, S., Ashford, A. J., Remus, M., Frank, R., and Dobberstein, B. (1993)
Assembly of the 68- and 72-kD proteins of signal recognition particle with 7S RNA,
J Cell Biol 121, 977-985

Miller, J. D., and Walter, P. (1993)
A GTPase cycle in initiation of protein translocation across the endoplasmic reticulum membrane. [Review],
Ciba Foundation Symposium 176, 147-59; discussion 159-63

Miller, J. D., Wilhelm, H., Gierasch, L., Gilmore, R., and Walter, P. (1993)
GTP binding and hydrolysis by the signal recognition particle during initiation of protein translocation,
Nature 366, 351-354

Bernstein, H. D., Zopf, D., Freymann, D. M., and Walter, P. (1993)
Functional substitution of the signal recognition particle 54-kDa subunit by its Escherichia coli homolog,
Proc Natl Acad Sci U S A 90, 5229-5233

Rizo, J., Blanco, F. J., Kobe, B., Bruch, M. D., and Gierasch, L. M. (1993)
Conformational behavior of Escherichia coli OmpA signal peptides in membrane mimetic environments,
Biochemistry 32, 4881-4894

Robinson, A., He, M., Westwood, O. M., and Austen, B. M. (1993)
Changes in levels of pancreatic endoplasmic reticulum proteins that function in translocation and maturation of secretory proteins in response to cholecystokinin,
Cytotechnology 11, 197-204

Selinger, D., Brennwald, P., Liao, X., and Wise, J. A. (1993)
Identification of RNA sequences and structural elements required for assembly of fission yeast SRP54 protein with signal recognition particle RNA,
Molecular & Cellular Biology 13, 1353-1362

Selinger, D., Liao, X., and Wise, J. A. (1993)
Functional interchangeability of the structurally similar tetranucleotide loops GAAA and UUCG in fission yeast signal recognition particle RNA,
Proceedings of the National Academy of Sciences of the United States of America 90, 5409-5413

Shelness, G. S., Lin, L., and Nicchitta, C. V. (1993)
Membrane topology and biogenesis of eukaryotic signal peptidase,
Journal of Biological Chemistry 268, 5201-5208

Connolly, T., and Gilmore, R. (1993)
GTP hydrolysis by complexes of the signal recognition particle and the signal recognition particle receptor,
Journal of Cell Biology 123, 799-807

Dierks, T., Klappa, P., Wiech, H., and Zimmermann, R. (1993)
The role of molecular chaperones in protein transport into the endoplasmic reticulum. [Review],
Philosophical Transactions of the Royal Society of London - Series B: Biological Sciences 339, 335-341

Doud, S. K., Chou, M. M., and Kendall, D. A. (1993)
Titration of protein transport activity by incremental changes in signal peptide hydrophobicity,
Biochemistry 32, 1251-1256

Hann, B. C., Stirling, C. J., and Walter, P. (1992)
SEC65 gene product is a subunit of the yeast signal recognition particle required for its integrity,
Nature 356, 532-533

He, F., Beckerich, J. M., and Gaillardin, C. (1992)
A mutant of 7SL RNA in Yarrowia lipolytica affecting the synthesis of a secreted protein,
Journal of Biological Chemistry 267, 1932-1937

Zwieb, C. (1992)
Conformity of RNAs that interact with tetranucleotide loop binding proteins,
Nucleic acids research 20, 4397-4400

Wood, H., Luirink, J., and Tollervey, D. (1992)
Evolutionary conserved nucleotides within the E. coli 4.5S RNA are required for association with P48 in vitro and for optimal function in vivo,
Nucleic Acids Research 20, 5919-5925

Zwieb, C. (1992)
Recognition of a tetranucleotide loop of signal recognition particle RNA by protein SRP19,
J. Biol. Chem. 267, 15650-15656

Yaver, D. S., Matoba, S., and Ogrydziak, D. M. (1992)
A mutation in the signal recognition particle 7S RNA of the yeast Yarrowia lipolytica preferentially affects synthesis of the alkaline extracellular protease: in vivo evidence for translational arrest,
Journal of Cell Biology 116, 605-616

Gropp, R., Gropp, F., and Betlach, M. C. (1992)
Association of the halobacterial 7S RNA to the polysome correlates with expression of the membrane protein bacterioopsin,
Proceedings of the National Academy of Sciences of the United States of America 89, 1204-1208

Görlich, D., Hartmann, E., Prehn, S., and Rapoport, T. A. (1992)
A protein of the endoplasmic reticulum involved early in polypeptide translocation,
Nature 357, 47-52

Zwieb, C., and Larsen, N. (1992)
The signal recognition particle (SRP) database,
Nucleic acids research 20, Supplement, 2207

High, S., and Dobberstein, B. (1992)
Mechanisms that determine the transmembrane disposition of proteins,
Curr Opin Cell Biol 4, 581-586

Janiak, F., Walter, P., and Johnson, A. E. (1992)
Fluorescence-detected assembly of the signal recognition particle: binding of the two SRP protein heterodimers to SRP RNA is noncooperative,
Biochemistry 31, 5830-5840

Janin, N., Delattre, O., and Lipinski, M. (1992)
PCR-assisted localization of the human SRPR gene,
Human Genetics 88, 583-585

Mitoma, J., and Ito, A. (1992)
The carboxy-terminal 10 amino acid residues of cytochrome b5 are necessary for its targeting to the endoplasmic reticulum,
EMBO Journal 11, 4197-4203

Andersson, H., Bakker, E., and von Heijne, G. (1992)
Different positively charged amino acids have similar effects on the topology of a polytopic transmembrane protein in Escherichia coli,
J Biol Chem 267, 1491-1495

Liao, X., Selinger, D., althoff, S., Chiang, A., Hamilton, D., Ma, M., and Wise, J. A. (1992)
Random mutagenesis of Schizosaccharomyces pombe SRP RNA: lethal and conditional lesions cluster in presumptive protein binding sites,
Nucleic Acids Research 20, 1607-1615

Luirink, J., High, S., Wood, H., Giner, A., and others, a. (1992)
Signal-sequence recognition by an Escherichia coli ribonucleoprotein complex,
Nature 359, 741-743

Lütcke, H., High, S., Römisch, K., Ashford, A. J., and Dobberstein, B. (1992)
The methionine-rich domain of the 54 kDa subunit of signal recognition particle is sufficient for the interaction with signal sequences,
EMBO Journal 11, 1543-1551

Michaeli, S., Podell, D., Agabian, N., and Ullu, E. (1992)
The 7SL RNA homologue of Trypanosoma brucei is closely related to mammalian 7SL RNA,
Molecular & Biochemical Parasitology 51, 55-64

Migliaccio, G., Nicchitta, C. V., and Blobel, G. (1992)
The signal sequence receptor, unlike the signal recognition particle receptor, is not essential for protein translocation,
Journal of Cell Biology 117, 15-25

Nunnari, J., and Walter, P. (1992)
Protein targeting to and translocation across the membrane of the endoplasmic reticulum,
Current Opinion in Cell Biology 4, 573-580

Ogg, S. C., Poritz, M. A., and Walter, P. (1992)
Signal recognition particle receptor is important for cell growth and protein secretion in Saccharomyces cerevisiae,
Molecular Biology of the Cell 3, 895-911

Okun, M. M., and Shields, D. (1992)
Translocation of preproinsulin across the endoplasmic reticulum membrane. The relationship between nascent polypeptide size and extent of signal recognition particle-mediated inhibition of protein synthesis,
Journal of Biological Chemistry 267, 11476-11482

Olender, E. H., and Simon, R. D. (1992)
The intracellular targeting and membrane topology of 3-hydroxy-3-methylglutaryl-CoA reductase,
Journal of Biological Chemistry 267, 4223-4235

Phillips, G. J., and Silhavy, T. J. (1992)
The E. coli ffh gene is necessary for viability and efficient protein export,
Nature (London) 359, 744-746

Rapiejko, P. J., and Gilmore, R. (1992)
Protein translocation across the ER requires a functional GTP binding site in the alpha subunit of the signal recognition particle receptor,
Journal of Cell Biology 117, 493-503

Sakaguchi, M., Tomiyoshi, R., Kuroiwa, T., Mihara, K., and Omura, T. (1992)
Functions of signal and signal-anchor sequences are determined by the balance between the hydrophobic segment and the N-terminal charge,
Proceedings of the National Academy of Sciences of the United States of America 89, 16-19

Schlenstedt, G., Gudmundsson, G. H., Boman, H. G., and Zimmermann, R. (1992)
Structural requirements for transport of preprocecropinA and related presecretory proteins into mammalian microsomes,
Journal of Biological Chemistry 267, 24328-24332

Stirling, C. J., and Hewitt, E. W. (1992)
The S. cerevisiae SEC65 gene encodes a components of yeast signal recognition particle with homology to human SRP19,
Nature (London) 356, 534-537

Andreazzoli, M., and Gerbi, S. A. (1991)
Changes in 7SL RNA conformation during the signal recognition particle cycle,
Embo J 10, 767-777

Lingappa, V. R. (1991)
The role of the endoplasmic reticulum in nascent chain translocation: a perspective from the study of chimeric proteins,
Intracellular trafficking of proteins 387-430

Larsen, N., and Zwieb, C. (1991)
SRP-RNA sequence alignment and secondary structure,
Nucleic Acids Res 19, 209-215

Zimmermann, R., Zimmermann, M., Mayinger, P., and Klappa, P. (1991)
Photoaffinity labeling of dog pancreas microsomes with 8-azido-ATP inhibits association of nascent preprolactin with the signal sequence receptor complex,
Febs Lett 286, 95-99

Görlich, D., Kurzchalia, T. V., Wiedmann, M., and Rapoport, T. A. (1991)
Probing the molecular environment of translocating polypeptide chains by cross-linking,
Meth. Cell Biol. 34, 241-262

Hann, B. C., and Walter, P. (1991)
The signal recognition particle in S. cerevisiae,
Cell 67, 131-144

Amaya, Y., and Nakano, A. (1991)
SRH1 protein, the yeast homologue of the 54 kDa subunit of signal recognition particle, is involved in ER translocation of secretory proteins,
Febs Lett 283, 325-328

Nunnari, J. M., Zimmerman, D. L., Ogg, S. C., and Walter, P. (1991)
Characterization of the rough endoplasmic reticulum ribosome-binding activity,
Nature 352, 638-640

Heus, H. A., and Pardi, A. (1991)
Structural features that give rise to the unusual stability of RNA hairpins containing GNRA loops,
Science 253, 191-194

High, S., and Dobberstein, B. (1991)
The signal sequence interacts with the methionine-rich domain of the 54-kD protein of signal recognition particle,
Journal of Cell Biology 113, 229-233

Zwieb, C. (1991)
Interaction of protein SRP19 with signal recognition particle RNA lacking individual RNA-helices,
Nucleic Acids Res 19, 2955-2960

Hoyt, D. W., and Gierasch, L. M. (1991)
A peptide corresponding to an export-defective mutant OmpA signal sequence with asparagine in the hydrophobic core is unable to insert into model membranes,
J Biol Chem 266, 14406-14412

Brown, S. (1991)
Genes for 7S RNAs can replace the gene for 4.5S RNA in growth of Escherichia coli,
J Bacteriol 173, 1835-1837

Zwieb, C. (1991)
A basic region neighboring the lysine-rich C-terminus of protein SRP19 is required for binding to signal recognition particle RNA,
Biochem Cell Biol 69, 649-654

Connolly, T., Rapiejko, P. J., and Gilmore, R. (1991)
Requirement of GTP hydrolysis for dissociation of the signal recognition particle from its receptor,
Science 252, 1171-1173

Strub, K., Moss, J., and Walter, P. (1991)
Binding sites of the 9- and 14-kilodalton heterodimeric protein subunit of the signal recognition particle (SRP) are contained exclusively in the Alu domain of SRP RNA and contain a sequence motif that is conserved in evolution,
Mol Cell Biol 11, 3949-3959

Zopf, D., Bernstein, H. D., Johnson, A. E., and Walter, P. (1990)
The methionine-rich domain of the 54 kd protein subunit of the signal recognition particle contains an RNA binding site and can be crosslinked to a signal sequence,
EMBO J 9, 4511-4517

Görlich, D., Prehn, S., Hartmann, E., Herz, J., Otto, A., Kraft, R., Wiedmann, M., Knespel, S., Dobberstein, B., and Rapoport, T. A. (1990)
The signal sequence receptor has a second subunit and is part of a translocation complex in the endoplasmic reticulum as probed by bifunctional reagents,
J Cell Biol 111, 2283-2294

Herz, J., Flint, N., Stanley, K., Frank, R., and Dobberstein, B. (1990)
The 68 kDa protein of signal recognition particle contains a glycine-rich region also found in certain RNA-binding proteins,
Febs Lett 276, 103-107

Amaya, Y., Nakano, A., Ito, K., and Mori, M. (1990)
Isolation of a yeast gene, SRH1, that encodes a homologue of the 54K subunit of mammalian signal recognition particle,
J Biochem (Tokyo) 107, 457-463

Jones, J. D., McKnight, C. J., and Gierasch, L. M. (1990)
Biophysical studies of signal peptides: implications for signal sequence functions and the involvement of lipid in protein export,
J Bioenerg Biomembr 22, 213-232

Poritz, M. A., Bernstein, H. D., Strub, K., Zopf, D., Wilhelm, H., and Walter, P. (1990)
An E. coli ribonucleoprotein containing 4.5S RNA resembles mammalian signal recognition particle,
Science 250, 1111-1117

Prehn, S., Herz, J., Hartmann, E., Kurzchalia, T. V., Frank, R., Römisch, K., Dobberstein, B., and Rapoport, T. A. (1990)
Structure and biosynthesis of the signal-sequence receptor,
Eur J Biochem 188, 439-445

Ribes, V., Römisch, K., Giner, A., Dobberstein, B., and Tollervey, D. (1990)
E. coli 4.5S RNA is part of a ribonucleoprotein particle that has properties related to signal recognition particle,
Cell 63, 591-600

Römisch, K., Webb, J., Lingelbach, K., Gausepohl, H., and Dobberstein, B. (1990)
The 54-kD protein of signal recognition particle contains a methionine-rich RNA binding domain,
Journal of Cell Biology 111, 1793-1802

Strub, K., and Walter, P. (1990)
Assembly of the alu domain of signal recognition particle (SRP): dimerization of the two protein components is required for efficient binding to SRP RNA,
Molecular and Cell Biology 10, 777-784

von Heijne, G. (1990)
The signal peptide,
J Membr Biol 115, 195-201

Ngsee, J. K., and Smith, M. (1990)
Changes in a mammalian signal sequence required for efficient protein secretion by yeasts,
Gene 86, 251-255

LeBlanc, J. M., and Infante, A. A. (1989)
Association of 7 SL RNA and an SRP-like particle with polysomes and endoplasmic reticulum in the developing sea urchin embryo,
Dev Biol 132, 139-152

Liao, X., Brennwald, P., and Wise, J. A. (1989)
Genetic analysis of Schizosaccharmyces pombe 7SL RNA: A structural motif that includes a conserved tetranucleotide loop is important for function,
Proc. Natl. Acad. Sci. USA 86, 4137-4141

Marshallsay, C., Prehn, S., and Zwieb, C. (1989)
cDNA cloning of the wheat germ SRP 7S RNAs,
Nucleic acids research 17, 1771

Hann, B. C., Poritz, M. A., and Walter, P. (1989)
Saccharomyces cerevisiae and Schizosaccharomyces pombe contain a homologue to the 54-kD subunit of the signal recognition particle that in S. cerevisiae is essential for growth,
J Cell Biol 109, 3223-3230

Gierasch, L. M. (1989)
Signal sequences [published erratum appears in Biochemistry 1989 Jun 27;28(13):5702],
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Zwieb, C., and Schüler, D. (1989)
Low resolution three-dimensional models of the 7SL RNA of the signal recognition particle, based on an intramolecular cross-link introduced by mild irradiation with ultraviolet light,
Biochem. and Cell Biol. 67, 434-442

Bernstein, H. D., Poritz, M. A., Strub, K., Hoben, P. J., Brenner, S., and Walter, P. (1989)
Model for signal sequence recognition from amino-acid sequence of 54K subunit of signal recognition particle,
Nature 340, 482-486

Bruch, M. D., McKnight, C. J., and Gierasch, L. M. (1989)
Helix formation and stability in a signal sequence,
Biochemistry 28, 8554-8561

Andrews, D. W., Lauffer, L., Walter, P., and Lingappa, V. R. (1989)
Evidence for a two-step mechanism involved in assembly of functional signal recognition particle receptor,
J Cell Biol 108, 797-810

Campos, N., Palau, J., and Zwieb, C. (1989)
Diversity of 7 SL RNA from the signal recognition particle of maize endosperm,
Nucleic Acids Res 17, 1573-1588

Connolly, T., and Gilmore, R. (1989)
The signal recognition particle receptor mediates the GTP-dependent displacement of SRP from the signal sequence of the nascent polypeptide,
Cell 57, 599-610

Strub, K., and Walter, P. (1989)
Cross-hybridization of differently primed polymerase chain reaction: isolation of a cDNA clone for the 14-kDa subunit of the signal recognition particle by cross-hybridization of differently primed polymerase chain reactions,
Proc Natl Acad Sci U S A 86, 9747-9751

Felici, F., Cesareni, G., and Hughes, J. M. (1989)
The most abundant small cytoplasmic RNA of Saccharomyces cerevisiae has an important function required for normal cell growth,
Mol Cell Biol 9, 3260-3268

Ribes, V., Dehoux, P., and Tollervey, D. (1988)
7SL RNA from Schizosaccharomyces pombe is encoded by a single copy essential gene,
EMBO Journal 7, 231-237

Brennwald, P., Liao, X., Holm, K., Porter, G., and Wise, J. A. (1988)
Identification of an essential Schizosaccharomyces pombe RNA homologous to the 7SL component of signal recognition particle,
Mol Cell Biol 8, 1580-1590

Zwieb, C. (1988)
4.5S RNA of E. coli and the conserved central domain of signal recognition particle RNA are homologous,
Endocyt. C. Res. 5, 327-336

Garcia, P. D., and Walter, P. (1988)
Full-length prepro-alpha-factor can be translocated across the mammalian microsomal membrane only if translation has not terminated,
J Cell Biol 106, 1043-1048

Poritz, M. A., Siegel, V., Hansen, W., and Walter, P. (1988)
Small ribonucleoproteins in Schizosaccharomyces pombe and Yarrowia lipolytica homologous to signal recognition particle,
Procedings of the National Academy of Sciences U.S.A. 85, 4315-4319

Poritz, M. A., Strub, K., and Walter, P. (1988)
Human SRP RNA and E. coli 4.5S RNA contain a highly homologous structural domain,
Cell 55, 4-6

Lingelbach, K., Zwieb, C., Webb, J. R., Marshallsay, C., Hoben, P. J., Walter, P., and Dobberstein, B. (1988)
Isolation and characterization of a cDNA clone encoding the 19 kDa protein of signal recognition particle (SRP): expression and binding to 7SL RNA,
Nucleic Acids Research 16, 9431-9442

Zwieb, C. (1988)
3D-modeling of the 7SL RNA of the signal recognition particle,
J. Cell. Biochem Supplement 12D, 27

Campos, N., Palau, J., Torrent, M., and Ludevid, D. (1988)
Signal recognition-like particles are present in maize,
J Biol Chem 263, 9646-9650

Siegel, V., and Walter, P. (1988)
Each of the activities of signal recognition particle (SRP) is contained with a distinct domain: analysis of biochemical mutants of SRP,
Cell 52, 39-49

Siegel, V., and Walter, P. (1988)
Binding sites of the 19-kDa and 68/72-kDa signal recognition particle (SRP) proteins on SRP RNA as determined in protein-RNA 'footprinting',
Proc Natl Acad Sci U.S.A. 85, 1801-1805

Siegel, V., and Walter, P. (1988)
The affinity of signal recognition particle for presecretory proteins is dependent on nascent chain length,
Embo J 7, 1769-1775

Andrews, D. W., Walter, P., and Ottensmeyer, F. P. (1987)
Evidence for an extended 7SL RNA structure in the signal recognition particle,
EMBO J 6, 3471-3477

Wiedmann, M., Kurzchalia, T. V., Hartman, E., and Rapoport, T. A. (1987)
A signal sequence receptor in the endoplasmic reticulum membrane,
Nature 328, 830-833

Wiedmann, M., Kurzchalia, T. V., Bielka, H., and Rapoport, T. A. (1987)
Direct probing of the interaction between the signal sequence of nascent preprolactin and the signal recognition particle by specific cross-linking,
Journal of Cell Biology 104, 201-208

Prehn, S., Wiedmann, M., Rapoport, T. A., and Zwieb, C. (1987)
Protein translocation across wheat germ microsomal membranes requires an SRP-like component,
EMBO J. 6, 2093-2097

Zwieb, C. (1987)
3D-modeling of the 7SL RNA of the signal recognition particle,
Mol. Biol. Reports 12, 221-222

Andrews, P. G., and Kole, R. (1987)
Alu RNA transcribed in vitro binds the 68-kDa subunit of the signal recognition particle,
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Scoulica, E., Krause, E., Meese, K., and Dobberstein, B. (1987)
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Is the 6S RNA of prokaryotes an equivalent to the 7SL RNA of eukaryotes?,
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Determinants for protein translocation across mammalian endoplasmic reticulum. Membrane insertion of truncated and full-length prelysozyme molecules,
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Removal of the Alu structural domain from signal recognition particle leaves its protein translocation activity intact,
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The signal recognition particle receptor is a complex that contains two distinct polypeptide chains,
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Mechanism of protein translocation across the endoplasmic reticulum,
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Structure of the signal recognition particle by electron microscopy,
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The secondary structure of the 7SL RNA in the signal recognition particle: functional implications,
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Characterization of the 7S RNA and its gene from halobacteria,
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Elongation arrest is not a prerequisite for secretory protein translocation across microsomal membranes,
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Upstream sequences modulate the internal promoter of the human 7SL RNA gene,
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Role of signal recognition particle in the membrane assembly of Sindbis viral glycoproteins,
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Association between the 7 S RNA and the lupus La protein varies among cell types,
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Secretory protein translocation across membranes - the role of the 'docking protein',
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Signal recognition particle contains a 7S RNA essential for protein translocation across the endoplasmic reticulum,
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Transfer of proteins across membranes. I. Presence of proteolytically processed and unprocessed nascent immunoglobulin light chains on membrane-bound ribosomes of murine myeloma,
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A possible precursor of immunoglobin light chains,
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