motif	category	term	side	ortholog	path	pathway
K00008_upstream.h1_2	High covariation	K00008	upstream	SORD, gutB; L-iditol 2-dehydrogenase [EC:1.1.1.14]	map00040	Pentose and glucuronate interconversions
K00008_upstream.h1_2	High covariation	K00008	upstream	SORD, gutB; L-iditol 2-dehydrogenase [EC:1.1.1.14]	ko00040	NA
K00008_upstream.h1_2	High covariation	K00008	upstream	SORD, gutB; L-iditol 2-dehydrogenase [EC:1.1.1.14]	map00051	Fructose and mannose metabolism
K00008_upstream.h1_2	High covariation	K00008	upstream	SORD, gutB; L-iditol 2-dehydrogenase [EC:1.1.1.14]	ko00051	NA
K00008_upstream.h1_2	High covariation	K00008	upstream	SORD, gutB; L-iditol 2-dehydrogenase [EC:1.1.1.14]	map01100	Metabolic pathways
K00008_upstream.h1_2	High covariation	K00008	upstream	SORD, gutB; L-iditol 2-dehydrogenase [EC:1.1.1.14]	ko01100	NA
K00012_upstream.h1_3	High power (low covariation)	K00012	upstream	UGDH, ugd; UDPglucose 6-dehydrogenase [EC:1.1.1.22]	map00040	Pentose and glucuronate interconversions
K00012_upstream.h1_3	High power (low covariation)	K00012	upstream	UGDH, ugd; UDPglucose 6-dehydrogenase [EC:1.1.1.22]	ko00040	NA
K00012_upstream.h1_3	High power (low covariation)	K00012	upstream	UGDH, ugd; UDPglucose 6-dehydrogenase [EC:1.1.1.22]	map00053	Ascorbate and aldarate metabolism
K00012_upstream.h1_3	High power (low covariation)	K00012	upstream	UGDH, ugd; UDPglucose 6-dehydrogenase [EC:1.1.1.22]	ko00053	NA
K00012_upstream.h1_3	High power (low covariation)	K00012	upstream	UGDH, ugd; UDPglucose 6-dehydrogenase [EC:1.1.1.22]	map00520	Amino sugar and nucleotide sugar metabolism
K00012_upstream.h1_3	High power (low covariation)	K00012	upstream	UGDH, ugd; UDPglucose 6-dehydrogenase [EC:1.1.1.22]	ko00520	NA
K00012_upstream.h1_3	High power (low covariation)	K00012	upstream	UGDH, ugd; UDPglucose 6-dehydrogenase [EC:1.1.1.22]	map00541	Biosynthesis of various nucleotide sugars
K00012_upstream.h1_3	High power (low covariation)	K00012	upstream	UGDH, ugd; UDPglucose 6-dehydrogenase [EC:1.1.1.22]	ko00541	NA
K00012_upstream.h1_3	High power (low covariation)	K00012	upstream	UGDH, ugd; UDPglucose 6-dehydrogenase [EC:1.1.1.22]	map01100	Metabolic pathways
K00012_upstream.h1_3	High power (low covariation)	K00012	upstream	UGDH, ugd; UDPglucose 6-dehydrogenase [EC:1.1.1.22]	ko01100	NA
K00012_upstream.h1_3	High power (low covariation)	K00012	upstream	UGDH, ugd; UDPglucose 6-dehydrogenase [EC:1.1.1.22]	map01240	Biosynthesis of cofactors
K00012_upstream.h1_3	High power (low covariation)	K00012	upstream	UGDH, ugd; UDPglucose 6-dehydrogenase [EC:1.1.1.22]	ko01240	NA
K00012_upstream.h1_3	High power (low covariation)	K00012	upstream	UGDH, ugd; UDPglucose 6-dehydrogenase [EC:1.1.1.22]	map01250	Biosynthesis of nucleotide sugars
K00012_upstream.h1_3	High power (low covariation)	K00012	upstream	UGDH, ugd; UDPglucose 6-dehydrogenase [EC:1.1.1.22]	ko01250	NA
K00031_upstream.h2_3.h2_5	High power (low covariation)	K00031	upstream	IDH1, IDH2, icd; isocitrate dehydrogenase [EC:1.1.1.42]	map00020	Citrate cycle (TCA cycle)
K00031_upstream.h2_3.h2_5	High power (low covariation)	K00031	upstream	IDH1, IDH2, icd; isocitrate dehydrogenase [EC:1.1.1.42]	ko00020	NA
K00031_upstream.h2_3.h2_5	High power (low covariation)	K00031	upstream	IDH1, IDH2, icd; isocitrate dehydrogenase [EC:1.1.1.42]	map00480	Glutathione metabolism
K00031_upstream.h2_3.h2_5	High power (low covariation)	K00031	upstream	IDH1, IDH2, icd; isocitrate dehydrogenase [EC:1.1.1.42]	ko00480	NA
K00031_upstream.h2_3.h2_5	High power (low covariation)	K00031	upstream	IDH1, IDH2, icd; isocitrate dehydrogenase [EC:1.1.1.42]	map00720	Other carbon fixation pathways
K00031_upstream.h2_3.h2_5	High power (low covariation)	K00031	upstream	IDH1, IDH2, icd; isocitrate dehydrogenase [EC:1.1.1.42]	ko00720	NA
K00031_upstream.h2_3.h2_5	High power (low covariation)	K00031	upstream	IDH1, IDH2, icd; isocitrate dehydrogenase [EC:1.1.1.42]	map01100	Metabolic pathways
K00031_upstream.h2_3.h2_5	High power (low covariation)	K00031	upstream	IDH1, IDH2, icd; isocitrate dehydrogenase [EC:1.1.1.42]	ko01100	NA
K00031_upstream.h2_3.h2_5	High power (low covariation)	K00031	upstream	IDH1, IDH2, icd; isocitrate dehydrogenase [EC:1.1.1.42]	map01110	Biosynthesis of secondary metabolites
K00031_upstream.h2_3.h2_5	High power (low covariation)	K00031	upstream	IDH1, IDH2, icd; isocitrate dehydrogenase [EC:1.1.1.42]	ko01110	NA
K00031_upstream.h2_3.h2_5	High power (low covariation)	K00031	upstream	IDH1, IDH2, icd; isocitrate dehydrogenase [EC:1.1.1.42]	map01120	Microbial metabolism in diverse environments
K00031_upstream.h2_3.h2_5	High power (low covariation)	K00031	upstream	IDH1, IDH2, icd; isocitrate dehydrogenase [EC:1.1.1.42]	ko01120	NA
K00031_upstream.h2_3.h2_5	High power (low covariation)	K00031	upstream	IDH1, IDH2, icd; isocitrate dehydrogenase [EC:1.1.1.42]	map01200	Carbon metabolism
K00031_upstream.h2_3.h2_5	High power (low covariation)	K00031	upstream	IDH1, IDH2, icd; isocitrate dehydrogenase [EC:1.1.1.42]	ko01200	NA
K00031_upstream.h2_3.h2_5	High power (low covariation)	K00031	upstream	IDH1, IDH2, icd; isocitrate dehydrogenase [EC:1.1.1.42]	map01210	2-Oxocarboxylic acid metabolism
K00031_upstream.h2_3.h2_5	High power (low covariation)	K00031	upstream	IDH1, IDH2, icd; isocitrate dehydrogenase [EC:1.1.1.42]	ko01210	NA
K00031_upstream.h2_3.h2_5	High power (low covariation)	K00031	upstream	IDH1, IDH2, icd; isocitrate dehydrogenase [EC:1.1.1.42]	map01230	Biosynthesis of amino acids
K00031_upstream.h2_3.h2_5	High power (low covariation)	K00031	upstream	IDH1, IDH2, icd; isocitrate dehydrogenase [EC:1.1.1.42]	ko01230	NA
K00031_upstream.h2_3.h2_5	High power (low covariation)	K00031	upstream	IDH1, IDH2, icd; isocitrate dehydrogenase [EC:1.1.1.42]	map04146	Peroxisome
K00031_upstream.h2_3.h2_5	High power (low covariation)	K00031	upstream	IDH1, IDH2, icd; isocitrate dehydrogenase [EC:1.1.1.42]	ko04146	NA
K00031_upstream.h2_3.h2_5	High power (low covariation)	K00031	upstream	IDH1, IDH2, icd; isocitrate dehydrogenase [EC:1.1.1.42]	map05230	Central carbon metabolism in cancer
K00031_upstream.h2_3.h2_5	High power (low covariation)	K00031	upstream	IDH1, IDH2, icd; isocitrate dehydrogenase [EC:1.1.1.42]	ko05230	NA
K00031_upstream.h2_4	Conserved sequence (low covariation and power)	K00031	upstream	IDH1, IDH2, icd; isocitrate dehydrogenase [EC:1.1.1.42]	map00020	Citrate cycle (TCA cycle)
K00031_upstream.h2_4	Conserved sequence (low covariation and power)	K00031	upstream	IDH1, IDH2, icd; isocitrate dehydrogenase [EC:1.1.1.42]	ko00020	NA
K00031_upstream.h2_4	Conserved sequence (low covariation and power)	K00031	upstream	IDH1, IDH2, icd; isocitrate dehydrogenase [EC:1.1.1.42]	map00480	Glutathione metabolism
K00031_upstream.h2_4	Conserved sequence (low covariation and power)	K00031	upstream	IDH1, IDH2, icd; isocitrate dehydrogenase [EC:1.1.1.42]	ko00480	NA
K00031_upstream.h2_4	Conserved sequence (low covariation and power)	K00031	upstream	IDH1, IDH2, icd; isocitrate dehydrogenase [EC:1.1.1.42]	map00720	Other carbon fixation pathways
K00031_upstream.h2_4	Conserved sequence (low covariation and power)	K00031	upstream	IDH1, IDH2, icd; isocitrate dehydrogenase [EC:1.1.1.42]	ko00720	NA
K00031_upstream.h2_4	Conserved sequence (low covariation and power)	K00031	upstream	IDH1, IDH2, icd; isocitrate dehydrogenase [EC:1.1.1.42]	map01100	Metabolic pathways
K00031_upstream.h2_4	Conserved sequence (low covariation and power)	K00031	upstream	IDH1, IDH2, icd; isocitrate dehydrogenase [EC:1.1.1.42]	ko01100	NA
K00031_upstream.h2_4	Conserved sequence (low covariation and power)	K00031	upstream	IDH1, IDH2, icd; isocitrate dehydrogenase [EC:1.1.1.42]	map01110	Biosynthesis of secondary metabolites
K00031_upstream.h2_4	Conserved sequence (low covariation and power)	K00031	upstream	IDH1, IDH2, icd; isocitrate dehydrogenase [EC:1.1.1.42]	ko01110	NA
K00031_upstream.h2_4	Conserved sequence (low covariation and power)	K00031	upstream	IDH1, IDH2, icd; isocitrate dehydrogenase [EC:1.1.1.42]	map01120	Microbial metabolism in diverse environments
K00031_upstream.h2_4	Conserved sequence (low covariation and power)	K00031	upstream	IDH1, IDH2, icd; isocitrate dehydrogenase [EC:1.1.1.42]	ko01120	NA
K00031_upstream.h2_4	Conserved sequence (low covariation and power)	K00031	upstream	IDH1, IDH2, icd; isocitrate dehydrogenase [EC:1.1.1.42]	map01200	Carbon metabolism
K00031_upstream.h2_4	Conserved sequence (low covariation and power)	K00031	upstream	IDH1, IDH2, icd; isocitrate dehydrogenase [EC:1.1.1.42]	ko01200	NA
K00031_upstream.h2_4	Conserved sequence (low covariation and power)	K00031	upstream	IDH1, IDH2, icd; isocitrate dehydrogenase [EC:1.1.1.42]	map01210	2-Oxocarboxylic acid metabolism
K00031_upstream.h2_4	Conserved sequence (low covariation and power)	K00031	upstream	IDH1, IDH2, icd; isocitrate dehydrogenase [EC:1.1.1.42]	ko01210	NA
K00031_upstream.h2_4	Conserved sequence (low covariation and power)	K00031	upstream	IDH1, IDH2, icd; isocitrate dehydrogenase [EC:1.1.1.42]	map01230	Biosynthesis of amino acids
K00031_upstream.h2_4	Conserved sequence (low covariation and power)	K00031	upstream	IDH1, IDH2, icd; isocitrate dehydrogenase [EC:1.1.1.42]	ko01230	NA
K00031_upstream.h2_4	Conserved sequence (low covariation and power)	K00031	upstream	IDH1, IDH2, icd; isocitrate dehydrogenase [EC:1.1.1.42]	map04146	Peroxisome
K00031_upstream.h2_4	Conserved sequence (low covariation and power)	K00031	upstream	IDH1, IDH2, icd; isocitrate dehydrogenase [EC:1.1.1.42]	ko04146	NA
K00031_upstream.h2_4	Conserved sequence (low covariation and power)	K00031	upstream	IDH1, IDH2, icd; isocitrate dehydrogenase [EC:1.1.1.42]	map05230	Central carbon metabolism in cancer
K00031_upstream.h2_4	Conserved sequence (low covariation and power)	K00031	upstream	IDH1, IDH2, icd; isocitrate dehydrogenase [EC:1.1.1.42]	ko05230	NA
K00036_upstream.h1_1	High covariation	K00036	upstream	G6PD, zwf; glucose-6-phosphate 1-dehydrogenase [EC:1.1.1.49 1.1.1.363]	map00030	Pentose phosphate pathway
K00036_upstream.h1_1	High covariation	K00036	upstream	G6PD, zwf; glucose-6-phosphate 1-dehydrogenase [EC:1.1.1.49 1.1.1.363]	ko00030	NA
K00036_upstream.h1_1	High covariation	K00036	upstream	G6PD, zwf; glucose-6-phosphate 1-dehydrogenase [EC:1.1.1.49 1.1.1.363]	map00480	Glutathione metabolism
K00036_upstream.h1_1	High covariation	K00036	upstream	G6PD, zwf; glucose-6-phosphate 1-dehydrogenase [EC:1.1.1.49 1.1.1.363]	ko00480	NA
K00036_upstream.h1_1	High covariation	K00036	upstream	G6PD, zwf; glucose-6-phosphate 1-dehydrogenase [EC:1.1.1.49 1.1.1.363]	map01100	Metabolic pathways
K00036_upstream.h1_1	High covariation	K00036	upstream	G6PD, zwf; glucose-6-phosphate 1-dehydrogenase [EC:1.1.1.49 1.1.1.363]	ko01100	NA
K00036_upstream.h1_1	High covariation	K00036	upstream	G6PD, zwf; glucose-6-phosphate 1-dehydrogenase [EC:1.1.1.49 1.1.1.363]	map01110	Biosynthesis of secondary metabolites
K00036_upstream.h1_1	High covariation	K00036	upstream	G6PD, zwf; glucose-6-phosphate 1-dehydrogenase [EC:1.1.1.49 1.1.1.363]	ko01110	NA
K00036_upstream.h1_1	High covariation	K00036	upstream	G6PD, zwf; glucose-6-phosphate 1-dehydrogenase [EC:1.1.1.49 1.1.1.363]	map01120	Microbial metabolism in diverse environments
K00036_upstream.h1_1	High covariation	K00036	upstream	G6PD, zwf; glucose-6-phosphate 1-dehydrogenase [EC:1.1.1.49 1.1.1.363]	ko01120	NA
K00036_upstream.h1_1	High covariation	K00036	upstream	G6PD, zwf; glucose-6-phosphate 1-dehydrogenase [EC:1.1.1.49 1.1.1.363]	map01200	Carbon metabolism
K00036_upstream.h1_1	High covariation	K00036	upstream	G6PD, zwf; glucose-6-phosphate 1-dehydrogenase [EC:1.1.1.49 1.1.1.363]	ko01200	NA
K00036_upstream.h1_1	High covariation	K00036	upstream	G6PD, zwf; glucose-6-phosphate 1-dehydrogenase [EC:1.1.1.49 1.1.1.363]	map05230	Central carbon metabolism in cancer
K00036_upstream.h1_1	High covariation	K00036	upstream	G6PD, zwf; glucose-6-phosphate 1-dehydrogenase [EC:1.1.1.49 1.1.1.363]	ko05230	NA
K00036_upstream.h1_1	High covariation	K00036	upstream	G6PD, zwf; glucose-6-phosphate 1-dehydrogenase [EC:1.1.1.49 1.1.1.363]	map05415	Diabetic cardiomyopathy
K00036_upstream.h1_1	High covariation	K00036	upstream	G6PD, zwf; glucose-6-phosphate 1-dehydrogenase [EC:1.1.1.49 1.1.1.363]	ko05415	NA
K00075_upstream.h2_1	High covariation	K00075	upstream	murB; UDP-N-acetylmuramate dehydrogenase [EC:1.3.1.98]	map00520	Amino sugar and nucleotide sugar metabolism
K00075_upstream.h2_1	High covariation	K00075	upstream	murB; UDP-N-acetylmuramate dehydrogenase [EC:1.3.1.98]	ko00520	NA
K00075_upstream.h2_1	High covariation	K00075	upstream	murB; UDP-N-acetylmuramate dehydrogenase [EC:1.3.1.98]	map00550	Peptidoglycan biosynthesis
K00075_upstream.h2_1	High covariation	K00075	upstream	murB; UDP-N-acetylmuramate dehydrogenase [EC:1.3.1.98]	ko00550	NA
K00075_upstream.h2_1	High covariation	K00075	upstream	murB; UDP-N-acetylmuramate dehydrogenase [EC:1.3.1.98]	map01100	Metabolic pathways
K00075_upstream.h2_1	High covariation	K00075	upstream	murB; UDP-N-acetylmuramate dehydrogenase [EC:1.3.1.98]	ko01100	NA
K00075_upstream.h2_1	High covariation	K00075	upstream	murB; UDP-N-acetylmuramate dehydrogenase [EC:1.3.1.98]	map01250	Biosynthesis of nucleotide sugars
K00075_upstream.h2_1	High covariation	K00075	upstream	murB; UDP-N-acetylmuramate dehydrogenase [EC:1.3.1.98]	ko01250	NA
K00133_upstream.h2_2	High covariation	K00133	upstream	asd; aspartate-semialdehyde dehydrogenase [EC:1.2.1.11]	map00260	Glycine, serine and threonine metabolism
K00133_upstream.h2_2	High covariation	K00133	upstream	asd; aspartate-semialdehyde dehydrogenase [EC:1.2.1.11]	ko00260	NA
K00133_upstream.h2_2	High covariation	K00133	upstream	asd; aspartate-semialdehyde dehydrogenase [EC:1.2.1.11]	map00261	Monobactam biosynthesis
K00133_upstream.h2_2	High covariation	K00133	upstream	asd; aspartate-semialdehyde dehydrogenase [EC:1.2.1.11]	ko00261	NA
K00133_upstream.h2_2	High covariation	K00133	upstream	asd; aspartate-semialdehyde dehydrogenase [EC:1.2.1.11]	map00270	Cysteine and methionine metabolism
K00133_upstream.h2_2	High covariation	K00133	upstream	asd; aspartate-semialdehyde dehydrogenase [EC:1.2.1.11]	ko00270	NA
K00133_upstream.h2_2	High covariation	K00133	upstream	asd; aspartate-semialdehyde dehydrogenase [EC:1.2.1.11]	map00300	Lysine biosynthesis
K00133_upstream.h2_2	High covariation	K00133	upstream	asd; aspartate-semialdehyde dehydrogenase [EC:1.2.1.11]	ko00300	NA
K00133_upstream.h2_2	High covariation	K00133	upstream	asd; aspartate-semialdehyde dehydrogenase [EC:1.2.1.11]	map01100	Metabolic pathways
K00133_upstream.h2_2	High covariation	K00133	upstream	asd; aspartate-semialdehyde dehydrogenase [EC:1.2.1.11]	ko01100	NA
K00133_upstream.h2_2	High covariation	K00133	upstream	asd; aspartate-semialdehyde dehydrogenase [EC:1.2.1.11]	map01110	Biosynthesis of secondary metabolites
K00133_upstream.h2_2	High covariation	K00133	upstream	asd; aspartate-semialdehyde dehydrogenase [EC:1.2.1.11]	ko01110	NA
K00133_upstream.h2_2	High covariation	K00133	upstream	asd; aspartate-semialdehyde dehydrogenase [EC:1.2.1.11]	map01120	Microbial metabolism in diverse environments
K00133_upstream.h2_2	High covariation	K00133	upstream	asd; aspartate-semialdehyde dehydrogenase [EC:1.2.1.11]	ko01120	NA
K00133_upstream.h2_2	High covariation	K00133	upstream	asd; aspartate-semialdehyde dehydrogenase [EC:1.2.1.11]	map01210	2-Oxocarboxylic acid metabolism
K00133_upstream.h2_2	High covariation	K00133	upstream	asd; aspartate-semialdehyde dehydrogenase [EC:1.2.1.11]	ko01210	NA
K00133_upstream.h2_2	High covariation	K00133	upstream	asd; aspartate-semialdehyde dehydrogenase [EC:1.2.1.11]	map01230	Biosynthesis of amino acids
K00133_upstream.h2_2	High covariation	K00133	upstream	asd; aspartate-semialdehyde dehydrogenase [EC:1.2.1.11]	ko01230	NA
K00133_upstream.h2_1	Conserved sequence (low covariation and power)	K00133	upstream	asd; aspartate-semialdehyde dehydrogenase [EC:1.2.1.11]	map00260	Glycine, serine and threonine metabolism
K00133_upstream.h2_1	Conserved sequence (low covariation and power)	K00133	upstream	asd; aspartate-semialdehyde dehydrogenase [EC:1.2.1.11]	ko00260	NA
K00133_upstream.h2_1	Conserved sequence (low covariation and power)	K00133	upstream	asd; aspartate-semialdehyde dehydrogenase [EC:1.2.1.11]	map00261	Monobactam biosynthesis
K00133_upstream.h2_1	Conserved sequence (low covariation and power)	K00133	upstream	asd; aspartate-semialdehyde dehydrogenase [EC:1.2.1.11]	ko00261	NA
K00133_upstream.h2_1	Conserved sequence (low covariation and power)	K00133	upstream	asd; aspartate-semialdehyde dehydrogenase [EC:1.2.1.11]	map00270	Cysteine and methionine metabolism
K00133_upstream.h2_1	Conserved sequence (low covariation and power)	K00133	upstream	asd; aspartate-semialdehyde dehydrogenase [EC:1.2.1.11]	ko00270	NA
K00133_upstream.h2_1	Conserved sequence (low covariation and power)	K00133	upstream	asd; aspartate-semialdehyde dehydrogenase [EC:1.2.1.11]	map00300	Lysine biosynthesis
K00133_upstream.h2_1	Conserved sequence (low covariation and power)	K00133	upstream	asd; aspartate-semialdehyde dehydrogenase [EC:1.2.1.11]	ko00300	NA
K00133_upstream.h2_1	Conserved sequence (low covariation and power)	K00133	upstream	asd; aspartate-semialdehyde dehydrogenase [EC:1.2.1.11]	map01100	Metabolic pathways
K00133_upstream.h2_1	Conserved sequence (low covariation and power)	K00133	upstream	asd; aspartate-semialdehyde dehydrogenase [EC:1.2.1.11]	ko01100	NA
K00133_upstream.h2_1	Conserved sequence (low covariation and power)	K00133	upstream	asd; aspartate-semialdehyde dehydrogenase [EC:1.2.1.11]	map01110	Biosynthesis of secondary metabolites
K00133_upstream.h2_1	Conserved sequence (low covariation and power)	K00133	upstream	asd; aspartate-semialdehyde dehydrogenase [EC:1.2.1.11]	ko01110	NA
K00133_upstream.h2_1	Conserved sequence (low covariation and power)	K00133	upstream	asd; aspartate-semialdehyde dehydrogenase [EC:1.2.1.11]	map01120	Microbial metabolism in diverse environments
K00133_upstream.h2_1	Conserved sequence (low covariation and power)	K00133	upstream	asd; aspartate-semialdehyde dehydrogenase [EC:1.2.1.11]	ko01120	NA
K00133_upstream.h2_1	Conserved sequence (low covariation and power)	K00133	upstream	asd; aspartate-semialdehyde dehydrogenase [EC:1.2.1.11]	map01210	2-Oxocarboxylic acid metabolism
K00133_upstream.h2_1	Conserved sequence (low covariation and power)	K00133	upstream	asd; aspartate-semialdehyde dehydrogenase [EC:1.2.1.11]	ko01210	NA
K00133_upstream.h2_1	Conserved sequence (low covariation and power)	K00133	upstream	asd; aspartate-semialdehyde dehydrogenase [EC:1.2.1.11]	map01230	Biosynthesis of amino acids
K00133_upstream.h2_1	Conserved sequence (low covariation and power)	K00133	upstream	asd; aspartate-semialdehyde dehydrogenase [EC:1.2.1.11]	ko01230	NA
K00133_upstream.h1_3	Conserved sequence (low covariation and power)	K00133	upstream	asd; aspartate-semialdehyde dehydrogenase [EC:1.2.1.11]	map00260	Glycine, serine and threonine metabolism
K00133_upstream.h1_3	Conserved sequence (low covariation and power)	K00133	upstream	asd; aspartate-semialdehyde dehydrogenase [EC:1.2.1.11]	ko00260	NA
K00133_upstream.h1_3	Conserved sequence (low covariation and power)	K00133	upstream	asd; aspartate-semialdehyde dehydrogenase [EC:1.2.1.11]	map00261	Monobactam biosynthesis
K00133_upstream.h1_3	Conserved sequence (low covariation and power)	K00133	upstream	asd; aspartate-semialdehyde dehydrogenase [EC:1.2.1.11]	ko00261	NA
K00133_upstream.h1_3	Conserved sequence (low covariation and power)	K00133	upstream	asd; aspartate-semialdehyde dehydrogenase [EC:1.2.1.11]	map00270	Cysteine and methionine metabolism
K00133_upstream.h1_3	Conserved sequence (low covariation and power)	K00133	upstream	asd; aspartate-semialdehyde dehydrogenase [EC:1.2.1.11]	ko00270	NA
K00133_upstream.h1_3	Conserved sequence (low covariation and power)	K00133	upstream	asd; aspartate-semialdehyde dehydrogenase [EC:1.2.1.11]	map00300	Lysine biosynthesis
K00133_upstream.h1_3	Conserved sequence (low covariation and power)	K00133	upstream	asd; aspartate-semialdehyde dehydrogenase [EC:1.2.1.11]	ko00300	NA
K00133_upstream.h1_3	Conserved sequence (low covariation and power)	K00133	upstream	asd; aspartate-semialdehyde dehydrogenase [EC:1.2.1.11]	map01100	Metabolic pathways
K00133_upstream.h1_3	Conserved sequence (low covariation and power)	K00133	upstream	asd; aspartate-semialdehyde dehydrogenase [EC:1.2.1.11]	ko01100	NA
K00133_upstream.h1_3	Conserved sequence (low covariation and power)	K00133	upstream	asd; aspartate-semialdehyde dehydrogenase [EC:1.2.1.11]	map01110	Biosynthesis of secondary metabolites
K00133_upstream.h1_3	Conserved sequence (low covariation and power)	K00133	upstream	asd; aspartate-semialdehyde dehydrogenase [EC:1.2.1.11]	ko01110	NA
K00133_upstream.h1_3	Conserved sequence (low covariation and power)	K00133	upstream	asd; aspartate-semialdehyde dehydrogenase [EC:1.2.1.11]	map01120	Microbial metabolism in diverse environments
K00133_upstream.h1_3	Conserved sequence (low covariation and power)	K00133	upstream	asd; aspartate-semialdehyde dehydrogenase [EC:1.2.1.11]	ko01120	NA
K00133_upstream.h1_3	Conserved sequence (low covariation and power)	K00133	upstream	asd; aspartate-semialdehyde dehydrogenase [EC:1.2.1.11]	map01210	2-Oxocarboxylic acid metabolism
K00133_upstream.h1_3	Conserved sequence (low covariation and power)	K00133	upstream	asd; aspartate-semialdehyde dehydrogenase [EC:1.2.1.11]	ko01210	NA
K00133_upstream.h1_3	Conserved sequence (low covariation and power)	K00133	upstream	asd; aspartate-semialdehyde dehydrogenase [EC:1.2.1.11]	map01230	Biosynthesis of amino acids
K00133_upstream.h1_3	Conserved sequence (low covariation and power)	K00133	upstream	asd; aspartate-semialdehyde dehydrogenase [EC:1.2.1.11]	ko01230	NA
K00133_upstream.h2_5	Conserved sequence (low covariation and power)	K00133	upstream	asd; aspartate-semialdehyde dehydrogenase [EC:1.2.1.11]	map00260	Glycine, serine and threonine metabolism
K00133_upstream.h2_5	Conserved sequence (low covariation and power)	K00133	upstream	asd; aspartate-semialdehyde dehydrogenase [EC:1.2.1.11]	ko00260	NA
K00133_upstream.h2_5	Conserved sequence (low covariation and power)	K00133	upstream	asd; aspartate-semialdehyde dehydrogenase [EC:1.2.1.11]	map00261	Monobactam biosynthesis
K00133_upstream.h2_5	Conserved sequence (low covariation and power)	K00133	upstream	asd; aspartate-semialdehyde dehydrogenase [EC:1.2.1.11]	ko00261	NA
K00133_upstream.h2_5	Conserved sequence (low covariation and power)	K00133	upstream	asd; aspartate-semialdehyde dehydrogenase [EC:1.2.1.11]	map00270	Cysteine and methionine metabolism
K00133_upstream.h2_5	Conserved sequence (low covariation and power)	K00133	upstream	asd; aspartate-semialdehyde dehydrogenase [EC:1.2.1.11]	ko00270	NA
K00133_upstream.h2_5	Conserved sequence (low covariation and power)	K00133	upstream	asd; aspartate-semialdehyde dehydrogenase [EC:1.2.1.11]	map00300	Lysine biosynthesis
K00133_upstream.h2_5	Conserved sequence (low covariation and power)	K00133	upstream	asd; aspartate-semialdehyde dehydrogenase [EC:1.2.1.11]	ko00300	NA
K00133_upstream.h2_5	Conserved sequence (low covariation and power)	K00133	upstream	asd; aspartate-semialdehyde dehydrogenase [EC:1.2.1.11]	map01100	Metabolic pathways
K00133_upstream.h2_5	Conserved sequence (low covariation and power)	K00133	upstream	asd; aspartate-semialdehyde dehydrogenase [EC:1.2.1.11]	ko01100	NA
K00133_upstream.h2_5	Conserved sequence (low covariation and power)	K00133	upstream	asd; aspartate-semialdehyde dehydrogenase [EC:1.2.1.11]	map01110	Biosynthesis of secondary metabolites
K00133_upstream.h2_5	Conserved sequence (low covariation and power)	K00133	upstream	asd; aspartate-semialdehyde dehydrogenase [EC:1.2.1.11]	ko01110	NA
K00133_upstream.h2_5	Conserved sequence (low covariation and power)	K00133	upstream	asd; aspartate-semialdehyde dehydrogenase [EC:1.2.1.11]	map01120	Microbial metabolism in diverse environments
K00133_upstream.h2_5	Conserved sequence (low covariation and power)	K00133	upstream	asd; aspartate-semialdehyde dehydrogenase [EC:1.2.1.11]	ko01120	NA
K00133_upstream.h2_5	Conserved sequence (low covariation and power)	K00133	upstream	asd; aspartate-semialdehyde dehydrogenase [EC:1.2.1.11]	map01210	2-Oxocarboxylic acid metabolism
K00133_upstream.h2_5	Conserved sequence (low covariation and power)	K00133	upstream	asd; aspartate-semialdehyde dehydrogenase [EC:1.2.1.11]	ko01210	NA
K00133_upstream.h2_5	Conserved sequence (low covariation and power)	K00133	upstream	asd; aspartate-semialdehyde dehydrogenase [EC:1.2.1.11]	map01230	Biosynthesis of amino acids
K00133_upstream.h2_5	Conserved sequence (low covariation and power)	K00133	upstream	asd; aspartate-semialdehyde dehydrogenase [EC:1.2.1.11]	ko01230	NA
K00145_upstream.h1_5.h2_4.h2_1.h1_1	Conserved sequence (low covariation and power)	K00145	upstream	argC; N-acetyl-gamma-glutamyl-phosphate reductase [EC:1.2.1.38]	map00220	Arginine biosynthesis
K00145_upstream.h1_5.h2_4.h2_1.h1_1	Conserved sequence (low covariation and power)	K00145	upstream	argC; N-acetyl-gamma-glutamyl-phosphate reductase [EC:1.2.1.38]	ko00220	NA
K00145_upstream.h1_5.h2_4.h2_1.h1_1	Conserved sequence (low covariation and power)	K00145	upstream	argC; N-acetyl-gamma-glutamyl-phosphate reductase [EC:1.2.1.38]	map01100	Metabolic pathways
K00145_upstream.h1_5.h2_4.h2_1.h1_1	Conserved sequence (low covariation and power)	K00145	upstream	argC; N-acetyl-gamma-glutamyl-phosphate reductase [EC:1.2.1.38]	ko01100	NA
K00145_upstream.h1_5.h2_4.h2_1.h1_1	Conserved sequence (low covariation and power)	K00145	upstream	argC; N-acetyl-gamma-glutamyl-phosphate reductase [EC:1.2.1.38]	map01110	Biosynthesis of secondary metabolites
K00145_upstream.h1_5.h2_4.h2_1.h1_1	Conserved sequence (low covariation and power)	K00145	upstream	argC; N-acetyl-gamma-glutamyl-phosphate reductase [EC:1.2.1.38]	ko01110	NA
K00145_upstream.h1_5.h2_4.h2_1.h1_1	Conserved sequence (low covariation and power)	K00145	upstream	argC; N-acetyl-gamma-glutamyl-phosphate reductase [EC:1.2.1.38]	map01210	2-Oxocarboxylic acid metabolism
K00145_upstream.h1_5.h2_4.h2_1.h1_1	Conserved sequence (low covariation and power)	K00145	upstream	argC; N-acetyl-gamma-glutamyl-phosphate reductase [EC:1.2.1.38]	ko01210	NA
K00145_upstream.h1_5.h2_4.h2_1.h1_1	Conserved sequence (low covariation and power)	K00145	upstream	argC; N-acetyl-gamma-glutamyl-phosphate reductase [EC:1.2.1.38]	map01230	Biosynthesis of amino acids
K00145_upstream.h1_5.h2_4.h2_1.h1_1	Conserved sequence (low covariation and power)	K00145	upstream	argC; N-acetyl-gamma-glutamyl-phosphate reductase [EC:1.2.1.38]	ko01230	NA
K00147_upstream.h1_1	High covariation	K00147	upstream	proA; glutamate-5-semialdehyde dehydrogenase [EC:1.2.1.41]	map00330	Arginine and proline metabolism
K00147_upstream.h1_1	High covariation	K00147	upstream	proA; glutamate-5-semialdehyde dehydrogenase [EC:1.2.1.41]	ko00330	NA
K00147_upstream.h1_1	High covariation	K00147	upstream	proA; glutamate-5-semialdehyde dehydrogenase [EC:1.2.1.41]	map00332	Carbapenem biosynthesis
K00147_upstream.h1_1	High covariation	K00147	upstream	proA; glutamate-5-semialdehyde dehydrogenase [EC:1.2.1.41]	ko00332	NA
K00147_upstream.h1_1	High covariation	K00147	upstream	proA; glutamate-5-semialdehyde dehydrogenase [EC:1.2.1.41]	map01100	Metabolic pathways
K00147_upstream.h1_1	High covariation	K00147	upstream	proA; glutamate-5-semialdehyde dehydrogenase [EC:1.2.1.41]	ko01100	NA
K00147_upstream.h1_1	High covariation	K00147	upstream	proA; glutamate-5-semialdehyde dehydrogenase [EC:1.2.1.41]	map01110	Biosynthesis of secondary metabolites
K00147_upstream.h1_1	High covariation	K00147	upstream	proA; glutamate-5-semialdehyde dehydrogenase [EC:1.2.1.41]	ko01110	NA
K00147_upstream.h1_1	High covariation	K00147	upstream	proA; glutamate-5-semialdehyde dehydrogenase [EC:1.2.1.41]	map01230	Biosynthesis of amino acids
K00147_upstream.h1_1	High covariation	K00147	upstream	proA; glutamate-5-semialdehyde dehydrogenase [EC:1.2.1.41]	ko01230	NA
K00215_upstream.h1_5.h2_5	Conserved sequence (low covariation and power)	K00215	upstream	dapB; 4-hydroxy-tetrahydrodipicolinate reductase [EC:1.17.1.8]	map00261	Monobactam biosynthesis
K00215_upstream.h1_5.h2_5	Conserved sequence (low covariation and power)	K00215	upstream	dapB; 4-hydroxy-tetrahydrodipicolinate reductase [EC:1.17.1.8]	ko00261	NA
K00215_upstream.h1_5.h2_5	Conserved sequence (low covariation and power)	K00215	upstream	dapB; 4-hydroxy-tetrahydrodipicolinate reductase [EC:1.17.1.8]	map00300	Lysine biosynthesis
K00215_upstream.h1_5.h2_5	Conserved sequence (low covariation and power)	K00215	upstream	dapB; 4-hydroxy-tetrahydrodipicolinate reductase [EC:1.17.1.8]	ko00300	NA
K00215_upstream.h1_5.h2_5	Conserved sequence (low covariation and power)	K00215	upstream	dapB; 4-hydroxy-tetrahydrodipicolinate reductase [EC:1.17.1.8]	map01100	Metabolic pathways
K00215_upstream.h1_5.h2_5	Conserved sequence (low covariation and power)	K00215	upstream	dapB; 4-hydroxy-tetrahydrodipicolinate reductase [EC:1.17.1.8]	ko01100	NA
K00215_upstream.h1_5.h2_5	Conserved sequence (low covariation and power)	K00215	upstream	dapB; 4-hydroxy-tetrahydrodipicolinate reductase [EC:1.17.1.8]	map01110	Biosynthesis of secondary metabolites
K00215_upstream.h1_5.h2_5	Conserved sequence (low covariation and power)	K00215	upstream	dapB; 4-hydroxy-tetrahydrodipicolinate reductase [EC:1.17.1.8]	ko01110	NA
K00215_upstream.h1_5.h2_5	Conserved sequence (low covariation and power)	K00215	upstream	dapB; 4-hydroxy-tetrahydrodipicolinate reductase [EC:1.17.1.8]	map01120	Microbial metabolism in diverse environments
K00215_upstream.h1_5.h2_5	Conserved sequence (low covariation and power)	K00215	upstream	dapB; 4-hydroxy-tetrahydrodipicolinate reductase [EC:1.17.1.8]	ko01120	NA
K00215_upstream.h1_5.h2_5	Conserved sequence (low covariation and power)	K00215	upstream	dapB; 4-hydroxy-tetrahydrodipicolinate reductase [EC:1.17.1.8]	map01230	Biosynthesis of amino acids
K00215_upstream.h1_5.h2_5	Conserved sequence (low covariation and power)	K00215	upstream	dapB; 4-hydroxy-tetrahydrodipicolinate reductase [EC:1.17.1.8]	ko01230	NA
K00215_upstream.h1_2.h2_1	High power (low covariation)	K00215	upstream	dapB; 4-hydroxy-tetrahydrodipicolinate reductase [EC:1.17.1.8]	map00261	Monobactam biosynthesis
K00215_upstream.h1_2.h2_1	High power (low covariation)	K00215	upstream	dapB; 4-hydroxy-tetrahydrodipicolinate reductase [EC:1.17.1.8]	ko00261	NA
K00215_upstream.h1_2.h2_1	High power (low covariation)	K00215	upstream	dapB; 4-hydroxy-tetrahydrodipicolinate reductase [EC:1.17.1.8]	map00300	Lysine biosynthesis
K00215_upstream.h1_2.h2_1	High power (low covariation)	K00215	upstream	dapB; 4-hydroxy-tetrahydrodipicolinate reductase [EC:1.17.1.8]	ko00300	NA
K00215_upstream.h1_2.h2_1	High power (low covariation)	K00215	upstream	dapB; 4-hydroxy-tetrahydrodipicolinate reductase [EC:1.17.1.8]	map01100	Metabolic pathways
K00215_upstream.h1_2.h2_1	High power (low covariation)	K00215	upstream	dapB; 4-hydroxy-tetrahydrodipicolinate reductase [EC:1.17.1.8]	ko01100	NA
K00215_upstream.h1_2.h2_1	High power (low covariation)	K00215	upstream	dapB; 4-hydroxy-tetrahydrodipicolinate reductase [EC:1.17.1.8]	map01110	Biosynthesis of secondary metabolites
K00215_upstream.h1_2.h2_1	High power (low covariation)	K00215	upstream	dapB; 4-hydroxy-tetrahydrodipicolinate reductase [EC:1.17.1.8]	ko01110	NA
K00215_upstream.h1_2.h2_1	High power (low covariation)	K00215	upstream	dapB; 4-hydroxy-tetrahydrodipicolinate reductase [EC:1.17.1.8]	map01120	Microbial metabolism in diverse environments
K00215_upstream.h1_2.h2_1	High power (low covariation)	K00215	upstream	dapB; 4-hydroxy-tetrahydrodipicolinate reductase [EC:1.17.1.8]	ko01120	NA
K00215_upstream.h1_2.h2_1	High power (low covariation)	K00215	upstream	dapB; 4-hydroxy-tetrahydrodipicolinate reductase [EC:1.17.1.8]	map01230	Biosynthesis of amino acids
K00215_upstream.h1_2.h2_1	High power (low covariation)	K00215	upstream	dapB; 4-hydroxy-tetrahydrodipicolinate reductase [EC:1.17.1.8]	ko01230	NA
K00215_upstream.h1_4.h2_2.h2_3	Conserved sequence (low covariation and power)	K00215	upstream	dapB; 4-hydroxy-tetrahydrodipicolinate reductase [EC:1.17.1.8]	map00261	Monobactam biosynthesis
K00215_upstream.h1_4.h2_2.h2_3	Conserved sequence (low covariation and power)	K00215	upstream	dapB; 4-hydroxy-tetrahydrodipicolinate reductase [EC:1.17.1.8]	ko00261	NA
K00215_upstream.h1_4.h2_2.h2_3	Conserved sequence (low covariation and power)	K00215	upstream	dapB; 4-hydroxy-tetrahydrodipicolinate reductase [EC:1.17.1.8]	map00300	Lysine biosynthesis
K00215_upstream.h1_4.h2_2.h2_3	Conserved sequence (low covariation and power)	K00215	upstream	dapB; 4-hydroxy-tetrahydrodipicolinate reductase [EC:1.17.1.8]	ko00300	NA
K00215_upstream.h1_4.h2_2.h2_3	Conserved sequence (low covariation and power)	K00215	upstream	dapB; 4-hydroxy-tetrahydrodipicolinate reductase [EC:1.17.1.8]	map01100	Metabolic pathways
K00215_upstream.h1_4.h2_2.h2_3	Conserved sequence (low covariation and power)	K00215	upstream	dapB; 4-hydroxy-tetrahydrodipicolinate reductase [EC:1.17.1.8]	ko01100	NA
K00215_upstream.h1_4.h2_2.h2_3	Conserved sequence (low covariation and power)	K00215	upstream	dapB; 4-hydroxy-tetrahydrodipicolinate reductase [EC:1.17.1.8]	map01110	Biosynthesis of secondary metabolites
K00215_upstream.h1_4.h2_2.h2_3	Conserved sequence (low covariation and power)	K00215	upstream	dapB; 4-hydroxy-tetrahydrodipicolinate reductase [EC:1.17.1.8]	ko01110	NA
K00215_upstream.h1_4.h2_2.h2_3	Conserved sequence (low covariation and power)	K00215	upstream	dapB; 4-hydroxy-tetrahydrodipicolinate reductase [EC:1.17.1.8]	map01120	Microbial metabolism in diverse environments
K00215_upstream.h1_4.h2_2.h2_3	Conserved sequence (low covariation and power)	K00215	upstream	dapB; 4-hydroxy-tetrahydrodipicolinate reductase [EC:1.17.1.8]	ko01120	NA
K00215_upstream.h1_4.h2_2.h2_3	Conserved sequence (low covariation and power)	K00215	upstream	dapB; 4-hydroxy-tetrahydrodipicolinate reductase [EC:1.17.1.8]	map01230	Biosynthesis of amino acids
K00215_upstream.h1_4.h2_2.h2_3	Conserved sequence (low covariation and power)	K00215	upstream	dapB; 4-hydroxy-tetrahydrodipicolinate reductase [EC:1.17.1.8]	ko01230	NA
K00228_upstream.h2_2	Conserved sequence (low covariation and power)	K00228	upstream	CPOX, hemF; coproporphyrinogen III oxidase [EC:1.3.3.3]	map00860	Porphyrin metabolism
K00228_upstream.h2_2	Conserved sequence (low covariation and power)	K00228	upstream	CPOX, hemF; coproporphyrinogen III oxidase [EC:1.3.3.3]	ko00860	NA
K00228_upstream.h2_2	Conserved sequence (low covariation and power)	K00228	upstream	CPOX, hemF; coproporphyrinogen III oxidase [EC:1.3.3.3]	map01100	Metabolic pathways
K00228_upstream.h2_2	Conserved sequence (low covariation and power)	K00228	upstream	CPOX, hemF; coproporphyrinogen III oxidase [EC:1.3.3.3]	ko01100	NA
K00228_upstream.h2_2	Conserved sequence (low covariation and power)	K00228	upstream	CPOX, hemF; coproporphyrinogen III oxidase [EC:1.3.3.3]	map01110	Biosynthesis of secondary metabolites
K00228_upstream.h2_2	Conserved sequence (low covariation and power)	K00228	upstream	CPOX, hemF; coproporphyrinogen III oxidase [EC:1.3.3.3]	ko01110	NA
K00228_upstream.h2_2	Conserved sequence (low covariation and power)	K00228	upstream	CPOX, hemF; coproporphyrinogen III oxidase [EC:1.3.3.3]	map01240	Biosynthesis of cofactors
K00228_upstream.h2_2	Conserved sequence (low covariation and power)	K00228	upstream	CPOX, hemF; coproporphyrinogen III oxidase [EC:1.3.3.3]	ko01240	NA
K00228_upstream.h1_1.h1_4	Conserved sequence (low covariation and power)	K00228	upstream	CPOX, hemF; coproporphyrinogen III oxidase [EC:1.3.3.3]	map00860	Porphyrin metabolism
K00228_upstream.h1_1.h1_4	Conserved sequence (low covariation and power)	K00228	upstream	CPOX, hemF; coproporphyrinogen III oxidase [EC:1.3.3.3]	ko00860	NA
K00228_upstream.h1_1.h1_4	Conserved sequence (low covariation and power)	K00228	upstream	CPOX, hemF; coproporphyrinogen III oxidase [EC:1.3.3.3]	map01100	Metabolic pathways
K00228_upstream.h1_1.h1_4	Conserved sequence (low covariation and power)	K00228	upstream	CPOX, hemF; coproporphyrinogen III oxidase [EC:1.3.3.3]	ko01100	NA
K00228_upstream.h1_1.h1_4	Conserved sequence (low covariation and power)	K00228	upstream	CPOX, hemF; coproporphyrinogen III oxidase [EC:1.3.3.3]	map01110	Biosynthesis of secondary metabolites
K00228_upstream.h1_1.h1_4	Conserved sequence (low covariation and power)	K00228	upstream	CPOX, hemF; coproporphyrinogen III oxidase [EC:1.3.3.3]	ko01110	NA
K00228_upstream.h1_1.h1_4	Conserved sequence (low covariation and power)	K00228	upstream	CPOX, hemF; coproporphyrinogen III oxidase [EC:1.3.3.3]	map01240	Biosynthesis of cofactors
K00228_upstream.h1_1.h1_4	Conserved sequence (low covariation and power)	K00228	upstream	CPOX, hemF; coproporphyrinogen III oxidase [EC:1.3.3.3]	ko01240	NA
K00228_upstream.h1_2	High power (low covariation)	K00228	upstream	CPOX, hemF; coproporphyrinogen III oxidase [EC:1.3.3.3]	map00860	Porphyrin metabolism
K00228_upstream.h1_2	High power (low covariation)	K00228	upstream	CPOX, hemF; coproporphyrinogen III oxidase [EC:1.3.3.3]	ko00860	NA
K00228_upstream.h1_2	High power (low covariation)	K00228	upstream	CPOX, hemF; coproporphyrinogen III oxidase [EC:1.3.3.3]	map01100	Metabolic pathways
K00228_upstream.h1_2	High power (low covariation)	K00228	upstream	CPOX, hemF; coproporphyrinogen III oxidase [EC:1.3.3.3]	ko01100	NA
K00228_upstream.h1_2	High power (low covariation)	K00228	upstream	CPOX, hemF; coproporphyrinogen III oxidase [EC:1.3.3.3]	map01110	Biosynthesis of secondary metabolites
K00228_upstream.h1_2	High power (low covariation)	K00228	upstream	CPOX, hemF; coproporphyrinogen III oxidase [EC:1.3.3.3]	ko01110	NA
K00228_upstream.h1_2	High power (low covariation)	K00228	upstream	CPOX, hemF; coproporphyrinogen III oxidase [EC:1.3.3.3]	map01240	Biosynthesis of cofactors
K00228_upstream.h1_2	High power (low covariation)	K00228	upstream	CPOX, hemF; coproporphyrinogen III oxidase [EC:1.3.3.3]	ko01240	NA
K00259_upstream.h2_1	Conserved sequence (low covariation and power)	K00259	upstream	ald; alanine dehydrogenase [EC:1.4.1.1]	map00250	Alanine, aspartate and glutamate metabolism
K00259_upstream.h2_1	Conserved sequence (low covariation and power)	K00259	upstream	ald; alanine dehydrogenase [EC:1.4.1.1]	ko00250	NA
K00259_upstream.h2_1	Conserved sequence (low covariation and power)	K00259	upstream	ald; alanine dehydrogenase [EC:1.4.1.1]	map00430	Taurine and hypotaurine metabolism
K00259_upstream.h2_1	Conserved sequence (low covariation and power)	K00259	upstream	ald; alanine dehydrogenase [EC:1.4.1.1]	ko00430	NA
K00259_upstream.h2_1	Conserved sequence (low covariation and power)	K00259	upstream	ald; alanine dehydrogenase [EC:1.4.1.1]	map01100	Metabolic pathways
K00259_upstream.h2_1	Conserved sequence (low covariation and power)	K00259	upstream	ald; alanine dehydrogenase [EC:1.4.1.1]	ko01100	NA
K00297_upstream.h2_1	High power (low covariation)	K00297	upstream	metF, MTHFR; methylenetetrahydrofolate reductase (NADH) [EC:1.5.1.54]	map00670	One carbon pool by folate
K00297_upstream.h2_1	High power (low covariation)	K00297	upstream	metF, MTHFR; methylenetetrahydrofolate reductase (NADH) [EC:1.5.1.54]	ko00670	NA
K00297_upstream.h2_1	High power (low covariation)	K00297	upstream	metF, MTHFR; methylenetetrahydrofolate reductase (NADH) [EC:1.5.1.54]	map00720	Other carbon fixation pathways
K00297_upstream.h2_1	High power (low covariation)	K00297	upstream	metF, MTHFR; methylenetetrahydrofolate reductase (NADH) [EC:1.5.1.54]	ko00720	NA
K00297_upstream.h2_1	High power (low covariation)	K00297	upstream	metF, MTHFR; methylenetetrahydrofolate reductase (NADH) [EC:1.5.1.54]	map01100	Metabolic pathways
K00297_upstream.h2_1	High power (low covariation)	K00297	upstream	metF, MTHFR; methylenetetrahydrofolate reductase (NADH) [EC:1.5.1.54]	ko01100	NA
K00297_upstream.h2_1	High power (low covariation)	K00297	upstream	metF, MTHFR; methylenetetrahydrofolate reductase (NADH) [EC:1.5.1.54]	map01120	Microbial metabolism in diverse environments
K00297_upstream.h2_1	High power (low covariation)	K00297	upstream	metF, MTHFR; methylenetetrahydrofolate reductase (NADH) [EC:1.5.1.54]	ko01120	NA
K00297_upstream.h2_1	High power (low covariation)	K00297	upstream	metF, MTHFR; methylenetetrahydrofolate reductase (NADH) [EC:1.5.1.54]	map01200	Carbon metabolism
K00297_upstream.h2_1	High power (low covariation)	K00297	upstream	metF, MTHFR; methylenetetrahydrofolate reductase (NADH) [EC:1.5.1.54]	ko01200	NA
K00297_upstream.h1_1.h1_3	High power (low covariation)	K00297	upstream	metF, MTHFR; methylenetetrahydrofolate reductase (NADH) [EC:1.5.1.54]	map00670	One carbon pool by folate
K00297_upstream.h1_1.h1_3	High power (low covariation)	K00297	upstream	metF, MTHFR; methylenetetrahydrofolate reductase (NADH) [EC:1.5.1.54]	ko00670	NA
K00297_upstream.h1_1.h1_3	High power (low covariation)	K00297	upstream	metF, MTHFR; methylenetetrahydrofolate reductase (NADH) [EC:1.5.1.54]	map00720	Other carbon fixation pathways
K00297_upstream.h1_1.h1_3	High power (low covariation)	K00297	upstream	metF, MTHFR; methylenetetrahydrofolate reductase (NADH) [EC:1.5.1.54]	ko00720	NA
K00297_upstream.h1_1.h1_3	High power (low covariation)	K00297	upstream	metF, MTHFR; methylenetetrahydrofolate reductase (NADH) [EC:1.5.1.54]	map01100	Metabolic pathways
K00297_upstream.h1_1.h1_3	High power (low covariation)	K00297	upstream	metF, MTHFR; methylenetetrahydrofolate reductase (NADH) [EC:1.5.1.54]	ko01100	NA
K00297_upstream.h1_1.h1_3	High power (low covariation)	K00297	upstream	metF, MTHFR; methylenetetrahydrofolate reductase (NADH) [EC:1.5.1.54]	map01120	Microbial metabolism in diverse environments
K00297_upstream.h1_1.h1_3	High power (low covariation)	K00297	upstream	metF, MTHFR; methylenetetrahydrofolate reductase (NADH) [EC:1.5.1.54]	ko01120	NA
K00297_upstream.h1_1.h1_3	High power (low covariation)	K00297	upstream	metF, MTHFR; methylenetetrahydrofolate reductase (NADH) [EC:1.5.1.54]	map01200	Carbon metabolism
K00297_upstream.h1_1.h1_3	High power (low covariation)	K00297	upstream	metF, MTHFR; methylenetetrahydrofolate reductase (NADH) [EC:1.5.1.54]	ko01200	NA
K00311_upstream.h1_3.h1_4	High power (low covariation)	K00311	upstream	ETFDH; electron-transferring-flavoprotein dehydrogenase [EC:1.5.5.1]	NA	NA
K00324_upstream.h2_1	Conserved sequence (low covariation and power)	K00324	upstream	pntA; proton-translocating NAD(P)+ transhydrogenase subunit alpha [EC:7.1.1.1]	map00760	Nicotinate and nicotinamide metabolism
K00324_upstream.h2_1	Conserved sequence (low covariation and power)	K00324	upstream	pntA; proton-translocating NAD(P)+ transhydrogenase subunit alpha [EC:7.1.1.1]	ko00760	NA
K00324_upstream.h2_1	Conserved sequence (low covariation and power)	K00324	upstream	pntA; proton-translocating NAD(P)+ transhydrogenase subunit alpha [EC:7.1.1.1]	map01100	Metabolic pathways
K00324_upstream.h2_1	Conserved sequence (low covariation and power)	K00324	upstream	pntA; proton-translocating NAD(P)+ transhydrogenase subunit alpha [EC:7.1.1.1]	ko01100	NA
K00324_upstream.h1_5	Conserved sequence (low covariation and power)	K00324	upstream	pntA; proton-translocating NAD(P)+ transhydrogenase subunit alpha [EC:7.1.1.1]	map00760	Nicotinate and nicotinamide metabolism
K00324_upstream.h1_5	Conserved sequence (low covariation and power)	K00324	upstream	pntA; proton-translocating NAD(P)+ transhydrogenase subunit alpha [EC:7.1.1.1]	ko00760	NA
K00324_upstream.h1_5	Conserved sequence (low covariation and power)	K00324	upstream	pntA; proton-translocating NAD(P)+ transhydrogenase subunit alpha [EC:7.1.1.1]	map01100	Metabolic pathways
K00324_upstream.h1_5	Conserved sequence (low covariation and power)	K00324	upstream	pntA; proton-translocating NAD(P)+ transhydrogenase subunit alpha [EC:7.1.1.1]	ko01100	NA
K00436_upstream.h1_4.h2_2	High power (low covariation)	K00436	upstream	hoxH; NAD-reducing hydrogenase large subunit [EC:1.12.1.2]	NA	NA
K00436_upstream.h2_1	Conserved sequence (low covariation and power)	K00436	upstream	hoxH; NAD-reducing hydrogenase large subunit [EC:1.12.1.2]	NA	NA
K00688_upstream.h2_2	Conserved sequence (low covariation and power)	K00688	upstream	PYG, glgP; glycogen phosphorylase [EC:2.4.1.1]	map00500	Starch and sucrose metabolism
K00688_upstream.h2_2	Conserved sequence (low covariation and power)	K00688	upstream	PYG, glgP; glycogen phosphorylase [EC:2.4.1.1]	ko00500	NA
K00688_upstream.h2_2	Conserved sequence (low covariation and power)	K00688	upstream	PYG, glgP; glycogen phosphorylase [EC:2.4.1.1]	map01100	Metabolic pathways
K00688_upstream.h2_2	Conserved sequence (low covariation and power)	K00688	upstream	PYG, glgP; glycogen phosphorylase [EC:2.4.1.1]	ko01100	NA
K00688_upstream.h2_2	Conserved sequence (low covariation and power)	K00688	upstream	PYG, glgP; glycogen phosphorylase [EC:2.4.1.1]	map01110	Biosynthesis of secondary metabolites
K00688_upstream.h2_2	Conserved sequence (low covariation and power)	K00688	upstream	PYG, glgP; glycogen phosphorylase [EC:2.4.1.1]	ko01110	NA
K00688_upstream.h2_2	Conserved sequence (low covariation and power)	K00688	upstream	PYG, glgP; glycogen phosphorylase [EC:2.4.1.1]	map02026	Biofilm formation - Escherichia coli
K00688_upstream.h2_2	Conserved sequence (low covariation and power)	K00688	upstream	PYG, glgP; glycogen phosphorylase [EC:2.4.1.1]	ko02026	NA
K00688_upstream.h2_2	Conserved sequence (low covariation and power)	K00688	upstream	PYG, glgP; glycogen phosphorylase [EC:2.4.1.1]	map04217	Necroptosis
K00688_upstream.h2_2	Conserved sequence (low covariation and power)	K00688	upstream	PYG, glgP; glycogen phosphorylase [EC:2.4.1.1]	ko04217	NA
K00688_upstream.h2_2	Conserved sequence (low covariation and power)	K00688	upstream	PYG, glgP; glycogen phosphorylase [EC:2.4.1.1]	map04910	Insulin signaling pathway
K00688_upstream.h2_2	Conserved sequence (low covariation and power)	K00688	upstream	PYG, glgP; glycogen phosphorylase [EC:2.4.1.1]	ko04910	NA
K00688_upstream.h2_2	Conserved sequence (low covariation and power)	K00688	upstream	PYG, glgP; glycogen phosphorylase [EC:2.4.1.1]	map04922	Glucagon signaling pathway
K00688_upstream.h2_2	Conserved sequence (low covariation and power)	K00688	upstream	PYG, glgP; glycogen phosphorylase [EC:2.4.1.1]	ko04922	NA
K00688_upstream.h2_2	Conserved sequence (low covariation and power)	K00688	upstream	PYG, glgP; glycogen phosphorylase [EC:2.4.1.1]	map04931	Insulin resistance
K00688_upstream.h2_2	Conserved sequence (low covariation and power)	K00688	upstream	PYG, glgP; glycogen phosphorylase [EC:2.4.1.1]	ko04931	NA
K00748_upstream.h1_1.h2_1	High covariation	K00748	upstream	lpxB; lipid-A-disaccharide synthase [EC:2.4.1.182]	map00540	Lipopolysaccharide biosynthesis
K00748_upstream.h1_1.h2_1	High covariation	K00748	upstream	lpxB; lipid-A-disaccharide synthase [EC:2.4.1.182]	ko00540	NA
K00748_upstream.h1_1.h2_1	High covariation	K00748	upstream	lpxB; lipid-A-disaccharide synthase [EC:2.4.1.182]	map01100	Metabolic pathways
K00748_upstream.h1_1.h2_1	High covariation	K00748	upstream	lpxB; lipid-A-disaccharide synthase [EC:2.4.1.182]	ko01100	NA
K00772_upstream.h1_5	Conserved sequence (low covariation and power)	K00772	upstream	mtaP, MTAP; 5'-methylthioadenosine phosphorylase [EC:2.4.2.28]	map00270	Cysteine and methionine metabolism
K00772_upstream.h1_5	Conserved sequence (low covariation and power)	K00772	upstream	mtaP, MTAP; 5'-methylthioadenosine phosphorylase [EC:2.4.2.28]	ko00270	NA
K00772_upstream.h1_5	Conserved sequence (low covariation and power)	K00772	upstream	mtaP, MTAP; 5'-methylthioadenosine phosphorylase [EC:2.4.2.28]	map01100	Metabolic pathways
K00772_upstream.h1_5	Conserved sequence (low covariation and power)	K00772	upstream	mtaP, MTAP; 5'-methylthioadenosine phosphorylase [EC:2.4.2.28]	ko01100	NA
K00790_upstream.h2_4.h2_5	Conserved sequence (low covariation and power)	K00790	upstream	murA; UDP-N-acetylglucosamine 1-carboxyvinyltransferase [EC:2.5.1.7]	map00520	Amino sugar and nucleotide sugar metabolism
K00790_upstream.h2_4.h2_5	Conserved sequence (low covariation and power)	K00790	upstream	murA; UDP-N-acetylglucosamine 1-carboxyvinyltransferase [EC:2.5.1.7]	ko00520	NA
K00790_upstream.h2_4.h2_5	Conserved sequence (low covariation and power)	K00790	upstream	murA; UDP-N-acetylglucosamine 1-carboxyvinyltransferase [EC:2.5.1.7]	map00550	Peptidoglycan biosynthesis
K00790_upstream.h2_4.h2_5	Conserved sequence (low covariation and power)	K00790	upstream	murA; UDP-N-acetylglucosamine 1-carboxyvinyltransferase [EC:2.5.1.7]	ko00550	NA
K00790_upstream.h2_4.h2_5	Conserved sequence (low covariation and power)	K00790	upstream	murA; UDP-N-acetylglucosamine 1-carboxyvinyltransferase [EC:2.5.1.7]	map01100	Metabolic pathways
K00790_upstream.h2_4.h2_5	Conserved sequence (low covariation and power)	K00790	upstream	murA; UDP-N-acetylglucosamine 1-carboxyvinyltransferase [EC:2.5.1.7]	ko01100	NA
K00790_upstream.h2_4.h2_5	Conserved sequence (low covariation and power)	K00790	upstream	murA; UDP-N-acetylglucosamine 1-carboxyvinyltransferase [EC:2.5.1.7]	map01250	Biosynthesis of nucleotide sugars
K00790_upstream.h2_4.h2_5	Conserved sequence (low covariation and power)	K00790	upstream	murA; UDP-N-acetylglucosamine 1-carboxyvinyltransferase [EC:2.5.1.7]	ko01250	NA
K00791_upstream.h1_4	Conserved sequence (low covariation and power)	K00791	upstream	miaA, TRIT1; tRNA dimethylallyltransferase [EC:2.5.1.75]	map00908	Zeatin biosynthesis
K00791_upstream.h1_4	Conserved sequence (low covariation and power)	K00791	upstream	miaA, TRIT1; tRNA dimethylallyltransferase [EC:2.5.1.75]	ko00908	NA
K00791_upstream.h1_4	Conserved sequence (low covariation and power)	K00791	upstream	miaA, TRIT1; tRNA dimethylallyltransferase [EC:2.5.1.75]	map01100	Metabolic pathways
K00791_upstream.h1_4	Conserved sequence (low covariation and power)	K00791	upstream	miaA, TRIT1; tRNA dimethylallyltransferase [EC:2.5.1.75]	ko01100	NA
K00791_upstream.h1_4	Conserved sequence (low covariation and power)	K00791	upstream	miaA, TRIT1; tRNA dimethylallyltransferase [EC:2.5.1.75]	map01110	Biosynthesis of secondary metabolites
K00791_upstream.h1_4	Conserved sequence (low covariation and power)	K00791	upstream	miaA, TRIT1; tRNA dimethylallyltransferase [EC:2.5.1.75]	ko01110	NA
K00791_upstream.h2_4	Conserved sequence (low covariation and power)	K00791	upstream	miaA, TRIT1; tRNA dimethylallyltransferase [EC:2.5.1.75]	map00908	Zeatin biosynthesis
K00791_upstream.h2_4	Conserved sequence (low covariation and power)	K00791	upstream	miaA, TRIT1; tRNA dimethylallyltransferase [EC:2.5.1.75]	ko00908	NA
K00791_upstream.h2_4	Conserved sequence (low covariation and power)	K00791	upstream	miaA, TRIT1; tRNA dimethylallyltransferase [EC:2.5.1.75]	map01100	Metabolic pathways
K00791_upstream.h2_4	Conserved sequence (low covariation and power)	K00791	upstream	miaA, TRIT1; tRNA dimethylallyltransferase [EC:2.5.1.75]	ko01100	NA
K00791_upstream.h2_4	Conserved sequence (low covariation and power)	K00791	upstream	miaA, TRIT1; tRNA dimethylallyltransferase [EC:2.5.1.75]	map01110	Biosynthesis of secondary metabolites
K00791_upstream.h2_4	Conserved sequence (low covariation and power)	K00791	upstream	miaA, TRIT1; tRNA dimethylallyltransferase [EC:2.5.1.75]	ko01110	NA
K00793_upstream.h2_1.h2_3	Conserved sequence (low covariation and power)	K00793	upstream	ribE, RIB5; riboflavin synthase [EC:2.5.1.9]	map00740	Riboflavin metabolism
K00793_upstream.h2_1.h2_3	Conserved sequence (low covariation and power)	K00793	upstream	ribE, RIB5; riboflavin synthase [EC:2.5.1.9]	ko00740	NA
K00793_upstream.h2_1.h2_3	Conserved sequence (low covariation and power)	K00793	upstream	ribE, RIB5; riboflavin synthase [EC:2.5.1.9]	map01100	Metabolic pathways
K00793_upstream.h2_1.h2_3	Conserved sequence (low covariation and power)	K00793	upstream	ribE, RIB5; riboflavin synthase [EC:2.5.1.9]	ko01100	NA
K00793_upstream.h2_1.h2_3	Conserved sequence (low covariation and power)	K00793	upstream	ribE, RIB5; riboflavin synthase [EC:2.5.1.9]	map01110	Biosynthesis of secondary metabolites
K00793_upstream.h2_1.h2_3	Conserved sequence (low covariation and power)	K00793	upstream	ribE, RIB5; riboflavin synthase [EC:2.5.1.9]	ko01110	NA
K00793_upstream.h2_1.h2_3	Conserved sequence (low covariation and power)	K00793	upstream	ribE, RIB5; riboflavin synthase [EC:2.5.1.9]	map01240	Biosynthesis of cofactors
K00793_upstream.h2_1.h2_3	Conserved sequence (low covariation and power)	K00793	upstream	ribE, RIB5; riboflavin synthase [EC:2.5.1.9]	ko01240	NA
K00793_upstream.h2_2.h2_5	Conserved sequence (low covariation and power)	K00793	upstream	ribE, RIB5; riboflavin synthase [EC:2.5.1.9]	map00740	Riboflavin metabolism
K00793_upstream.h2_2.h2_5	Conserved sequence (low covariation and power)	K00793	upstream	ribE, RIB5; riboflavin synthase [EC:2.5.1.9]	ko00740	NA
K00793_upstream.h2_2.h2_5	Conserved sequence (low covariation and power)	K00793	upstream	ribE, RIB5; riboflavin synthase [EC:2.5.1.9]	map01100	Metabolic pathways
K00793_upstream.h2_2.h2_5	Conserved sequence (low covariation and power)	K00793	upstream	ribE, RIB5; riboflavin synthase [EC:2.5.1.9]	ko01100	NA
K00793_upstream.h2_2.h2_5	Conserved sequence (low covariation and power)	K00793	upstream	ribE, RIB5; riboflavin synthase [EC:2.5.1.9]	map01110	Biosynthesis of secondary metabolites
K00793_upstream.h2_2.h2_5	Conserved sequence (low covariation and power)	K00793	upstream	ribE, RIB5; riboflavin synthase [EC:2.5.1.9]	ko01110	NA
K00793_upstream.h2_2.h2_5	Conserved sequence (low covariation and power)	K00793	upstream	ribE, RIB5; riboflavin synthase [EC:2.5.1.9]	map01240	Biosynthesis of cofactors
K00793_upstream.h2_2.h2_5	Conserved sequence (low covariation and power)	K00793	upstream	ribE, RIB5; riboflavin synthase [EC:2.5.1.9]	ko01240	NA
K00793_upstream.h2_4	High power (low covariation)	K00793	upstream	ribE, RIB5; riboflavin synthase [EC:2.5.1.9]	map00740	Riboflavin metabolism
K00793_upstream.h2_4	High power (low covariation)	K00793	upstream	ribE, RIB5; riboflavin synthase [EC:2.5.1.9]	ko00740	NA
K00793_upstream.h2_4	High power (low covariation)	K00793	upstream	ribE, RIB5; riboflavin synthase [EC:2.5.1.9]	map01100	Metabolic pathways
K00793_upstream.h2_4	High power (low covariation)	K00793	upstream	ribE, RIB5; riboflavin synthase [EC:2.5.1.9]	ko01100	NA
K00793_upstream.h2_4	High power (low covariation)	K00793	upstream	ribE, RIB5; riboflavin synthase [EC:2.5.1.9]	map01110	Biosynthesis of secondary metabolites
K00793_upstream.h2_4	High power (low covariation)	K00793	upstream	ribE, RIB5; riboflavin synthase [EC:2.5.1.9]	ko01110	NA
K00793_upstream.h2_4	High power (low covariation)	K00793	upstream	ribE, RIB5; riboflavin synthase [EC:2.5.1.9]	map01240	Biosynthesis of cofactors
K00793_upstream.h2_4	High power (low covariation)	K00793	upstream	ribE, RIB5; riboflavin synthase [EC:2.5.1.9]	ko01240	NA
K00793_upstream.h1_1	Conserved sequence (low covariation and power)	K00793	upstream	ribE, RIB5; riboflavin synthase [EC:2.5.1.9]	map00740	Riboflavin metabolism
K00793_upstream.h1_1	Conserved sequence (low covariation and power)	K00793	upstream	ribE, RIB5; riboflavin synthase [EC:2.5.1.9]	ko00740	NA
K00793_upstream.h1_1	Conserved sequence (low covariation and power)	K00793	upstream	ribE, RIB5; riboflavin synthase [EC:2.5.1.9]	map01100	Metabolic pathways
K00793_upstream.h1_1	Conserved sequence (low covariation and power)	K00793	upstream	ribE, RIB5; riboflavin synthase [EC:2.5.1.9]	ko01100	NA
K00793_upstream.h1_1	Conserved sequence (low covariation and power)	K00793	upstream	ribE, RIB5; riboflavin synthase [EC:2.5.1.9]	map01110	Biosynthesis of secondary metabolites
K00793_upstream.h1_1	Conserved sequence (low covariation and power)	K00793	upstream	ribE, RIB5; riboflavin synthase [EC:2.5.1.9]	ko01110	NA
K00793_upstream.h1_1	Conserved sequence (low covariation and power)	K00793	upstream	ribE, RIB5; riboflavin synthase [EC:2.5.1.9]	map01240	Biosynthesis of cofactors
K00793_upstream.h1_1	Conserved sequence (low covariation and power)	K00793	upstream	ribE, RIB5; riboflavin synthase [EC:2.5.1.9]	ko01240	NA
K00820_upstream.h1_1	Conserved sequence (low covariation and power)	K00820	upstream	glmS, GFPT; glutamine---fructose-6-phosphate transaminase (isomerizing) [EC:2.6.1.16]	map00250	Alanine, aspartate and glutamate metabolism
K00820_upstream.h1_1	Conserved sequence (low covariation and power)	K00820	upstream	glmS, GFPT; glutamine---fructose-6-phosphate transaminase (isomerizing) [EC:2.6.1.16]	ko00250	NA
K00820_upstream.h1_1	Conserved sequence (low covariation and power)	K00820	upstream	glmS, GFPT; glutamine---fructose-6-phosphate transaminase (isomerizing) [EC:2.6.1.16]	map00520	Amino sugar and nucleotide sugar metabolism
K00820_upstream.h1_1	Conserved sequence (low covariation and power)	K00820	upstream	glmS, GFPT; glutamine---fructose-6-phosphate transaminase (isomerizing) [EC:2.6.1.16]	ko00520	NA
K00820_upstream.h1_1	Conserved sequence (low covariation and power)	K00820	upstream	glmS, GFPT; glutamine---fructose-6-phosphate transaminase (isomerizing) [EC:2.6.1.16]	map01100	Metabolic pathways
K00820_upstream.h1_1	Conserved sequence (low covariation and power)	K00820	upstream	glmS, GFPT; glutamine---fructose-6-phosphate transaminase (isomerizing) [EC:2.6.1.16]	ko01100	NA
K00820_upstream.h1_1	Conserved sequence (low covariation and power)	K00820	upstream	glmS, GFPT; glutamine---fructose-6-phosphate transaminase (isomerizing) [EC:2.6.1.16]	map01250	Biosynthesis of nucleotide sugars
K00820_upstream.h1_1	Conserved sequence (low covariation and power)	K00820	upstream	glmS, GFPT; glutamine---fructose-6-phosphate transaminase (isomerizing) [EC:2.6.1.16]	ko01250	NA
K00820_upstream.h1_1	Conserved sequence (low covariation and power)	K00820	upstream	glmS, GFPT; glutamine---fructose-6-phosphate transaminase (isomerizing) [EC:2.6.1.16]	map04931	Insulin resistance
K00820_upstream.h1_1	Conserved sequence (low covariation and power)	K00820	upstream	glmS, GFPT; glutamine---fructose-6-phosphate transaminase (isomerizing) [EC:2.6.1.16]	ko04931	NA
K00820_upstream.h1_1	Conserved sequence (low covariation and power)	K00820	upstream	glmS, GFPT; glutamine---fructose-6-phosphate transaminase (isomerizing) [EC:2.6.1.16]	map05415	Diabetic cardiomyopathy
K00820_upstream.h1_1	Conserved sequence (low covariation and power)	K00820	upstream	glmS, GFPT; glutamine---fructose-6-phosphate transaminase (isomerizing) [EC:2.6.1.16]	ko05415	NA
K00940_upstream.h2_2.h2_5	Conserved sequence (low covariation and power)	K00940	upstream	ndk, NME; nucleoside-diphosphate kinase [EC:2.7.4.6]	map00230	Purine metabolism
K00940_upstream.h2_2.h2_5	Conserved sequence (low covariation and power)	K00940	upstream	ndk, NME; nucleoside-diphosphate kinase [EC:2.7.4.6]	ko00230	NA
K00940_upstream.h2_2.h2_5	Conserved sequence (low covariation and power)	K00940	upstream	ndk, NME; nucleoside-diphosphate kinase [EC:2.7.4.6]	map00240	Pyrimidine metabolism
K00940_upstream.h2_2.h2_5	Conserved sequence (low covariation and power)	K00940	upstream	ndk, NME; nucleoside-diphosphate kinase [EC:2.7.4.6]	ko00240	NA
K00940_upstream.h2_2.h2_5	Conserved sequence (low covariation and power)	K00940	upstream	ndk, NME; nucleoside-diphosphate kinase [EC:2.7.4.6]	map00983	Drug metabolism - other enzymes
K00940_upstream.h2_2.h2_5	Conserved sequence (low covariation and power)	K00940	upstream	ndk, NME; nucleoside-diphosphate kinase [EC:2.7.4.6]	ko00983	NA
K00940_upstream.h2_2.h2_5	Conserved sequence (low covariation and power)	K00940	upstream	ndk, NME; nucleoside-diphosphate kinase [EC:2.7.4.6]	map01100	Metabolic pathways
K00940_upstream.h2_2.h2_5	Conserved sequence (low covariation and power)	K00940	upstream	ndk, NME; nucleoside-diphosphate kinase [EC:2.7.4.6]	ko01100	NA
K00940_upstream.h2_2.h2_5	Conserved sequence (low covariation and power)	K00940	upstream	ndk, NME; nucleoside-diphosphate kinase [EC:2.7.4.6]	map01110	Biosynthesis of secondary metabolites
K00940_upstream.h2_2.h2_5	Conserved sequence (low covariation and power)	K00940	upstream	ndk, NME; nucleoside-diphosphate kinase [EC:2.7.4.6]	ko01110	NA
K00940_upstream.h2_2.h2_5	Conserved sequence (low covariation and power)	K00940	upstream	ndk, NME; nucleoside-diphosphate kinase [EC:2.7.4.6]	map01232	Nucleotide metabolism
K00940_upstream.h2_2.h2_5	Conserved sequence (low covariation and power)	K00940	upstream	ndk, NME; nucleoside-diphosphate kinase [EC:2.7.4.6]	ko01232	NA
K00940_upstream.h2_2.h2_5	Conserved sequence (low covariation and power)	K00940	upstream	ndk, NME; nucleoside-diphosphate kinase [EC:2.7.4.6]	map01240	Biosynthesis of cofactors
K00940_upstream.h2_2.h2_5	Conserved sequence (low covariation and power)	K00940	upstream	ndk, NME; nucleoside-diphosphate kinase [EC:2.7.4.6]	ko01240	NA
K00940_upstream.h2_2.h2_5	Conserved sequence (low covariation and power)	K00940	upstream	ndk, NME; nucleoside-diphosphate kinase [EC:2.7.4.6]	map04016	MAPK signaling pathway - plant
K00940_upstream.h2_2.h2_5	Conserved sequence (low covariation and power)	K00940	upstream	ndk, NME; nucleoside-diphosphate kinase [EC:2.7.4.6]	ko04016	NA
K00940_upstream.h1_4.h2_1	High covariation	K00940	upstream	ndk, NME; nucleoside-diphosphate kinase [EC:2.7.4.6]	map00230	Purine metabolism
K00940_upstream.h1_4.h2_1	High covariation	K00940	upstream	ndk, NME; nucleoside-diphosphate kinase [EC:2.7.4.6]	ko00230	NA
K00940_upstream.h1_4.h2_1	High covariation	K00940	upstream	ndk, NME; nucleoside-diphosphate kinase [EC:2.7.4.6]	map00240	Pyrimidine metabolism
K00940_upstream.h1_4.h2_1	High covariation	K00940	upstream	ndk, NME; nucleoside-diphosphate kinase [EC:2.7.4.6]	ko00240	NA
K00940_upstream.h1_4.h2_1	High covariation	K00940	upstream	ndk, NME; nucleoside-diphosphate kinase [EC:2.7.4.6]	map00983	Drug metabolism - other enzymes
K00940_upstream.h1_4.h2_1	High covariation	K00940	upstream	ndk, NME; nucleoside-diphosphate kinase [EC:2.7.4.6]	ko00983	NA
K00940_upstream.h1_4.h2_1	High covariation	K00940	upstream	ndk, NME; nucleoside-diphosphate kinase [EC:2.7.4.6]	map01100	Metabolic pathways
K00940_upstream.h1_4.h2_1	High covariation	K00940	upstream	ndk, NME; nucleoside-diphosphate kinase [EC:2.7.4.6]	ko01100	NA
K00940_upstream.h1_4.h2_1	High covariation	K00940	upstream	ndk, NME; nucleoside-diphosphate kinase [EC:2.7.4.6]	map01110	Biosynthesis of secondary metabolites
K00940_upstream.h1_4.h2_1	High covariation	K00940	upstream	ndk, NME; nucleoside-diphosphate kinase [EC:2.7.4.6]	ko01110	NA
K00940_upstream.h1_4.h2_1	High covariation	K00940	upstream	ndk, NME; nucleoside-diphosphate kinase [EC:2.7.4.6]	map01232	Nucleotide metabolism
K00940_upstream.h1_4.h2_1	High covariation	K00940	upstream	ndk, NME; nucleoside-diphosphate kinase [EC:2.7.4.6]	ko01232	NA
K00940_upstream.h1_4.h2_1	High covariation	K00940	upstream	ndk, NME; nucleoside-diphosphate kinase [EC:2.7.4.6]	map01240	Biosynthesis of cofactors
K00940_upstream.h1_4.h2_1	High covariation	K00940	upstream	ndk, NME; nucleoside-diphosphate kinase [EC:2.7.4.6]	ko01240	NA
K00940_upstream.h1_4.h2_1	High covariation	K00940	upstream	ndk, NME; nucleoside-diphosphate kinase [EC:2.7.4.6]	map04016	MAPK signaling pathway - plant
K00940_upstream.h1_4.h2_1	High covariation	K00940	upstream	ndk, NME; nucleoside-diphosphate kinase [EC:2.7.4.6]	ko04016	NA
K00981_upstream.h1_4	High covariation	K00981	upstream	E2.7.7.41, CDS1, CDS2, cdsA; phosphatidate cytidylyltransferase [EC:2.7.7.41]	map00564	Glycerophospholipid metabolism
K00981_upstream.h1_4	High covariation	K00981	upstream	E2.7.7.41, CDS1, CDS2, cdsA; phosphatidate cytidylyltransferase [EC:2.7.7.41]	ko00564	NA
K00981_upstream.h1_4	High covariation	K00981	upstream	E2.7.7.41, CDS1, CDS2, cdsA; phosphatidate cytidylyltransferase [EC:2.7.7.41]	map01100	Metabolic pathways
K00981_upstream.h1_4	High covariation	K00981	upstream	E2.7.7.41, CDS1, CDS2, cdsA; phosphatidate cytidylyltransferase [EC:2.7.7.41]	ko01100	NA
K00981_upstream.h1_4	High covariation	K00981	upstream	E2.7.7.41, CDS1, CDS2, cdsA; phosphatidate cytidylyltransferase [EC:2.7.7.41]	map01110	Biosynthesis of secondary metabolites
K00981_upstream.h1_4	High covariation	K00981	upstream	E2.7.7.41, CDS1, CDS2, cdsA; phosphatidate cytidylyltransferase [EC:2.7.7.41]	ko01110	NA
K00981_upstream.h1_4	High covariation	K00981	upstream	E2.7.7.41, CDS1, CDS2, cdsA; phosphatidate cytidylyltransferase [EC:2.7.7.41]	map04070	Phosphatidylinositol signaling system
K00981_upstream.h1_4	High covariation	K00981	upstream	E2.7.7.41, CDS1, CDS2, cdsA; phosphatidate cytidylyltransferase [EC:2.7.7.41]	ko04070	NA
K00981_upstream.h1_1	High covariation	K00981	upstream	E2.7.7.41, CDS1, CDS2, cdsA; phosphatidate cytidylyltransferase [EC:2.7.7.41]	map00564	Glycerophospholipid metabolism
K00981_upstream.h1_1	High covariation	K00981	upstream	E2.7.7.41, CDS1, CDS2, cdsA; phosphatidate cytidylyltransferase [EC:2.7.7.41]	ko00564	NA
K00981_upstream.h1_1	High covariation	K00981	upstream	E2.7.7.41, CDS1, CDS2, cdsA; phosphatidate cytidylyltransferase [EC:2.7.7.41]	map01100	Metabolic pathways
K00981_upstream.h1_1	High covariation	K00981	upstream	E2.7.7.41, CDS1, CDS2, cdsA; phosphatidate cytidylyltransferase [EC:2.7.7.41]	ko01100	NA
K00981_upstream.h1_1	High covariation	K00981	upstream	E2.7.7.41, CDS1, CDS2, cdsA; phosphatidate cytidylyltransferase [EC:2.7.7.41]	map01110	Biosynthesis of secondary metabolites
K00981_upstream.h1_1	High covariation	K00981	upstream	E2.7.7.41, CDS1, CDS2, cdsA; phosphatidate cytidylyltransferase [EC:2.7.7.41]	ko01110	NA
K00981_upstream.h1_1	High covariation	K00981	upstream	E2.7.7.41, CDS1, CDS2, cdsA; phosphatidate cytidylyltransferase [EC:2.7.7.41]	map04070	Phosphatidylinositol signaling system
K00981_upstream.h1_1	High covariation	K00981	upstream	E2.7.7.41, CDS1, CDS2, cdsA; phosphatidate cytidylyltransferase [EC:2.7.7.41]	ko04070	NA
K01000_upstream.h1_1.h1_3	Conserved sequence (low covariation and power)	K01000	upstream	mraY; phospho-N-acetylmuramoyl-pentapeptide-transferase [EC:2.7.8.13]	map00550	Peptidoglycan biosynthesis
K01000_upstream.h1_1.h1_3	Conserved sequence (low covariation and power)	K01000	upstream	mraY; phospho-N-acetylmuramoyl-pentapeptide-transferase [EC:2.7.8.13]	ko00550	NA
K01000_upstream.h1_1.h1_3	Conserved sequence (low covariation and power)	K01000	upstream	mraY; phospho-N-acetylmuramoyl-pentapeptide-transferase [EC:2.7.8.13]	map01100	Metabolic pathways
K01000_upstream.h1_1.h1_3	Conserved sequence (low covariation and power)	K01000	upstream	mraY; phospho-N-acetylmuramoyl-pentapeptide-transferase [EC:2.7.8.13]	ko01100	NA
K01000_upstream.h1_1.h1_3	Conserved sequence (low covariation and power)	K01000	upstream	mraY; phospho-N-acetylmuramoyl-pentapeptide-transferase [EC:2.7.8.13]	map01502	Vancomycin resistance
K01000_upstream.h1_1.h1_3	Conserved sequence (low covariation and power)	K01000	upstream	mraY; phospho-N-acetylmuramoyl-pentapeptide-transferase [EC:2.7.8.13]	ko01502	NA
K01056_upstream.h1_1	High covariation	K01056	upstream	PTH1, PTRH1, pth, spoVC; peptidyl-tRNA hydrolase, PTH1 family [EC:3.1.1.29]	NA	NA
K01071_upstream.h1_1	High covariation	K01071	upstream	MCH; medium-chain acyl-[acyl-carrier-protein] hydrolase [EC:3.1.2.21]	map00061	Fatty acid biosynthesis
K01071_upstream.h1_1	High covariation	K01071	upstream	MCH; medium-chain acyl-[acyl-carrier-protein] hydrolase [EC:3.1.2.21]	ko00061	NA
K01071_upstream.h1_1	High covariation	K01071	upstream	MCH; medium-chain acyl-[acyl-carrier-protein] hydrolase [EC:3.1.2.21]	map01100	Metabolic pathways
K01071_upstream.h1_1	High covariation	K01071	upstream	MCH; medium-chain acyl-[acyl-carrier-protein] hydrolase [EC:3.1.2.21]	ko01100	NA
K01082_upstream.h1_5	Conserved sequence (low covariation and power)	K01082	upstream	cysQ, MET22, BPNT1; 3'(2'), 5'-bisphosphate nucleotidase [EC:3.1.3.7]	map00920	Sulfur metabolism
K01082_upstream.h1_5	Conserved sequence (low covariation and power)	K01082	upstream	cysQ, MET22, BPNT1; 3'(2'), 5'-bisphosphate nucleotidase [EC:3.1.3.7]	ko00920	NA
K01082_upstream.h1_5	Conserved sequence (low covariation and power)	K01082	upstream	cysQ, MET22, BPNT1; 3'(2'), 5'-bisphosphate nucleotidase [EC:3.1.3.7]	map01100	Metabolic pathways
K01082_upstream.h1_5	Conserved sequence (low covariation and power)	K01082	upstream	cysQ, MET22, BPNT1; 3'(2'), 5'-bisphosphate nucleotidase [EC:3.1.3.7]	ko01100	NA
K01082_upstream.h1_5	Conserved sequence (low covariation and power)	K01082	upstream	cysQ, MET22, BPNT1; 3'(2'), 5'-bisphosphate nucleotidase [EC:3.1.3.7]	map01120	Microbial metabolism in diverse environments
K01082_upstream.h1_5	Conserved sequence (low covariation and power)	K01082	upstream	cysQ, MET22, BPNT1; 3'(2'), 5'-bisphosphate nucleotidase [EC:3.1.3.7]	ko01120	NA
K01159_upstream.h1_3	Conserved sequence (low covariation and power)	K01159	upstream	ruvC; crossover junction endodeoxyribonuclease RuvC [EC:3.1.21.10]	map03440	Homologous recombination
K01159_upstream.h1_3	Conserved sequence (low covariation and power)	K01159	upstream	ruvC; crossover junction endodeoxyribonuclease RuvC [EC:3.1.21.10]	ko03440	NA
K01191_upstream.h1_4	High covariation	K01191	upstream	MAN2C1; alpha-mannosidase [EC:3.2.1.24]	map00511	Other glycan degradation
K01191_upstream.h1_4	High covariation	K01191	upstream	MAN2C1; alpha-mannosidase [EC:3.2.1.24]	ko00511	NA
K01251_upstream.h1_4	Conserved sequence (low covariation and power)	K01251	upstream	AHCY, ahcY; adenosylhomocysteinase [EC:3.13.2.1]	map00270	Cysteine and methionine metabolism
K01251_upstream.h1_4	Conserved sequence (low covariation and power)	K01251	upstream	AHCY, ahcY; adenosylhomocysteinase [EC:3.13.2.1]	ko00270	NA
K01251_upstream.h1_4	Conserved sequence (low covariation and power)	K01251	upstream	AHCY, ahcY; adenosylhomocysteinase [EC:3.13.2.1]	map00670	One carbon pool by folate
K01251_upstream.h1_4	Conserved sequence (low covariation and power)	K01251	upstream	AHCY, ahcY; adenosylhomocysteinase [EC:3.13.2.1]	ko00670	NA
K01251_upstream.h1_4	Conserved sequence (low covariation and power)	K01251	upstream	AHCY, ahcY; adenosylhomocysteinase [EC:3.13.2.1]	map01100	Metabolic pathways
K01251_upstream.h1_4	Conserved sequence (low covariation and power)	K01251	upstream	AHCY, ahcY; adenosylhomocysteinase [EC:3.13.2.1]	ko01100	NA
K01265_upstream.h2_1	Conserved sequence (low covariation and power)	K01265	upstream	map; methionyl aminopeptidase [EC:3.4.11.18]	NA	NA
K01347_upstream.h2_4	High power (low covariation)	K01347	upstream	iga; IgA-specific serine endopeptidase [EC:3.4.21.72]	NA	NA
K01356_upstream.h1_5	Conserved sequence (low covariation and power)	K01356	upstream	lexA; repressor LexA [EC:3.4.21.88]	NA	NA
K01424_upstream.h1_1	High covariation	K01424	upstream	E3.5.1.1, ansA, ansB; L-asparaginase [EC:3.5.1.1]	map00250	Alanine, aspartate and glutamate metabolism
K01424_upstream.h1_1	High covariation	K01424	upstream	E3.5.1.1, ansA, ansB; L-asparaginase [EC:3.5.1.1]	ko00250	NA
K01424_upstream.h1_1	High covariation	K01424	upstream	E3.5.1.1, ansA, ansB; L-asparaginase [EC:3.5.1.1]	map00460	Cyanoamino acid metabolism
K01424_upstream.h1_1	High covariation	K01424	upstream	E3.5.1.1, ansA, ansB; L-asparaginase [EC:3.5.1.1]	ko00460	NA
K01424_upstream.h1_1	High covariation	K01424	upstream	E3.5.1.1, ansA, ansB; L-asparaginase [EC:3.5.1.1]	map01100	Metabolic pathways
K01424_upstream.h1_1	High covariation	K01424	upstream	E3.5.1.1, ansA, ansB; L-asparaginase [EC:3.5.1.1]	ko01100	NA
K01424_upstream.h1_1	High covariation	K01424	upstream	E3.5.1.1, ansA, ansB; L-asparaginase [EC:3.5.1.1]	map01110	Biosynthesis of secondary metabolites
K01424_upstream.h1_1	High covariation	K01424	upstream	E3.5.1.1, ansA, ansB; L-asparaginase [EC:3.5.1.1]	ko01110	NA
K01437_upstream.h1_4.h2_1.h1_2	High power (low covariation)	K01437	upstream	ASPA, aspA; aspartoacylase [EC:3.5.1.15]	map00250	Alanine, aspartate and glutamate metabolism
K01437_upstream.h1_4.h2_1.h1_2	High power (low covariation)	K01437	upstream	ASPA, aspA; aspartoacylase [EC:3.5.1.15]	ko00250	NA
K01437_upstream.h1_4.h2_1.h1_2	High power (low covariation)	K01437	upstream	ASPA, aspA; aspartoacylase [EC:3.5.1.15]	map00340	Histidine metabolism
K01437_upstream.h1_4.h2_1.h1_2	High power (low covariation)	K01437	upstream	ASPA, aspA; aspartoacylase [EC:3.5.1.15]	ko00340	NA
K01437_upstream.h1_4.h2_1.h1_2	High power (low covariation)	K01437	upstream	ASPA, aspA; aspartoacylase [EC:3.5.1.15]	map01100	Metabolic pathways
K01437_upstream.h1_4.h2_1.h1_2	High power (low covariation)	K01437	upstream	ASPA, aspA; aspartoacylase [EC:3.5.1.15]	ko01100	NA
K01465_upstream.h2_1	Conserved sequence (low covariation and power)	K01465	upstream	URA4, pyrC; dihydroorotase [EC:3.5.2.3]	map00240	Pyrimidine metabolism
K01465_upstream.h2_1	Conserved sequence (low covariation and power)	K01465	upstream	URA4, pyrC; dihydroorotase [EC:3.5.2.3]	ko00240	NA
K01465_upstream.h2_1	Conserved sequence (low covariation and power)	K01465	upstream	URA4, pyrC; dihydroorotase [EC:3.5.2.3]	map01100	Metabolic pathways
K01465_upstream.h2_1	Conserved sequence (low covariation and power)	K01465	upstream	URA4, pyrC; dihydroorotase [EC:3.5.2.3]	ko01100	NA
K01465_upstream.h2_1	Conserved sequence (low covariation and power)	K01465	upstream	URA4, pyrC; dihydroorotase [EC:3.5.2.3]	map01240	Biosynthesis of cofactors
K01465_upstream.h2_1	Conserved sequence (low covariation and power)	K01465	upstream	URA4, pyrC; dihydroorotase [EC:3.5.2.3]	ko01240	NA
K01524_upstream.h1_2	High power (low covariation)	K01524	upstream	ppx-gppA; exopolyphosphatase / guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase [EC:3.6.1.11 3.6.1.40]	map00230	Purine metabolism
K01524_upstream.h1_2	High power (low covariation)	K01524	upstream	ppx-gppA; exopolyphosphatase / guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase [EC:3.6.1.11 3.6.1.40]	ko00230	NA
K01524_upstream.h1_2	High power (low covariation)	K01524	upstream	ppx-gppA; exopolyphosphatase / guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase [EC:3.6.1.11 3.6.1.40]	map01100	Metabolic pathways
K01524_upstream.h1_2	High power (low covariation)	K01524	upstream	ppx-gppA; exopolyphosphatase / guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase [EC:3.6.1.11 3.6.1.40]	ko01100	NA
K01537_upstream.h2_3	High covariation	K01537	upstream	ATP2C; P-type Ca2+ transporter type 2C [EC:7.2.2.10]	NA	NA
K01579_upstream.h1_3	High covariation	K01579	upstream	panD; aspartate 1-decarboxylase [EC:4.1.1.11]	map00410	beta-Alanine metabolism
K01579_upstream.h1_3	High covariation	K01579	upstream	panD; aspartate 1-decarboxylase [EC:4.1.1.11]	ko00410	NA
K01579_upstream.h1_3	High covariation	K01579	upstream	panD; aspartate 1-decarboxylase [EC:4.1.1.11]	map00770	Pantothenate and CoA biosynthesis
K01579_upstream.h1_3	High covariation	K01579	upstream	panD; aspartate 1-decarboxylase [EC:4.1.1.11]	ko00770	NA
K01579_upstream.h1_3	High covariation	K01579	upstream	panD; aspartate 1-decarboxylase [EC:4.1.1.11]	map01100	Metabolic pathways
K01579_upstream.h1_3	High covariation	K01579	upstream	panD; aspartate 1-decarboxylase [EC:4.1.1.11]	ko01100	NA
K01579_upstream.h1_3	High covariation	K01579	upstream	panD; aspartate 1-decarboxylase [EC:4.1.1.11]	map01110	Biosynthesis of secondary metabolites
K01579_upstream.h1_3	High covariation	K01579	upstream	panD; aspartate 1-decarboxylase [EC:4.1.1.11]	ko01110	NA
K01579_upstream.h1_3	High covariation	K01579	upstream	panD; aspartate 1-decarboxylase [EC:4.1.1.11]	map01240	Biosynthesis of cofactors
K01579_upstream.h1_3	High covariation	K01579	upstream	panD; aspartate 1-decarboxylase [EC:4.1.1.11]	ko01240	NA
K01624_upstream.h1_2	Conserved sequence (low covariation and power)	K01624	upstream	FBA, fbaA; fructose-bisphosphate aldolase, class II [EC:4.1.2.13]	map00010	Glycolysis / Gluconeogenesis
K01624_upstream.h1_2	Conserved sequence (low covariation and power)	K01624	upstream	FBA, fbaA; fructose-bisphosphate aldolase, class II [EC:4.1.2.13]	ko00010	NA
K01624_upstream.h1_2	Conserved sequence (low covariation and power)	K01624	upstream	FBA, fbaA; fructose-bisphosphate aldolase, class II [EC:4.1.2.13]	map00030	Pentose phosphate pathway
K01624_upstream.h1_2	Conserved sequence (low covariation and power)	K01624	upstream	FBA, fbaA; fructose-bisphosphate aldolase, class II [EC:4.1.2.13]	ko00030	NA
K01624_upstream.h1_2	Conserved sequence (low covariation and power)	K01624	upstream	FBA, fbaA; fructose-bisphosphate aldolase, class II [EC:4.1.2.13]	map00051	Fructose and mannose metabolism
K01624_upstream.h1_2	Conserved sequence (low covariation and power)	K01624	upstream	FBA, fbaA; fructose-bisphosphate aldolase, class II [EC:4.1.2.13]	ko00051	NA
K01624_upstream.h1_2	Conserved sequence (low covariation and power)	K01624	upstream	FBA, fbaA; fructose-bisphosphate aldolase, class II [EC:4.1.2.13]	map00680	Methane metabolism
K01624_upstream.h1_2	Conserved sequence (low covariation and power)	K01624	upstream	FBA, fbaA; fructose-bisphosphate aldolase, class II [EC:4.1.2.13]	ko00680	NA
K01624_upstream.h1_2	Conserved sequence (low covariation and power)	K01624	upstream	FBA, fbaA; fructose-bisphosphate aldolase, class II [EC:4.1.2.13]	map00710	Carbon fixation by Calvin cycle
K01624_upstream.h1_2	Conserved sequence (low covariation and power)	K01624	upstream	FBA, fbaA; fructose-bisphosphate aldolase, class II [EC:4.1.2.13]	ko00710	NA
K01624_upstream.h1_2	Conserved sequence (low covariation and power)	K01624	upstream	FBA, fbaA; fructose-bisphosphate aldolase, class II [EC:4.1.2.13]	map01100	Metabolic pathways
K01624_upstream.h1_2	Conserved sequence (low covariation and power)	K01624	upstream	FBA, fbaA; fructose-bisphosphate aldolase, class II [EC:4.1.2.13]	ko01100	NA
K01624_upstream.h1_2	Conserved sequence (low covariation and power)	K01624	upstream	FBA, fbaA; fructose-bisphosphate aldolase, class II [EC:4.1.2.13]	map01110	Biosynthesis of secondary metabolites
K01624_upstream.h1_2	Conserved sequence (low covariation and power)	K01624	upstream	FBA, fbaA; fructose-bisphosphate aldolase, class II [EC:4.1.2.13]	ko01110	NA
K01624_upstream.h1_2	Conserved sequence (low covariation and power)	K01624	upstream	FBA, fbaA; fructose-bisphosphate aldolase, class II [EC:4.1.2.13]	map01120	Microbial metabolism in diverse environments
K01624_upstream.h1_2	Conserved sequence (low covariation and power)	K01624	upstream	FBA, fbaA; fructose-bisphosphate aldolase, class II [EC:4.1.2.13]	ko01120	NA
K01624_upstream.h1_2	Conserved sequence (low covariation and power)	K01624	upstream	FBA, fbaA; fructose-bisphosphate aldolase, class II [EC:4.1.2.13]	map01200	Carbon metabolism
K01624_upstream.h1_2	Conserved sequence (low covariation and power)	K01624	upstream	FBA, fbaA; fructose-bisphosphate aldolase, class II [EC:4.1.2.13]	ko01200	NA
K01624_upstream.h1_2	Conserved sequence (low covariation and power)	K01624	upstream	FBA, fbaA; fructose-bisphosphate aldolase, class II [EC:4.1.2.13]	map01230	Biosynthesis of amino acids
K01624_upstream.h1_2	Conserved sequence (low covariation and power)	K01624	upstream	FBA, fbaA; fructose-bisphosphate aldolase, class II [EC:4.1.2.13]	ko01230	NA
K01626_upstream.h2_1.h2_3	Conserved sequence (low covariation and power)	K01626	upstream	E2.5.1.54, aroF, aroG, aroH; 3-deoxy-7-phosphoheptulonate synthase [EC:2.5.1.54]	map00400	Phenylalanine, tyrosine and tryptophan biosynthesis
K01626_upstream.h2_1.h2_3	Conserved sequence (low covariation and power)	K01626	upstream	E2.5.1.54, aroF, aroG, aroH; 3-deoxy-7-phosphoheptulonate synthase [EC:2.5.1.54]	ko00400	NA
K01626_upstream.h2_1.h2_3	Conserved sequence (low covariation and power)	K01626	upstream	E2.5.1.54, aroF, aroG, aroH; 3-deoxy-7-phosphoheptulonate synthase [EC:2.5.1.54]	map01100	Metabolic pathways
K01626_upstream.h2_1.h2_3	Conserved sequence (low covariation and power)	K01626	upstream	E2.5.1.54, aroF, aroG, aroH; 3-deoxy-7-phosphoheptulonate synthase [EC:2.5.1.54]	ko01100	NA
K01626_upstream.h2_1.h2_3	Conserved sequence (low covariation and power)	K01626	upstream	E2.5.1.54, aroF, aroG, aroH; 3-deoxy-7-phosphoheptulonate synthase [EC:2.5.1.54]	map01110	Biosynthesis of secondary metabolites
K01626_upstream.h2_1.h2_3	Conserved sequence (low covariation and power)	K01626	upstream	E2.5.1.54, aroF, aroG, aroH; 3-deoxy-7-phosphoheptulonate synthase [EC:2.5.1.54]	ko01110	NA
K01626_upstream.h2_1.h2_3	Conserved sequence (low covariation and power)	K01626	upstream	E2.5.1.54, aroF, aroG, aroH; 3-deoxy-7-phosphoheptulonate synthase [EC:2.5.1.54]	map01230	Biosynthesis of amino acids
K01626_upstream.h2_1.h2_3	Conserved sequence (low covariation and power)	K01626	upstream	E2.5.1.54, aroF, aroG, aroH; 3-deoxy-7-phosphoheptulonate synthase [EC:2.5.1.54]	ko01230	NA
K01626_upstream.h2_1.h2_3	Conserved sequence (low covariation and power)	K01626	upstream	E2.5.1.54, aroF, aroG, aroH; 3-deoxy-7-phosphoheptulonate synthase [EC:2.5.1.54]	map02024	Quorum sensing
K01626_upstream.h2_1.h2_3	Conserved sequence (low covariation and power)	K01626	upstream	E2.5.1.54, aroF, aroG, aroH; 3-deoxy-7-phosphoheptulonate synthase [EC:2.5.1.54]	ko02024	NA
K01626_upstream.h1_5.h2_4	High covariation	K01626	upstream	E2.5.1.54, aroF, aroG, aroH; 3-deoxy-7-phosphoheptulonate synthase [EC:2.5.1.54]	map00400	Phenylalanine, tyrosine and tryptophan biosynthesis
K01626_upstream.h1_5.h2_4	High covariation	K01626	upstream	E2.5.1.54, aroF, aroG, aroH; 3-deoxy-7-phosphoheptulonate synthase [EC:2.5.1.54]	ko00400	NA
K01626_upstream.h1_5.h2_4	High covariation	K01626	upstream	E2.5.1.54, aroF, aroG, aroH; 3-deoxy-7-phosphoheptulonate synthase [EC:2.5.1.54]	map01100	Metabolic pathways
K01626_upstream.h1_5.h2_4	High covariation	K01626	upstream	E2.5.1.54, aroF, aroG, aroH; 3-deoxy-7-phosphoheptulonate synthase [EC:2.5.1.54]	ko01100	NA
K01626_upstream.h1_5.h2_4	High covariation	K01626	upstream	E2.5.1.54, aroF, aroG, aroH; 3-deoxy-7-phosphoheptulonate synthase [EC:2.5.1.54]	map01110	Biosynthesis of secondary metabolites
K01626_upstream.h1_5.h2_4	High covariation	K01626	upstream	E2.5.1.54, aroF, aroG, aroH; 3-deoxy-7-phosphoheptulonate synthase [EC:2.5.1.54]	ko01110	NA
K01626_upstream.h1_5.h2_4	High covariation	K01626	upstream	E2.5.1.54, aroF, aroG, aroH; 3-deoxy-7-phosphoheptulonate synthase [EC:2.5.1.54]	map01230	Biosynthesis of amino acids
K01626_upstream.h1_5.h2_4	High covariation	K01626	upstream	E2.5.1.54, aroF, aroG, aroH; 3-deoxy-7-phosphoheptulonate synthase [EC:2.5.1.54]	ko01230	NA
K01626_upstream.h1_5.h2_4	High covariation	K01626	upstream	E2.5.1.54, aroF, aroG, aroH; 3-deoxy-7-phosphoheptulonate synthase [EC:2.5.1.54]	map02024	Quorum sensing
K01626_upstream.h1_5.h2_4	High covariation	K01626	upstream	E2.5.1.54, aroF, aroG, aroH; 3-deoxy-7-phosphoheptulonate synthase [EC:2.5.1.54]	ko02024	NA
K01649_upstream.h1_3	Conserved sequence (low covariation and power)	K01649	upstream	leuA, IMS; 2-isopropylmalate synthase [EC:2.3.3.13]	map00290	Valine, leucine and isoleucine biosynthesis
K01649_upstream.h1_3	Conserved sequence (low covariation and power)	K01649	upstream	leuA, IMS; 2-isopropylmalate synthase [EC:2.3.3.13]	ko00290	NA
K01649_upstream.h1_3	Conserved sequence (low covariation and power)	K01649	upstream	leuA, IMS; 2-isopropylmalate synthase [EC:2.3.3.13]	map00620	Pyruvate metabolism
K01649_upstream.h1_3	Conserved sequence (low covariation and power)	K01649	upstream	leuA, IMS; 2-isopropylmalate synthase [EC:2.3.3.13]	ko00620	NA
K01649_upstream.h1_3	Conserved sequence (low covariation and power)	K01649	upstream	leuA, IMS; 2-isopropylmalate synthase [EC:2.3.3.13]	map01100	Metabolic pathways
K01649_upstream.h1_3	Conserved sequence (low covariation and power)	K01649	upstream	leuA, IMS; 2-isopropylmalate synthase [EC:2.3.3.13]	ko01100	NA
K01649_upstream.h1_3	Conserved sequence (low covariation and power)	K01649	upstream	leuA, IMS; 2-isopropylmalate synthase [EC:2.3.3.13]	map01110	Biosynthesis of secondary metabolites
K01649_upstream.h1_3	Conserved sequence (low covariation and power)	K01649	upstream	leuA, IMS; 2-isopropylmalate synthase [EC:2.3.3.13]	ko01110	NA
K01649_upstream.h1_3	Conserved sequence (low covariation and power)	K01649	upstream	leuA, IMS; 2-isopropylmalate synthase [EC:2.3.3.13]	map01210	2-Oxocarboxylic acid metabolism
K01649_upstream.h1_3	Conserved sequence (low covariation and power)	K01649	upstream	leuA, IMS; 2-isopropylmalate synthase [EC:2.3.3.13]	ko01210	NA
K01649_upstream.h1_3	Conserved sequence (low covariation and power)	K01649	upstream	leuA, IMS; 2-isopropylmalate synthase [EC:2.3.3.13]	map01230	Biosynthesis of amino acids
K01649_upstream.h1_3	Conserved sequence (low covariation and power)	K01649	upstream	leuA, IMS; 2-isopropylmalate synthase [EC:2.3.3.13]	ko01230	NA
K01649_upstream.h2_2	Conserved sequence (low covariation and power)	K01649	upstream	leuA, IMS; 2-isopropylmalate synthase [EC:2.3.3.13]	map00290	Valine, leucine and isoleucine biosynthesis
K01649_upstream.h2_2	Conserved sequence (low covariation and power)	K01649	upstream	leuA, IMS; 2-isopropylmalate synthase [EC:2.3.3.13]	ko00290	NA
K01649_upstream.h2_2	Conserved sequence (low covariation and power)	K01649	upstream	leuA, IMS; 2-isopropylmalate synthase [EC:2.3.3.13]	map00620	Pyruvate metabolism
K01649_upstream.h2_2	Conserved sequence (low covariation and power)	K01649	upstream	leuA, IMS; 2-isopropylmalate synthase [EC:2.3.3.13]	ko00620	NA
K01649_upstream.h2_2	Conserved sequence (low covariation and power)	K01649	upstream	leuA, IMS; 2-isopropylmalate synthase [EC:2.3.3.13]	map01100	Metabolic pathways
K01649_upstream.h2_2	Conserved sequence (low covariation and power)	K01649	upstream	leuA, IMS; 2-isopropylmalate synthase [EC:2.3.3.13]	ko01100	NA
K01649_upstream.h2_2	Conserved sequence (low covariation and power)	K01649	upstream	leuA, IMS; 2-isopropylmalate synthase [EC:2.3.3.13]	map01110	Biosynthesis of secondary metabolites
K01649_upstream.h2_2	Conserved sequence (low covariation and power)	K01649	upstream	leuA, IMS; 2-isopropylmalate synthase [EC:2.3.3.13]	ko01110	NA
K01649_upstream.h2_2	Conserved sequence (low covariation and power)	K01649	upstream	leuA, IMS; 2-isopropylmalate synthase [EC:2.3.3.13]	map01210	2-Oxocarboxylic acid metabolism
K01649_upstream.h2_2	Conserved sequence (low covariation and power)	K01649	upstream	leuA, IMS; 2-isopropylmalate synthase [EC:2.3.3.13]	ko01210	NA
K01649_upstream.h2_2	Conserved sequence (low covariation and power)	K01649	upstream	leuA, IMS; 2-isopropylmalate synthase [EC:2.3.3.13]	map01230	Biosynthesis of amino acids
K01649_upstream.h2_2	Conserved sequence (low covariation and power)	K01649	upstream	leuA, IMS; 2-isopropylmalate synthase [EC:2.3.3.13]	ko01230	NA
K01652_upstream.h1_1	High covariation	K01652	upstream	E2.2.1.6L, ilvB, ilvG, ilvI; acetolactate synthase I/II/III large subunit [EC:2.2.1.6]	map00290	Valine, leucine and isoleucine biosynthesis
K01652_upstream.h1_1	High covariation	K01652	upstream	E2.2.1.6L, ilvB, ilvG, ilvI; acetolactate synthase I/II/III large subunit [EC:2.2.1.6]	ko00290	NA
K01652_upstream.h1_1	High covariation	K01652	upstream	E2.2.1.6L, ilvB, ilvG, ilvI; acetolactate synthase I/II/III large subunit [EC:2.2.1.6]	map00650	Butanoate metabolism
K01652_upstream.h1_1	High covariation	K01652	upstream	E2.2.1.6L, ilvB, ilvG, ilvI; acetolactate synthase I/II/III large subunit [EC:2.2.1.6]	ko00650	NA
K01652_upstream.h1_1	High covariation	K01652	upstream	E2.2.1.6L, ilvB, ilvG, ilvI; acetolactate synthase I/II/III large subunit [EC:2.2.1.6]	map00660	C5-Branched dibasic acid metabolism
K01652_upstream.h1_1	High covariation	K01652	upstream	E2.2.1.6L, ilvB, ilvG, ilvI; acetolactate synthase I/II/III large subunit [EC:2.2.1.6]	ko00660	NA
K01652_upstream.h1_1	High covariation	K01652	upstream	E2.2.1.6L, ilvB, ilvG, ilvI; acetolactate synthase I/II/III large subunit [EC:2.2.1.6]	map00770	Pantothenate and CoA biosynthesis
K01652_upstream.h1_1	High covariation	K01652	upstream	E2.2.1.6L, ilvB, ilvG, ilvI; acetolactate synthase I/II/III large subunit [EC:2.2.1.6]	ko00770	NA
K01652_upstream.h1_1	High covariation	K01652	upstream	E2.2.1.6L, ilvB, ilvG, ilvI; acetolactate synthase I/II/III large subunit [EC:2.2.1.6]	map01100	Metabolic pathways
K01652_upstream.h1_1	High covariation	K01652	upstream	E2.2.1.6L, ilvB, ilvG, ilvI; acetolactate synthase I/II/III large subunit [EC:2.2.1.6]	ko01100	NA
K01652_upstream.h1_1	High covariation	K01652	upstream	E2.2.1.6L, ilvB, ilvG, ilvI; acetolactate synthase I/II/III large subunit [EC:2.2.1.6]	map01110	Biosynthesis of secondary metabolites
K01652_upstream.h1_1	High covariation	K01652	upstream	E2.2.1.6L, ilvB, ilvG, ilvI; acetolactate synthase I/II/III large subunit [EC:2.2.1.6]	ko01110	NA
K01652_upstream.h1_1	High covariation	K01652	upstream	E2.2.1.6L, ilvB, ilvG, ilvI; acetolactate synthase I/II/III large subunit [EC:2.2.1.6]	map01210	2-Oxocarboxylic acid metabolism
K01652_upstream.h1_1	High covariation	K01652	upstream	E2.2.1.6L, ilvB, ilvG, ilvI; acetolactate synthase I/II/III large subunit [EC:2.2.1.6]	ko01210	NA
K01652_upstream.h1_1	High covariation	K01652	upstream	E2.2.1.6L, ilvB, ilvG, ilvI; acetolactate synthase I/II/III large subunit [EC:2.2.1.6]	map01230	Biosynthesis of amino acids
K01652_upstream.h1_1	High covariation	K01652	upstream	E2.2.1.6L, ilvB, ilvG, ilvI; acetolactate synthase I/II/III large subunit [EC:2.2.1.6]	ko01230	NA
K01652_upstream.h1_2	High covariation	K01652	upstream	E2.2.1.6L, ilvB, ilvG, ilvI; acetolactate synthase I/II/III large subunit [EC:2.2.1.6]	map00290	Valine, leucine and isoleucine biosynthesis
K01652_upstream.h1_2	High covariation	K01652	upstream	E2.2.1.6L, ilvB, ilvG, ilvI; acetolactate synthase I/II/III large subunit [EC:2.2.1.6]	ko00290	NA
K01652_upstream.h1_2	High covariation	K01652	upstream	E2.2.1.6L, ilvB, ilvG, ilvI; acetolactate synthase I/II/III large subunit [EC:2.2.1.6]	map00650	Butanoate metabolism
K01652_upstream.h1_2	High covariation	K01652	upstream	E2.2.1.6L, ilvB, ilvG, ilvI; acetolactate synthase I/II/III large subunit [EC:2.2.1.6]	ko00650	NA
K01652_upstream.h1_2	High covariation	K01652	upstream	E2.2.1.6L, ilvB, ilvG, ilvI; acetolactate synthase I/II/III large subunit [EC:2.2.1.6]	map00660	C5-Branched dibasic acid metabolism
K01652_upstream.h1_2	High covariation	K01652	upstream	E2.2.1.6L, ilvB, ilvG, ilvI; acetolactate synthase I/II/III large subunit [EC:2.2.1.6]	ko00660	NA
K01652_upstream.h1_2	High covariation	K01652	upstream	E2.2.1.6L, ilvB, ilvG, ilvI; acetolactate synthase I/II/III large subunit [EC:2.2.1.6]	map00770	Pantothenate and CoA biosynthesis
K01652_upstream.h1_2	High covariation	K01652	upstream	E2.2.1.6L, ilvB, ilvG, ilvI; acetolactate synthase I/II/III large subunit [EC:2.2.1.6]	ko00770	NA
K01652_upstream.h1_2	High covariation	K01652	upstream	E2.2.1.6L, ilvB, ilvG, ilvI; acetolactate synthase I/II/III large subunit [EC:2.2.1.6]	map01100	Metabolic pathways
K01652_upstream.h1_2	High covariation	K01652	upstream	E2.2.1.6L, ilvB, ilvG, ilvI; acetolactate synthase I/II/III large subunit [EC:2.2.1.6]	ko01100	NA
K01652_upstream.h1_2	High covariation	K01652	upstream	E2.2.1.6L, ilvB, ilvG, ilvI; acetolactate synthase I/II/III large subunit [EC:2.2.1.6]	map01110	Biosynthesis of secondary metabolites
K01652_upstream.h1_2	High covariation	K01652	upstream	E2.2.1.6L, ilvB, ilvG, ilvI; acetolactate synthase I/II/III large subunit [EC:2.2.1.6]	ko01110	NA
K01652_upstream.h1_2	High covariation	K01652	upstream	E2.2.1.6L, ilvB, ilvG, ilvI; acetolactate synthase I/II/III large subunit [EC:2.2.1.6]	map01210	2-Oxocarboxylic acid metabolism
K01652_upstream.h1_2	High covariation	K01652	upstream	E2.2.1.6L, ilvB, ilvG, ilvI; acetolactate synthase I/II/III large subunit [EC:2.2.1.6]	ko01210	NA
K01652_upstream.h1_2	High covariation	K01652	upstream	E2.2.1.6L, ilvB, ilvG, ilvI; acetolactate synthase I/II/III large subunit [EC:2.2.1.6]	map01230	Biosynthesis of amino acids
K01652_upstream.h1_2	High covariation	K01652	upstream	E2.2.1.6L, ilvB, ilvG, ilvI; acetolactate synthase I/II/III large subunit [EC:2.2.1.6]	ko01230	NA
K01698_upstream.h1_2	Conserved sequence (low covariation and power)	K01698	upstream	hemB, ALAD; porphobilinogen synthase [EC:4.2.1.24]	map00860	Porphyrin metabolism
K01698_upstream.h1_2	Conserved sequence (low covariation and power)	K01698	upstream	hemB, ALAD; porphobilinogen synthase [EC:4.2.1.24]	ko00860	NA
K01698_upstream.h1_2	Conserved sequence (low covariation and power)	K01698	upstream	hemB, ALAD; porphobilinogen synthase [EC:4.2.1.24]	map01100	Metabolic pathways
K01698_upstream.h1_2	Conserved sequence (low covariation and power)	K01698	upstream	hemB, ALAD; porphobilinogen synthase [EC:4.2.1.24]	ko01100	NA
K01698_upstream.h1_2	Conserved sequence (low covariation and power)	K01698	upstream	hemB, ALAD; porphobilinogen synthase [EC:4.2.1.24]	map01110	Biosynthesis of secondary metabolites
K01698_upstream.h1_2	Conserved sequence (low covariation and power)	K01698	upstream	hemB, ALAD; porphobilinogen synthase [EC:4.2.1.24]	ko01110	NA
K01698_upstream.h1_2	Conserved sequence (low covariation and power)	K01698	upstream	hemB, ALAD; porphobilinogen synthase [EC:4.2.1.24]	map01120	Microbial metabolism in diverse environments
K01698_upstream.h1_2	Conserved sequence (low covariation and power)	K01698	upstream	hemB, ALAD; porphobilinogen synthase [EC:4.2.1.24]	ko01120	NA
K01698_upstream.h1_2	Conserved sequence (low covariation and power)	K01698	upstream	hemB, ALAD; porphobilinogen synthase [EC:4.2.1.24]	map01240	Biosynthesis of cofactors
K01698_upstream.h1_2	Conserved sequence (low covariation and power)	K01698	upstream	hemB, ALAD; porphobilinogen synthase [EC:4.2.1.24]	ko01240	NA
K01698_upstream.h2_2	Conserved sequence (low covariation and power)	K01698	upstream	hemB, ALAD; porphobilinogen synthase [EC:4.2.1.24]	map00860	Porphyrin metabolism
K01698_upstream.h2_2	Conserved sequence (low covariation and power)	K01698	upstream	hemB, ALAD; porphobilinogen synthase [EC:4.2.1.24]	ko00860	NA
K01698_upstream.h2_2	Conserved sequence (low covariation and power)	K01698	upstream	hemB, ALAD; porphobilinogen synthase [EC:4.2.1.24]	map01100	Metabolic pathways
K01698_upstream.h2_2	Conserved sequence (low covariation and power)	K01698	upstream	hemB, ALAD; porphobilinogen synthase [EC:4.2.1.24]	ko01100	NA
K01698_upstream.h2_2	Conserved sequence (low covariation and power)	K01698	upstream	hemB, ALAD; porphobilinogen synthase [EC:4.2.1.24]	map01110	Biosynthesis of secondary metabolites
K01698_upstream.h2_2	Conserved sequence (low covariation and power)	K01698	upstream	hemB, ALAD; porphobilinogen synthase [EC:4.2.1.24]	ko01110	NA
K01698_upstream.h2_2	Conserved sequence (low covariation and power)	K01698	upstream	hemB, ALAD; porphobilinogen synthase [EC:4.2.1.24]	map01120	Microbial metabolism in diverse environments
K01698_upstream.h2_2	Conserved sequence (low covariation and power)	K01698	upstream	hemB, ALAD; porphobilinogen synthase [EC:4.2.1.24]	ko01120	NA
K01698_upstream.h2_2	Conserved sequence (low covariation and power)	K01698	upstream	hemB, ALAD; porphobilinogen synthase [EC:4.2.1.24]	map01240	Biosynthesis of cofactors
K01698_upstream.h2_2	Conserved sequence (low covariation and power)	K01698	upstream	hemB, ALAD; porphobilinogen synthase [EC:4.2.1.24]	ko01240	NA
K01698_upstream.h1_1	High covariation	K01698	upstream	hemB, ALAD; porphobilinogen synthase [EC:4.2.1.24]	map00860	Porphyrin metabolism
K01698_upstream.h1_1	High covariation	K01698	upstream	hemB, ALAD; porphobilinogen synthase [EC:4.2.1.24]	ko00860	NA
K01698_upstream.h1_1	High covariation	K01698	upstream	hemB, ALAD; porphobilinogen synthase [EC:4.2.1.24]	map01100	Metabolic pathways
K01698_upstream.h1_1	High covariation	K01698	upstream	hemB, ALAD; porphobilinogen synthase [EC:4.2.1.24]	ko01100	NA
K01698_upstream.h1_1	High covariation	K01698	upstream	hemB, ALAD; porphobilinogen synthase [EC:4.2.1.24]	map01110	Biosynthesis of secondary metabolites
K01698_upstream.h1_1	High covariation	K01698	upstream	hemB, ALAD; porphobilinogen synthase [EC:4.2.1.24]	ko01110	NA
K01698_upstream.h1_1	High covariation	K01698	upstream	hemB, ALAD; porphobilinogen synthase [EC:4.2.1.24]	map01120	Microbial metabolism in diverse environments
K01698_upstream.h1_1	High covariation	K01698	upstream	hemB, ALAD; porphobilinogen synthase [EC:4.2.1.24]	ko01120	NA
K01698_upstream.h1_1	High covariation	K01698	upstream	hemB, ALAD; porphobilinogen synthase [EC:4.2.1.24]	map01240	Biosynthesis of cofactors
K01698_upstream.h1_1	High covariation	K01698	upstream	hemB, ALAD; porphobilinogen synthase [EC:4.2.1.24]	ko01240	NA
K01737_upstream.h1_4	High covariation	K01737	upstream	queD, ptpS, PTS; 6-pyruvoyltetrahydropterin/6-carboxytetrahydropterin synthase [EC:4.2.3.12 4.1.2.50]	map00790	Folate biosynthesis
K01737_upstream.h1_4	High covariation	K01737	upstream	queD, ptpS, PTS; 6-pyruvoyltetrahydropterin/6-carboxytetrahydropterin synthase [EC:4.2.3.12 4.1.2.50]	ko00790	NA
K01737_upstream.h1_4	High covariation	K01737	upstream	queD, ptpS, PTS; 6-pyruvoyltetrahydropterin/6-carboxytetrahydropterin synthase [EC:4.2.3.12 4.1.2.50]	map01100	Metabolic pathways
K01737_upstream.h1_4	High covariation	K01737	upstream	queD, ptpS, PTS; 6-pyruvoyltetrahydropterin/6-carboxytetrahydropterin synthase [EC:4.2.3.12 4.1.2.50]	ko01100	NA
K01737_upstream.h1_4	High covariation	K01737	upstream	queD, ptpS, PTS; 6-pyruvoyltetrahydropterin/6-carboxytetrahydropterin synthase [EC:4.2.3.12 4.1.2.50]	map01240	Biosynthesis of cofactors
K01737_upstream.h1_4	High covariation	K01737	upstream	queD, ptpS, PTS; 6-pyruvoyltetrahydropterin/6-carboxytetrahydropterin synthase [EC:4.2.3.12 4.1.2.50]	ko01240	NA
K01738_upstream.h2_1	Conserved sequence (low covariation and power)	K01738	upstream	cysK; cysteine synthase [EC:2.5.1.47]	map00270	Cysteine and methionine metabolism
K01738_upstream.h2_1	Conserved sequence (low covariation and power)	K01738	upstream	cysK; cysteine synthase [EC:2.5.1.47]	ko00270	NA
K01738_upstream.h2_1	Conserved sequence (low covariation and power)	K01738	upstream	cysK; cysteine synthase [EC:2.5.1.47]	map00920	Sulfur metabolism
K01738_upstream.h2_1	Conserved sequence (low covariation and power)	K01738	upstream	cysK; cysteine synthase [EC:2.5.1.47]	ko00920	NA
K01738_upstream.h2_1	Conserved sequence (low covariation and power)	K01738	upstream	cysK; cysteine synthase [EC:2.5.1.47]	map01100	Metabolic pathways
K01738_upstream.h2_1	Conserved sequence (low covariation and power)	K01738	upstream	cysK; cysteine synthase [EC:2.5.1.47]	ko01100	NA
K01738_upstream.h2_1	Conserved sequence (low covariation and power)	K01738	upstream	cysK; cysteine synthase [EC:2.5.1.47]	map01110	Biosynthesis of secondary metabolites
K01738_upstream.h2_1	Conserved sequence (low covariation and power)	K01738	upstream	cysK; cysteine synthase [EC:2.5.1.47]	ko01110	NA
K01738_upstream.h2_1	Conserved sequence (low covariation and power)	K01738	upstream	cysK; cysteine synthase [EC:2.5.1.47]	map01120	Microbial metabolism in diverse environments
K01738_upstream.h2_1	Conserved sequence (low covariation and power)	K01738	upstream	cysK; cysteine synthase [EC:2.5.1.47]	ko01120	NA
K01738_upstream.h2_1	Conserved sequence (low covariation and power)	K01738	upstream	cysK; cysteine synthase [EC:2.5.1.47]	map01200	Carbon metabolism
K01738_upstream.h2_1	Conserved sequence (low covariation and power)	K01738	upstream	cysK; cysteine synthase [EC:2.5.1.47]	ko01200	NA
K01738_upstream.h2_1	Conserved sequence (low covariation and power)	K01738	upstream	cysK; cysteine synthase [EC:2.5.1.47]	map01230	Biosynthesis of amino acids
K01738_upstream.h2_1	Conserved sequence (low covariation and power)	K01738	upstream	cysK; cysteine synthase [EC:2.5.1.47]	ko01230	NA
K01738_upstream.h2_1	Conserved sequence (low covariation and power)	K01738	upstream	cysK; cysteine synthase [EC:2.5.1.47]	map01320	Sulfur cycle
K01738_upstream.h2_1	Conserved sequence (low covariation and power)	K01738	upstream	cysK; cysteine synthase [EC:2.5.1.47]	ko01320	NA
K01754_upstream.h1_5	High power (low covariation)	K01754	upstream	E4.3.1.19, ilvA, tdcB; threonine dehydratase [EC:4.3.1.19]	map00260	Glycine, serine and threonine metabolism
K01754_upstream.h1_5	High power (low covariation)	K01754	upstream	E4.3.1.19, ilvA, tdcB; threonine dehydratase [EC:4.3.1.19]	ko00260	NA
K01754_upstream.h1_5	High power (low covariation)	K01754	upstream	E4.3.1.19, ilvA, tdcB; threonine dehydratase [EC:4.3.1.19]	map00290	Valine, leucine and isoleucine biosynthesis
K01754_upstream.h1_5	High power (low covariation)	K01754	upstream	E4.3.1.19, ilvA, tdcB; threonine dehydratase [EC:4.3.1.19]	ko00290	NA
K01754_upstream.h1_5	High power (low covariation)	K01754	upstream	E4.3.1.19, ilvA, tdcB; threonine dehydratase [EC:4.3.1.19]	map01100	Metabolic pathways
K01754_upstream.h1_5	High power (low covariation)	K01754	upstream	E4.3.1.19, ilvA, tdcB; threonine dehydratase [EC:4.3.1.19]	ko01100	NA
K01754_upstream.h1_5	High power (low covariation)	K01754	upstream	E4.3.1.19, ilvA, tdcB; threonine dehydratase [EC:4.3.1.19]	map01110	Biosynthesis of secondary metabolites
K01754_upstream.h1_5	High power (low covariation)	K01754	upstream	E4.3.1.19, ilvA, tdcB; threonine dehydratase [EC:4.3.1.19]	ko01110	NA
K01754_upstream.h1_5	High power (low covariation)	K01754	upstream	E4.3.1.19, ilvA, tdcB; threonine dehydratase [EC:4.3.1.19]	map01200	Carbon metabolism
K01754_upstream.h1_5	High power (low covariation)	K01754	upstream	E4.3.1.19, ilvA, tdcB; threonine dehydratase [EC:4.3.1.19]	ko01200	NA
K01754_upstream.h1_5	High power (low covariation)	K01754	upstream	E4.3.1.19, ilvA, tdcB; threonine dehydratase [EC:4.3.1.19]	map01230	Biosynthesis of amino acids
K01754_upstream.h1_5	High power (low covariation)	K01754	upstream	E4.3.1.19, ilvA, tdcB; threonine dehydratase [EC:4.3.1.19]	ko01230	NA
K01835_upstream.h2_2	Conserved sequence (low covariation and power)	K01835	upstream	pgm; phosphoglucomutase [EC:5.4.2.2]	map00010	Glycolysis / Gluconeogenesis
K01835_upstream.h2_2	Conserved sequence (low covariation and power)	K01835	upstream	pgm; phosphoglucomutase [EC:5.4.2.2]	ko00010	NA
K01835_upstream.h2_2	Conserved sequence (low covariation and power)	K01835	upstream	pgm; phosphoglucomutase [EC:5.4.2.2]	map00030	Pentose phosphate pathway
K01835_upstream.h2_2	Conserved sequence (low covariation and power)	K01835	upstream	pgm; phosphoglucomutase [EC:5.4.2.2]	ko00030	NA
K01835_upstream.h2_2	Conserved sequence (low covariation and power)	K01835	upstream	pgm; phosphoglucomutase [EC:5.4.2.2]	map00052	Galactose metabolism
K01835_upstream.h2_2	Conserved sequence (low covariation and power)	K01835	upstream	pgm; phosphoglucomutase [EC:5.4.2.2]	ko00052	NA
K01835_upstream.h2_2	Conserved sequence (low covariation and power)	K01835	upstream	pgm; phosphoglucomutase [EC:5.4.2.2]	map00230	Purine metabolism
K01835_upstream.h2_2	Conserved sequence (low covariation and power)	K01835	upstream	pgm; phosphoglucomutase [EC:5.4.2.2]	ko00230	NA
K01835_upstream.h2_2	Conserved sequence (low covariation and power)	K01835	upstream	pgm; phosphoglucomutase [EC:5.4.2.2]	map00500	Starch and sucrose metabolism
K01835_upstream.h2_2	Conserved sequence (low covariation and power)	K01835	upstream	pgm; phosphoglucomutase [EC:5.4.2.2]	ko00500	NA
K01835_upstream.h2_2	Conserved sequence (low covariation and power)	K01835	upstream	pgm; phosphoglucomutase [EC:5.4.2.2]	map00520	Amino sugar and nucleotide sugar metabolism
K01835_upstream.h2_2	Conserved sequence (low covariation and power)	K01835	upstream	pgm; phosphoglucomutase [EC:5.4.2.2]	ko00520	NA
K01835_upstream.h2_2	Conserved sequence (low covariation and power)	K01835	upstream	pgm; phosphoglucomutase [EC:5.4.2.2]	map00521	Streptomycin biosynthesis
K01835_upstream.h2_2	Conserved sequence (low covariation and power)	K01835	upstream	pgm; phosphoglucomutase [EC:5.4.2.2]	ko00521	NA
K01835_upstream.h2_2	Conserved sequence (low covariation and power)	K01835	upstream	pgm; phosphoglucomutase [EC:5.4.2.2]	map01100	Metabolic pathways
K01835_upstream.h2_2	Conserved sequence (low covariation and power)	K01835	upstream	pgm; phosphoglucomutase [EC:5.4.2.2]	ko01100	NA
K01835_upstream.h2_2	Conserved sequence (low covariation and power)	K01835	upstream	pgm; phosphoglucomutase [EC:5.4.2.2]	map01110	Biosynthesis of secondary metabolites
K01835_upstream.h2_2	Conserved sequence (low covariation and power)	K01835	upstream	pgm; phosphoglucomutase [EC:5.4.2.2]	ko01110	NA
K01835_upstream.h2_2	Conserved sequence (low covariation and power)	K01835	upstream	pgm; phosphoglucomutase [EC:5.4.2.2]	map01120	Microbial metabolism in diverse environments
K01835_upstream.h2_2	Conserved sequence (low covariation and power)	K01835	upstream	pgm; phosphoglucomutase [EC:5.4.2.2]	ko01120	NA
K01835_upstream.h2_2	Conserved sequence (low covariation and power)	K01835	upstream	pgm; phosphoglucomutase [EC:5.4.2.2]	map01250	Biosynthesis of nucleotide sugars
K01835_upstream.h2_2	Conserved sequence (low covariation and power)	K01835	upstream	pgm; phosphoglucomutase [EC:5.4.2.2]	ko01250	NA
K01867_upstream.h1_2.h1_4	Conserved sequence (low covariation and power)	K01867	upstream	WARS, trpS; tryptophanyl-tRNA synthetase [EC:6.1.1.2]	map00970	Aminoacyl-tRNA biosynthesis
K01867_upstream.h1_2.h1_4	Conserved sequence (low covariation and power)	K01867	upstream	WARS, trpS; tryptophanyl-tRNA synthetase [EC:6.1.1.2]	ko00970	NA
K01867_upstream.h2_1.h2_2	Conserved sequence (low covariation and power)	K01867	upstream	WARS, trpS; tryptophanyl-tRNA synthetase [EC:6.1.1.2]	map00970	Aminoacyl-tRNA biosynthesis
K01867_upstream.h2_1.h2_2	Conserved sequence (low covariation and power)	K01867	upstream	WARS, trpS; tryptophanyl-tRNA synthetase [EC:6.1.1.2]	ko00970	NA
K01872_upstream.h2_3	Conserved sequence (low covariation and power)	K01872	upstream	AARS, alaS; alanyl-tRNA synthetase [EC:6.1.1.7]	map00970	Aminoacyl-tRNA biosynthesis
K01872_upstream.h2_3	Conserved sequence (low covariation and power)	K01872	upstream	AARS, alaS; alanyl-tRNA synthetase [EC:6.1.1.7]	ko00970	NA
K01895_upstream.h1_5.h2_1	High covariation	K01895	upstream	ACSS1_2, acs; acetyl-CoA synthetase [EC:6.2.1.1]	map00010	Glycolysis / Gluconeogenesis
K01895_upstream.h1_5.h2_1	High covariation	K01895	upstream	ACSS1_2, acs; acetyl-CoA synthetase [EC:6.2.1.1]	ko00010	NA
K01895_upstream.h1_5.h2_1	High covariation	K01895	upstream	ACSS1_2, acs; acetyl-CoA synthetase [EC:6.2.1.1]	map00620	Pyruvate metabolism
K01895_upstream.h1_5.h2_1	High covariation	K01895	upstream	ACSS1_2, acs; acetyl-CoA synthetase [EC:6.2.1.1]	ko00620	NA
K01895_upstream.h1_5.h2_1	High covariation	K01895	upstream	ACSS1_2, acs; acetyl-CoA synthetase [EC:6.2.1.1]	map00630	Glyoxylate and dicarboxylate metabolism
K01895_upstream.h1_5.h2_1	High covariation	K01895	upstream	ACSS1_2, acs; acetyl-CoA synthetase [EC:6.2.1.1]	ko00630	NA
K01895_upstream.h1_5.h2_1	High covariation	K01895	upstream	ACSS1_2, acs; acetyl-CoA synthetase [EC:6.2.1.1]	map00640	Propanoate metabolism
K01895_upstream.h1_5.h2_1	High covariation	K01895	upstream	ACSS1_2, acs; acetyl-CoA synthetase [EC:6.2.1.1]	ko00640	NA
K01895_upstream.h1_5.h2_1	High covariation	K01895	upstream	ACSS1_2, acs; acetyl-CoA synthetase [EC:6.2.1.1]	map00680	Methane metabolism
K01895_upstream.h1_5.h2_1	High covariation	K01895	upstream	ACSS1_2, acs; acetyl-CoA synthetase [EC:6.2.1.1]	ko00680	NA
K01895_upstream.h1_5.h2_1	High covariation	K01895	upstream	ACSS1_2, acs; acetyl-CoA synthetase [EC:6.2.1.1]	map00720	Other carbon fixation pathways
K01895_upstream.h1_5.h2_1	High covariation	K01895	upstream	ACSS1_2, acs; acetyl-CoA synthetase [EC:6.2.1.1]	ko00720	NA
K01895_upstream.h1_5.h2_1	High covariation	K01895	upstream	ACSS1_2, acs; acetyl-CoA synthetase [EC:6.2.1.1]	map01100	Metabolic pathways
K01895_upstream.h1_5.h2_1	High covariation	K01895	upstream	ACSS1_2, acs; acetyl-CoA synthetase [EC:6.2.1.1]	ko01100	NA
K01895_upstream.h1_5.h2_1	High covariation	K01895	upstream	ACSS1_2, acs; acetyl-CoA synthetase [EC:6.2.1.1]	map01110	Biosynthesis of secondary metabolites
K01895_upstream.h1_5.h2_1	High covariation	K01895	upstream	ACSS1_2, acs; acetyl-CoA synthetase [EC:6.2.1.1]	ko01110	NA
K01895_upstream.h1_5.h2_1	High covariation	K01895	upstream	ACSS1_2, acs; acetyl-CoA synthetase [EC:6.2.1.1]	map01120	Microbial metabolism in diverse environments
K01895_upstream.h1_5.h2_1	High covariation	K01895	upstream	ACSS1_2, acs; acetyl-CoA synthetase [EC:6.2.1.1]	ko01120	NA
K01895_upstream.h1_5.h2_1	High covariation	K01895	upstream	ACSS1_2, acs; acetyl-CoA synthetase [EC:6.2.1.1]	map01200	Carbon metabolism
K01895_upstream.h1_5.h2_1	High covariation	K01895	upstream	ACSS1_2, acs; acetyl-CoA synthetase [EC:6.2.1.1]	ko01200	NA
K01924_upstream.h1_4	Conserved sequence (low covariation and power)	K01924	upstream	murC; UDP-N-acetylmuramate--alanine ligase [EC:6.3.2.8]	map00550	Peptidoglycan biosynthesis
K01924_upstream.h1_4	Conserved sequence (low covariation and power)	K01924	upstream	murC; UDP-N-acetylmuramate--alanine ligase [EC:6.3.2.8]	ko00550	NA
K01924_upstream.h1_4	Conserved sequence (low covariation and power)	K01924	upstream	murC; UDP-N-acetylmuramate--alanine ligase [EC:6.3.2.8]	map01100	Metabolic pathways
K01924_upstream.h1_4	Conserved sequence (low covariation and power)	K01924	upstream	murC; UDP-N-acetylmuramate--alanine ligase [EC:6.3.2.8]	ko01100	NA
K01951_upstream.h1_3	Conserved sequence (low covariation and power)	K01951	upstream	guaA, GMPS; GMP synthase (glutamine-hydrolysing) [EC:6.3.5.2]	map00230	Purine metabolism
K01951_upstream.h1_3	Conserved sequence (low covariation and power)	K01951	upstream	guaA, GMPS; GMP synthase (glutamine-hydrolysing) [EC:6.3.5.2]	ko00230	NA
K01951_upstream.h1_3	Conserved sequence (low covariation and power)	K01951	upstream	guaA, GMPS; GMP synthase (glutamine-hydrolysing) [EC:6.3.5.2]	map00983	Drug metabolism - other enzymes
K01951_upstream.h1_3	Conserved sequence (low covariation and power)	K01951	upstream	guaA, GMPS; GMP synthase (glutamine-hydrolysing) [EC:6.3.5.2]	ko00983	NA
K01951_upstream.h1_3	Conserved sequence (low covariation and power)	K01951	upstream	guaA, GMPS; GMP synthase (glutamine-hydrolysing) [EC:6.3.5.2]	map01100	Metabolic pathways
K01951_upstream.h1_3	Conserved sequence (low covariation and power)	K01951	upstream	guaA, GMPS; GMP synthase (glutamine-hydrolysing) [EC:6.3.5.2]	ko01100	NA
K01951_upstream.h1_3	Conserved sequence (low covariation and power)	K01951	upstream	guaA, GMPS; GMP synthase (glutamine-hydrolysing) [EC:6.3.5.2]	map01232	Nucleotide metabolism
K01951_upstream.h1_3	Conserved sequence (low covariation and power)	K01951	upstream	guaA, GMPS; GMP synthase (glutamine-hydrolysing) [EC:6.3.5.2]	ko01232	NA
K02014_upstream.h1_4	High covariation	K02014	upstream	TC.FEV.OM; iron complex outermembrane recepter protein	NA	NA
K02033_upstream.h1_3	High covariation	K02033	upstream	ABC.PE.P; peptide/nickel transport system permease protein	map02024	Quorum sensing
K02033_upstream.h1_3	High covariation	K02033	upstream	ABC.PE.P; peptide/nickel transport system permease protein	ko02024	NA
K02078_upstream.h1_1	High power (low covariation)	K02078	upstream	acpP, acpM; acyl carrier protein	map00998	Biosynthesis of various antibiotics
K02078_upstream.h1_1	High power (low covariation)	K02078	upstream	acpP, acpM; acyl carrier protein	ko00998	NA
K02078_upstream.h1_1	High power (low covariation)	K02078	upstream	acpP, acpM; acyl carrier protein	map01100	Metabolic pathways
K02078_upstream.h1_1	High power (low covariation)	K02078	upstream	acpP, acpM; acyl carrier protein	ko01100	NA
K02078_upstream.h1_1	High power (low covariation)	K02078	upstream	acpP, acpM; acyl carrier protein	map01110	Biosynthesis of secondary metabolites
K02078_upstream.h1_1	High power (low covariation)	K02078	upstream	acpP, acpM; acyl carrier protein	ko01110	NA
K02094_upstream.h1_1	Conserved sequence (low covariation and power)	K02094	upstream	apcC; phycobilisome core linker protein	map00196	Photosynthesis - antenna proteins
K02094_upstream.h1_1	Conserved sequence (low covariation and power)	K02094	upstream	apcC; phycobilisome core linker protein	ko00196	NA
K02094_upstream.h1_1	Conserved sequence (low covariation and power)	K02094	upstream	apcC; phycobilisome core linker protein	map01100	Metabolic pathways
K02094_upstream.h1_1	Conserved sequence (low covariation and power)	K02094	upstream	apcC; phycobilisome core linker protein	ko01100	NA
K02094_upstream.h1_2.h1_4	High power (low covariation)	K02094	upstream	apcC; phycobilisome core linker protein	map00196	Photosynthesis - antenna proteins
K02094_upstream.h1_2.h1_4	High power (low covariation)	K02094	upstream	apcC; phycobilisome core linker protein	ko00196	NA
K02094_upstream.h1_2.h1_4	High power (low covariation)	K02094	upstream	apcC; phycobilisome core linker protein	map01100	Metabolic pathways
K02094_upstream.h1_2.h1_4	High power (low covariation)	K02094	upstream	apcC; phycobilisome core linker protein	ko01100	NA
K02097_upstream.h2_1.h2_4	High power (low covariation)	K02097	upstream	apcF; phycobilisome core component	map00196	Photosynthesis - antenna proteins
K02097_upstream.h2_1.h2_4	High power (low covariation)	K02097	upstream	apcF; phycobilisome core component	ko00196	NA
K02097_upstream.h2_1.h2_4	High power (low covariation)	K02097	upstream	apcF; phycobilisome core component	map01100	Metabolic pathways
K02097_upstream.h2_1.h2_4	High power (low covariation)	K02097	upstream	apcF; phycobilisome core component	ko01100	NA
K02097_upstream.h1_2	High power (low covariation)	K02097	upstream	apcF; phycobilisome core component	map00196	Photosynthesis - antenna proteins
K02097_upstream.h1_2	High power (low covariation)	K02097	upstream	apcF; phycobilisome core component	ko00196	NA
K02097_upstream.h1_2	High power (low covariation)	K02097	upstream	apcF; phycobilisome core component	map01100	Metabolic pathways
K02097_upstream.h1_2	High power (low covariation)	K02097	upstream	apcF; phycobilisome core component	ko01100	NA
K02097_upstream.h1_3	Conserved sequence (low covariation and power)	K02097	upstream	apcF; phycobilisome core component	map00196	Photosynthesis - antenna proteins
K02097_upstream.h1_3	Conserved sequence (low covariation and power)	K02097	upstream	apcF; phycobilisome core component	ko00196	NA
K02097_upstream.h1_3	Conserved sequence (low covariation and power)	K02097	upstream	apcF; phycobilisome core component	map01100	Metabolic pathways
K02097_upstream.h1_3	Conserved sequence (low covariation and power)	K02097	upstream	apcF; phycobilisome core component	ko01100	NA
K02217_upstream.h1_5.h2_2	Conserved sequence (low covariation and power)	K02217	upstream	ftnA, ftn; ferritin [EC:1.16.3.2]	NA	NA
K02221_upstream.h2_1	Conserved sequence (low covariation and power)	K02221	upstream	yggT; YggT family protein	NA	NA
K02233_upstream.h1_2	Conserved sequence (low covariation and power)	K02233	upstream	E2.7.8.26, cobS, cobV; adenosylcobinamide-GDP ribazoletransferase [EC:2.7.8.26]	map00860	Porphyrin metabolism
K02233_upstream.h1_2	Conserved sequence (low covariation and power)	K02233	upstream	E2.7.8.26, cobS, cobV; adenosylcobinamide-GDP ribazoletransferase [EC:2.7.8.26]	ko00860	NA
K02233_upstream.h1_2	Conserved sequence (low covariation and power)	K02233	upstream	E2.7.8.26, cobS, cobV; adenosylcobinamide-GDP ribazoletransferase [EC:2.7.8.26]	map01100	Metabolic pathways
K02233_upstream.h1_2	Conserved sequence (low covariation and power)	K02233	upstream	E2.7.8.26, cobS, cobV; adenosylcobinamide-GDP ribazoletransferase [EC:2.7.8.26]	ko01100	NA
K02233_upstream.h1_2	Conserved sequence (low covariation and power)	K02233	upstream	E2.7.8.26, cobS, cobV; adenosylcobinamide-GDP ribazoletransferase [EC:2.7.8.26]	map01240	Biosynthesis of cofactors
K02233_upstream.h1_2	Conserved sequence (low covariation and power)	K02233	upstream	E2.7.8.26, cobS, cobV; adenosylcobinamide-GDP ribazoletransferase [EC:2.7.8.26]	ko01240	NA
K02257_upstream.h1_2	Conserved sequence (low covariation and power)	K02257	upstream	COX10, ctaB, cyoE; heme o synthase [EC:2.5.1.141]	map00190	Oxidative phosphorylation
K02257_upstream.h1_2	Conserved sequence (low covariation and power)	K02257	upstream	COX10, ctaB, cyoE; heme o synthase [EC:2.5.1.141]	ko00190	NA
K02257_upstream.h1_2	Conserved sequence (low covariation and power)	K02257	upstream	COX10, ctaB, cyoE; heme o synthase [EC:2.5.1.141]	map00860	Porphyrin metabolism
K02257_upstream.h1_2	Conserved sequence (low covariation and power)	K02257	upstream	COX10, ctaB, cyoE; heme o synthase [EC:2.5.1.141]	ko00860	NA
K02257_upstream.h1_2	Conserved sequence (low covariation and power)	K02257	upstream	COX10, ctaB, cyoE; heme o synthase [EC:2.5.1.141]	map01100	Metabolic pathways
K02257_upstream.h1_2	Conserved sequence (low covariation and power)	K02257	upstream	COX10, ctaB, cyoE; heme o synthase [EC:2.5.1.141]	ko01100	NA
K02257_upstream.h1_2	Conserved sequence (low covariation and power)	K02257	upstream	COX10, ctaB, cyoE; heme o synthase [EC:2.5.1.141]	map01110	Biosynthesis of secondary metabolites
K02257_upstream.h1_2	Conserved sequence (low covariation and power)	K02257	upstream	COX10, ctaB, cyoE; heme o synthase [EC:2.5.1.141]	ko01110	NA
K02257_upstream.h1_2	Conserved sequence (low covariation and power)	K02257	upstream	COX10, ctaB, cyoE; heme o synthase [EC:2.5.1.141]	map01240	Biosynthesis of cofactors
K02257_upstream.h1_2	Conserved sequence (low covariation and power)	K02257	upstream	COX10, ctaB, cyoE; heme o synthase [EC:2.5.1.141]	ko01240	NA
K02257_upstream.h1_2	Conserved sequence (low covariation and power)	K02257	upstream	COX10, ctaB, cyoE; heme o synthase [EC:2.5.1.141]	map04714	Thermogenesis
K02257_upstream.h1_2	Conserved sequence (low covariation and power)	K02257	upstream	COX10, ctaB, cyoE; heme o synthase [EC:2.5.1.141]	ko04714	NA
K02257_upstream.h1_1	High covariation	K02257	upstream	COX10, ctaB, cyoE; heme o synthase [EC:2.5.1.141]	map00190	Oxidative phosphorylation
K02257_upstream.h1_1	High covariation	K02257	upstream	COX10, ctaB, cyoE; heme o synthase [EC:2.5.1.141]	ko00190	NA
K02257_upstream.h1_1	High covariation	K02257	upstream	COX10, ctaB, cyoE; heme o synthase [EC:2.5.1.141]	map00860	Porphyrin metabolism
K02257_upstream.h1_1	High covariation	K02257	upstream	COX10, ctaB, cyoE; heme o synthase [EC:2.5.1.141]	ko00860	NA
K02257_upstream.h1_1	High covariation	K02257	upstream	COX10, ctaB, cyoE; heme o synthase [EC:2.5.1.141]	map01100	Metabolic pathways
K02257_upstream.h1_1	High covariation	K02257	upstream	COX10, ctaB, cyoE; heme o synthase [EC:2.5.1.141]	ko01100	NA
K02257_upstream.h1_1	High covariation	K02257	upstream	COX10, ctaB, cyoE; heme o synthase [EC:2.5.1.141]	map01110	Biosynthesis of secondary metabolites
K02257_upstream.h1_1	High covariation	K02257	upstream	COX10, ctaB, cyoE; heme o synthase [EC:2.5.1.141]	ko01110	NA
K02257_upstream.h1_1	High covariation	K02257	upstream	COX10, ctaB, cyoE; heme o synthase [EC:2.5.1.141]	map01240	Biosynthesis of cofactors
K02257_upstream.h1_1	High covariation	K02257	upstream	COX10, ctaB, cyoE; heme o synthase [EC:2.5.1.141]	ko01240	NA
K02257_upstream.h1_1	High covariation	K02257	upstream	COX10, ctaB, cyoE; heme o synthase [EC:2.5.1.141]	map04714	Thermogenesis
K02257_upstream.h1_1	High covariation	K02257	upstream	COX10, ctaB, cyoE; heme o synthase [EC:2.5.1.141]	ko04714	NA
K02316_upstream.h2_3	High power (low covariation)	K02316	upstream	dnaG; DNA primase [EC:2.7.7.101]	map03030	DNA replication
K02316_upstream.h2_3	High power (low covariation)	K02316	upstream	dnaG; DNA primase [EC:2.7.7.101]	ko03030	NA
K02340_upstream.h2_1	Conserved sequence (low covariation and power)	K02340	upstream	holA; DNA polymerase III subunit delta [EC:2.7.7.7]	map03030	DNA replication
K02340_upstream.h2_1	Conserved sequence (low covariation and power)	K02340	upstream	holA; DNA polymerase III subunit delta [EC:2.7.7.7]	ko03030	NA
K02340_upstream.h2_1	Conserved sequence (low covariation and power)	K02340	upstream	holA; DNA polymerase III subunit delta [EC:2.7.7.7]	map03430	Mismatch repair
K02340_upstream.h2_1	Conserved sequence (low covariation and power)	K02340	upstream	holA; DNA polymerase III subunit delta [EC:2.7.7.7]	ko03430	NA
K02340_upstream.h2_1	Conserved sequence (low covariation and power)	K02340	upstream	holA; DNA polymerase III subunit delta [EC:2.7.7.7]	map03440	Homologous recombination
K02340_upstream.h2_1	Conserved sequence (low covariation and power)	K02340	upstream	holA; DNA polymerase III subunit delta [EC:2.7.7.7]	ko03440	NA
K02340_upstream.h2_3	High power (low covariation)	K02340	upstream	holA; DNA polymerase III subunit delta [EC:2.7.7.7]	map03030	DNA replication
K02340_upstream.h2_3	High power (low covariation)	K02340	upstream	holA; DNA polymerase III subunit delta [EC:2.7.7.7]	ko03030	NA
K02340_upstream.h2_3	High power (low covariation)	K02340	upstream	holA; DNA polymerase III subunit delta [EC:2.7.7.7]	map03430	Mismatch repair
K02340_upstream.h2_3	High power (low covariation)	K02340	upstream	holA; DNA polymerase III subunit delta [EC:2.7.7.7]	ko03430	NA
K02340_upstream.h2_3	High power (low covariation)	K02340	upstream	holA; DNA polymerase III subunit delta [EC:2.7.7.7]	map03440	Homologous recombination
K02340_upstream.h2_3	High power (low covariation)	K02340	upstream	holA; DNA polymerase III subunit delta [EC:2.7.7.7]	ko03440	NA
K02355_upstream.h1_5.h2_1	Conserved sequence (low covariation and power)	K02355	upstream	fusA, GFM, EFG; elongation factor G	NA	NA
K02355_upstream.h1_1	High covariation	K02355	upstream	fusA, GFM, EFG; elongation factor G	NA	NA
K02469_upstream.h1_4.h2_1	High covariation	K02469	upstream	gyrA; DNA gyrase subunit A [EC:5.6.2.2]	NA	NA
K02470_upstream.h1_5.h2_4.h2_1.h2_2	Conserved sequence (low covariation and power)	K02470	upstream	gyrB; DNA gyrase subunit B [EC:5.6.2.2]	NA	NA
K02470_upstream.h1_1	High covariation	K02470	upstream	gyrB; DNA gyrase subunit B [EC:5.6.2.2]	NA	NA
K02495_upstream.h1_3	High covariation	K02495	upstream	hemN, hemZ; oxygen-independent coproporphyrinogen III oxidase [EC:1.3.98.3]	map00860	Porphyrin metabolism
K02495_upstream.h1_3	High covariation	K02495	upstream	hemN, hemZ; oxygen-independent coproporphyrinogen III oxidase [EC:1.3.98.3]	ko00860	NA
K02495_upstream.h1_3	High covariation	K02495	upstream	hemN, hemZ; oxygen-independent coproporphyrinogen III oxidase [EC:1.3.98.3]	map01100	Metabolic pathways
K02495_upstream.h1_3	High covariation	K02495	upstream	hemN, hemZ; oxygen-independent coproporphyrinogen III oxidase [EC:1.3.98.3]	ko01100	NA
K02495_upstream.h1_3	High covariation	K02495	upstream	hemN, hemZ; oxygen-independent coproporphyrinogen III oxidase [EC:1.3.98.3]	map01110	Biosynthesis of secondary metabolites
K02495_upstream.h1_3	High covariation	K02495	upstream	hemN, hemZ; oxygen-independent coproporphyrinogen III oxidase [EC:1.3.98.3]	ko01110	NA
K02495_upstream.h1_3	High covariation	K02495	upstream	hemN, hemZ; oxygen-independent coproporphyrinogen III oxidase [EC:1.3.98.3]	map01240	Biosynthesis of cofactors
K02495_upstream.h1_3	High covariation	K02495	upstream	hemN, hemZ; oxygen-independent coproporphyrinogen III oxidase [EC:1.3.98.3]	ko01240	NA
K02495_upstream.h1_2	High covariation	K02495	upstream	hemN, hemZ; oxygen-independent coproporphyrinogen III oxidase [EC:1.3.98.3]	map00860	Porphyrin metabolism
K02495_upstream.h1_2	High covariation	K02495	upstream	hemN, hemZ; oxygen-independent coproporphyrinogen III oxidase [EC:1.3.98.3]	ko00860	NA
K02495_upstream.h1_2	High covariation	K02495	upstream	hemN, hemZ; oxygen-independent coproporphyrinogen III oxidase [EC:1.3.98.3]	map01100	Metabolic pathways
K02495_upstream.h1_2	High covariation	K02495	upstream	hemN, hemZ; oxygen-independent coproporphyrinogen III oxidase [EC:1.3.98.3]	ko01100	NA
K02495_upstream.h1_2	High covariation	K02495	upstream	hemN, hemZ; oxygen-independent coproporphyrinogen III oxidase [EC:1.3.98.3]	map01110	Biosynthesis of secondary metabolites
K02495_upstream.h1_2	High covariation	K02495	upstream	hemN, hemZ; oxygen-independent coproporphyrinogen III oxidase [EC:1.3.98.3]	ko01110	NA
K02495_upstream.h1_2	High covariation	K02495	upstream	hemN, hemZ; oxygen-independent coproporphyrinogen III oxidase [EC:1.3.98.3]	map01240	Biosynthesis of cofactors
K02495_upstream.h1_2	High covariation	K02495	upstream	hemN, hemZ; oxygen-independent coproporphyrinogen III oxidase [EC:1.3.98.3]	ko01240	NA
K02548_upstream.h1_4.h2_4	High covariation	K02548	upstream	menA; 1,4-dihydroxy-2-naphthoate polyprenyltransferase [EC:2.5.1.74]	map00130	Ubiquinone and other terpenoid-quinone biosynthesis
K02548_upstream.h1_4.h2_4	High covariation	K02548	upstream	menA; 1,4-dihydroxy-2-naphthoate polyprenyltransferase [EC:2.5.1.74]	ko00130	NA
K02548_upstream.h1_4.h2_4	High covariation	K02548	upstream	menA; 1,4-dihydroxy-2-naphthoate polyprenyltransferase [EC:2.5.1.74]	map01100	Metabolic pathways
K02548_upstream.h1_4.h2_4	High covariation	K02548	upstream	menA; 1,4-dihydroxy-2-naphthoate polyprenyltransferase [EC:2.5.1.74]	ko01100	NA
K02548_upstream.h1_4.h2_4	High covariation	K02548	upstream	menA; 1,4-dihydroxy-2-naphthoate polyprenyltransferase [EC:2.5.1.74]	map01110	Biosynthesis of secondary metabolites
K02548_upstream.h1_4.h2_4	High covariation	K02548	upstream	menA; 1,4-dihydroxy-2-naphthoate polyprenyltransferase [EC:2.5.1.74]	ko01110	NA
K02548_upstream.h1_4.h2_4	High covariation	K02548	upstream	menA; 1,4-dihydroxy-2-naphthoate polyprenyltransferase [EC:2.5.1.74]	map01240	Biosynthesis of cofactors
K02548_upstream.h1_4.h2_4	High covariation	K02548	upstream	menA; 1,4-dihydroxy-2-naphthoate polyprenyltransferase [EC:2.5.1.74]	ko01240	NA
K02548_upstream.h1_1.h2_3.h1_2	Conserved sequence (low covariation and power)	K02548	upstream	menA; 1,4-dihydroxy-2-naphthoate polyprenyltransferase [EC:2.5.1.74]	map00130	Ubiquinone and other terpenoid-quinone biosynthesis
K02548_upstream.h1_1.h2_3.h1_2	Conserved sequence (low covariation and power)	K02548	upstream	menA; 1,4-dihydroxy-2-naphthoate polyprenyltransferase [EC:2.5.1.74]	ko00130	NA
K02548_upstream.h1_1.h2_3.h1_2	Conserved sequence (low covariation and power)	K02548	upstream	menA; 1,4-dihydroxy-2-naphthoate polyprenyltransferase [EC:2.5.1.74]	map01100	Metabolic pathways
K02548_upstream.h1_1.h2_3.h1_2	Conserved sequence (low covariation and power)	K02548	upstream	menA; 1,4-dihydroxy-2-naphthoate polyprenyltransferase [EC:2.5.1.74]	ko01100	NA
K02548_upstream.h1_1.h2_3.h1_2	Conserved sequence (low covariation and power)	K02548	upstream	menA; 1,4-dihydroxy-2-naphthoate polyprenyltransferase [EC:2.5.1.74]	map01110	Biosynthesis of secondary metabolites
K02548_upstream.h1_1.h2_3.h1_2	Conserved sequence (low covariation and power)	K02548	upstream	menA; 1,4-dihydroxy-2-naphthoate polyprenyltransferase [EC:2.5.1.74]	ko01110	NA
K02548_upstream.h1_1.h2_3.h1_2	Conserved sequence (low covariation and power)	K02548	upstream	menA; 1,4-dihydroxy-2-naphthoate polyprenyltransferase [EC:2.5.1.74]	map01240	Biosynthesis of cofactors
K02548_upstream.h1_1.h2_3.h1_2	Conserved sequence (low covariation and power)	K02548	upstream	menA; 1,4-dihydroxy-2-naphthoate polyprenyltransferase [EC:2.5.1.74]	ko01240	NA
K02548_upstream.h1_5.h2_2	High covariation	K02548	upstream	menA; 1,4-dihydroxy-2-naphthoate polyprenyltransferase [EC:2.5.1.74]	map00130	Ubiquinone and other terpenoid-quinone biosynthesis
K02548_upstream.h1_5.h2_2	High covariation	K02548	upstream	menA; 1,4-dihydroxy-2-naphthoate polyprenyltransferase [EC:2.5.1.74]	ko00130	NA
K02548_upstream.h1_5.h2_2	High covariation	K02548	upstream	menA; 1,4-dihydroxy-2-naphthoate polyprenyltransferase [EC:2.5.1.74]	map01100	Metabolic pathways
K02548_upstream.h1_5.h2_2	High covariation	K02548	upstream	menA; 1,4-dihydroxy-2-naphthoate polyprenyltransferase [EC:2.5.1.74]	ko01100	NA
K02548_upstream.h1_5.h2_2	High covariation	K02548	upstream	menA; 1,4-dihydroxy-2-naphthoate polyprenyltransferase [EC:2.5.1.74]	map01110	Biosynthesis of secondary metabolites
K02548_upstream.h1_5.h2_2	High covariation	K02548	upstream	menA; 1,4-dihydroxy-2-naphthoate polyprenyltransferase [EC:2.5.1.74]	ko01110	NA
K02548_upstream.h1_5.h2_2	High covariation	K02548	upstream	menA; 1,4-dihydroxy-2-naphthoate polyprenyltransferase [EC:2.5.1.74]	map01240	Biosynthesis of cofactors
K02548_upstream.h1_5.h2_2	High covariation	K02548	upstream	menA; 1,4-dihydroxy-2-naphthoate polyprenyltransferase [EC:2.5.1.74]	ko01240	NA
K02588_upstream.h2_1	High power (low covariation)	K02588	upstream	nifH; nitrogenase iron protein NifH	map00625	Chloroalkane and chloroalkene degradation
K02588_upstream.h2_1	High power (low covariation)	K02588	upstream	nifH; nitrogenase iron protein NifH	ko00625	NA
K02588_upstream.h2_1	High power (low covariation)	K02588	upstream	nifH; nitrogenase iron protein NifH	map00910	Nitrogen metabolism
K02588_upstream.h2_1	High power (low covariation)	K02588	upstream	nifH; nitrogenase iron protein NifH	ko00910	NA
K02588_upstream.h2_1	High power (low covariation)	K02588	upstream	nifH; nitrogenase iron protein NifH	map01100	Metabolic pathways
K02588_upstream.h2_1	High power (low covariation)	K02588	upstream	nifH; nitrogenase iron protein NifH	ko01100	NA
K02588_upstream.h2_1	High power (low covariation)	K02588	upstream	nifH; nitrogenase iron protein NifH	map01120	Microbial metabolism in diverse environments
K02588_upstream.h2_1	High power (low covariation)	K02588	upstream	nifH; nitrogenase iron protein NifH	ko01120	NA
K02588_upstream.h2_1	High power (low covariation)	K02588	upstream	nifH; nitrogenase iron protein NifH	map01310	Nitrogen cycle
K02588_upstream.h2_1	High power (low covariation)	K02588	upstream	nifH; nitrogenase iron protein NifH	ko01310	NA
K02588_upstream.h1_1	High covariation	K02588	upstream	nifH; nitrogenase iron protein NifH	map00625	Chloroalkane and chloroalkene degradation
K02588_upstream.h1_1	High covariation	K02588	upstream	nifH; nitrogenase iron protein NifH	ko00625	NA
K02588_upstream.h1_1	High covariation	K02588	upstream	nifH; nitrogenase iron protein NifH	map00910	Nitrogen metabolism
K02588_upstream.h1_1	High covariation	K02588	upstream	nifH; nitrogenase iron protein NifH	ko00910	NA
K02588_upstream.h1_1	High covariation	K02588	upstream	nifH; nitrogenase iron protein NifH	map01100	Metabolic pathways
K02588_upstream.h1_1	High covariation	K02588	upstream	nifH; nitrogenase iron protein NifH	ko01100	NA
K02588_upstream.h1_1	High covariation	K02588	upstream	nifH; nitrogenase iron protein NifH	map01120	Microbial metabolism in diverse environments
K02588_upstream.h1_1	High covariation	K02588	upstream	nifH; nitrogenase iron protein NifH	ko01120	NA
K02588_upstream.h1_1	High covariation	K02588	upstream	nifH; nitrogenase iron protein NifH	map01310	Nitrogen cycle
K02588_upstream.h1_1	High covariation	K02588	upstream	nifH; nitrogenase iron protein NifH	ko01310	NA
K02591_upstream.h1_1.h2_1.h1_4	High covariation	K02591	upstream	nifK; nitrogenase molybdenum-iron protein beta chain [EC:1.18.6.1]	map00625	Chloroalkane and chloroalkene degradation
K02591_upstream.h1_1.h2_1.h1_4	High covariation	K02591	upstream	nifK; nitrogenase molybdenum-iron protein beta chain [EC:1.18.6.1]	ko00625	NA
K02591_upstream.h1_1.h2_1.h1_4	High covariation	K02591	upstream	nifK; nitrogenase molybdenum-iron protein beta chain [EC:1.18.6.1]	map00910	Nitrogen metabolism
K02591_upstream.h1_1.h2_1.h1_4	High covariation	K02591	upstream	nifK; nitrogenase molybdenum-iron protein beta chain [EC:1.18.6.1]	ko00910	NA
K02591_upstream.h1_1.h2_1.h1_4	High covariation	K02591	upstream	nifK; nitrogenase molybdenum-iron protein beta chain [EC:1.18.6.1]	map01100	Metabolic pathways
K02591_upstream.h1_1.h2_1.h1_4	High covariation	K02591	upstream	nifK; nitrogenase molybdenum-iron protein beta chain [EC:1.18.6.1]	ko01100	NA
K02591_upstream.h1_1.h2_1.h1_4	High covariation	K02591	upstream	nifK; nitrogenase molybdenum-iron protein beta chain [EC:1.18.6.1]	map01120	Microbial metabolism in diverse environments
K02591_upstream.h1_1.h2_1.h1_4	High covariation	K02591	upstream	nifK; nitrogenase molybdenum-iron protein beta chain [EC:1.18.6.1]	ko01120	NA
K02591_upstream.h1_1.h2_1.h1_4	High covariation	K02591	upstream	nifK; nitrogenase molybdenum-iron protein beta chain [EC:1.18.6.1]	map01310	Nitrogen cycle
K02591_upstream.h1_1.h2_1.h1_4	High covariation	K02591	upstream	nifK; nitrogenase molybdenum-iron protein beta chain [EC:1.18.6.1]	ko01310	NA
K02636_upstream.h1_2	High power (low covariation)	K02636	upstream	petC; cytochrome b6-f complex iron-sulfur subunit [EC:7.1.1.6]	map00195	Photosynthesis
K02636_upstream.h1_2	High power (low covariation)	K02636	upstream	petC; cytochrome b6-f complex iron-sulfur subunit [EC:7.1.1.6]	ko00195	NA
K02636_upstream.h1_2	High power (low covariation)	K02636	upstream	petC; cytochrome b6-f complex iron-sulfur subunit [EC:7.1.1.6]	map01100	Metabolic pathways
K02636_upstream.h1_2	High power (low covariation)	K02636	upstream	petC; cytochrome b6-f complex iron-sulfur subunit [EC:7.1.1.6]	ko01100	NA
K02704_upstream.h2_2	High covariation	K02704	upstream	psbB; photosystem II CP47 chlorophyll apoprotein	map00195	Photosynthesis
K02704_upstream.h2_2	High covariation	K02704	upstream	psbB; photosystem II CP47 chlorophyll apoprotein	ko00195	NA
K02704_upstream.h2_2	High covariation	K02704	upstream	psbB; photosystem II CP47 chlorophyll apoprotein	map01100	Metabolic pathways
K02704_upstream.h2_2	High covariation	K02704	upstream	psbB; photosystem II CP47 chlorophyll apoprotein	ko01100	NA
K02705_upstream.h1_5	High covariation	K02705	upstream	psbC; photosystem II CP43 chlorophyll apoprotein	map00195	Photosynthesis
K02705_upstream.h1_5	High covariation	K02705	upstream	psbC; photosystem II CP43 chlorophyll apoprotein	ko00195	NA
K02705_upstream.h1_5	High covariation	K02705	upstream	psbC; photosystem II CP43 chlorophyll apoprotein	map01100	Metabolic pathways
K02705_upstream.h1_5	High covariation	K02705	upstream	psbC; photosystem II CP43 chlorophyll apoprotein	ko01100	NA
K02707_upstream.h1_1	Conserved sequence (low covariation and power)	K02707	upstream	psbE; photosystem II cytochrome b559 subunit alpha	map00195	Photosynthesis
K02707_upstream.h1_1	Conserved sequence (low covariation and power)	K02707	upstream	psbE; photosystem II cytochrome b559 subunit alpha	ko00195	NA
K02707_upstream.h1_1	Conserved sequence (low covariation and power)	K02707	upstream	psbE; photosystem II cytochrome b559 subunit alpha	map01100	Metabolic pathways
K02707_upstream.h1_1	Conserved sequence (low covariation and power)	K02707	upstream	psbE; photosystem II cytochrome b559 subunit alpha	ko01100	NA
K02716_upstream.h1_3	Conserved sequence (low covariation and power)	K02716	upstream	psbO; photosystem II oxygen-evolving enhancer protein 1	map00195	Photosynthesis
K02716_upstream.h1_3	Conserved sequence (low covariation and power)	K02716	upstream	psbO; photosystem II oxygen-evolving enhancer protein 1	ko00195	NA
K02716_upstream.h1_3	Conserved sequence (low covariation and power)	K02716	upstream	psbO; photosystem II oxygen-evolving enhancer protein 1	map01100	Metabolic pathways
K02716_upstream.h1_3	Conserved sequence (low covariation and power)	K02716	upstream	psbO; photosystem II oxygen-evolving enhancer protein 1	ko01100	NA
K02716_upstream.h1_5	Conserved sequence (low covariation and power)	K02716	upstream	psbO; photosystem II oxygen-evolving enhancer protein 1	map00195	Photosynthesis
K02716_upstream.h1_5	Conserved sequence (low covariation and power)	K02716	upstream	psbO; photosystem II oxygen-evolving enhancer protein 1	ko00195	NA
K02716_upstream.h1_5	Conserved sequence (low covariation and power)	K02716	upstream	psbO; photosystem II oxygen-evolving enhancer protein 1	map01100	Metabolic pathways
K02716_upstream.h1_5	Conserved sequence (low covariation and power)	K02716	upstream	psbO; photosystem II oxygen-evolving enhancer protein 1	ko01100	NA
K02717_upstream.h1_5.h2_1.h2_2.h2_4.h1_4	Conserved sequence (low covariation and power)	K02717	upstream	psbP; photosystem II oxygen-evolving enhancer protein 2	map00195	Photosynthesis
K02717_upstream.h1_5.h2_1.h2_2.h2_4.h1_4	Conserved sequence (low covariation and power)	K02717	upstream	psbP; photosystem II oxygen-evolving enhancer protein 2	ko00195	NA
K02717_upstream.h1_5.h2_1.h2_2.h2_4.h1_4	Conserved sequence (low covariation and power)	K02717	upstream	psbP; photosystem II oxygen-evolving enhancer protein 2	map01100	Metabolic pathways
K02717_upstream.h1_5.h2_1.h2_2.h2_4.h1_4	Conserved sequence (low covariation and power)	K02717	upstream	psbP; photosystem II oxygen-evolving enhancer protein 2	ko01100	NA
K02717_upstream.h2_3	Conserved sequence (low covariation and power)	K02717	upstream	psbP; photosystem II oxygen-evolving enhancer protein 2	map00195	Photosynthesis
K02717_upstream.h2_3	Conserved sequence (low covariation and power)	K02717	upstream	psbP; photosystem II oxygen-evolving enhancer protein 2	ko00195	NA
K02717_upstream.h2_3	Conserved sequence (low covariation and power)	K02717	upstream	psbP; photosystem II oxygen-evolving enhancer protein 2	map01100	Metabolic pathways
K02717_upstream.h2_3	Conserved sequence (low covariation and power)	K02717	upstream	psbP; photosystem II oxygen-evolving enhancer protein 2	ko01100	NA
K02717_upstream.h1_3	High power (low covariation)	K02717	upstream	psbP; photosystem II oxygen-evolving enhancer protein 2	map00195	Photosynthesis
K02717_upstream.h1_3	High power (low covariation)	K02717	upstream	psbP; photosystem II oxygen-evolving enhancer protein 2	ko00195	NA
K02717_upstream.h1_3	High power (low covariation)	K02717	upstream	psbP; photosystem II oxygen-evolving enhancer protein 2	map01100	Metabolic pathways
K02717_upstream.h1_3	High power (low covariation)	K02717	upstream	psbP; photosystem II oxygen-evolving enhancer protein 2	ko01100	NA
K02834_upstream.h2_3	High power (low covariation)	K02834	upstream	rbfA; ribosome-binding factor A	NA	NA
K02834_upstream.h1_3	Conserved sequence (low covariation and power)	K02834	upstream	rbfA; ribosome-binding factor A	NA	NA
K02836_upstream.h1_1	High covariation	K02836	upstream	prfB; peptide chain release factor 2	NA	NA
K02836_upstream.h2_2.h2_3	High covariation	K02836	upstream	prfB; peptide chain release factor 2	NA	NA
K02836_upstream.h2_4	High power (low covariation)	K02836	upstream	prfB; peptide chain release factor 2	NA	NA
K02836_upstream.h1_4.h2_1	Conserved sequence (low covariation and power)	K02836	upstream	prfB; peptide chain release factor 2	NA	NA
K02836_upstream.h1_3	Conserved sequence (low covariation and power)	K02836	upstream	prfB; peptide chain release factor 2	NA	NA
K02851_upstream.h2_1	Conserved sequence (low covariation and power)	K02851	upstream	wecA, tagO, rfe; UDP-GlcNAc:undecaprenyl-phosphate/decaprenyl-phosphate GlcNAc-1-phosphate transferase [EC:2.7.8.33 2.7.8.35]	map00542	O-Antigen repeat unit biosynthesis
K02851_upstream.h2_1	Conserved sequence (low covariation and power)	K02851	upstream	wecA, tagO, rfe; UDP-GlcNAc:undecaprenyl-phosphate/decaprenyl-phosphate GlcNAc-1-phosphate transferase [EC:2.7.8.33 2.7.8.35]	ko00542	NA
K02851_upstream.h2_1	Conserved sequence (low covariation and power)	K02851	upstream	wecA, tagO, rfe; UDP-GlcNAc:undecaprenyl-phosphate/decaprenyl-phosphate GlcNAc-1-phosphate transferase [EC:2.7.8.33 2.7.8.35]	map00543	Exopolysaccharide biosynthesis
K02851_upstream.h2_1	Conserved sequence (low covariation and power)	K02851	upstream	wecA, tagO, rfe; UDP-GlcNAc:undecaprenyl-phosphate/decaprenyl-phosphate GlcNAc-1-phosphate transferase [EC:2.7.8.33 2.7.8.35]	ko00543	NA
K02851_upstream.h2_1	Conserved sequence (low covariation and power)	K02851	upstream	wecA, tagO, rfe; UDP-GlcNAc:undecaprenyl-phosphate/decaprenyl-phosphate GlcNAc-1-phosphate transferase [EC:2.7.8.33 2.7.8.35]	map00552	Teichoic acid biosynthesis
K02851_upstream.h2_1	Conserved sequence (low covariation and power)	K02851	upstream	wecA, tagO, rfe; UDP-GlcNAc:undecaprenyl-phosphate/decaprenyl-phosphate GlcNAc-1-phosphate transferase [EC:2.7.8.33 2.7.8.35]	ko00552	NA
K02851_upstream.h2_1	Conserved sequence (low covariation and power)	K02851	upstream	wecA, tagO, rfe; UDP-GlcNAc:undecaprenyl-phosphate/decaprenyl-phosphate GlcNAc-1-phosphate transferase [EC:2.7.8.33 2.7.8.35]	map00572	Arabinogalactan biosynthesis - Mycobacterium
K02851_upstream.h2_1	Conserved sequence (low covariation and power)	K02851	upstream	wecA, tagO, rfe; UDP-GlcNAc:undecaprenyl-phosphate/decaprenyl-phosphate GlcNAc-1-phosphate transferase [EC:2.7.8.33 2.7.8.35]	ko00572	NA
K02851_upstream.h2_1	Conserved sequence (low covariation and power)	K02851	upstream	wecA, tagO, rfe; UDP-GlcNAc:undecaprenyl-phosphate/decaprenyl-phosphate GlcNAc-1-phosphate transferase [EC:2.7.8.33 2.7.8.35]	map01100	Metabolic pathways
K02851_upstream.h2_1	Conserved sequence (low covariation and power)	K02851	upstream	wecA, tagO, rfe; UDP-GlcNAc:undecaprenyl-phosphate/decaprenyl-phosphate GlcNAc-1-phosphate transferase [EC:2.7.8.33 2.7.8.35]	ko01100	NA
K02863_upstream.h1_1.h1_3	High covariation	K02863	upstream	RP-L1, MRPL1, rplA; large subunit ribosomal protein L1	map03010	Ribosome
K02863_upstream.h1_1.h1_3	High covariation	K02863	upstream	RP-L1, MRPL1, rplA; large subunit ribosomal protein L1	ko03010	NA
K02878_upstream.h1_1	High covariation	K02878	upstream	RP-L16, MRPL16, rplP; large subunit ribosomal protein L16	map03010	Ribosome
K02878_upstream.h1_1	High covariation	K02878	upstream	RP-L16, MRPL16, rplP; large subunit ribosomal protein L16	ko03010	NA
K02888_upstream.h1_4.h2_2	High covariation	K02888	upstream	RP-L21, MRPL21, rplU; large subunit ribosomal protein L21	map03010	Ribosome
K02888_upstream.h1_4.h2_2	High covariation	K02888	upstream	RP-L21, MRPL21, rplU; large subunit ribosomal protein L21	ko03010	NA
K02888_upstream.h2_4	High power (low covariation)	K02888	upstream	RP-L21, MRPL21, rplU; large subunit ribosomal protein L21	map03010	Ribosome
K02888_upstream.h2_4	High power (low covariation)	K02888	upstream	RP-L21, MRPL21, rplU; large subunit ribosomal protein L21	ko03010	NA
K02906_upstream.h2_2	High covariation	K02906	upstream	RP-L3, MRPL3, rplC; large subunit ribosomal protein L3	map03010	Ribosome
K02906_upstream.h2_2	High covariation	K02906	upstream	RP-L3, MRPL3, rplC; large subunit ribosomal protein L3	ko03010	NA
K02906_upstream.h2_5	High covariation	K02906	upstream	RP-L3, MRPL3, rplC; large subunit ribosomal protein L3	map03010	Ribosome
K02906_upstream.h2_5	High covariation	K02906	upstream	RP-L3, MRPL3, rplC; large subunit ribosomal protein L3	ko03010	NA
K02906_upstream.h2_1	High covariation	K02906	upstream	RP-L3, MRPL3, rplC; large subunit ribosomal protein L3	map03010	Ribosome
K02906_upstream.h2_1	High covariation	K02906	upstream	RP-L3, MRPL3, rplC; large subunit ribosomal protein L3	ko03010	NA
K02906_upstream.h1_2	High covariation	K02906	upstream	RP-L3, MRPL3, rplC; large subunit ribosomal protein L3	map03010	Ribosome
K02906_upstream.h1_2	High covariation	K02906	upstream	RP-L3, MRPL3, rplC; large subunit ribosomal protein L3	ko03010	NA
K02906_upstream.h1_5	Conserved sequence (low covariation and power)	K02906	upstream	RP-L3, MRPL3, rplC; large subunit ribosomal protein L3	map03010	Ribosome
K02906_upstream.h1_5	Conserved sequence (low covariation and power)	K02906	upstream	RP-L3, MRPL3, rplC; large subunit ribosomal protein L3	ko03010	NA
K02906_upstream.h1_3	Conserved sequence (low covariation and power)	K02906	upstream	RP-L3, MRPL3, rplC; large subunit ribosomal protein L3	map03010	Ribosome
K02906_upstream.h1_3	Conserved sequence (low covariation and power)	K02906	upstream	RP-L3, MRPL3, rplC; large subunit ribosomal protein L3	ko03010	NA
K02931_upstream.h1_1	High covariation	K02931	upstream	RP-L5, MRPL5, rplE; large subunit ribosomal protein L5	map03010	Ribosome
K02931_upstream.h1_1	High covariation	K02931	upstream	RP-L5, MRPL5, rplE; large subunit ribosomal protein L5	ko03010	NA
K02950_upstream.h2_1	Conserved sequence (low covariation and power)	K02950	upstream	RP-S12, MRPS12, rpsL; small subunit ribosomal protein S12	map03010	Ribosome
K02950_upstream.h2_1	Conserved sequence (low covariation and power)	K02950	upstream	RP-S12, MRPS12, rpsL; small subunit ribosomal protein S12	ko03010	NA
K02950_upstream.h1_2	Conserved sequence (low covariation and power)	K02950	upstream	RP-S12, MRPS12, rpsL; small subunit ribosomal protein S12	map03010	Ribosome
K02950_upstream.h1_2	Conserved sequence (low covariation and power)	K02950	upstream	RP-S12, MRPS12, rpsL; small subunit ribosomal protein S12	ko03010	NA
K02968_upstream.h1_2	Conserved sequence (low covariation and power)	K02968	upstream	RP-S20, rpsT; small subunit ribosomal protein S20	map03010	Ribosome
K02968_upstream.h1_2	Conserved sequence (low covariation and power)	K02968	upstream	RP-S20, rpsT; small subunit ribosomal protein S20	ko03010	NA
K02968_upstream.h1_3	Conserved sequence (low covariation and power)	K02968	upstream	RP-S20, rpsT; small subunit ribosomal protein S20	map03010	Ribosome
K02968_upstream.h1_3	Conserved sequence (low covariation and power)	K02968	upstream	RP-S20, rpsT; small subunit ribosomal protein S20	ko03010	NA
K02986_upstream.h1_3.h2_4	High covariation	K02986	upstream	RP-S4, NAM9, rpsD; small subunit ribosomal protein S4	map03010	Ribosome
K02986_upstream.h1_3.h2_4	High covariation	K02986	upstream	RP-S4, NAM9, rpsD; small subunit ribosomal protein S4	ko03010	NA
K02990_upstream.h1_2.h2_1	High covariation	K02990	upstream	RP-S6, MRPS6, rpsF; small subunit ribosomal protein S6	map03010	Ribosome
K02990_upstream.h1_2.h2_1	High covariation	K02990	upstream	RP-S6, MRPS6, rpsF; small subunit ribosomal protein S6	ko03010	NA
K03168_upstream.h1_3	Conserved sequence (low covariation and power)	K03168	upstream	topA; DNA topoisomerase I [EC:5.6.2.1]	NA	NA
K03168_upstream.h2_4	High power (low covariation)	K03168	upstream	topA; DNA topoisomerase I [EC:5.6.2.1]	NA	NA
K03183_upstream.h1_4	High covariation	K03183	upstream	ubiE; demethylmenaquinone methyltransferase / 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase [EC:2.1.1.163 2.1.1.201]	map00130	Ubiquinone and other terpenoid-quinone biosynthesis
K03183_upstream.h1_4	High covariation	K03183	upstream	ubiE; demethylmenaquinone methyltransferase / 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase [EC:2.1.1.163 2.1.1.201]	ko00130	NA
K03183_upstream.h1_4	High covariation	K03183	upstream	ubiE; demethylmenaquinone methyltransferase / 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase [EC:2.1.1.163 2.1.1.201]	map01100	Metabolic pathways
K03183_upstream.h1_4	High covariation	K03183	upstream	ubiE; demethylmenaquinone methyltransferase / 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase [EC:2.1.1.163 2.1.1.201]	ko01100	NA
K03183_upstream.h1_4	High covariation	K03183	upstream	ubiE; demethylmenaquinone methyltransferase / 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase [EC:2.1.1.163 2.1.1.201]	map01110	Biosynthesis of secondary metabolites
K03183_upstream.h1_4	High covariation	K03183	upstream	ubiE; demethylmenaquinone methyltransferase / 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase [EC:2.1.1.163 2.1.1.201]	ko01110	NA
K03183_upstream.h1_4	High covariation	K03183	upstream	ubiE; demethylmenaquinone methyltransferase / 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase [EC:2.1.1.163 2.1.1.201]	map01240	Biosynthesis of cofactors
K03183_upstream.h1_4	High covariation	K03183	upstream	ubiE; demethylmenaquinone methyltransferase / 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase [EC:2.1.1.163 2.1.1.201]	ko01240	NA
K03183_upstream.h1_1	Conserved sequence (low covariation and power)	K03183	upstream	ubiE; demethylmenaquinone methyltransferase / 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase [EC:2.1.1.163 2.1.1.201]	map00130	Ubiquinone and other terpenoid-quinone biosynthesis
K03183_upstream.h1_1	Conserved sequence (low covariation and power)	K03183	upstream	ubiE; demethylmenaquinone methyltransferase / 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase [EC:2.1.1.163 2.1.1.201]	ko00130	NA
K03183_upstream.h1_1	Conserved sequence (low covariation and power)	K03183	upstream	ubiE; demethylmenaquinone methyltransferase / 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase [EC:2.1.1.163 2.1.1.201]	map01100	Metabolic pathways
K03183_upstream.h1_1	Conserved sequence (low covariation and power)	K03183	upstream	ubiE; demethylmenaquinone methyltransferase / 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase [EC:2.1.1.163 2.1.1.201]	ko01100	NA
K03183_upstream.h1_1	Conserved sequence (low covariation and power)	K03183	upstream	ubiE; demethylmenaquinone methyltransferase / 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase [EC:2.1.1.163 2.1.1.201]	map01110	Biosynthesis of secondary metabolites
K03183_upstream.h1_1	Conserved sequence (low covariation and power)	K03183	upstream	ubiE; demethylmenaquinone methyltransferase / 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase [EC:2.1.1.163 2.1.1.201]	ko01110	NA
K03183_upstream.h1_1	Conserved sequence (low covariation and power)	K03183	upstream	ubiE; demethylmenaquinone methyltransferase / 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase [EC:2.1.1.163 2.1.1.201]	map01240	Biosynthesis of cofactors
K03183_upstream.h1_1	Conserved sequence (low covariation and power)	K03183	upstream	ubiE; demethylmenaquinone methyltransferase / 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase [EC:2.1.1.163 2.1.1.201]	ko01240	NA
K03187_upstream.h1_3.h2_3.h2_1	Conserved sequence (low covariation and power)	K03187	upstream	ureE; urease accessory protein	NA	NA
K03187_upstream.h1_2	Conserved sequence (low covariation and power)	K03187	upstream	ureE; urease accessory protein	NA	NA
K03320_upstream.h1_3	High covariation	K03320	upstream	amt, AMT, MEP; ammonium transporter, Amt family	NA	NA
K03320_upstream.h2_2	Conserved sequence (low covariation and power)	K03320	upstream	amt, AMT, MEP; ammonium transporter, Amt family	NA	NA
K03325_upstream.h2_1	High power (low covariation)	K03325	upstream	ACR3, arsB; arsenite transporter	NA	NA
K03424_upstream.h1_1	High power (low covariation)	K03424	upstream	tatD; TatD DNase family protein [EC:3.1.21.-]	NA	NA
K03428_upstream.h2_1.h2_2	Conserved sequence (low covariation and power)	K03428	upstream	bchM, chlM; magnesium-protoporphyrin O-methyltransferase [EC:2.1.1.11]	map00860	Porphyrin metabolism
K03428_upstream.h2_1.h2_2	Conserved sequence (low covariation and power)	K03428	upstream	bchM, chlM; magnesium-protoporphyrin O-methyltransferase [EC:2.1.1.11]	ko00860	NA
K03428_upstream.h2_1.h2_2	Conserved sequence (low covariation and power)	K03428	upstream	bchM, chlM; magnesium-protoporphyrin O-methyltransferase [EC:2.1.1.11]	map01100	Metabolic pathways
K03428_upstream.h2_1.h2_2	Conserved sequence (low covariation and power)	K03428	upstream	bchM, chlM; magnesium-protoporphyrin O-methyltransferase [EC:2.1.1.11]	ko01100	NA
K03428_upstream.h2_1.h2_2	Conserved sequence (low covariation and power)	K03428	upstream	bchM, chlM; magnesium-protoporphyrin O-methyltransferase [EC:2.1.1.11]	map01110	Biosynthesis of secondary metabolites
K03428_upstream.h2_1.h2_2	Conserved sequence (low covariation and power)	K03428	upstream	bchM, chlM; magnesium-protoporphyrin O-methyltransferase [EC:2.1.1.11]	ko01110	NA
K03428_upstream.h1_3.h1_5	Conserved sequence (low covariation and power)	K03428	upstream	bchM, chlM; magnesium-protoporphyrin O-methyltransferase [EC:2.1.1.11]	map00860	Porphyrin metabolism
K03428_upstream.h1_3.h1_5	Conserved sequence (low covariation and power)	K03428	upstream	bchM, chlM; magnesium-protoporphyrin O-methyltransferase [EC:2.1.1.11]	ko00860	NA
K03428_upstream.h1_3.h1_5	Conserved sequence (low covariation and power)	K03428	upstream	bchM, chlM; magnesium-protoporphyrin O-methyltransferase [EC:2.1.1.11]	map01100	Metabolic pathways
K03428_upstream.h1_3.h1_5	Conserved sequence (low covariation and power)	K03428	upstream	bchM, chlM; magnesium-protoporphyrin O-methyltransferase [EC:2.1.1.11]	ko01100	NA
K03428_upstream.h1_3.h1_5	Conserved sequence (low covariation and power)	K03428	upstream	bchM, chlM; magnesium-protoporphyrin O-methyltransferase [EC:2.1.1.11]	map01110	Biosynthesis of secondary metabolites
K03428_upstream.h1_3.h1_5	Conserved sequence (low covariation and power)	K03428	upstream	bchM, chlM; magnesium-protoporphyrin O-methyltransferase [EC:2.1.1.11]	ko01110	NA
K03428_upstream.h1_2	Conserved sequence (low covariation and power)	K03428	upstream	bchM, chlM; magnesium-protoporphyrin O-methyltransferase [EC:2.1.1.11]	map00860	Porphyrin metabolism
K03428_upstream.h1_2	Conserved sequence (low covariation and power)	K03428	upstream	bchM, chlM; magnesium-protoporphyrin O-methyltransferase [EC:2.1.1.11]	ko00860	NA
K03428_upstream.h1_2	Conserved sequence (low covariation and power)	K03428	upstream	bchM, chlM; magnesium-protoporphyrin O-methyltransferase [EC:2.1.1.11]	map01100	Metabolic pathways
K03428_upstream.h1_2	Conserved sequence (low covariation and power)	K03428	upstream	bchM, chlM; magnesium-protoporphyrin O-methyltransferase [EC:2.1.1.11]	ko01100	NA
K03428_upstream.h1_2	Conserved sequence (low covariation and power)	K03428	upstream	bchM, chlM; magnesium-protoporphyrin O-methyltransferase [EC:2.1.1.11]	map01110	Biosynthesis of secondary metabolites
K03428_upstream.h1_2	Conserved sequence (low covariation and power)	K03428	upstream	bchM, chlM; magnesium-protoporphyrin O-methyltransferase [EC:2.1.1.11]	ko01110	NA
K10716_upstream.h1_4	Conserved sequence (low covariation and power)	K10716	upstream	kch, trkA, mthK, pch; voltage-gated potassium channel	NA	NA
K03501_upstream.h1_1.h2_2	High covariation	K03501	upstream	gidB, rsmG; 16S rRNA (guanine527-N7)-methyltransferase [EC:2.1.1.170]	NA	NA
K03501_upstream.h1_5	Conserved sequence (low covariation and power)	K03501	upstream	gidB, rsmG; 16S rRNA (guanine527-N7)-methyltransferase [EC:2.1.1.170]	NA	NA
K03524_upstream.h1_4.h2_2	Conserved sequence (low covariation and power)	K03524	upstream	birA; BirA family transcriptional regulator, biotin operon repressor / biotin---[acetyl-CoA-carboxylase] ligase [EC:6.3.4.15]	map00780	Biotin metabolism
K03524_upstream.h1_4.h2_2	Conserved sequence (low covariation and power)	K03524	upstream	birA; BirA family transcriptional regulator, biotin operon repressor / biotin---[acetyl-CoA-carboxylase] ligase [EC:6.3.4.15]	ko00780	NA
K03524_upstream.h1_4.h2_2	Conserved sequence (low covariation and power)	K03524	upstream	birA; BirA family transcriptional regulator, biotin operon repressor / biotin---[acetyl-CoA-carboxylase] ligase [EC:6.3.4.15]	map01100	Metabolic pathways
K03524_upstream.h1_4.h2_2	Conserved sequence (low covariation and power)	K03524	upstream	birA; BirA family transcriptional regulator, biotin operon repressor / biotin---[acetyl-CoA-carboxylase] ligase [EC:6.3.4.15]	ko01100	NA
K03524_upstream.h1_2	Conserved sequence (low covariation and power)	K03524	upstream	birA; BirA family transcriptional regulator, biotin operon repressor / biotin---[acetyl-CoA-carboxylase] ligase [EC:6.3.4.15]	map00780	Biotin metabolism
K03524_upstream.h1_2	Conserved sequence (low covariation and power)	K03524	upstream	birA; BirA family transcriptional regulator, biotin operon repressor / biotin---[acetyl-CoA-carboxylase] ligase [EC:6.3.4.15]	ko00780	NA
K03524_upstream.h1_2	Conserved sequence (low covariation and power)	K03524	upstream	birA; BirA family transcriptional regulator, biotin operon repressor / biotin---[acetyl-CoA-carboxylase] ligase [EC:6.3.4.15]	map01100	Metabolic pathways
K03524_upstream.h1_2	Conserved sequence (low covariation and power)	K03524	upstream	birA; BirA family transcriptional regulator, biotin operon repressor / biotin---[acetyl-CoA-carboxylase] ligase [EC:6.3.4.15]	ko01100	NA
K03531_upstream.h1_1.h2_1	Conserved sequence (low covariation and power)	K03531	upstream	ftsZ; cell division protein FtsZ	map04112	Cell cycle - Caulobacter
K03531_upstream.h1_1.h2_1	Conserved sequence (low covariation and power)	K03531	upstream	ftsZ; cell division protein FtsZ	ko04112	NA
K03553_upstream.h1_4.h2_1	Conserved sequence (low covariation and power)	K03553	upstream	recA; recombination protein RecA	map03440	Homologous recombination
K03553_upstream.h1_4.h2_1	Conserved sequence (low covariation and power)	K03553	upstream	recA; recombination protein RecA	ko03440	NA
K03555_upstream.h2_1	Conserved sequence (low covariation and power)	K03555	upstream	mutS; DNA mismatch repair protein MutS	map03430	Mismatch repair
K03555_upstream.h2_1	Conserved sequence (low covariation and power)	K03555	upstream	mutS; DNA mismatch repair protein MutS	ko03430	NA
K03593_upstream.h1_5	Conserved sequence (low covariation and power)	K03593	upstream	mrp, NUBPL; ATP-binding protein involved in chromosome partitioning	NA	NA
K03593_upstream.h1_4	Conserved sequence (low covariation and power)	K03593	upstream	mrp, NUBPL; ATP-binding protein involved in chromosome partitioning	NA	NA
K03593_upstream.h1_2.h1_3	High power (low covariation)	K03593	upstream	mrp, NUBPL; ATP-binding protein involved in chromosome partitioning	NA	NA
K03631_upstream.h1_5.h2_2.h2_1	High power (low covariation)	K03631	upstream	recN; DNA repair protein RecN (Recombination protein N)	NA	NA
K03631_upstream.h1_2	High covariation	K03631	upstream	recN; DNA repair protein RecN (Recombination protein N)	NA	NA
K03650_upstream.h1_1.h2_5.h2_1.h2_4	High power (low covariation)	K03650	upstream	mnmE, trmE, MSS1; tRNA modification GTPase [EC:3.6.-.-]	NA	NA
K03650_upstream.h1_3	Conserved sequence (low covariation and power)	K03650	upstream	mnmE, trmE, MSS1; tRNA modification GTPase [EC:3.6.-.-]	NA	NA
K03665_upstream.h1_2.h2_1	High power (low covariation)	K03665	upstream	hflX; GTPase	NA	NA
K03665_upstream.h1_5	Conserved sequence (low covariation and power)	K03665	upstream	hflX; GTPase	NA	NA
K03727_upstream.h2_2	Conserved sequence (low covariation and power)	K03727	upstream	helY; ATP-dependent RNA helicase HelY [EC:5.6.2.6]	NA	NA
K03797_upstream.h2_1	High power (low covariation)	K03797	upstream	E3.4.21.102, prc, ctpA; carboxyl-terminal processing protease [EC:3.4.21.102]	NA	NA
K03856_upstream.h2_2	Conserved sequence (low covariation and power)	K03856	upstream	AROA2, aroA; 3-deoxy-7-phosphoheptulonate synthase [EC:2.5.1.54]	map00400	Phenylalanine, tyrosine and tryptophan biosynthesis
K03856_upstream.h2_2	Conserved sequence (low covariation and power)	K03856	upstream	AROA2, aroA; 3-deoxy-7-phosphoheptulonate synthase [EC:2.5.1.54]	ko00400	NA
K03856_upstream.h2_2	Conserved sequence (low covariation and power)	K03856	upstream	AROA2, aroA; 3-deoxy-7-phosphoheptulonate synthase [EC:2.5.1.54]	map01100	Metabolic pathways
K03856_upstream.h2_2	Conserved sequence (low covariation and power)	K03856	upstream	AROA2, aroA; 3-deoxy-7-phosphoheptulonate synthase [EC:2.5.1.54]	ko01100	NA
K03856_upstream.h2_2	Conserved sequence (low covariation and power)	K03856	upstream	AROA2, aroA; 3-deoxy-7-phosphoheptulonate synthase [EC:2.5.1.54]	map01110	Biosynthesis of secondary metabolites
K03856_upstream.h2_2	Conserved sequence (low covariation and power)	K03856	upstream	AROA2, aroA; 3-deoxy-7-phosphoheptulonate synthase [EC:2.5.1.54]	ko01110	NA
K03856_upstream.h2_2	Conserved sequence (low covariation and power)	K03856	upstream	AROA2, aroA; 3-deoxy-7-phosphoheptulonate synthase [EC:2.5.1.54]	map01230	Biosynthesis of amino acids
K03856_upstream.h2_2	Conserved sequence (low covariation and power)	K03856	upstream	AROA2, aroA; 3-deoxy-7-phosphoheptulonate synthase [EC:2.5.1.54]	ko01230	NA
K21903_upstream.h2_1	High covariation	K21903	upstream	cadC, smtB; ArsR family transcriptional regulator, lead/cadmium/zinc/bismuth-responsive transcriptional repressor	NA	NA
K03980_upstream.h1_2.h2_1	Conserved sequence (low covariation and power)	K03980	upstream	murJ, mviN; putative peptidoglycan lipid II flippase	NA	NA
K04075_upstream.h2_3.h2_4.h1_5.h2_5	High power (low covariation)	K04075	upstream	tilS, mesJ; tRNA(Ile)-lysidine synthase [EC:6.3.4.19]	NA	NA
K04485_upstream.h1_1	High power (low covariation)	K04485	upstream	radA, sms; DNA repair protein RadA/Sms	NA	NA
K04485_upstream.h2_3	High power (low covariation)	K04485	upstream	radA, sms; DNA repair protein RadA/Sms	NA	NA
K04485_upstream.h1_3	High covariation	K04485	upstream	radA, sms; DNA repair protein RadA/Sms	NA	NA
K04485_upstream.h1_4	Conserved sequence (low covariation and power)	K04485	upstream	radA, sms; DNA repair protein RadA/Sms	NA	NA
K04518_upstream.h1_1.h1_4	Conserved sequence (low covariation and power)	K04518	upstream	pheA2; prephenate dehydratase [EC:4.2.1.51]	map00400	Phenylalanine, tyrosine and tryptophan biosynthesis
K04518_upstream.h1_1.h1_4	Conserved sequence (low covariation and power)	K04518	upstream	pheA2; prephenate dehydratase [EC:4.2.1.51]	ko00400	NA
K04518_upstream.h1_1.h1_4	Conserved sequence (low covariation and power)	K04518	upstream	pheA2; prephenate dehydratase [EC:4.2.1.51]	map01100	Metabolic pathways
K04518_upstream.h1_1.h1_4	Conserved sequence (low covariation and power)	K04518	upstream	pheA2; prephenate dehydratase [EC:4.2.1.51]	ko01100	NA
K04518_upstream.h1_1.h1_4	Conserved sequence (low covariation and power)	K04518	upstream	pheA2; prephenate dehydratase [EC:4.2.1.51]	map01110	Biosynthesis of secondary metabolites
K04518_upstream.h1_1.h1_4	Conserved sequence (low covariation and power)	K04518	upstream	pheA2; prephenate dehydratase [EC:4.2.1.51]	ko01110	NA
K04518_upstream.h1_1.h1_4	Conserved sequence (low covariation and power)	K04518	upstream	pheA2; prephenate dehydratase [EC:4.2.1.51]	map01230	Biosynthesis of amino acids
K04518_upstream.h1_1.h1_4	Conserved sequence (low covariation and power)	K04518	upstream	pheA2; prephenate dehydratase [EC:4.2.1.51]	ko01230	NA
K04518_upstream.h1_2.h1_5	Conserved sequence (low covariation and power)	K04518	upstream	pheA2; prephenate dehydratase [EC:4.2.1.51]	map00400	Phenylalanine, tyrosine and tryptophan biosynthesis
K04518_upstream.h1_2.h1_5	Conserved sequence (low covariation and power)	K04518	upstream	pheA2; prephenate dehydratase [EC:4.2.1.51]	ko00400	NA
K04518_upstream.h1_2.h1_5	Conserved sequence (low covariation and power)	K04518	upstream	pheA2; prephenate dehydratase [EC:4.2.1.51]	map01100	Metabolic pathways
K04518_upstream.h1_2.h1_5	Conserved sequence (low covariation and power)	K04518	upstream	pheA2; prephenate dehydratase [EC:4.2.1.51]	ko01100	NA
K04518_upstream.h1_2.h1_5	Conserved sequence (low covariation and power)	K04518	upstream	pheA2; prephenate dehydratase [EC:4.2.1.51]	map01110	Biosynthesis of secondary metabolites
K04518_upstream.h1_2.h1_5	Conserved sequence (low covariation and power)	K04518	upstream	pheA2; prephenate dehydratase [EC:4.2.1.51]	ko01110	NA
K04518_upstream.h1_2.h1_5	Conserved sequence (low covariation and power)	K04518	upstream	pheA2; prephenate dehydratase [EC:4.2.1.51]	map01230	Biosynthesis of amino acids
K04518_upstream.h1_2.h1_5	Conserved sequence (low covariation and power)	K04518	upstream	pheA2; prephenate dehydratase [EC:4.2.1.51]	ko01230	NA
K04518_upstream.h2_4	Conserved sequence (low covariation and power)	K04518	upstream	pheA2; prephenate dehydratase [EC:4.2.1.51]	map00400	Phenylalanine, tyrosine and tryptophan biosynthesis
K04518_upstream.h2_4	Conserved sequence (low covariation and power)	K04518	upstream	pheA2; prephenate dehydratase [EC:4.2.1.51]	ko00400	NA
K04518_upstream.h2_4	Conserved sequence (low covariation and power)	K04518	upstream	pheA2; prephenate dehydratase [EC:4.2.1.51]	map01100	Metabolic pathways
K04518_upstream.h2_4	Conserved sequence (low covariation and power)	K04518	upstream	pheA2; prephenate dehydratase [EC:4.2.1.51]	ko01100	NA
K04518_upstream.h2_4	Conserved sequence (low covariation and power)	K04518	upstream	pheA2; prephenate dehydratase [EC:4.2.1.51]	map01110	Biosynthesis of secondary metabolites
K04518_upstream.h2_4	Conserved sequence (low covariation and power)	K04518	upstream	pheA2; prephenate dehydratase [EC:4.2.1.51]	ko01110	NA
K04518_upstream.h2_4	Conserved sequence (low covariation and power)	K04518	upstream	pheA2; prephenate dehydratase [EC:4.2.1.51]	map01230	Biosynthesis of amino acids
K04518_upstream.h2_4	Conserved sequence (low covariation and power)	K04518	upstream	pheA2; prephenate dehydratase [EC:4.2.1.51]	ko01230	NA
K04564_upstream.h1_1	High covariation	K04564	upstream	SOD2; superoxide dismutase, Fe-Mn family [EC:1.15.1.1]	map04013	MAPK signaling pathway - fly
K04564_upstream.h1_1	High covariation	K04564	upstream	SOD2; superoxide dismutase, Fe-Mn family [EC:1.15.1.1]	ko04013	NA
K04564_upstream.h1_1	High covariation	K04564	upstream	SOD2; superoxide dismutase, Fe-Mn family [EC:1.15.1.1]	map04068	FoxO signaling pathway
K04564_upstream.h1_1	High covariation	K04564	upstream	SOD2; superoxide dismutase, Fe-Mn family [EC:1.15.1.1]	ko04068	NA
K04564_upstream.h1_1	High covariation	K04564	upstream	SOD2; superoxide dismutase, Fe-Mn family [EC:1.15.1.1]	map04146	Peroxisome
K04564_upstream.h1_1	High covariation	K04564	upstream	SOD2; superoxide dismutase, Fe-Mn family [EC:1.15.1.1]	ko04146	NA
K04564_upstream.h1_1	High covariation	K04564	upstream	SOD2; superoxide dismutase, Fe-Mn family [EC:1.15.1.1]	map04211	Longevity regulating pathway
K04564_upstream.h1_1	High covariation	K04564	upstream	SOD2; superoxide dismutase, Fe-Mn family [EC:1.15.1.1]	ko04211	NA
K04564_upstream.h1_1	High covariation	K04564	upstream	SOD2; superoxide dismutase, Fe-Mn family [EC:1.15.1.1]	map04212	Longevity regulating pathway - worm
K04564_upstream.h1_1	High covariation	K04564	upstream	SOD2; superoxide dismutase, Fe-Mn family [EC:1.15.1.1]	ko04212	NA
K04564_upstream.h1_1	High covariation	K04564	upstream	SOD2; superoxide dismutase, Fe-Mn family [EC:1.15.1.1]	map04213	Longevity regulating pathway - multiple species
K04564_upstream.h1_1	High covariation	K04564	upstream	SOD2; superoxide dismutase, Fe-Mn family [EC:1.15.1.1]	ko04213	NA
K04564_upstream.h1_1	High covariation	K04564	upstream	SOD2; superoxide dismutase, Fe-Mn family [EC:1.15.1.1]	map05016	Huntington disease
K04564_upstream.h1_1	High covariation	K04564	upstream	SOD2; superoxide dismutase, Fe-Mn family [EC:1.15.1.1]	ko05016	NA
K04564_upstream.h1_1	High covariation	K04564	upstream	SOD2; superoxide dismutase, Fe-Mn family [EC:1.15.1.1]	map05208	Chemical carcinogenesis - reactive oxygen species
K04564_upstream.h1_1	High covariation	K04564	upstream	SOD2; superoxide dismutase, Fe-Mn family [EC:1.15.1.1]	ko05208	NA
K04564_upstream.h1_1	High covariation	K04564	upstream	SOD2; superoxide dismutase, Fe-Mn family [EC:1.15.1.1]	map05417	Lipid and atherosclerosis
K04564_upstream.h1_1	High covariation	K04564	upstream	SOD2; superoxide dismutase, Fe-Mn family [EC:1.15.1.1]	ko05417	NA
K05377_upstream.h1_5.h2_2	Conserved sequence (low covariation and power)	K05377	upstream	cpeB, mpeB; phycoerythrin beta chain	map00196	Photosynthesis - antenna proteins
K05377_upstream.h1_5.h2_2	Conserved sequence (low covariation and power)	K05377	upstream	cpeB, mpeB; phycoerythrin beta chain	ko00196	NA
K05377_upstream.h1_5.h2_2	Conserved sequence (low covariation and power)	K05377	upstream	cpeB, mpeB; phycoerythrin beta chain	map01100	Metabolic pathways
K05377_upstream.h1_5.h2_2	Conserved sequence (low covariation and power)	K05377	upstream	cpeB, mpeB; phycoerythrin beta chain	ko01100	NA
K05567_upstream.h1_4	Conserved sequence (low covariation and power)	K05567	upstream	mnhC, mrpC; multicomponent Na+:H+ antiporter subunit C	NA	NA
K05584_upstream.h2_1.h2_2.h1_2	High power (low covariation)	K05584	upstream	ndhM; NAD(P)H-quinone oxidoreductase subunit M [EC:7.1.1.2]	map00190	Oxidative phosphorylation
K05584_upstream.h2_1.h2_2.h1_2	High power (low covariation)	K05584	upstream	ndhM; NAD(P)H-quinone oxidoreductase subunit M [EC:7.1.1.2]	ko00190	NA
K05584_upstream.h2_1.h2_2.h1_2	High power (low covariation)	K05584	upstream	ndhM; NAD(P)H-quinone oxidoreductase subunit M [EC:7.1.1.2]	map01100	Metabolic pathways
K05584_upstream.h2_1.h2_2.h1_2	High power (low covariation)	K05584	upstream	ndhM; NAD(P)H-quinone oxidoreductase subunit M [EC:7.1.1.2]	ko01100	NA
K05584_upstream.h1_1	Conserved sequence (low covariation and power)	K05584	upstream	ndhM; NAD(P)H-quinone oxidoreductase subunit M [EC:7.1.1.2]	map00190	Oxidative phosphorylation
K05584_upstream.h1_1	Conserved sequence (low covariation and power)	K05584	upstream	ndhM; NAD(P)H-quinone oxidoreductase subunit M [EC:7.1.1.2]	ko00190	NA
K05584_upstream.h1_1	Conserved sequence (low covariation and power)	K05584	upstream	ndhM; NAD(P)H-quinone oxidoreductase subunit M [EC:7.1.1.2]	map01100	Metabolic pathways
K05584_upstream.h1_1	Conserved sequence (low covariation and power)	K05584	upstream	ndhM; NAD(P)H-quinone oxidoreductase subunit M [EC:7.1.1.2]	ko01100	NA
K05585_upstream.h1_2.h2_2.h1_1	Conserved sequence (low covariation and power)	K05585	upstream	ndhN; NAD(P)H-quinone oxidoreductase subunit N [EC:7.1.1.2]	map00190	Oxidative phosphorylation
K05585_upstream.h1_2.h2_2.h1_1	Conserved sequence (low covariation and power)	K05585	upstream	ndhN; NAD(P)H-quinone oxidoreductase subunit N [EC:7.1.1.2]	ko00190	NA
K05585_upstream.h1_2.h2_2.h1_1	Conserved sequence (low covariation and power)	K05585	upstream	ndhN; NAD(P)H-quinone oxidoreductase subunit N [EC:7.1.1.2]	map01100	Metabolic pathways
K05585_upstream.h1_2.h2_2.h1_1	Conserved sequence (low covariation and power)	K05585	upstream	ndhN; NAD(P)H-quinone oxidoreductase subunit N [EC:7.1.1.2]	ko01100	NA
K05585_upstream.h2_1	High covariation	K05585	upstream	ndhN; NAD(P)H-quinone oxidoreductase subunit N [EC:7.1.1.2]	map00190	Oxidative phosphorylation
K05585_upstream.h2_1	High covariation	K05585	upstream	ndhN; NAD(P)H-quinone oxidoreductase subunit N [EC:7.1.1.2]	ko00190	NA
K05585_upstream.h2_1	High covariation	K05585	upstream	ndhN; NAD(P)H-quinone oxidoreductase subunit N [EC:7.1.1.2]	map01100	Metabolic pathways
K05585_upstream.h2_1	High covariation	K05585	upstream	ndhN; NAD(P)H-quinone oxidoreductase subunit N [EC:7.1.1.2]	ko01100	NA
K05585_upstream.h2_3.h2_4	High covariation	K05585	upstream	ndhN; NAD(P)H-quinone oxidoreductase subunit N [EC:7.1.1.2]	map00190	Oxidative phosphorylation
K05585_upstream.h2_3.h2_4	High covariation	K05585	upstream	ndhN; NAD(P)H-quinone oxidoreductase subunit N [EC:7.1.1.2]	ko00190	NA
K05585_upstream.h2_3.h2_4	High covariation	K05585	upstream	ndhN; NAD(P)H-quinone oxidoreductase subunit N [EC:7.1.1.2]	map01100	Metabolic pathways
K05585_upstream.h2_3.h2_4	High covariation	K05585	upstream	ndhN; NAD(P)H-quinone oxidoreductase subunit N [EC:7.1.1.2]	ko01100	NA
K05585_upstream.h1_3	High covariation	K05585	upstream	ndhN; NAD(P)H-quinone oxidoreductase subunit N [EC:7.1.1.2]	map00190	Oxidative phosphorylation
K05585_upstream.h1_3	High covariation	K05585	upstream	ndhN; NAD(P)H-quinone oxidoreductase subunit N [EC:7.1.1.2]	ko00190	NA
K05585_upstream.h1_3	High covariation	K05585	upstream	ndhN; NAD(P)H-quinone oxidoreductase subunit N [EC:7.1.1.2]	map01100	Metabolic pathways
K05585_upstream.h1_3	High covariation	K05585	upstream	ndhN; NAD(P)H-quinone oxidoreductase subunit N [EC:7.1.1.2]	ko01100	NA
K05592_upstream.h1_3.h1_4.h2_1	Conserved sequence (low covariation and power)	K05592	upstream	deaD, cshA; ATP-dependent RNA helicase DeaD [EC:5.6.2.7]	map03018	RNA degradation
K05592_upstream.h1_3.h1_4.h2_1	Conserved sequence (low covariation and power)	K05592	upstream	deaD, cshA; ATP-dependent RNA helicase DeaD [EC:5.6.2.7]	ko03018	NA
K05841_upstream.h1_3	Conserved sequence (low covariation and power)	K05841	upstream	E2.4.1.173; sterol 3beta-glucosyltransferase [EC:2.4.1.173]	NA	NA
K05979_upstream.h2_3	Conserved sequence (low covariation and power)	K05979	upstream	comB; 2-phosphosulfolactate phosphatase [EC:3.1.3.71]	map00680	Methane metabolism
K05979_upstream.h2_3	Conserved sequence (low covariation and power)	K05979	upstream	comB; 2-phosphosulfolactate phosphatase [EC:3.1.3.71]	ko00680	NA
K05979_upstream.h2_3	Conserved sequence (low covariation and power)	K05979	upstream	comB; 2-phosphosulfolactate phosphatase [EC:3.1.3.71]	map01100	Metabolic pathways
K05979_upstream.h2_3	Conserved sequence (low covariation and power)	K05979	upstream	comB; 2-phosphosulfolactate phosphatase [EC:3.1.3.71]	ko01100	NA
K05979_upstream.h2_3	Conserved sequence (low covariation and power)	K05979	upstream	comB; 2-phosphosulfolactate phosphatase [EC:3.1.3.71]	map01120	Microbial metabolism in diverse environments
K05979_upstream.h2_3	Conserved sequence (low covariation and power)	K05979	upstream	comB; 2-phosphosulfolactate phosphatase [EC:3.1.3.71]	ko01120	NA
K05979_upstream.h2_3	Conserved sequence (low covariation and power)	K05979	upstream	comB; 2-phosphosulfolactate phosphatase [EC:3.1.3.71]	map01240	Biosynthesis of cofactors
K05979_upstream.h2_3	Conserved sequence (low covariation and power)	K05979	upstream	comB; 2-phosphosulfolactate phosphatase [EC:3.1.3.71]	ko01240	NA
K06076_upstream.h1_1	High covariation	K06076	upstream	fadL; long-chain fatty acid transport protein	NA	NA
K06153_upstream.h1_1	High covariation	K06153	upstream	bacA; undecaprenyl-diphosphatase [EC:3.6.1.27]	map00550	Peptidoglycan biosynthesis
K06153_upstream.h1_1	High covariation	K06153	upstream	bacA; undecaprenyl-diphosphatase [EC:3.6.1.27]	ko00550	NA
K06153_upstream.h1_1	High covariation	K06153	upstream	bacA; undecaprenyl-diphosphatase [EC:3.6.1.27]	map00552	Teichoic acid biosynthesis
K06153_upstream.h1_1	High covariation	K06153	upstream	bacA; undecaprenyl-diphosphatase [EC:3.6.1.27]	ko00552	NA
K06197_upstream.h1_3	Conserved sequence (low covariation and power)	K06197	upstream	chaB; cation transport regulator	NA	NA
K06197_upstream.h2_1	Conserved sequence (low covariation and power)	K06197	upstream	chaB; cation transport regulator	NA	NA
K06197_upstream.h2_2	Conserved sequence (low covariation and power)	K06197	upstream	chaB; cation transport regulator	NA	NA
K06197_upstream.h1_5	Conserved sequence (low covariation and power)	K06197	upstream	chaB; cation transport regulator	NA	NA
K06213_upstream.h1_1.h2_1.h1_4	Conserved sequence (low covariation and power)	K06213	upstream	mgtE; magnesium transporter	NA	NA
K06213_upstream.h1_3.h2_3	High power (low covariation)	K06213	upstream	mgtE; magnesium transporter	NA	NA
K06282_upstream.h1_5	High covariation	K06282	upstream	hyaA, hybO; hydrogenase small subunit [EC:1.12.99.6]	map00633	Nitrotoluene degradation
K06282_upstream.h1_5	High covariation	K06282	upstream	hyaA, hybO; hydrogenase small subunit [EC:1.12.99.6]	ko00633	NA
K06282_upstream.h1_5	High covariation	K06282	upstream	hyaA, hybO; hydrogenase small subunit [EC:1.12.99.6]	map01120	Microbial metabolism in diverse environments
K06282_upstream.h1_5	High covariation	K06282	upstream	hyaA, hybO; hydrogenase small subunit [EC:1.12.99.6]	ko01120	NA
K06282_upstream.h1_5	High covariation	K06282	upstream	hyaA, hybO; hydrogenase small subunit [EC:1.12.99.6]	map02020	Two-component system
K06282_upstream.h1_5	High covariation	K06282	upstream	hyaA, hybO; hydrogenase small subunit [EC:1.12.99.6]	ko02020	NA
K06442_upstream.h1_1.h2_2	High power (low covariation)	K06442	upstream	tlyA; 23S rRNA (cytidine1920-2'-O)/16S rRNA (cytidine1409-2'-O)-methyltransferase [EC:2.1.1.226 2.1.1.227]	NA	NA
K06610_upstream.h2_3	High covariation	K06610	upstream	iolF; MFS transporter, SP family, inositol transporter	NA	NA
K06864_upstream.h2_1.h2_2.h2_3	Conserved sequence (low covariation and power)	K06864	upstream	larE; cysteine-dependent pyridinium-3,5-bisthiocarboxylic acid mononucleotide synthase [EC:4.4.1.37 4.4.1.45]	NA	NA
K06873_upstream.h1_2	Conserved sequence (low covariation and power)	K06873	upstream	K06873; uncharacterized protein	NA	NA
K06890_upstream.h1_1	Conserved sequence (low covariation and power)	K06890	upstream	K06890; uncharacterized protein	NA	NA
K06891_upstream.h1_3	High power (low covariation)	K06891	upstream	clpS; ATP-dependent Clp protease adaptor protein ClpS	NA	NA
K06920_upstream.h1_2.h1_5.h1_4	Conserved sequence (low covariation and power)	K06920	upstream	queC; 7-cyano-7-deazaguanine synthase [EC:6.3.4.20]	map00790	Folate biosynthesis
K06920_upstream.h1_2.h1_5.h1_4	Conserved sequence (low covariation and power)	K06920	upstream	queC; 7-cyano-7-deazaguanine synthase [EC:6.3.4.20]	ko00790	NA
K06920_upstream.h1_2.h1_5.h1_4	Conserved sequence (low covariation and power)	K06920	upstream	queC; 7-cyano-7-deazaguanine synthase [EC:6.3.4.20]	map01100	Metabolic pathways
K06920_upstream.h1_2.h1_5.h1_4	Conserved sequence (low covariation and power)	K06920	upstream	queC; 7-cyano-7-deazaguanine synthase [EC:6.3.4.20]	ko01100	NA
K06949_upstream.h1_2	Conserved sequence (low covariation and power)	K06949	upstream	rsgA, engC; ribosome biogenesis GTPase / thiamine phosphate phosphatase [EC:3.6.1.- 3.1.3.100]	map00730	Thiamine metabolism
K06949_upstream.h1_2	Conserved sequence (low covariation and power)	K06949	upstream	rsgA, engC; ribosome biogenesis GTPase / thiamine phosphate phosphatase [EC:3.6.1.- 3.1.3.100]	ko00730	NA
K06949_upstream.h1_2	Conserved sequence (low covariation and power)	K06949	upstream	rsgA, engC; ribosome biogenesis GTPase / thiamine phosphate phosphatase [EC:3.6.1.- 3.1.3.100]	map01100	Metabolic pathways
K06949_upstream.h1_2	Conserved sequence (low covariation and power)	K06949	upstream	rsgA, engC; ribosome biogenesis GTPase / thiamine phosphate phosphatase [EC:3.6.1.- 3.1.3.100]	ko01100	NA
K06966_upstream.h1_1	High covariation	K06966	upstream	ppnN; pyrimidine/purine-5'-nucleotide nucleosidase [EC:3.2.2.10 3.2.2.-]	map00230	Purine metabolism
K06966_upstream.h1_1	High covariation	K06966	upstream	ppnN; pyrimidine/purine-5'-nucleotide nucleosidase [EC:3.2.2.10 3.2.2.-]	ko00230	NA
K06966_upstream.h1_1	High covariation	K06966	upstream	ppnN; pyrimidine/purine-5'-nucleotide nucleosidase [EC:3.2.2.10 3.2.2.-]	map00240	Pyrimidine metabolism
K06966_upstream.h1_1	High covariation	K06966	upstream	ppnN; pyrimidine/purine-5'-nucleotide nucleosidase [EC:3.2.2.10 3.2.2.-]	ko00240	NA
K06966_upstream.h1_1	High covariation	K06966	upstream	ppnN; pyrimidine/purine-5'-nucleotide nucleosidase [EC:3.2.2.10 3.2.2.-]	map01100	Metabolic pathways
K06966_upstream.h1_1	High covariation	K06966	upstream	ppnN; pyrimidine/purine-5'-nucleotide nucleosidase [EC:3.2.2.10 3.2.2.-]	ko01100	NA
K06966_upstream.h1_1	High covariation	K06966	upstream	ppnN; pyrimidine/purine-5'-nucleotide nucleosidase [EC:3.2.2.10 3.2.2.-]	map01232	Nucleotide metabolism
K06966_upstream.h1_1	High covariation	K06966	upstream	ppnN; pyrimidine/purine-5'-nucleotide nucleosidase [EC:3.2.2.10 3.2.2.-]	ko01232	NA
K06971_upstream.h1_4.h2_4	Conserved sequence (low covariation and power)	K06971	upstream	K06971; uncharacterized protein	NA	NA
K06997_upstream.h1_1	Conserved sequence (low covariation and power)	K06997	upstream	yggS, PROSC; PLP dependent protein	NA	NA
K07015_upstream.h1_1	Conserved sequence (low covariation and power)	K07015	upstream	yqeG; putative phosphatase [EC:3.1.3.-]	NA	NA
K07037_upstream.h1_3.h2_1	High power (low covariation)	K07037	upstream	pgpH; cyclic-di-AMP phosphodiesterase PgpH [EC:3.1.4.-]	NA	NA
K07079_upstream.h1_5	High covariation	K07079	upstream	K07079; uncharacterized protein	NA	NA
K07086_upstream.h2_3	High power (low covariation)	K07086	upstream	K07086; uncharacterized protein	NA	NA
K07086_upstream.h1_1	High power (low covariation)	K07086	upstream	K07086; uncharacterized protein	NA	NA
K07090_upstream.h1_3	Conserved sequence (low covariation and power)	K07090	upstream	K07090; uncharacterized protein	NA	NA
K07243_upstream.h1_1	High covariation	K07243	upstream	FTR, FTH1, efeU; high-affinity iron transporter	NA	NA
K07301_upstream.h2_2.h2_4.h1_3	Conserved sequence (low covariation and power)	K07301	upstream	yrbG; cation:H+ antiporter	NA	NA
K07456_upstream.h1_4	High covariation	K07456	upstream	mutS2; DNA mismatch repair protein MutS2	map03430	Mismatch repair
K07456_upstream.h1_4	High covariation	K07456	upstream	mutS2; DNA mismatch repair protein MutS2	ko03430	NA
K07486_upstream.h2_1	Conserved sequence (low covariation and power)	K07486	upstream	K07486; transposase	NA	NA
K08480_upstream.h2_2	High covariation	K08480	upstream	kaiA; circadian clock protein KaiA	NA	NA
K08482_upstream.h1_1	High covariation	K08482	upstream	kaiC; circadian clock protein KaiC	NA	NA
K09121_upstream.h1_4	Conserved sequence (low covariation and power)	K09121	upstream	larC; pyridinium-3,5-bisthiocarboxylic acid mononucleotide nickel chelatase [EC:4.99.1.12]	NA	NA
K09748_upstream.h1_4	Conserved sequence (low covariation and power)	K09748	upstream	rimP; ribosome maturation factor RimP	NA	NA
K09772_upstream.h1_4.h2_1.h1_2	Conserved sequence (low covariation and power)	K09772	upstream	sepF; cell division inhibitor SepF	NA	NA
K09772_upstream.h1_1	Conserved sequence (low covariation and power)	K09772	upstream	sepF; cell division inhibitor SepF	NA	NA
K09836_upstream.h1_5	High covariation	K09836	upstream	crtW, BKT; beta-carotene/zeaxanthin 4-ketolase [EC:1.14.99.63 1.14.99.64]	map00906	Carotenoid biosynthesis
K09836_upstream.h1_5	High covariation	K09836	upstream	crtW, BKT; beta-carotene/zeaxanthin 4-ketolase [EC:1.14.99.63 1.14.99.64]	ko00906	NA
K09836_upstream.h1_5	High covariation	K09836	upstream	crtW, BKT; beta-carotene/zeaxanthin 4-ketolase [EC:1.14.99.63 1.14.99.64]	map01110	Biosynthesis of secondary metabolites
K09836_upstream.h1_5	High covariation	K09836	upstream	crtW, BKT; beta-carotene/zeaxanthin 4-ketolase [EC:1.14.99.63 1.14.99.64]	ko01110	NA
K09928_upstream.h1_2.h2_1.h1_1	High power (low covariation)	K09928	upstream	K09928; uncharacterized protein	NA	NA
K09942_upstream.h2_1	Conserved sequence (low covariation and power)	K09942	upstream	K09942; uncharacterized protein	NA	NA
K09942_upstream.h1_4.h2_2.h1_2	Conserved sequence (low covariation and power)	K09942	upstream	K09942; uncharacterized protein	NA	NA
K09966_upstream.h2_1	Conserved sequence (low covariation and power)	K09966	upstream	K09966; uncharacterized protein	NA	NA
K10257_upstream.h2_2	Conserved sequence (low covariation and power)	K10257	upstream	FAD3, FAD7, FAD8, desB; acyl-lipid omega-3 desaturase [EC:1.14.19.25 1.14.19.35 1.14.19.36]	NA	NA
K10773_upstream.h1_5.h2_1	Conserved sequence (low covariation and power)	K10773	upstream	NTHL1, nth; endonuclease III [EC:3.2.2.- 4.2.99.18]	map03410	Base excision repair
K10773_upstream.h1_5.h2_1	Conserved sequence (low covariation and power)	K10773	upstream	NTHL1, nth; endonuclease III [EC:3.2.2.- 4.2.99.18]	ko03410	NA
K10917_upstream.h1_3	High power (low covariation)	K10917	upstream	aphA; PadR family transcriptional regulator, regulatory protein AphA	map02024	Quorum sensing
K10917_upstream.h1_3	High power (low covariation)	K10917	upstream	aphA; PadR family transcriptional regulator, regulatory protein AphA	ko02024	NA
K10917_upstream.h1_3	High power (low covariation)	K10917	upstream	aphA; PadR family transcriptional regulator, regulatory protein AphA	map05111	Biofilm formation - Vibrio cholerae
K10917_upstream.h1_3	High power (low covariation)	K10917	upstream	aphA; PadR family transcriptional regulator, regulatory protein AphA	ko05111	NA
K10960_upstream.h1_5.h2_3.h2_1.h1_1	Conserved sequence (low covariation and power)	K10960	upstream	chlP, bchP; geranylgeranyl diphosphate/geranylgeranyl-bacteriochlorophyllide a reductase [EC:1.3.1.83 1.3.1.111]	map00860	Porphyrin metabolism
K10960_upstream.h1_5.h2_3.h2_1.h1_1	Conserved sequence (low covariation and power)	K10960	upstream	chlP, bchP; geranylgeranyl diphosphate/geranylgeranyl-bacteriochlorophyllide a reductase [EC:1.3.1.83 1.3.1.111]	ko00860	NA
K10960_upstream.h1_5.h2_3.h2_1.h1_1	Conserved sequence (low covariation and power)	K10960	upstream	chlP, bchP; geranylgeranyl diphosphate/geranylgeranyl-bacteriochlorophyllide a reductase [EC:1.3.1.83 1.3.1.111]	map00900	Terpenoid backbone biosynthesis
K10960_upstream.h1_5.h2_3.h2_1.h1_1	Conserved sequence (low covariation and power)	K10960	upstream	chlP, bchP; geranylgeranyl diphosphate/geranylgeranyl-bacteriochlorophyllide a reductase [EC:1.3.1.83 1.3.1.111]	ko00900	NA
K10960_upstream.h1_5.h2_3.h2_1.h1_1	Conserved sequence (low covariation and power)	K10960	upstream	chlP, bchP; geranylgeranyl diphosphate/geranylgeranyl-bacteriochlorophyllide a reductase [EC:1.3.1.83 1.3.1.111]	map01100	Metabolic pathways
K10960_upstream.h1_5.h2_3.h2_1.h1_1	Conserved sequence (low covariation and power)	K10960	upstream	chlP, bchP; geranylgeranyl diphosphate/geranylgeranyl-bacteriochlorophyllide a reductase [EC:1.3.1.83 1.3.1.111]	ko01100	NA
K10960_upstream.h1_5.h2_3.h2_1.h1_1	Conserved sequence (low covariation and power)	K10960	upstream	chlP, bchP; geranylgeranyl diphosphate/geranylgeranyl-bacteriochlorophyllide a reductase [EC:1.3.1.83 1.3.1.111]	map01110	Biosynthesis of secondary metabolites
K10960_upstream.h1_5.h2_3.h2_1.h1_1	Conserved sequence (low covariation and power)	K10960	upstream	chlP, bchP; geranylgeranyl diphosphate/geranylgeranyl-bacteriochlorophyllide a reductase [EC:1.3.1.83 1.3.1.111]	ko01110	NA
K12574_upstream.h1_1.h1_3	High covariation	K12574	upstream	rnj; ribonuclease J [EC:3.1.-.-]	map03018	RNA degradation
K12574_upstream.h1_1.h1_3	High covariation	K12574	upstream	rnj; ribonuclease J [EC:3.1.-.-]	ko03018	NA
K12574_upstream.h1_2	High covariation	K12574	upstream	rnj; ribonuclease J [EC:3.1.-.-]	map03018	RNA degradation
K12574_upstream.h1_2	High covariation	K12574	upstream	rnj; ribonuclease J [EC:3.1.-.-]	ko03018	NA
K12984_upstream.h1_2	High covariation	K12984	upstream	waaE, kdtX; (heptosyl)LPS beta-1,4-glucosyltransferase [EC:2.4.1.-]	NA	NA
K13005_upstream.h1_3	High covariation	K13005	upstream	rfbV, wbaV; O-antigen biosynthesis alpha-1,3-abequosyltransferase [EC:2.4.1.60]	NA	NA
K13005_upstream.h1_4	High covariation	K13005	upstream	rfbV, wbaV; O-antigen biosynthesis alpha-1,3-abequosyltransferase [EC:2.4.1.60]	NA	NA
K14379_upstream.h1_1.h1_5	Conserved sequence (low covariation and power)	K14379	upstream	ACP5; tartrate-resistant acid phosphatase type 5 [EC:3.1.3.2]	map00740	Riboflavin metabolism
K14379_upstream.h1_1.h1_5	Conserved sequence (low covariation and power)	K14379	upstream	ACP5; tartrate-resistant acid phosphatase type 5 [EC:3.1.3.2]	ko00740	NA
K14379_upstream.h1_1.h1_5	Conserved sequence (low covariation and power)	K14379	upstream	ACP5; tartrate-resistant acid phosphatase type 5 [EC:3.1.3.2]	map01100	Metabolic pathways
K14379_upstream.h1_1.h1_5	Conserved sequence (low covariation and power)	K14379	upstream	ACP5; tartrate-resistant acid phosphatase type 5 [EC:3.1.3.2]	ko01100	NA
K14379_upstream.h1_1.h1_5	Conserved sequence (low covariation and power)	K14379	upstream	ACP5; tartrate-resistant acid phosphatase type 5 [EC:3.1.3.2]	map04142	Lysosome
K14379_upstream.h1_1.h1_5	Conserved sequence (low covariation and power)	K14379	upstream	ACP5; tartrate-resistant acid phosphatase type 5 [EC:3.1.3.2]	ko04142	NA
K14379_upstream.h1_1.h1_5	Conserved sequence (low covariation and power)	K14379	upstream	ACP5; tartrate-resistant acid phosphatase type 5 [EC:3.1.3.2]	map04380	Osteoclast differentiation
K14379_upstream.h1_1.h1_5	Conserved sequence (low covariation and power)	K14379	upstream	ACP5; tartrate-resistant acid phosphatase type 5 [EC:3.1.3.2]	ko04380	NA
K14379_upstream.h1_1.h1_5	Conserved sequence (low covariation and power)	K14379	upstream	ACP5; tartrate-resistant acid phosphatase type 5 [EC:3.1.3.2]	map05323	Rheumatoid arthritis
K14379_upstream.h1_1.h1_5	Conserved sequence (low covariation and power)	K14379	upstream	ACP5; tartrate-resistant acid phosphatase type 5 [EC:3.1.3.2]	ko05323	NA
K14441_upstream.h2_4	High covariation	K14441	upstream	rimO; ribosomal protein S12 methylthiotransferase [EC:2.8.4.4]	NA	NA
K14441_upstream.h2_3	High covariation	K14441	upstream	rimO; ribosomal protein S12 methylthiotransferase [EC:2.8.4.4]	NA	NA
K14540_upstream.h1_2	Conserved sequence (low covariation and power)	K14540	upstream	rbgA; ribosome biogenesis GTPase A	NA	NA
K14540_upstream.h1_1.h2_1	Conserved sequence (low covariation and power)	K14540	upstream	rbgA; ribosome biogenesis GTPase A	NA	NA
K14761_upstream.h1_5	High power (low covariation)	K14761	upstream	rlbA, ybcJ; ribosome-associated protein	NA	NA
K15633_upstream.h2_3	High covariation	K15633	upstream	gpmI; 2,3-bisphosphoglycerate-independent phosphoglycerate mutase [EC:5.4.2.12]	map00010	Glycolysis / Gluconeogenesis
K15633_upstream.h2_3	High covariation	K15633	upstream	gpmI; 2,3-bisphosphoglycerate-independent phosphoglycerate mutase [EC:5.4.2.12]	ko00010	NA
K15633_upstream.h2_3	High covariation	K15633	upstream	gpmI; 2,3-bisphosphoglycerate-independent phosphoglycerate mutase [EC:5.4.2.12]	map00260	Glycine, serine and threonine metabolism
K15633_upstream.h2_3	High covariation	K15633	upstream	gpmI; 2,3-bisphosphoglycerate-independent phosphoglycerate mutase [EC:5.4.2.12]	ko00260	NA
K15633_upstream.h2_3	High covariation	K15633	upstream	gpmI; 2,3-bisphosphoglycerate-independent phosphoglycerate mutase [EC:5.4.2.12]	map00680	Methane metabolism
K15633_upstream.h2_3	High covariation	K15633	upstream	gpmI; 2,3-bisphosphoglycerate-independent phosphoglycerate mutase [EC:5.4.2.12]	ko00680	NA
K15633_upstream.h2_3	High covariation	K15633	upstream	gpmI; 2,3-bisphosphoglycerate-independent phosphoglycerate mutase [EC:5.4.2.12]	map01100	Metabolic pathways
K15633_upstream.h2_3	High covariation	K15633	upstream	gpmI; 2,3-bisphosphoglycerate-independent phosphoglycerate mutase [EC:5.4.2.12]	ko01100	NA
K15633_upstream.h2_3	High covariation	K15633	upstream	gpmI; 2,3-bisphosphoglycerate-independent phosphoglycerate mutase [EC:5.4.2.12]	map01110	Biosynthesis of secondary metabolites
K15633_upstream.h2_3	High covariation	K15633	upstream	gpmI; 2,3-bisphosphoglycerate-independent phosphoglycerate mutase [EC:5.4.2.12]	ko01110	NA
K15633_upstream.h2_3	High covariation	K15633	upstream	gpmI; 2,3-bisphosphoglycerate-independent phosphoglycerate mutase [EC:5.4.2.12]	map01120	Microbial metabolism in diverse environments
K15633_upstream.h2_3	High covariation	K15633	upstream	gpmI; 2,3-bisphosphoglycerate-independent phosphoglycerate mutase [EC:5.4.2.12]	ko01120	NA
K15633_upstream.h2_3	High covariation	K15633	upstream	gpmI; 2,3-bisphosphoglycerate-independent phosphoglycerate mutase [EC:5.4.2.12]	map01200	Carbon metabolism
K15633_upstream.h2_3	High covariation	K15633	upstream	gpmI; 2,3-bisphosphoglycerate-independent phosphoglycerate mutase [EC:5.4.2.12]	ko01200	NA
K15633_upstream.h2_3	High covariation	K15633	upstream	gpmI; 2,3-bisphosphoglycerate-independent phosphoglycerate mutase [EC:5.4.2.12]	map01230	Biosynthesis of amino acids
K15633_upstream.h2_3	High covariation	K15633	upstream	gpmI; 2,3-bisphosphoglycerate-independent phosphoglycerate mutase [EC:5.4.2.12]	ko01230	NA
K15633_upstream.h1_1	Conserved sequence (low covariation and power)	K15633	upstream	gpmI; 2,3-bisphosphoglycerate-independent phosphoglycerate mutase [EC:5.4.2.12]	map00010	Glycolysis / Gluconeogenesis
K15633_upstream.h1_1	Conserved sequence (low covariation and power)	K15633	upstream	gpmI; 2,3-bisphosphoglycerate-independent phosphoglycerate mutase [EC:5.4.2.12]	ko00010	NA
K15633_upstream.h1_1	Conserved sequence (low covariation and power)	K15633	upstream	gpmI; 2,3-bisphosphoglycerate-independent phosphoglycerate mutase [EC:5.4.2.12]	map00260	Glycine, serine and threonine metabolism
K15633_upstream.h1_1	Conserved sequence (low covariation and power)	K15633	upstream	gpmI; 2,3-bisphosphoglycerate-independent phosphoglycerate mutase [EC:5.4.2.12]	ko00260	NA
K15633_upstream.h1_1	Conserved sequence (low covariation and power)	K15633	upstream	gpmI; 2,3-bisphosphoglycerate-independent phosphoglycerate mutase [EC:5.4.2.12]	map00680	Methane metabolism
K15633_upstream.h1_1	Conserved sequence (low covariation and power)	K15633	upstream	gpmI; 2,3-bisphosphoglycerate-independent phosphoglycerate mutase [EC:5.4.2.12]	ko00680	NA
K15633_upstream.h1_1	Conserved sequence (low covariation and power)	K15633	upstream	gpmI; 2,3-bisphosphoglycerate-independent phosphoglycerate mutase [EC:5.4.2.12]	map01100	Metabolic pathways
K15633_upstream.h1_1	Conserved sequence (low covariation and power)	K15633	upstream	gpmI; 2,3-bisphosphoglycerate-independent phosphoglycerate mutase [EC:5.4.2.12]	ko01100	NA
K15633_upstream.h1_1	Conserved sequence (low covariation and power)	K15633	upstream	gpmI; 2,3-bisphosphoglycerate-independent phosphoglycerate mutase [EC:5.4.2.12]	map01110	Biosynthesis of secondary metabolites
K15633_upstream.h1_1	Conserved sequence (low covariation and power)	K15633	upstream	gpmI; 2,3-bisphosphoglycerate-independent phosphoglycerate mutase [EC:5.4.2.12]	ko01110	NA
K15633_upstream.h1_1	Conserved sequence (low covariation and power)	K15633	upstream	gpmI; 2,3-bisphosphoglycerate-independent phosphoglycerate mutase [EC:5.4.2.12]	map01120	Microbial metabolism in diverse environments
K15633_upstream.h1_1	Conserved sequence (low covariation and power)	K15633	upstream	gpmI; 2,3-bisphosphoglycerate-independent phosphoglycerate mutase [EC:5.4.2.12]	ko01120	NA
K15633_upstream.h1_1	Conserved sequence (low covariation and power)	K15633	upstream	gpmI; 2,3-bisphosphoglycerate-independent phosphoglycerate mutase [EC:5.4.2.12]	map01200	Carbon metabolism
K15633_upstream.h1_1	Conserved sequence (low covariation and power)	K15633	upstream	gpmI; 2,3-bisphosphoglycerate-independent phosphoglycerate mutase [EC:5.4.2.12]	ko01200	NA
K15633_upstream.h1_1	Conserved sequence (low covariation and power)	K15633	upstream	gpmI; 2,3-bisphosphoglycerate-independent phosphoglycerate mutase [EC:5.4.2.12]	map01230	Biosynthesis of amino acids
K15633_upstream.h1_1	Conserved sequence (low covariation and power)	K15633	upstream	gpmI; 2,3-bisphosphoglycerate-independent phosphoglycerate mutase [EC:5.4.2.12]	ko01230	NA
K16091_upstream.h1_3	High covariation	K16091	upstream	fecA; Fe(3+) dicitrate transport protein	NA	NA
K18678_upstream.h1_3	Conserved sequence (low covariation and power)	K18678	upstream	VTE5; phytol kinase [EC:2.7.1.182]	NA	NA
K19002_upstream.h1_4	High covariation	K19002	upstream	mgs, bgsB; 1,2-diacylglycerol 3-alpha-glucosyltransferase [EC:2.4.1.337]	map00552	Teichoic acid biosynthesis
K19002_upstream.h1_4	High covariation	K19002	upstream	mgs, bgsB; 1,2-diacylglycerol 3-alpha-glucosyltransferase [EC:2.4.1.337]	ko00552	NA
K19002_upstream.h1_4	High covariation	K19002	upstream	mgs, bgsB; 1,2-diacylglycerol 3-alpha-glucosyltransferase [EC:2.4.1.337]	map00561	Glycerolipid metabolism
K19002_upstream.h1_4	High covariation	K19002	upstream	mgs, bgsB; 1,2-diacylglycerol 3-alpha-glucosyltransferase [EC:2.4.1.337]	ko00561	NA
K19002_upstream.h1_4	High covariation	K19002	upstream	mgs, bgsB; 1,2-diacylglycerol 3-alpha-glucosyltransferase [EC:2.4.1.337]	map01100	Metabolic pathways
K19002_upstream.h1_4	High covariation	K19002	upstream	mgs, bgsB; 1,2-diacylglycerol 3-alpha-glucosyltransferase [EC:2.4.1.337]	ko01100	NA
K19002_upstream.h1_1	High covariation	K19002	upstream	mgs, bgsB; 1,2-diacylglycerol 3-alpha-glucosyltransferase [EC:2.4.1.337]	map00552	Teichoic acid biosynthesis
K19002_upstream.h1_1	High covariation	K19002	upstream	mgs, bgsB; 1,2-diacylglycerol 3-alpha-glucosyltransferase [EC:2.4.1.337]	ko00552	NA
K19002_upstream.h1_1	High covariation	K19002	upstream	mgs, bgsB; 1,2-diacylglycerol 3-alpha-glucosyltransferase [EC:2.4.1.337]	map00561	Glycerolipid metabolism
K19002_upstream.h1_1	High covariation	K19002	upstream	mgs, bgsB; 1,2-diacylglycerol 3-alpha-glucosyltransferase [EC:2.4.1.337]	ko00561	NA
K19002_upstream.h1_1	High covariation	K19002	upstream	mgs, bgsB; 1,2-diacylglycerol 3-alpha-glucosyltransferase [EC:2.4.1.337]	map01100	Metabolic pathways
K19002_upstream.h1_1	High covariation	K19002	upstream	mgs, bgsB; 1,2-diacylglycerol 3-alpha-glucosyltransferase [EC:2.4.1.337]	ko01100	NA
K19166_upstream.h1_4	High covariation	K19166	upstream	higB; mRNA interferase HigB [EC:3.1.-.-]	NA	NA
K19166_upstream.h1_1	High covariation	K19166	upstream	higB; mRNA interferase HigB [EC:3.1.-.-]	NA	NA
K19170_upstream.h1_3	High covariation	K19170	upstream	dndC; DNA sulfur modification protein DndC	NA	NA
K19294_upstream.h1_2	High covariation	K19294	upstream	algI; alginate O-acetyltransferase complex protein AlgI	map00543	Exopolysaccharide biosynthesis
K19294_upstream.h1_2	High covariation	K19294	upstream	algI; alginate O-acetyltransferase complex protein AlgI	ko00543	NA
K21480_upstream.h1_1	High covariation	K21480	upstream	HO, pbsA1, hmuO; heme oxygenase (biliverdin-producing, ferredoxin) [EC:1.14.15.20]	map00860	Porphyrin metabolism
K21480_upstream.h1_1	High covariation	K21480	upstream	HO, pbsA1, hmuO; heme oxygenase (biliverdin-producing, ferredoxin) [EC:1.14.15.20]	ko00860	NA
K21480_upstream.h1_1	High covariation	K21480	upstream	HO, pbsA1, hmuO; heme oxygenase (biliverdin-producing, ferredoxin) [EC:1.14.15.20]	map01100	Metabolic pathways
K21480_upstream.h1_1	High covariation	K21480	upstream	HO, pbsA1, hmuO; heme oxygenase (biliverdin-producing, ferredoxin) [EC:1.14.15.20]	ko01100	NA
K21480_upstream.h1_1	High covariation	K21480	upstream	HO, pbsA1, hmuO; heme oxygenase (biliverdin-producing, ferredoxin) [EC:1.14.15.20]	map01110	Biosynthesis of secondary metabolites
K21480_upstream.h1_1	High covariation	K21480	upstream	HO, pbsA1, hmuO; heme oxygenase (biliverdin-producing, ferredoxin) [EC:1.14.15.20]	ko01110	NA
K21480_upstream.h1_3	High covariation	K21480	upstream	HO, pbsA1, hmuO; heme oxygenase (biliverdin-producing, ferredoxin) [EC:1.14.15.20]	map00860	Porphyrin metabolism
K21480_upstream.h1_3	High covariation	K21480	upstream	HO, pbsA1, hmuO; heme oxygenase (biliverdin-producing, ferredoxin) [EC:1.14.15.20]	ko00860	NA
K21480_upstream.h1_3	High covariation	K21480	upstream	HO, pbsA1, hmuO; heme oxygenase (biliverdin-producing, ferredoxin) [EC:1.14.15.20]	map01100	Metabolic pathways
K21480_upstream.h1_3	High covariation	K21480	upstream	HO, pbsA1, hmuO; heme oxygenase (biliverdin-producing, ferredoxin) [EC:1.14.15.20]	ko01100	NA
K21480_upstream.h1_3	High covariation	K21480	upstream	HO, pbsA1, hmuO; heme oxygenase (biliverdin-producing, ferredoxin) [EC:1.14.15.20]	map01110	Biosynthesis of secondary metabolites
K21480_upstream.h1_3	High covariation	K21480	upstream	HO, pbsA1, hmuO; heme oxygenase (biliverdin-producing, ferredoxin) [EC:1.14.15.20]	ko01110	NA
K21703_upstream.h2_1	High power (low covariation)	K21703	upstream	cbbR, cmpR, ndhR; LysR family transcriptional regulator, low CO2-responsive transcriptional regulator	NA	NA
K21929_upstream.h2_1	Conserved sequence (low covariation and power)	K21929	upstream	udg; uracil-DNA glycosylase [EC:3.2.2.27]	map03410	Base excision repair
K21929_upstream.h2_1	Conserved sequence (low covariation and power)	K21929	upstream	udg; uracil-DNA glycosylase [EC:3.2.2.27]	ko03410	NA
K00036_downstream.h1_1	High covariation	K00036	downstream	G6PD, zwf; glucose-6-phosphate 1-dehydrogenase [EC:1.1.1.49 1.1.1.363]	map00030	Pentose phosphate pathway
K00036_downstream.h1_1	High covariation	K00036	downstream	G6PD, zwf; glucose-6-phosphate 1-dehydrogenase [EC:1.1.1.49 1.1.1.363]	ko00030	NA
K00036_downstream.h1_1	High covariation	K00036	downstream	G6PD, zwf; glucose-6-phosphate 1-dehydrogenase [EC:1.1.1.49 1.1.1.363]	map00480	Glutathione metabolism
K00036_downstream.h1_1	High covariation	K00036	downstream	G6PD, zwf; glucose-6-phosphate 1-dehydrogenase [EC:1.1.1.49 1.1.1.363]	ko00480	NA
K00036_downstream.h1_1	High covariation	K00036	downstream	G6PD, zwf; glucose-6-phosphate 1-dehydrogenase [EC:1.1.1.49 1.1.1.363]	map01100	Metabolic pathways
K00036_downstream.h1_1	High covariation	K00036	downstream	G6PD, zwf; glucose-6-phosphate 1-dehydrogenase [EC:1.1.1.49 1.1.1.363]	ko01100	NA
K00036_downstream.h1_1	High covariation	K00036	downstream	G6PD, zwf; glucose-6-phosphate 1-dehydrogenase [EC:1.1.1.49 1.1.1.363]	map01110	Biosynthesis of secondary metabolites
K00036_downstream.h1_1	High covariation	K00036	downstream	G6PD, zwf; glucose-6-phosphate 1-dehydrogenase [EC:1.1.1.49 1.1.1.363]	ko01110	NA
K00036_downstream.h1_1	High covariation	K00036	downstream	G6PD, zwf; glucose-6-phosphate 1-dehydrogenase [EC:1.1.1.49 1.1.1.363]	map01120	Microbial metabolism in diverse environments
K00036_downstream.h1_1	High covariation	K00036	downstream	G6PD, zwf; glucose-6-phosphate 1-dehydrogenase [EC:1.1.1.49 1.1.1.363]	ko01120	NA
K00036_downstream.h1_1	High covariation	K00036	downstream	G6PD, zwf; glucose-6-phosphate 1-dehydrogenase [EC:1.1.1.49 1.1.1.363]	map01200	Carbon metabolism
K00036_downstream.h1_1	High covariation	K00036	downstream	G6PD, zwf; glucose-6-phosphate 1-dehydrogenase [EC:1.1.1.49 1.1.1.363]	ko01200	NA
K00036_downstream.h1_1	High covariation	K00036	downstream	G6PD, zwf; glucose-6-phosphate 1-dehydrogenase [EC:1.1.1.49 1.1.1.363]	map05230	Central carbon metabolism in cancer
K00036_downstream.h1_1	High covariation	K00036	downstream	G6PD, zwf; glucose-6-phosphate 1-dehydrogenase [EC:1.1.1.49 1.1.1.363]	ko05230	NA
K00036_downstream.h1_1	High covariation	K00036	downstream	G6PD, zwf; glucose-6-phosphate 1-dehydrogenase [EC:1.1.1.49 1.1.1.363]	map05415	Diabetic cardiomyopathy
K00036_downstream.h1_1	High covariation	K00036	downstream	G6PD, zwf; glucose-6-phosphate 1-dehydrogenase [EC:1.1.1.49 1.1.1.363]	ko05415	NA
K00161_downstream.h2_1	Conserved sequence (low covariation and power)	K00161	downstream	PDHA, pdhA; pyruvate dehydrogenase E1 component subunit alpha [EC:1.2.4.1]	map00010	Glycolysis / Gluconeogenesis
K00161_downstream.h2_1	Conserved sequence (low covariation and power)	K00161	downstream	PDHA, pdhA; pyruvate dehydrogenase E1 component subunit alpha [EC:1.2.4.1]	ko00010	NA
K00161_downstream.h2_1	Conserved sequence (low covariation and power)	K00161	downstream	PDHA, pdhA; pyruvate dehydrogenase E1 component subunit alpha [EC:1.2.4.1]	map00020	Citrate cycle (TCA cycle)
K00161_downstream.h2_1	Conserved sequence (low covariation and power)	K00161	downstream	PDHA, pdhA; pyruvate dehydrogenase E1 component subunit alpha [EC:1.2.4.1]	ko00020	NA
K00161_downstream.h2_1	Conserved sequence (low covariation and power)	K00161	downstream	PDHA, pdhA; pyruvate dehydrogenase E1 component subunit alpha [EC:1.2.4.1]	map00620	Pyruvate metabolism
K00161_downstream.h2_1	Conserved sequence (low covariation and power)	K00161	downstream	PDHA, pdhA; pyruvate dehydrogenase E1 component subunit alpha [EC:1.2.4.1]	ko00620	NA
K00161_downstream.h2_1	Conserved sequence (low covariation and power)	K00161	downstream	PDHA, pdhA; pyruvate dehydrogenase E1 component subunit alpha [EC:1.2.4.1]	map00785	Lipoic acid metabolism
K00161_downstream.h2_1	Conserved sequence (low covariation and power)	K00161	downstream	PDHA, pdhA; pyruvate dehydrogenase E1 component subunit alpha [EC:1.2.4.1]	ko00785	NA
K00161_downstream.h2_1	Conserved sequence (low covariation and power)	K00161	downstream	PDHA, pdhA; pyruvate dehydrogenase E1 component subunit alpha [EC:1.2.4.1]	map01100	Metabolic pathways
K00161_downstream.h2_1	Conserved sequence (low covariation and power)	K00161	downstream	PDHA, pdhA; pyruvate dehydrogenase E1 component subunit alpha [EC:1.2.4.1]	ko01100	NA
K00161_downstream.h2_1	Conserved sequence (low covariation and power)	K00161	downstream	PDHA, pdhA; pyruvate dehydrogenase E1 component subunit alpha [EC:1.2.4.1]	map01110	Biosynthesis of secondary metabolites
K00161_downstream.h2_1	Conserved sequence (low covariation and power)	K00161	downstream	PDHA, pdhA; pyruvate dehydrogenase E1 component subunit alpha [EC:1.2.4.1]	ko01110	NA
K00161_downstream.h2_1	Conserved sequence (low covariation and power)	K00161	downstream	PDHA, pdhA; pyruvate dehydrogenase E1 component subunit alpha [EC:1.2.4.1]	map01120	Microbial metabolism in diverse environments
K00161_downstream.h2_1	Conserved sequence (low covariation and power)	K00161	downstream	PDHA, pdhA; pyruvate dehydrogenase E1 component subunit alpha [EC:1.2.4.1]	ko01120	NA
K00161_downstream.h2_1	Conserved sequence (low covariation and power)	K00161	downstream	PDHA, pdhA; pyruvate dehydrogenase E1 component subunit alpha [EC:1.2.4.1]	map01200	Carbon metabolism
K00161_downstream.h2_1	Conserved sequence (low covariation and power)	K00161	downstream	PDHA, pdhA; pyruvate dehydrogenase E1 component subunit alpha [EC:1.2.4.1]	ko01200	NA
K00161_downstream.h2_1	Conserved sequence (low covariation and power)	K00161	downstream	PDHA, pdhA; pyruvate dehydrogenase E1 component subunit alpha [EC:1.2.4.1]	map01210	2-Oxocarboxylic acid metabolism
K00161_downstream.h2_1	Conserved sequence (low covariation and power)	K00161	downstream	PDHA, pdhA; pyruvate dehydrogenase E1 component subunit alpha [EC:1.2.4.1]	ko01210	NA
K00161_downstream.h2_1	Conserved sequence (low covariation and power)	K00161	downstream	PDHA, pdhA; pyruvate dehydrogenase E1 component subunit alpha [EC:1.2.4.1]	map04066	HIF-1 signaling pathway
K00161_downstream.h2_1	Conserved sequence (low covariation and power)	K00161	downstream	PDHA, pdhA; pyruvate dehydrogenase E1 component subunit alpha [EC:1.2.4.1]	ko04066	NA
K00161_downstream.h2_1	Conserved sequence (low covariation and power)	K00161	downstream	PDHA, pdhA; pyruvate dehydrogenase E1 component subunit alpha [EC:1.2.4.1]	map04922	Glucagon signaling pathway
K00161_downstream.h2_1	Conserved sequence (low covariation and power)	K00161	downstream	PDHA, pdhA; pyruvate dehydrogenase E1 component subunit alpha [EC:1.2.4.1]	ko04922	NA
K00161_downstream.h2_1	Conserved sequence (low covariation and power)	K00161	downstream	PDHA, pdhA; pyruvate dehydrogenase E1 component subunit alpha [EC:1.2.4.1]	map05230	Central carbon metabolism in cancer
K00161_downstream.h2_1	Conserved sequence (low covariation and power)	K00161	downstream	PDHA, pdhA; pyruvate dehydrogenase E1 component subunit alpha [EC:1.2.4.1]	ko05230	NA
K00161_downstream.h2_1	Conserved sequence (low covariation and power)	K00161	downstream	PDHA, pdhA; pyruvate dehydrogenase E1 component subunit alpha [EC:1.2.4.1]	map05415	Diabetic cardiomyopathy
K00161_downstream.h2_1	Conserved sequence (low covariation and power)	K00161	downstream	PDHA, pdhA; pyruvate dehydrogenase E1 component subunit alpha [EC:1.2.4.1]	ko05415	NA
K00161_downstream.h1_1	Conserved sequence (low covariation and power)	K00161	downstream	PDHA, pdhA; pyruvate dehydrogenase E1 component subunit alpha [EC:1.2.4.1]	map00010	Glycolysis / Gluconeogenesis
K00161_downstream.h1_1	Conserved sequence (low covariation and power)	K00161	downstream	PDHA, pdhA; pyruvate dehydrogenase E1 component subunit alpha [EC:1.2.4.1]	ko00010	NA
K00161_downstream.h1_1	Conserved sequence (low covariation and power)	K00161	downstream	PDHA, pdhA; pyruvate dehydrogenase E1 component subunit alpha [EC:1.2.4.1]	map00020	Citrate cycle (TCA cycle)
K00161_downstream.h1_1	Conserved sequence (low covariation and power)	K00161	downstream	PDHA, pdhA; pyruvate dehydrogenase E1 component subunit alpha [EC:1.2.4.1]	ko00020	NA
K00161_downstream.h1_1	Conserved sequence (low covariation and power)	K00161	downstream	PDHA, pdhA; pyruvate dehydrogenase E1 component subunit alpha [EC:1.2.4.1]	map00620	Pyruvate metabolism
K00161_downstream.h1_1	Conserved sequence (low covariation and power)	K00161	downstream	PDHA, pdhA; pyruvate dehydrogenase E1 component subunit alpha [EC:1.2.4.1]	ko00620	NA
K00161_downstream.h1_1	Conserved sequence (low covariation and power)	K00161	downstream	PDHA, pdhA; pyruvate dehydrogenase E1 component subunit alpha [EC:1.2.4.1]	map00785	Lipoic acid metabolism
K00161_downstream.h1_1	Conserved sequence (low covariation and power)	K00161	downstream	PDHA, pdhA; pyruvate dehydrogenase E1 component subunit alpha [EC:1.2.4.1]	ko00785	NA
K00161_downstream.h1_1	Conserved sequence (low covariation and power)	K00161	downstream	PDHA, pdhA; pyruvate dehydrogenase E1 component subunit alpha [EC:1.2.4.1]	map01100	Metabolic pathways
K00161_downstream.h1_1	Conserved sequence (low covariation and power)	K00161	downstream	PDHA, pdhA; pyruvate dehydrogenase E1 component subunit alpha [EC:1.2.4.1]	ko01100	NA
K00161_downstream.h1_1	Conserved sequence (low covariation and power)	K00161	downstream	PDHA, pdhA; pyruvate dehydrogenase E1 component subunit alpha [EC:1.2.4.1]	map01110	Biosynthesis of secondary metabolites
K00161_downstream.h1_1	Conserved sequence (low covariation and power)	K00161	downstream	PDHA, pdhA; pyruvate dehydrogenase E1 component subunit alpha [EC:1.2.4.1]	ko01110	NA
K00161_downstream.h1_1	Conserved sequence (low covariation and power)	K00161	downstream	PDHA, pdhA; pyruvate dehydrogenase E1 component subunit alpha [EC:1.2.4.1]	map01120	Microbial metabolism in diverse environments
K00161_downstream.h1_1	Conserved sequence (low covariation and power)	K00161	downstream	PDHA, pdhA; pyruvate dehydrogenase E1 component subunit alpha [EC:1.2.4.1]	ko01120	NA
K00161_downstream.h1_1	Conserved sequence (low covariation and power)	K00161	downstream	PDHA, pdhA; pyruvate dehydrogenase E1 component subunit alpha [EC:1.2.4.1]	map01200	Carbon metabolism
K00161_downstream.h1_1	Conserved sequence (low covariation and power)	K00161	downstream	PDHA, pdhA; pyruvate dehydrogenase E1 component subunit alpha [EC:1.2.4.1]	ko01200	NA
K00161_downstream.h1_1	Conserved sequence (low covariation and power)	K00161	downstream	PDHA, pdhA; pyruvate dehydrogenase E1 component subunit alpha [EC:1.2.4.1]	map01210	2-Oxocarboxylic acid metabolism
K00161_downstream.h1_1	Conserved sequence (low covariation and power)	K00161	downstream	PDHA, pdhA; pyruvate dehydrogenase E1 component subunit alpha [EC:1.2.4.1]	ko01210	NA
K00161_downstream.h1_1	Conserved sequence (low covariation and power)	K00161	downstream	PDHA, pdhA; pyruvate dehydrogenase E1 component subunit alpha [EC:1.2.4.1]	map04066	HIF-1 signaling pathway
K00161_downstream.h1_1	Conserved sequence (low covariation and power)	K00161	downstream	PDHA, pdhA; pyruvate dehydrogenase E1 component subunit alpha [EC:1.2.4.1]	ko04066	NA
K00161_downstream.h1_1	Conserved sequence (low covariation and power)	K00161	downstream	PDHA, pdhA; pyruvate dehydrogenase E1 component subunit alpha [EC:1.2.4.1]	map04922	Glucagon signaling pathway
K00161_downstream.h1_1	Conserved sequence (low covariation and power)	K00161	downstream	PDHA, pdhA; pyruvate dehydrogenase E1 component subunit alpha [EC:1.2.4.1]	ko04922	NA
K00161_downstream.h1_1	Conserved sequence (low covariation and power)	K00161	downstream	PDHA, pdhA; pyruvate dehydrogenase E1 component subunit alpha [EC:1.2.4.1]	map05230	Central carbon metabolism in cancer
K00161_downstream.h1_1	Conserved sequence (low covariation and power)	K00161	downstream	PDHA, pdhA; pyruvate dehydrogenase E1 component subunit alpha [EC:1.2.4.1]	ko05230	NA
K00161_downstream.h1_1	Conserved sequence (low covariation and power)	K00161	downstream	PDHA, pdhA; pyruvate dehydrogenase E1 component subunit alpha [EC:1.2.4.1]	map05415	Diabetic cardiomyopathy
K00161_downstream.h1_1	Conserved sequence (low covariation and power)	K00161	downstream	PDHA, pdhA; pyruvate dehydrogenase E1 component subunit alpha [EC:1.2.4.1]	ko05415	NA
K00297_downstream.h1_4	Conserved sequence (low covariation and power)	K00297	downstream	metF, MTHFR; methylenetetrahydrofolate reductase (NADH) [EC:1.5.1.54]	map00670	One carbon pool by folate
K00297_downstream.h1_4	Conserved sequence (low covariation and power)	K00297	downstream	metF, MTHFR; methylenetetrahydrofolate reductase (NADH) [EC:1.5.1.54]	ko00670	NA
K00297_downstream.h1_4	Conserved sequence (low covariation and power)	K00297	downstream	metF, MTHFR; methylenetetrahydrofolate reductase (NADH) [EC:1.5.1.54]	map00720	Other carbon fixation pathways
K00297_downstream.h1_4	Conserved sequence (low covariation and power)	K00297	downstream	metF, MTHFR; methylenetetrahydrofolate reductase (NADH) [EC:1.5.1.54]	ko00720	NA
K00297_downstream.h1_4	Conserved sequence (low covariation and power)	K00297	downstream	metF, MTHFR; methylenetetrahydrofolate reductase (NADH) [EC:1.5.1.54]	map01100	Metabolic pathways
K00297_downstream.h1_4	Conserved sequence (low covariation and power)	K00297	downstream	metF, MTHFR; methylenetetrahydrofolate reductase (NADH) [EC:1.5.1.54]	ko01100	NA
K00297_downstream.h1_4	Conserved sequence (low covariation and power)	K00297	downstream	metF, MTHFR; methylenetetrahydrofolate reductase (NADH) [EC:1.5.1.54]	map01120	Microbial metabolism in diverse environments
K00297_downstream.h1_4	Conserved sequence (low covariation and power)	K00297	downstream	metF, MTHFR; methylenetetrahydrofolate reductase (NADH) [EC:1.5.1.54]	ko01120	NA
K00297_downstream.h1_4	Conserved sequence (low covariation and power)	K00297	downstream	metF, MTHFR; methylenetetrahydrofolate reductase (NADH) [EC:1.5.1.54]	map01200	Carbon metabolism
K00297_downstream.h1_4	Conserved sequence (low covariation and power)	K00297	downstream	metF, MTHFR; methylenetetrahydrofolate reductase (NADH) [EC:1.5.1.54]	ko01200	NA
K00297_downstream.h2_2.h2_3	High power (low covariation)	K00297	downstream	metF, MTHFR; methylenetetrahydrofolate reductase (NADH) [EC:1.5.1.54]	map00670	One carbon pool by folate
K00297_downstream.h2_2.h2_3	High power (low covariation)	K00297	downstream	metF, MTHFR; methylenetetrahydrofolate reductase (NADH) [EC:1.5.1.54]	ko00670	NA
K00297_downstream.h2_2.h2_3	High power (low covariation)	K00297	downstream	metF, MTHFR; methylenetetrahydrofolate reductase (NADH) [EC:1.5.1.54]	map00720	Other carbon fixation pathways
K00297_downstream.h2_2.h2_3	High power (low covariation)	K00297	downstream	metF, MTHFR; methylenetetrahydrofolate reductase (NADH) [EC:1.5.1.54]	ko00720	NA
K00297_downstream.h2_2.h2_3	High power (low covariation)	K00297	downstream	metF, MTHFR; methylenetetrahydrofolate reductase (NADH) [EC:1.5.1.54]	map01100	Metabolic pathways
K00297_downstream.h2_2.h2_3	High power (low covariation)	K00297	downstream	metF, MTHFR; methylenetetrahydrofolate reductase (NADH) [EC:1.5.1.54]	ko01100	NA
K00297_downstream.h2_2.h2_3	High power (low covariation)	K00297	downstream	metF, MTHFR; methylenetetrahydrofolate reductase (NADH) [EC:1.5.1.54]	map01120	Microbial metabolism in diverse environments
K00297_downstream.h2_2.h2_3	High power (low covariation)	K00297	downstream	metF, MTHFR; methylenetetrahydrofolate reductase (NADH) [EC:1.5.1.54]	ko01120	NA
K00297_downstream.h2_2.h2_3	High power (low covariation)	K00297	downstream	metF, MTHFR; methylenetetrahydrofolate reductase (NADH) [EC:1.5.1.54]	map01200	Carbon metabolism
K00297_downstream.h2_2.h2_3	High power (low covariation)	K00297	downstream	metF, MTHFR; methylenetetrahydrofolate reductase (NADH) [EC:1.5.1.54]	ko01200	NA
K00297_downstream.h1_1	High covariation	K00297	downstream	metF, MTHFR; methylenetetrahydrofolate reductase (NADH) [EC:1.5.1.54]	map00670	One carbon pool by folate
K00297_downstream.h1_1	High covariation	K00297	downstream	metF, MTHFR; methylenetetrahydrofolate reductase (NADH) [EC:1.5.1.54]	ko00670	NA
K00297_downstream.h1_1	High covariation	K00297	downstream	metF, MTHFR; methylenetetrahydrofolate reductase (NADH) [EC:1.5.1.54]	map00720	Other carbon fixation pathways
K00297_downstream.h1_1	High covariation	K00297	downstream	metF, MTHFR; methylenetetrahydrofolate reductase (NADH) [EC:1.5.1.54]	ko00720	NA
K00297_downstream.h1_1	High covariation	K00297	downstream	metF, MTHFR; methylenetetrahydrofolate reductase (NADH) [EC:1.5.1.54]	map01100	Metabolic pathways
K00297_downstream.h1_1	High covariation	K00297	downstream	metF, MTHFR; methylenetetrahydrofolate reductase (NADH) [EC:1.5.1.54]	ko01100	NA
K00297_downstream.h1_1	High covariation	K00297	downstream	metF, MTHFR; methylenetetrahydrofolate reductase (NADH) [EC:1.5.1.54]	map01120	Microbial metabolism in diverse environments
K00297_downstream.h1_1	High covariation	K00297	downstream	metF, MTHFR; methylenetetrahydrofolate reductase (NADH) [EC:1.5.1.54]	ko01120	NA
K00297_downstream.h1_1	High covariation	K00297	downstream	metF, MTHFR; methylenetetrahydrofolate reductase (NADH) [EC:1.5.1.54]	map01200	Carbon metabolism
K00297_downstream.h1_1	High covariation	K00297	downstream	metF, MTHFR; methylenetetrahydrofolate reductase (NADH) [EC:1.5.1.54]	ko01200	NA
K00604_downstream.h1_2	Conserved sequence (low covariation and power)	K00604	downstream	MTFMT, fmt; methionyl-tRNA formyltransferase [EC:2.1.2.9]	map00970	Aminoacyl-tRNA biosynthesis
K00604_downstream.h1_2	Conserved sequence (low covariation and power)	K00604	downstream	MTFMT, fmt; methionyl-tRNA formyltransferase [EC:2.1.2.9]	ko00970	NA
K00604_downstream.h1_2	Conserved sequence (low covariation and power)	K00604	downstream	MTFMT, fmt; methionyl-tRNA formyltransferase [EC:2.1.2.9]	map01100	Metabolic pathways
K00604_downstream.h1_2	Conserved sequence (low covariation and power)	K00604	downstream	MTFMT, fmt; methionyl-tRNA formyltransferase [EC:2.1.2.9]	ko01100	NA
K00615_downstream.h2_1	High power (low covariation)	K00615	downstream	E2.2.1.1, tktA, tktB; transketolase [EC:2.2.1.1]	map00030	Pentose phosphate pathway
K00615_downstream.h2_1	High power (low covariation)	K00615	downstream	E2.2.1.1, tktA, tktB; transketolase [EC:2.2.1.1]	ko00030	NA
K00615_downstream.h2_1	High power (low covariation)	K00615	downstream	E2.2.1.1, tktA, tktB; transketolase [EC:2.2.1.1]	map00710	Carbon fixation by Calvin cycle
K00615_downstream.h2_1	High power (low covariation)	K00615	downstream	E2.2.1.1, tktA, tktB; transketolase [EC:2.2.1.1]	ko00710	NA
K00615_downstream.h2_1	High power (low covariation)	K00615	downstream	E2.2.1.1, tktA, tktB; transketolase [EC:2.2.1.1]	map01051	Biosynthesis of ansamycins
K00615_downstream.h2_1	High power (low covariation)	K00615	downstream	E2.2.1.1, tktA, tktB; transketolase [EC:2.2.1.1]	ko01051	NA
K00615_downstream.h2_1	High power (low covariation)	K00615	downstream	E2.2.1.1, tktA, tktB; transketolase [EC:2.2.1.1]	map01100	Metabolic pathways
K00615_downstream.h2_1	High power (low covariation)	K00615	downstream	E2.2.1.1, tktA, tktB; transketolase [EC:2.2.1.1]	ko01100	NA
K00615_downstream.h2_1	High power (low covariation)	K00615	downstream	E2.2.1.1, tktA, tktB; transketolase [EC:2.2.1.1]	map01110	Biosynthesis of secondary metabolites
K00615_downstream.h2_1	High power (low covariation)	K00615	downstream	E2.2.1.1, tktA, tktB; transketolase [EC:2.2.1.1]	ko01110	NA
K00615_downstream.h2_1	High power (low covariation)	K00615	downstream	E2.2.1.1, tktA, tktB; transketolase [EC:2.2.1.1]	map01120	Microbial metabolism in diverse environments
K00615_downstream.h2_1	High power (low covariation)	K00615	downstream	E2.2.1.1, tktA, tktB; transketolase [EC:2.2.1.1]	ko01120	NA
K00615_downstream.h2_1	High power (low covariation)	K00615	downstream	E2.2.1.1, tktA, tktB; transketolase [EC:2.2.1.1]	map01200	Carbon metabolism
K00615_downstream.h2_1	High power (low covariation)	K00615	downstream	E2.2.1.1, tktA, tktB; transketolase [EC:2.2.1.1]	ko01200	NA
K00615_downstream.h2_1	High power (low covariation)	K00615	downstream	E2.2.1.1, tktA, tktB; transketolase [EC:2.2.1.1]	map01230	Biosynthesis of amino acids
K00615_downstream.h2_1	High power (low covariation)	K00615	downstream	E2.2.1.1, tktA, tktB; transketolase [EC:2.2.1.1]	ko01230	NA
K00615_downstream.h1_1	Conserved sequence (low covariation and power)	K00615	downstream	E2.2.1.1, tktA, tktB; transketolase [EC:2.2.1.1]	map00030	Pentose phosphate pathway
K00615_downstream.h1_1	Conserved sequence (low covariation and power)	K00615	downstream	E2.2.1.1, tktA, tktB; transketolase [EC:2.2.1.1]	ko00030	NA
K00615_downstream.h1_1	Conserved sequence (low covariation and power)	K00615	downstream	E2.2.1.1, tktA, tktB; transketolase [EC:2.2.1.1]	map00710	Carbon fixation by Calvin cycle
K00615_downstream.h1_1	Conserved sequence (low covariation and power)	K00615	downstream	E2.2.1.1, tktA, tktB; transketolase [EC:2.2.1.1]	ko00710	NA
K00615_downstream.h1_1	Conserved sequence (low covariation and power)	K00615	downstream	E2.2.1.1, tktA, tktB; transketolase [EC:2.2.1.1]	map01051	Biosynthesis of ansamycins
K00615_downstream.h1_1	Conserved sequence (low covariation and power)	K00615	downstream	E2.2.1.1, tktA, tktB; transketolase [EC:2.2.1.1]	ko01051	NA
K00615_downstream.h1_1	Conserved sequence (low covariation and power)	K00615	downstream	E2.2.1.1, tktA, tktB; transketolase [EC:2.2.1.1]	map01100	Metabolic pathways
K00615_downstream.h1_1	Conserved sequence (low covariation and power)	K00615	downstream	E2.2.1.1, tktA, tktB; transketolase [EC:2.2.1.1]	ko01100	NA
K00615_downstream.h1_1	Conserved sequence (low covariation and power)	K00615	downstream	E2.2.1.1, tktA, tktB; transketolase [EC:2.2.1.1]	map01110	Biosynthesis of secondary metabolites
K00615_downstream.h1_1	Conserved sequence (low covariation and power)	K00615	downstream	E2.2.1.1, tktA, tktB; transketolase [EC:2.2.1.1]	ko01110	NA
K00615_downstream.h1_1	Conserved sequence (low covariation and power)	K00615	downstream	E2.2.1.1, tktA, tktB; transketolase [EC:2.2.1.1]	map01120	Microbial metabolism in diverse environments
K00615_downstream.h1_1	Conserved sequence (low covariation and power)	K00615	downstream	E2.2.1.1, tktA, tktB; transketolase [EC:2.2.1.1]	ko01120	NA
K00615_downstream.h1_1	Conserved sequence (low covariation and power)	K00615	downstream	E2.2.1.1, tktA, tktB; transketolase [EC:2.2.1.1]	map01200	Carbon metabolism
K00615_downstream.h1_1	Conserved sequence (low covariation and power)	K00615	downstream	E2.2.1.1, tktA, tktB; transketolase [EC:2.2.1.1]	ko01200	NA
K00615_downstream.h1_1	Conserved sequence (low covariation and power)	K00615	downstream	E2.2.1.1, tktA, tktB; transketolase [EC:2.2.1.1]	map01230	Biosynthesis of amino acids
K00615_downstream.h1_1	Conserved sequence (low covariation and power)	K00615	downstream	E2.2.1.1, tktA, tktB; transketolase [EC:2.2.1.1]	ko01230	NA
K00640_downstream.h1_4.h2_1	Conserved sequence (low covariation and power)	K00640	downstream	cysE; serine O-acetyltransferase [EC:2.3.1.30]	map00270	Cysteine and methionine metabolism
K00640_downstream.h1_4.h2_1	Conserved sequence (low covariation and power)	K00640	downstream	cysE; serine O-acetyltransferase [EC:2.3.1.30]	ko00270	NA
K00640_downstream.h1_4.h2_1	Conserved sequence (low covariation and power)	K00640	downstream	cysE; serine O-acetyltransferase [EC:2.3.1.30]	map00543	Exopolysaccharide biosynthesis
K00640_downstream.h1_4.h2_1	Conserved sequence (low covariation and power)	K00640	downstream	cysE; serine O-acetyltransferase [EC:2.3.1.30]	ko00543	NA
K00640_downstream.h1_4.h2_1	Conserved sequence (low covariation and power)	K00640	downstream	cysE; serine O-acetyltransferase [EC:2.3.1.30]	map00920	Sulfur metabolism
K00640_downstream.h1_4.h2_1	Conserved sequence (low covariation and power)	K00640	downstream	cysE; serine O-acetyltransferase [EC:2.3.1.30]	ko00920	NA
K00640_downstream.h1_4.h2_1	Conserved sequence (low covariation and power)	K00640	downstream	cysE; serine O-acetyltransferase [EC:2.3.1.30]	map01100	Metabolic pathways
K00640_downstream.h1_4.h2_1	Conserved sequence (low covariation and power)	K00640	downstream	cysE; serine O-acetyltransferase [EC:2.3.1.30]	ko01100	NA
K00640_downstream.h1_4.h2_1	Conserved sequence (low covariation and power)	K00640	downstream	cysE; serine O-acetyltransferase [EC:2.3.1.30]	map01110	Biosynthesis of secondary metabolites
K00640_downstream.h1_4.h2_1	Conserved sequence (low covariation and power)	K00640	downstream	cysE; serine O-acetyltransferase [EC:2.3.1.30]	ko01110	NA
K00640_downstream.h1_4.h2_1	Conserved sequence (low covariation and power)	K00640	downstream	cysE; serine O-acetyltransferase [EC:2.3.1.30]	map01120	Microbial metabolism in diverse environments
K00640_downstream.h1_4.h2_1	Conserved sequence (low covariation and power)	K00640	downstream	cysE; serine O-acetyltransferase [EC:2.3.1.30]	ko01120	NA
K00640_downstream.h1_4.h2_1	Conserved sequence (low covariation and power)	K00640	downstream	cysE; serine O-acetyltransferase [EC:2.3.1.30]	map01200	Carbon metabolism
K00640_downstream.h1_4.h2_1	Conserved sequence (low covariation and power)	K00640	downstream	cysE; serine O-acetyltransferase [EC:2.3.1.30]	ko01200	NA
K00640_downstream.h1_4.h2_1	Conserved sequence (low covariation and power)	K00640	downstream	cysE; serine O-acetyltransferase [EC:2.3.1.30]	map01230	Biosynthesis of amino acids
K00640_downstream.h1_4.h2_1	Conserved sequence (low covariation and power)	K00640	downstream	cysE; serine O-acetyltransferase [EC:2.3.1.30]	ko01230	NA
K00640_downstream.h1_4.h2_1	Conserved sequence (low covariation and power)	K00640	downstream	cysE; serine O-acetyltransferase [EC:2.3.1.30]	map05111	Biofilm formation - Vibrio cholerae
K00640_downstream.h1_4.h2_1	Conserved sequence (low covariation and power)	K00640	downstream	cysE; serine O-acetyltransferase [EC:2.3.1.30]	ko05111	NA
K00640_downstream.h1_1	Conserved sequence (low covariation and power)	K00640	downstream	cysE; serine O-acetyltransferase [EC:2.3.1.30]	map00270	Cysteine and methionine metabolism
K00640_downstream.h1_1	Conserved sequence (low covariation and power)	K00640	downstream	cysE; serine O-acetyltransferase [EC:2.3.1.30]	ko00270	NA
K00640_downstream.h1_1	Conserved sequence (low covariation and power)	K00640	downstream	cysE; serine O-acetyltransferase [EC:2.3.1.30]	map00543	Exopolysaccharide biosynthesis
K00640_downstream.h1_1	Conserved sequence (low covariation and power)	K00640	downstream	cysE; serine O-acetyltransferase [EC:2.3.1.30]	ko00543	NA
K00640_downstream.h1_1	Conserved sequence (low covariation and power)	K00640	downstream	cysE; serine O-acetyltransferase [EC:2.3.1.30]	map00920	Sulfur metabolism
K00640_downstream.h1_1	Conserved sequence (low covariation and power)	K00640	downstream	cysE; serine O-acetyltransferase [EC:2.3.1.30]	ko00920	NA
K00640_downstream.h1_1	Conserved sequence (low covariation and power)	K00640	downstream	cysE; serine O-acetyltransferase [EC:2.3.1.30]	map01100	Metabolic pathways
K00640_downstream.h1_1	Conserved sequence (low covariation and power)	K00640	downstream	cysE; serine O-acetyltransferase [EC:2.3.1.30]	ko01100	NA
K00640_downstream.h1_1	Conserved sequence (low covariation and power)	K00640	downstream	cysE; serine O-acetyltransferase [EC:2.3.1.30]	map01110	Biosynthesis of secondary metabolites
K00640_downstream.h1_1	Conserved sequence (low covariation and power)	K00640	downstream	cysE; serine O-acetyltransferase [EC:2.3.1.30]	ko01110	NA
K00640_downstream.h1_1	Conserved sequence (low covariation and power)	K00640	downstream	cysE; serine O-acetyltransferase [EC:2.3.1.30]	map01120	Microbial metabolism in diverse environments
K00640_downstream.h1_1	Conserved sequence (low covariation and power)	K00640	downstream	cysE; serine O-acetyltransferase [EC:2.3.1.30]	ko01120	NA
K00640_downstream.h1_1	Conserved sequence (low covariation and power)	K00640	downstream	cysE; serine O-acetyltransferase [EC:2.3.1.30]	map01200	Carbon metabolism
K00640_downstream.h1_1	Conserved sequence (low covariation and power)	K00640	downstream	cysE; serine O-acetyltransferase [EC:2.3.1.30]	ko01200	NA
K00640_downstream.h1_1	Conserved sequence (low covariation and power)	K00640	downstream	cysE; serine O-acetyltransferase [EC:2.3.1.30]	map01230	Biosynthesis of amino acids
K00640_downstream.h1_1	Conserved sequence (low covariation and power)	K00640	downstream	cysE; serine O-acetyltransferase [EC:2.3.1.30]	ko01230	NA
K00640_downstream.h1_1	Conserved sequence (low covariation and power)	K00640	downstream	cysE; serine O-acetyltransferase [EC:2.3.1.30]	map05111	Biofilm formation - Vibrio cholerae
K00640_downstream.h1_1	Conserved sequence (low covariation and power)	K00640	downstream	cysE; serine O-acetyltransferase [EC:2.3.1.30]	ko05111	NA
K00748_downstream.h1_5	High covariation	K00748	downstream	lpxB; lipid-A-disaccharide synthase [EC:2.4.1.182]	map00540	Lipopolysaccharide biosynthesis
K00748_downstream.h1_5	High covariation	K00748	downstream	lpxB; lipid-A-disaccharide synthase [EC:2.4.1.182]	ko00540	NA
K00748_downstream.h1_5	High covariation	K00748	downstream	lpxB; lipid-A-disaccharide synthase [EC:2.4.1.182]	map01100	Metabolic pathways
K00748_downstream.h1_5	High covariation	K00748	downstream	lpxB; lipid-A-disaccharide synthase [EC:2.4.1.182]	ko01100	NA
K00764_downstream.h2_2	Conserved sequence (low covariation and power)	K00764	downstream	purF, PPAT; amidophosphoribosyltransferase [EC:2.4.2.14]	map00230	Purine metabolism
K00764_downstream.h2_2	Conserved sequence (low covariation and power)	K00764	downstream	purF, PPAT; amidophosphoribosyltransferase [EC:2.4.2.14]	ko00230	NA
K00764_downstream.h2_2	Conserved sequence (low covariation and power)	K00764	downstream	purF, PPAT; amidophosphoribosyltransferase [EC:2.4.2.14]	map00250	Alanine, aspartate and glutamate metabolism
K00764_downstream.h2_2	Conserved sequence (low covariation and power)	K00764	downstream	purF, PPAT; amidophosphoribosyltransferase [EC:2.4.2.14]	ko00250	NA
K00764_downstream.h2_2	Conserved sequence (low covariation and power)	K00764	downstream	purF, PPAT; amidophosphoribosyltransferase [EC:2.4.2.14]	map01100	Metabolic pathways
K00764_downstream.h2_2	Conserved sequence (low covariation and power)	K00764	downstream	purF, PPAT; amidophosphoribosyltransferase [EC:2.4.2.14]	ko01100	NA
K00764_downstream.h2_2	Conserved sequence (low covariation and power)	K00764	downstream	purF, PPAT; amidophosphoribosyltransferase [EC:2.4.2.14]	map01110	Biosynthesis of secondary metabolites
K00764_downstream.h2_2	Conserved sequence (low covariation and power)	K00764	downstream	purF, PPAT; amidophosphoribosyltransferase [EC:2.4.2.14]	ko01110	NA
K00937_downstream.h1_1	High covariation	K00937	downstream	ppk1; polyphosphate kinase [EC:2.7.4.1]	map00190	Oxidative phosphorylation
K00937_downstream.h1_1	High covariation	K00937	downstream	ppk1; polyphosphate kinase [EC:2.7.4.1]	ko00190	NA
K00937_downstream.h1_1	High covariation	K00937	downstream	ppk1; polyphosphate kinase [EC:2.7.4.1]	map03018	RNA degradation
K00937_downstream.h1_1	High covariation	K00937	downstream	ppk1; polyphosphate kinase [EC:2.7.4.1]	ko03018	NA
K00937_downstream.h2_2	Conserved sequence (low covariation and power)	K00937	downstream	ppk1; polyphosphate kinase [EC:2.7.4.1]	map00190	Oxidative phosphorylation
K00937_downstream.h2_2	Conserved sequence (low covariation and power)	K00937	downstream	ppk1; polyphosphate kinase [EC:2.7.4.1]	ko00190	NA
K00937_downstream.h2_2	Conserved sequence (low covariation and power)	K00937	downstream	ppk1; polyphosphate kinase [EC:2.7.4.1]	map03018	RNA degradation
K00937_downstream.h2_2	Conserved sequence (low covariation and power)	K00937	downstream	ppk1; polyphosphate kinase [EC:2.7.4.1]	ko03018	NA
K00940_downstream.h2_3	High power (low covariation)	K00940	downstream	ndk, NME; nucleoside-diphosphate kinase [EC:2.7.4.6]	map00230	Purine metabolism
K00940_downstream.h2_3	High power (low covariation)	K00940	downstream	ndk, NME; nucleoside-diphosphate kinase [EC:2.7.4.6]	ko00230	NA
K00940_downstream.h2_3	High power (low covariation)	K00940	downstream	ndk, NME; nucleoside-diphosphate kinase [EC:2.7.4.6]	map00240	Pyrimidine metabolism
K00940_downstream.h2_3	High power (low covariation)	K00940	downstream	ndk, NME; nucleoside-diphosphate kinase [EC:2.7.4.6]	ko00240	NA
K00940_downstream.h2_3	High power (low covariation)	K00940	downstream	ndk, NME; nucleoside-diphosphate kinase [EC:2.7.4.6]	map00983	Drug metabolism - other enzymes
K00940_downstream.h2_3	High power (low covariation)	K00940	downstream	ndk, NME; nucleoside-diphosphate kinase [EC:2.7.4.6]	ko00983	NA
K00940_downstream.h2_3	High power (low covariation)	K00940	downstream	ndk, NME; nucleoside-diphosphate kinase [EC:2.7.4.6]	map01100	Metabolic pathways
K00940_downstream.h2_3	High power (low covariation)	K00940	downstream	ndk, NME; nucleoside-diphosphate kinase [EC:2.7.4.6]	ko01100	NA
K00940_downstream.h2_3	High power (low covariation)	K00940	downstream	ndk, NME; nucleoside-diphosphate kinase [EC:2.7.4.6]	map01110	Biosynthesis of secondary metabolites
K00940_downstream.h2_3	High power (low covariation)	K00940	downstream	ndk, NME; nucleoside-diphosphate kinase [EC:2.7.4.6]	ko01110	NA
K00940_downstream.h2_3	High power (low covariation)	K00940	downstream	ndk, NME; nucleoside-diphosphate kinase [EC:2.7.4.6]	map01232	Nucleotide metabolism
K00940_downstream.h2_3	High power (low covariation)	K00940	downstream	ndk, NME; nucleoside-diphosphate kinase [EC:2.7.4.6]	ko01232	NA
K00940_downstream.h2_3	High power (low covariation)	K00940	downstream	ndk, NME; nucleoside-diphosphate kinase [EC:2.7.4.6]	map01240	Biosynthesis of cofactors
K00940_downstream.h2_3	High power (low covariation)	K00940	downstream	ndk, NME; nucleoside-diphosphate kinase [EC:2.7.4.6]	ko01240	NA
K00940_downstream.h2_3	High power (low covariation)	K00940	downstream	ndk, NME; nucleoside-diphosphate kinase [EC:2.7.4.6]	map04016	MAPK signaling pathway - plant
K00940_downstream.h2_3	High power (low covariation)	K00940	downstream	ndk, NME; nucleoside-diphosphate kinase [EC:2.7.4.6]	ko04016	NA
K00940_downstream.h1_5	High power (low covariation)	K00940	downstream	ndk, NME; nucleoside-diphosphate kinase [EC:2.7.4.6]	map00230	Purine metabolism
K00940_downstream.h1_5	High power (low covariation)	K00940	downstream	ndk, NME; nucleoside-diphosphate kinase [EC:2.7.4.6]	ko00230	NA
K00940_downstream.h1_5	High power (low covariation)	K00940	downstream	ndk, NME; nucleoside-diphosphate kinase [EC:2.7.4.6]	map00240	Pyrimidine metabolism
K00940_downstream.h1_5	High power (low covariation)	K00940	downstream	ndk, NME; nucleoside-diphosphate kinase [EC:2.7.4.6]	ko00240	NA
K00940_downstream.h1_5	High power (low covariation)	K00940	downstream	ndk, NME; nucleoside-diphosphate kinase [EC:2.7.4.6]	map00983	Drug metabolism - other enzymes
K00940_downstream.h1_5	High power (low covariation)	K00940	downstream	ndk, NME; nucleoside-diphosphate kinase [EC:2.7.4.6]	ko00983	NA
K00940_downstream.h1_5	High power (low covariation)	K00940	downstream	ndk, NME; nucleoside-diphosphate kinase [EC:2.7.4.6]	map01100	Metabolic pathways
K00940_downstream.h1_5	High power (low covariation)	K00940	downstream	ndk, NME; nucleoside-diphosphate kinase [EC:2.7.4.6]	ko01100	NA
K00940_downstream.h1_5	High power (low covariation)	K00940	downstream	ndk, NME; nucleoside-diphosphate kinase [EC:2.7.4.6]	map01110	Biosynthesis of secondary metabolites
K00940_downstream.h1_5	High power (low covariation)	K00940	downstream	ndk, NME; nucleoside-diphosphate kinase [EC:2.7.4.6]	ko01110	NA
K00940_downstream.h1_5	High power (low covariation)	K00940	downstream	ndk, NME; nucleoside-diphosphate kinase [EC:2.7.4.6]	map01232	Nucleotide metabolism
K00940_downstream.h1_5	High power (low covariation)	K00940	downstream	ndk, NME; nucleoside-diphosphate kinase [EC:2.7.4.6]	ko01232	NA
K00940_downstream.h1_5	High power (low covariation)	K00940	downstream	ndk, NME; nucleoside-diphosphate kinase [EC:2.7.4.6]	map01240	Biosynthesis of cofactors
K00940_downstream.h1_5	High power (low covariation)	K00940	downstream	ndk, NME; nucleoside-diphosphate kinase [EC:2.7.4.6]	ko01240	NA
K00940_downstream.h1_5	High power (low covariation)	K00940	downstream	ndk, NME; nucleoside-diphosphate kinase [EC:2.7.4.6]	map04016	MAPK signaling pathway - plant
K00940_downstream.h1_5	High power (low covariation)	K00940	downstream	ndk, NME; nucleoside-diphosphate kinase [EC:2.7.4.6]	ko04016	NA
K00940_downstream.h2_1	Conserved sequence (low covariation and power)	K00940	downstream	ndk, NME; nucleoside-diphosphate kinase [EC:2.7.4.6]	map00230	Purine metabolism
K00940_downstream.h2_1	Conserved sequence (low covariation and power)	K00940	downstream	ndk, NME; nucleoside-diphosphate kinase [EC:2.7.4.6]	ko00230	NA
K00940_downstream.h2_1	Conserved sequence (low covariation and power)	K00940	downstream	ndk, NME; nucleoside-diphosphate kinase [EC:2.7.4.6]	map00240	Pyrimidine metabolism
K00940_downstream.h2_1	Conserved sequence (low covariation and power)	K00940	downstream	ndk, NME; nucleoside-diphosphate kinase [EC:2.7.4.6]	ko00240	NA
K00940_downstream.h2_1	Conserved sequence (low covariation and power)	K00940	downstream	ndk, NME; nucleoside-diphosphate kinase [EC:2.7.4.6]	map00983	Drug metabolism - other enzymes
K00940_downstream.h2_1	Conserved sequence (low covariation and power)	K00940	downstream	ndk, NME; nucleoside-diphosphate kinase [EC:2.7.4.6]	ko00983	NA
K00940_downstream.h2_1	Conserved sequence (low covariation and power)	K00940	downstream	ndk, NME; nucleoside-diphosphate kinase [EC:2.7.4.6]	map01100	Metabolic pathways
K00940_downstream.h2_1	Conserved sequence (low covariation and power)	K00940	downstream	ndk, NME; nucleoside-diphosphate kinase [EC:2.7.4.6]	ko01100	NA
K00940_downstream.h2_1	Conserved sequence (low covariation and power)	K00940	downstream	ndk, NME; nucleoside-diphosphate kinase [EC:2.7.4.6]	map01110	Biosynthesis of secondary metabolites
K00940_downstream.h2_1	Conserved sequence (low covariation and power)	K00940	downstream	ndk, NME; nucleoside-diphosphate kinase [EC:2.7.4.6]	ko01110	NA
K00940_downstream.h2_1	Conserved sequence (low covariation and power)	K00940	downstream	ndk, NME; nucleoside-diphosphate kinase [EC:2.7.4.6]	map01232	Nucleotide metabolism
K00940_downstream.h2_1	Conserved sequence (low covariation and power)	K00940	downstream	ndk, NME; nucleoside-diphosphate kinase [EC:2.7.4.6]	ko01232	NA
K00940_downstream.h2_1	Conserved sequence (low covariation and power)	K00940	downstream	ndk, NME; nucleoside-diphosphate kinase [EC:2.7.4.6]	map01240	Biosynthesis of cofactors
K00940_downstream.h2_1	Conserved sequence (low covariation and power)	K00940	downstream	ndk, NME; nucleoside-diphosphate kinase [EC:2.7.4.6]	ko01240	NA
K00940_downstream.h2_1	Conserved sequence (low covariation and power)	K00940	downstream	ndk, NME; nucleoside-diphosphate kinase [EC:2.7.4.6]	map04016	MAPK signaling pathway - plant
K00940_downstream.h2_1	Conserved sequence (low covariation and power)	K00940	downstream	ndk, NME; nucleoside-diphosphate kinase [EC:2.7.4.6]	ko04016	NA
K00988_downstream.h1_5	High covariation	K00988	downstream	APA1_2; sulfate adenylyltransferase (ADP) / ATP adenylyltransferase [EC:2.7.7.5 2.7.7.53]	map00230	Purine metabolism
K00988_downstream.h1_5	High covariation	K00988	downstream	APA1_2; sulfate adenylyltransferase (ADP) / ATP adenylyltransferase [EC:2.7.7.5 2.7.7.53]	ko00230	NA
K00988_downstream.h1_5	High covariation	K00988	downstream	APA1_2; sulfate adenylyltransferase (ADP) / ATP adenylyltransferase [EC:2.7.7.5 2.7.7.53]	map00920	Sulfur metabolism
K00988_downstream.h1_5	High covariation	K00988	downstream	APA1_2; sulfate adenylyltransferase (ADP) / ATP adenylyltransferase [EC:2.7.7.5 2.7.7.53]	ko00920	NA
K00988_downstream.h1_5	High covariation	K00988	downstream	APA1_2; sulfate adenylyltransferase (ADP) / ATP adenylyltransferase [EC:2.7.7.5 2.7.7.53]	map01100	Metabolic pathways
K00988_downstream.h1_5	High covariation	K00988	downstream	APA1_2; sulfate adenylyltransferase (ADP) / ATP adenylyltransferase [EC:2.7.7.5 2.7.7.53]	ko01100	NA
K00988_downstream.h1_5	High covariation	K00988	downstream	APA1_2; sulfate adenylyltransferase (ADP) / ATP adenylyltransferase [EC:2.7.7.5 2.7.7.53]	map01120	Microbial metabolism in diverse environments
K00988_downstream.h1_5	High covariation	K00988	downstream	APA1_2; sulfate adenylyltransferase (ADP) / ATP adenylyltransferase [EC:2.7.7.5 2.7.7.53]	ko01120	NA
K00988_downstream.h2_1	High covariation	K00988	downstream	APA1_2; sulfate adenylyltransferase (ADP) / ATP adenylyltransferase [EC:2.7.7.5 2.7.7.53]	map00230	Purine metabolism
K00988_downstream.h2_1	High covariation	K00988	downstream	APA1_2; sulfate adenylyltransferase (ADP) / ATP adenylyltransferase [EC:2.7.7.5 2.7.7.53]	ko00230	NA
K00988_downstream.h2_1	High covariation	K00988	downstream	APA1_2; sulfate adenylyltransferase (ADP) / ATP adenylyltransferase [EC:2.7.7.5 2.7.7.53]	map00920	Sulfur metabolism
K00988_downstream.h2_1	High covariation	K00988	downstream	APA1_2; sulfate adenylyltransferase (ADP) / ATP adenylyltransferase [EC:2.7.7.5 2.7.7.53]	ko00920	NA
K00988_downstream.h2_1	High covariation	K00988	downstream	APA1_2; sulfate adenylyltransferase (ADP) / ATP adenylyltransferase [EC:2.7.7.5 2.7.7.53]	map01100	Metabolic pathways
K00988_downstream.h2_1	High covariation	K00988	downstream	APA1_2; sulfate adenylyltransferase (ADP) / ATP adenylyltransferase [EC:2.7.7.5 2.7.7.53]	ko01100	NA
K00988_downstream.h2_1	High covariation	K00988	downstream	APA1_2; sulfate adenylyltransferase (ADP) / ATP adenylyltransferase [EC:2.7.7.5 2.7.7.53]	map01120	Microbial metabolism in diverse environments
K00988_downstream.h2_1	High covariation	K00988	downstream	APA1_2; sulfate adenylyltransferase (ADP) / ATP adenylyltransferase [EC:2.7.7.5 2.7.7.53]	ko01120	NA
K00995_downstream.h1_3	Conserved sequence (low covariation and power)	K00995	downstream	PGS1, pgsA; CDP-diacylglycerol---glycerol-3-phosphate 3-phosphatidyltransferase [EC:2.7.8.5]	map00564	Glycerophospholipid metabolism
K00995_downstream.h1_3	Conserved sequence (low covariation and power)	K00995	downstream	PGS1, pgsA; CDP-diacylglycerol---glycerol-3-phosphate 3-phosphatidyltransferase [EC:2.7.8.5]	ko00564	NA
K00995_downstream.h1_3	Conserved sequence (low covariation and power)	K00995	downstream	PGS1, pgsA; CDP-diacylglycerol---glycerol-3-phosphate 3-phosphatidyltransferase [EC:2.7.8.5]	map01100	Metabolic pathways
K00995_downstream.h1_3	Conserved sequence (low covariation and power)	K00995	downstream	PGS1, pgsA; CDP-diacylglycerol---glycerol-3-phosphate 3-phosphatidyltransferase [EC:2.7.8.5]	ko01100	NA
K00995_downstream.h1_4.h2_3	Conserved sequence (low covariation and power)	K00995	downstream	PGS1, pgsA; CDP-diacylglycerol---glycerol-3-phosphate 3-phosphatidyltransferase [EC:2.7.8.5]	map00564	Glycerophospholipid metabolism
K00995_downstream.h1_4.h2_3	Conserved sequence (low covariation and power)	K00995	downstream	PGS1, pgsA; CDP-diacylglycerol---glycerol-3-phosphate 3-phosphatidyltransferase [EC:2.7.8.5]	ko00564	NA
K00995_downstream.h1_4.h2_3	Conserved sequence (low covariation and power)	K00995	downstream	PGS1, pgsA; CDP-diacylglycerol---glycerol-3-phosphate 3-phosphatidyltransferase [EC:2.7.8.5]	map01100	Metabolic pathways
K00995_downstream.h1_4.h2_3	Conserved sequence (low covariation and power)	K00995	downstream	PGS1, pgsA; CDP-diacylglycerol---glycerol-3-phosphate 3-phosphatidyltransferase [EC:2.7.8.5]	ko01100	NA
K01008_downstream.h2_3	Conserved sequence (low covariation and power)	K01008	downstream	selD, SEPHS; selenide, water dikinase [EC:2.7.9.3]	map00450	Selenocompound metabolism
K01008_downstream.h2_3	Conserved sequence (low covariation and power)	K01008	downstream	selD, SEPHS; selenide, water dikinase [EC:2.7.9.3]	ko00450	NA
K01008_downstream.h2_3	Conserved sequence (low covariation and power)	K01008	downstream	selD, SEPHS; selenide, water dikinase [EC:2.7.9.3]	map01100	Metabolic pathways
K01008_downstream.h2_3	Conserved sequence (low covariation and power)	K01008	downstream	selD, SEPHS; selenide, water dikinase [EC:2.7.9.3]	ko01100	NA
K01056_downstream.h2_1	Conserved sequence (low covariation and power)	K01056	downstream	PTH1, PTRH1, pth, spoVC; peptidyl-tRNA hydrolase, PTH1 family [EC:3.1.1.29]	NA	NA
K01193_downstream.h1_2.h2_4	High power (low covariation)	K01193	downstream	INV, sacA; beta-fructofuranosidase [EC:3.2.1.26]	map00052	Galactose metabolism
K01193_downstream.h1_2.h2_4	High power (low covariation)	K01193	downstream	INV, sacA; beta-fructofuranosidase [EC:3.2.1.26]	ko00052	NA
K01193_downstream.h1_2.h2_4	High power (low covariation)	K01193	downstream	INV, sacA; beta-fructofuranosidase [EC:3.2.1.26]	map00500	Starch and sucrose metabolism
K01193_downstream.h1_2.h2_4	High power (low covariation)	K01193	downstream	INV, sacA; beta-fructofuranosidase [EC:3.2.1.26]	ko00500	NA
K01193_downstream.h1_2.h2_4	High power (low covariation)	K01193	downstream	INV, sacA; beta-fructofuranosidase [EC:3.2.1.26]	map01100	Metabolic pathways
K01193_downstream.h1_2.h2_4	High power (low covariation)	K01193	downstream	INV, sacA; beta-fructofuranosidase [EC:3.2.1.26]	ko01100	NA
K01193_downstream.h1_2.h2_4	High power (low covariation)	K01193	downstream	INV, sacA; beta-fructofuranosidase [EC:3.2.1.26]	map01110	Biosynthesis of secondary metabolites
K01193_downstream.h1_2.h2_4	High power (low covariation)	K01193	downstream	INV, sacA; beta-fructofuranosidase [EC:3.2.1.26]	ko01110	NA
K01356_downstream.h1_3	High covariation	K01356	downstream	lexA; repressor LexA [EC:3.4.21.88]	NA	NA
K01414_downstream.h2_1.h2_4	Conserved sequence (low covariation and power)	K01414	downstream	prlC; oligopeptidase A [EC:3.4.24.70]	NA	NA
K01428_downstream.h1_3	Conserved sequence (low covariation and power)	K01428	downstream	ureC; urease subunit alpha [EC:3.5.1.5]	map00220	Arginine biosynthesis
K01428_downstream.h1_3	Conserved sequence (low covariation and power)	K01428	downstream	ureC; urease subunit alpha [EC:3.5.1.5]	ko00220	NA
K01428_downstream.h1_3	Conserved sequence (low covariation and power)	K01428	downstream	ureC; urease subunit alpha [EC:3.5.1.5]	map00230	Purine metabolism
K01428_downstream.h1_3	Conserved sequence (low covariation and power)	K01428	downstream	ureC; urease subunit alpha [EC:3.5.1.5]	ko00230	NA
K01428_downstream.h1_3	Conserved sequence (low covariation and power)	K01428	downstream	ureC; urease subunit alpha [EC:3.5.1.5]	map00791	Atrazine degradation
K01428_downstream.h1_3	Conserved sequence (low covariation and power)	K01428	downstream	ureC; urease subunit alpha [EC:3.5.1.5]	ko00791	NA
K01428_downstream.h1_3	Conserved sequence (low covariation and power)	K01428	downstream	ureC; urease subunit alpha [EC:3.5.1.5]	map01100	Metabolic pathways
K01428_downstream.h1_3	Conserved sequence (low covariation and power)	K01428	downstream	ureC; urease subunit alpha [EC:3.5.1.5]	ko01100	NA
K01428_downstream.h1_3	Conserved sequence (low covariation and power)	K01428	downstream	ureC; urease subunit alpha [EC:3.5.1.5]	map01120	Microbial metabolism in diverse environments
K01428_downstream.h1_3	Conserved sequence (low covariation and power)	K01428	downstream	ureC; urease subunit alpha [EC:3.5.1.5]	ko01120	NA
K01428_downstream.h1_3	Conserved sequence (low covariation and power)	K01428	downstream	ureC; urease subunit alpha [EC:3.5.1.5]	map05120	Epithelial cell signaling in Helicobacter pylori infection
K01428_downstream.h1_3	Conserved sequence (low covariation and power)	K01428	downstream	ureC; urease subunit alpha [EC:3.5.1.5]	ko05120	NA
K01437_downstream.h1_1.h2_1.h1_4	Conserved sequence (low covariation and power)	K01437	downstream	ASPA, aspA; aspartoacylase [EC:3.5.1.15]	map00250	Alanine, aspartate and glutamate metabolism
K01437_downstream.h1_1.h2_1.h1_4	Conserved sequence (low covariation and power)	K01437	downstream	ASPA, aspA; aspartoacylase [EC:3.5.1.15]	ko00250	NA
K01437_downstream.h1_1.h2_1.h1_4	Conserved sequence (low covariation and power)	K01437	downstream	ASPA, aspA; aspartoacylase [EC:3.5.1.15]	map00340	Histidine metabolism
K01437_downstream.h1_1.h2_1.h1_4	Conserved sequence (low covariation and power)	K01437	downstream	ASPA, aspA; aspartoacylase [EC:3.5.1.15]	ko00340	NA
K01437_downstream.h1_1.h2_1.h1_4	Conserved sequence (low covariation and power)	K01437	downstream	ASPA, aspA; aspartoacylase [EC:3.5.1.15]	map01100	Metabolic pathways
K01437_downstream.h1_1.h2_1.h1_4	Conserved sequence (low covariation and power)	K01437	downstream	ASPA, aspA; aspartoacylase [EC:3.5.1.15]	ko01100	NA
K01437_downstream.h1_5	Conserved sequence (low covariation and power)	K01437	downstream	ASPA, aspA; aspartoacylase [EC:3.5.1.15]	map00250	Alanine, aspartate and glutamate metabolism
K01437_downstream.h1_5	Conserved sequence (low covariation and power)	K01437	downstream	ASPA, aspA; aspartoacylase [EC:3.5.1.15]	ko00250	NA
K01437_downstream.h1_5	Conserved sequence (low covariation and power)	K01437	downstream	ASPA, aspA; aspartoacylase [EC:3.5.1.15]	map00340	Histidine metabolism
K01437_downstream.h1_5	Conserved sequence (low covariation and power)	K01437	downstream	ASPA, aspA; aspartoacylase [EC:3.5.1.15]	ko00340	NA
K01437_downstream.h1_5	Conserved sequence (low covariation and power)	K01437	downstream	ASPA, aspA; aspartoacylase [EC:3.5.1.15]	map01100	Metabolic pathways
K01437_downstream.h1_5	Conserved sequence (low covariation and power)	K01437	downstream	ASPA, aspA; aspartoacylase [EC:3.5.1.15]	ko01100	NA
K01601_downstream.h1_2	High covariation	K01601	downstream	rbcL, cbbL; ribulose-bisphosphate carboxylase large chain [EC:4.1.1.39]	map00630	Glyoxylate and dicarboxylate metabolism
K01601_downstream.h1_2	High covariation	K01601	downstream	rbcL, cbbL; ribulose-bisphosphate carboxylase large chain [EC:4.1.1.39]	ko00630	NA
K01601_downstream.h1_2	High covariation	K01601	downstream	rbcL, cbbL; ribulose-bisphosphate carboxylase large chain [EC:4.1.1.39]	map00710	Carbon fixation by Calvin cycle
K01601_downstream.h1_2	High covariation	K01601	downstream	rbcL, cbbL; ribulose-bisphosphate carboxylase large chain [EC:4.1.1.39]	ko00710	NA
K01601_downstream.h1_2	High covariation	K01601	downstream	rbcL, cbbL; ribulose-bisphosphate carboxylase large chain [EC:4.1.1.39]	map01100	Metabolic pathways
K01601_downstream.h1_2	High covariation	K01601	downstream	rbcL, cbbL; ribulose-bisphosphate carboxylase large chain [EC:4.1.1.39]	ko01100	NA
K01601_downstream.h1_2	High covariation	K01601	downstream	rbcL, cbbL; ribulose-bisphosphate carboxylase large chain [EC:4.1.1.39]	map01110	Biosynthesis of secondary metabolites
K01601_downstream.h1_2	High covariation	K01601	downstream	rbcL, cbbL; ribulose-bisphosphate carboxylase large chain [EC:4.1.1.39]	ko01110	NA
K01601_downstream.h1_2	High covariation	K01601	downstream	rbcL, cbbL; ribulose-bisphosphate carboxylase large chain [EC:4.1.1.39]	map01120	Microbial metabolism in diverse environments
K01601_downstream.h1_2	High covariation	K01601	downstream	rbcL, cbbL; ribulose-bisphosphate carboxylase large chain [EC:4.1.1.39]	ko01120	NA
K01601_downstream.h1_2	High covariation	K01601	downstream	rbcL, cbbL; ribulose-bisphosphate carboxylase large chain [EC:4.1.1.39]	map01200	Carbon metabolism
K01601_downstream.h1_2	High covariation	K01601	downstream	rbcL, cbbL; ribulose-bisphosphate carboxylase large chain [EC:4.1.1.39]	ko01200	NA
K01601_downstream.h1_1	High power (low covariation)	K01601	downstream	rbcL, cbbL; ribulose-bisphosphate carboxylase large chain [EC:4.1.1.39]	map00630	Glyoxylate and dicarboxylate metabolism
K01601_downstream.h1_1	High power (low covariation)	K01601	downstream	rbcL, cbbL; ribulose-bisphosphate carboxylase large chain [EC:4.1.1.39]	ko00630	NA
K01601_downstream.h1_1	High power (low covariation)	K01601	downstream	rbcL, cbbL; ribulose-bisphosphate carboxylase large chain [EC:4.1.1.39]	map00710	Carbon fixation by Calvin cycle
K01601_downstream.h1_1	High power (low covariation)	K01601	downstream	rbcL, cbbL; ribulose-bisphosphate carboxylase large chain [EC:4.1.1.39]	ko00710	NA
K01601_downstream.h1_1	High power (low covariation)	K01601	downstream	rbcL, cbbL; ribulose-bisphosphate carboxylase large chain [EC:4.1.1.39]	map01100	Metabolic pathways
K01601_downstream.h1_1	High power (low covariation)	K01601	downstream	rbcL, cbbL; ribulose-bisphosphate carboxylase large chain [EC:4.1.1.39]	ko01100	NA
K01601_downstream.h1_1	High power (low covariation)	K01601	downstream	rbcL, cbbL; ribulose-bisphosphate carboxylase large chain [EC:4.1.1.39]	map01110	Biosynthesis of secondary metabolites
K01601_downstream.h1_1	High power (low covariation)	K01601	downstream	rbcL, cbbL; ribulose-bisphosphate carboxylase large chain [EC:4.1.1.39]	ko01110	NA
K01601_downstream.h1_1	High power (low covariation)	K01601	downstream	rbcL, cbbL; ribulose-bisphosphate carboxylase large chain [EC:4.1.1.39]	map01120	Microbial metabolism in diverse environments
K01601_downstream.h1_1	High power (low covariation)	K01601	downstream	rbcL, cbbL; ribulose-bisphosphate carboxylase large chain [EC:4.1.1.39]	ko01120	NA
K01601_downstream.h1_1	High power (low covariation)	K01601	downstream	rbcL, cbbL; ribulose-bisphosphate carboxylase large chain [EC:4.1.1.39]	map01200	Carbon metabolism
K01601_downstream.h1_1	High power (low covariation)	K01601	downstream	rbcL, cbbL; ribulose-bisphosphate carboxylase large chain [EC:4.1.1.39]	ko01200	NA
K01626_downstream.h1_2	Conserved sequence (low covariation and power)	K01626	downstream	E2.5.1.54, aroF, aroG, aroH; 3-deoxy-7-phosphoheptulonate synthase [EC:2.5.1.54]	map00400	Phenylalanine, tyrosine and tryptophan biosynthesis
K01626_downstream.h1_2	Conserved sequence (low covariation and power)	K01626	downstream	E2.5.1.54, aroF, aroG, aroH; 3-deoxy-7-phosphoheptulonate synthase [EC:2.5.1.54]	ko00400	NA
K01626_downstream.h1_2	Conserved sequence (low covariation and power)	K01626	downstream	E2.5.1.54, aroF, aroG, aroH; 3-deoxy-7-phosphoheptulonate synthase [EC:2.5.1.54]	map01100	Metabolic pathways
K01626_downstream.h1_2	Conserved sequence (low covariation and power)	K01626	downstream	E2.5.1.54, aroF, aroG, aroH; 3-deoxy-7-phosphoheptulonate synthase [EC:2.5.1.54]	ko01100	NA
K01626_downstream.h1_2	Conserved sequence (low covariation and power)	K01626	downstream	E2.5.1.54, aroF, aroG, aroH; 3-deoxy-7-phosphoheptulonate synthase [EC:2.5.1.54]	map01110	Biosynthesis of secondary metabolites
K01626_downstream.h1_2	Conserved sequence (low covariation and power)	K01626	downstream	E2.5.1.54, aroF, aroG, aroH; 3-deoxy-7-phosphoheptulonate synthase [EC:2.5.1.54]	ko01110	NA
K01626_downstream.h1_2	Conserved sequence (low covariation and power)	K01626	downstream	E2.5.1.54, aroF, aroG, aroH; 3-deoxy-7-phosphoheptulonate synthase [EC:2.5.1.54]	map01230	Biosynthesis of amino acids
K01626_downstream.h1_2	Conserved sequence (low covariation and power)	K01626	downstream	E2.5.1.54, aroF, aroG, aroH; 3-deoxy-7-phosphoheptulonate synthase [EC:2.5.1.54]	ko01230	NA
K01626_downstream.h1_2	Conserved sequence (low covariation and power)	K01626	downstream	E2.5.1.54, aroF, aroG, aroH; 3-deoxy-7-phosphoheptulonate synthase [EC:2.5.1.54]	map02024	Quorum sensing
K01626_downstream.h1_2	Conserved sequence (low covariation and power)	K01626	downstream	E2.5.1.54, aroF, aroG, aroH; 3-deoxy-7-phosphoheptulonate synthase [EC:2.5.1.54]	ko02024	NA
K01647_downstream.h1_2	High covariation	K01647	downstream	CS, gltA; citrate synthase [EC:2.3.3.1]	map00020	Citrate cycle (TCA cycle)
K01647_downstream.h1_2	High covariation	K01647	downstream	CS, gltA; citrate synthase [EC:2.3.3.1]	ko00020	NA
K01647_downstream.h1_2	High covariation	K01647	downstream	CS, gltA; citrate synthase [EC:2.3.3.1]	map00630	Glyoxylate and dicarboxylate metabolism
K01647_downstream.h1_2	High covariation	K01647	downstream	CS, gltA; citrate synthase [EC:2.3.3.1]	ko00630	NA
K01647_downstream.h1_2	High covariation	K01647	downstream	CS, gltA; citrate synthase [EC:2.3.3.1]	map01100	Metabolic pathways
K01647_downstream.h1_2	High covariation	K01647	downstream	CS, gltA; citrate synthase [EC:2.3.3.1]	ko01100	NA
K01647_downstream.h1_2	High covariation	K01647	downstream	CS, gltA; citrate synthase [EC:2.3.3.1]	map01110	Biosynthesis of secondary metabolites
K01647_downstream.h1_2	High covariation	K01647	downstream	CS, gltA; citrate synthase [EC:2.3.3.1]	ko01110	NA
K01647_downstream.h1_2	High covariation	K01647	downstream	CS, gltA; citrate synthase [EC:2.3.3.1]	map01120	Microbial metabolism in diverse environments
K01647_downstream.h1_2	High covariation	K01647	downstream	CS, gltA; citrate synthase [EC:2.3.3.1]	ko01120	NA
K01647_downstream.h1_2	High covariation	K01647	downstream	CS, gltA; citrate synthase [EC:2.3.3.1]	map01200	Carbon metabolism
K01647_downstream.h1_2	High covariation	K01647	downstream	CS, gltA; citrate synthase [EC:2.3.3.1]	ko01200	NA
K01647_downstream.h1_2	High covariation	K01647	downstream	CS, gltA; citrate synthase [EC:2.3.3.1]	map01210	2-Oxocarboxylic acid metabolism
K01647_downstream.h1_2	High covariation	K01647	downstream	CS, gltA; citrate synthase [EC:2.3.3.1]	ko01210	NA
K01647_downstream.h1_2	High covariation	K01647	downstream	CS, gltA; citrate synthase [EC:2.3.3.1]	map01230	Biosynthesis of amino acids
K01647_downstream.h1_2	High covariation	K01647	downstream	CS, gltA; citrate synthase [EC:2.3.3.1]	ko01230	NA
K01662_downstream.h2_2.h2_3.h2_1.h2_4	Conserved sequence (low covariation and power)	K01662	downstream	dxs; 1-deoxy-D-xylulose-5-phosphate synthase [EC:2.2.1.7]	map00730	Thiamine metabolism
K01662_downstream.h2_2.h2_3.h2_1.h2_4	Conserved sequence (low covariation and power)	K01662	downstream	dxs; 1-deoxy-D-xylulose-5-phosphate synthase [EC:2.2.1.7]	ko00730	NA
K01662_downstream.h2_2.h2_3.h2_1.h2_4	Conserved sequence (low covariation and power)	K01662	downstream	dxs; 1-deoxy-D-xylulose-5-phosphate synthase [EC:2.2.1.7]	map00900	Terpenoid backbone biosynthesis
K01662_downstream.h2_2.h2_3.h2_1.h2_4	Conserved sequence (low covariation and power)	K01662	downstream	dxs; 1-deoxy-D-xylulose-5-phosphate synthase [EC:2.2.1.7]	ko00900	NA
K01662_downstream.h2_2.h2_3.h2_1.h2_4	Conserved sequence (low covariation and power)	K01662	downstream	dxs; 1-deoxy-D-xylulose-5-phosphate synthase [EC:2.2.1.7]	map01100	Metabolic pathways
K01662_downstream.h2_2.h2_3.h2_1.h2_4	Conserved sequence (low covariation and power)	K01662	downstream	dxs; 1-deoxy-D-xylulose-5-phosphate synthase [EC:2.2.1.7]	ko01100	NA
K01662_downstream.h2_2.h2_3.h2_1.h2_4	Conserved sequence (low covariation and power)	K01662	downstream	dxs; 1-deoxy-D-xylulose-5-phosphate synthase [EC:2.2.1.7]	map01110	Biosynthesis of secondary metabolites
K01662_downstream.h2_2.h2_3.h2_1.h2_4	Conserved sequence (low covariation and power)	K01662	downstream	dxs; 1-deoxy-D-xylulose-5-phosphate synthase [EC:2.2.1.7]	ko01110	NA
K01687_downstream.h1_3.h2_5	Conserved sequence (low covariation and power)	K01687	downstream	ilvD; dihydroxy-acid dehydratase [EC:4.2.1.9]	map00290	Valine, leucine and isoleucine biosynthesis
K01687_downstream.h1_3.h2_5	Conserved sequence (low covariation and power)	K01687	downstream	ilvD; dihydroxy-acid dehydratase [EC:4.2.1.9]	ko00290	NA
K01687_downstream.h1_3.h2_5	Conserved sequence (low covariation and power)	K01687	downstream	ilvD; dihydroxy-acid dehydratase [EC:4.2.1.9]	map00770	Pantothenate and CoA biosynthesis
K01687_downstream.h1_3.h2_5	Conserved sequence (low covariation and power)	K01687	downstream	ilvD; dihydroxy-acid dehydratase [EC:4.2.1.9]	ko00770	NA
K01687_downstream.h1_3.h2_5	Conserved sequence (low covariation and power)	K01687	downstream	ilvD; dihydroxy-acid dehydratase [EC:4.2.1.9]	map01100	Metabolic pathways
K01687_downstream.h1_3.h2_5	Conserved sequence (low covariation and power)	K01687	downstream	ilvD; dihydroxy-acid dehydratase [EC:4.2.1.9]	ko01100	NA
K01687_downstream.h1_3.h2_5	Conserved sequence (low covariation and power)	K01687	downstream	ilvD; dihydroxy-acid dehydratase [EC:4.2.1.9]	map01110	Biosynthesis of secondary metabolites
K01687_downstream.h1_3.h2_5	Conserved sequence (low covariation and power)	K01687	downstream	ilvD; dihydroxy-acid dehydratase [EC:4.2.1.9]	ko01110	NA
K01687_downstream.h1_3.h2_5	Conserved sequence (low covariation and power)	K01687	downstream	ilvD; dihydroxy-acid dehydratase [EC:4.2.1.9]	map01210	2-Oxocarboxylic acid metabolism
K01687_downstream.h1_3.h2_5	Conserved sequence (low covariation and power)	K01687	downstream	ilvD; dihydroxy-acid dehydratase [EC:4.2.1.9]	ko01210	NA
K01687_downstream.h1_3.h2_5	Conserved sequence (low covariation and power)	K01687	downstream	ilvD; dihydroxy-acid dehydratase [EC:4.2.1.9]	map01230	Biosynthesis of amino acids
K01687_downstream.h1_3.h2_5	Conserved sequence (low covariation and power)	K01687	downstream	ilvD; dihydroxy-acid dehydratase [EC:4.2.1.9]	ko01230	NA
K01687_downstream.h1_4.h2_2.h2_3	Conserved sequence (low covariation and power)	K01687	downstream	ilvD; dihydroxy-acid dehydratase [EC:4.2.1.9]	map00290	Valine, leucine and isoleucine biosynthesis
K01687_downstream.h1_4.h2_2.h2_3	Conserved sequence (low covariation and power)	K01687	downstream	ilvD; dihydroxy-acid dehydratase [EC:4.2.1.9]	ko00290	NA
K01687_downstream.h1_4.h2_2.h2_3	Conserved sequence (low covariation and power)	K01687	downstream	ilvD; dihydroxy-acid dehydratase [EC:4.2.1.9]	map00770	Pantothenate and CoA biosynthesis
K01687_downstream.h1_4.h2_2.h2_3	Conserved sequence (low covariation and power)	K01687	downstream	ilvD; dihydroxy-acid dehydratase [EC:4.2.1.9]	ko00770	NA
K01687_downstream.h1_4.h2_2.h2_3	Conserved sequence (low covariation and power)	K01687	downstream	ilvD; dihydroxy-acid dehydratase [EC:4.2.1.9]	map01100	Metabolic pathways
K01687_downstream.h1_4.h2_2.h2_3	Conserved sequence (low covariation and power)	K01687	downstream	ilvD; dihydroxy-acid dehydratase [EC:4.2.1.9]	ko01100	NA
K01687_downstream.h1_4.h2_2.h2_3	Conserved sequence (low covariation and power)	K01687	downstream	ilvD; dihydroxy-acid dehydratase [EC:4.2.1.9]	map01110	Biosynthesis of secondary metabolites
K01687_downstream.h1_4.h2_2.h2_3	Conserved sequence (low covariation and power)	K01687	downstream	ilvD; dihydroxy-acid dehydratase [EC:4.2.1.9]	ko01110	NA
K01687_downstream.h1_4.h2_2.h2_3	Conserved sequence (low covariation and power)	K01687	downstream	ilvD; dihydroxy-acid dehydratase [EC:4.2.1.9]	map01210	2-Oxocarboxylic acid metabolism
K01687_downstream.h1_4.h2_2.h2_3	Conserved sequence (low covariation and power)	K01687	downstream	ilvD; dihydroxy-acid dehydratase [EC:4.2.1.9]	ko01210	NA
K01687_downstream.h1_4.h2_2.h2_3	Conserved sequence (low covariation and power)	K01687	downstream	ilvD; dihydroxy-acid dehydratase [EC:4.2.1.9]	map01230	Biosynthesis of amino acids
K01687_downstream.h1_4.h2_2.h2_3	Conserved sequence (low covariation and power)	K01687	downstream	ilvD; dihydroxy-acid dehydratase [EC:4.2.1.9]	ko01230	NA
K01736_downstream.h2_1	Conserved sequence (low covariation and power)	K01736	downstream	aroC; chorismate synthase [EC:4.2.3.5]	map00400	Phenylalanine, tyrosine and tryptophan biosynthesis
K01736_downstream.h2_1	Conserved sequence (low covariation and power)	K01736	downstream	aroC; chorismate synthase [EC:4.2.3.5]	ko00400	NA
K01736_downstream.h2_1	Conserved sequence (low covariation and power)	K01736	downstream	aroC; chorismate synthase [EC:4.2.3.5]	map01100	Metabolic pathways
K01736_downstream.h2_1	Conserved sequence (low covariation and power)	K01736	downstream	aroC; chorismate synthase [EC:4.2.3.5]	ko01100	NA
K01736_downstream.h2_1	Conserved sequence (low covariation and power)	K01736	downstream	aroC; chorismate synthase [EC:4.2.3.5]	map01110	Biosynthesis of secondary metabolites
K01736_downstream.h2_1	Conserved sequence (low covariation and power)	K01736	downstream	aroC; chorismate synthase [EC:4.2.3.5]	ko01110	NA
K01736_downstream.h2_1	Conserved sequence (low covariation and power)	K01736	downstream	aroC; chorismate synthase [EC:4.2.3.5]	map01230	Biosynthesis of amino acids
K01736_downstream.h2_1	Conserved sequence (low covariation and power)	K01736	downstream	aroC; chorismate synthase [EC:4.2.3.5]	ko01230	NA
K01807_downstream.h1_4	High covariation	K01807	downstream	rpiA; ribose 5-phosphate isomerase A [EC:5.3.1.6]	map00030	Pentose phosphate pathway
K01807_downstream.h1_4	High covariation	K01807	downstream	rpiA; ribose 5-phosphate isomerase A [EC:5.3.1.6]	ko00030	NA
K01807_downstream.h1_4	High covariation	K01807	downstream	rpiA; ribose 5-phosphate isomerase A [EC:5.3.1.6]	map00710	Carbon fixation by Calvin cycle
K01807_downstream.h1_4	High covariation	K01807	downstream	rpiA; ribose 5-phosphate isomerase A [EC:5.3.1.6]	ko00710	NA
K01807_downstream.h1_4	High covariation	K01807	downstream	rpiA; ribose 5-phosphate isomerase A [EC:5.3.1.6]	map01100	Metabolic pathways
K01807_downstream.h1_4	High covariation	K01807	downstream	rpiA; ribose 5-phosphate isomerase A [EC:5.3.1.6]	ko01100	NA
K01807_downstream.h1_4	High covariation	K01807	downstream	rpiA; ribose 5-phosphate isomerase A [EC:5.3.1.6]	map01110	Biosynthesis of secondary metabolites
K01807_downstream.h1_4	High covariation	K01807	downstream	rpiA; ribose 5-phosphate isomerase A [EC:5.3.1.6]	ko01110	NA
K01807_downstream.h1_4	High covariation	K01807	downstream	rpiA; ribose 5-phosphate isomerase A [EC:5.3.1.6]	map01120	Microbial metabolism in diverse environments
K01807_downstream.h1_4	High covariation	K01807	downstream	rpiA; ribose 5-phosphate isomerase A [EC:5.3.1.6]	ko01120	NA
K01807_downstream.h1_4	High covariation	K01807	downstream	rpiA; ribose 5-phosphate isomerase A [EC:5.3.1.6]	map01200	Carbon metabolism
K01807_downstream.h1_4	High covariation	K01807	downstream	rpiA; ribose 5-phosphate isomerase A [EC:5.3.1.6]	ko01200	NA
K01807_downstream.h1_4	High covariation	K01807	downstream	rpiA; ribose 5-phosphate isomerase A [EC:5.3.1.6]	map01230	Biosynthesis of amino acids
K01807_downstream.h1_4	High covariation	K01807	downstream	rpiA; ribose 5-phosphate isomerase A [EC:5.3.1.6]	ko01230	NA
K01807_downstream.h2_2.h2_3	Conserved sequence (low covariation and power)	K01807	downstream	rpiA; ribose 5-phosphate isomerase A [EC:5.3.1.6]	map00030	Pentose phosphate pathway
K01807_downstream.h2_2.h2_3	Conserved sequence (low covariation and power)	K01807	downstream	rpiA; ribose 5-phosphate isomerase A [EC:5.3.1.6]	ko00030	NA
K01807_downstream.h2_2.h2_3	Conserved sequence (low covariation and power)	K01807	downstream	rpiA; ribose 5-phosphate isomerase A [EC:5.3.1.6]	map00710	Carbon fixation by Calvin cycle
K01807_downstream.h2_2.h2_3	Conserved sequence (low covariation and power)	K01807	downstream	rpiA; ribose 5-phosphate isomerase A [EC:5.3.1.6]	ko00710	NA
K01807_downstream.h2_2.h2_3	Conserved sequence (low covariation and power)	K01807	downstream	rpiA; ribose 5-phosphate isomerase A [EC:5.3.1.6]	map01100	Metabolic pathways
K01807_downstream.h2_2.h2_3	Conserved sequence (low covariation and power)	K01807	downstream	rpiA; ribose 5-phosphate isomerase A [EC:5.3.1.6]	ko01100	NA
K01807_downstream.h2_2.h2_3	Conserved sequence (low covariation and power)	K01807	downstream	rpiA; ribose 5-phosphate isomerase A [EC:5.3.1.6]	map01110	Biosynthesis of secondary metabolites
K01807_downstream.h2_2.h2_3	Conserved sequence (low covariation and power)	K01807	downstream	rpiA; ribose 5-phosphate isomerase A [EC:5.3.1.6]	ko01110	NA
K01807_downstream.h2_2.h2_3	Conserved sequence (low covariation and power)	K01807	downstream	rpiA; ribose 5-phosphate isomerase A [EC:5.3.1.6]	map01120	Microbial metabolism in diverse environments
K01807_downstream.h2_2.h2_3	Conserved sequence (low covariation and power)	K01807	downstream	rpiA; ribose 5-phosphate isomerase A [EC:5.3.1.6]	ko01120	NA
K01807_downstream.h2_2.h2_3	Conserved sequence (low covariation and power)	K01807	downstream	rpiA; ribose 5-phosphate isomerase A [EC:5.3.1.6]	map01200	Carbon metabolism
K01807_downstream.h2_2.h2_3	Conserved sequence (low covariation and power)	K01807	downstream	rpiA; ribose 5-phosphate isomerase A [EC:5.3.1.6]	ko01200	NA
K01807_downstream.h2_2.h2_3	Conserved sequence (low covariation and power)	K01807	downstream	rpiA; ribose 5-phosphate isomerase A [EC:5.3.1.6]	map01230	Biosynthesis of amino acids
K01807_downstream.h2_2.h2_3	Conserved sequence (low covariation and power)	K01807	downstream	rpiA; ribose 5-phosphate isomerase A [EC:5.3.1.6]	ko01230	NA
K01807_downstream.h1_3	Conserved sequence (low covariation and power)	K01807	downstream	rpiA; ribose 5-phosphate isomerase A [EC:5.3.1.6]	map00030	Pentose phosphate pathway
K01807_downstream.h1_3	Conserved sequence (low covariation and power)	K01807	downstream	rpiA; ribose 5-phosphate isomerase A [EC:5.3.1.6]	ko00030	NA
K01807_downstream.h1_3	Conserved sequence (low covariation and power)	K01807	downstream	rpiA; ribose 5-phosphate isomerase A [EC:5.3.1.6]	map00710	Carbon fixation by Calvin cycle
K01807_downstream.h1_3	Conserved sequence (low covariation and power)	K01807	downstream	rpiA; ribose 5-phosphate isomerase A [EC:5.3.1.6]	ko00710	NA
K01807_downstream.h1_3	Conserved sequence (low covariation and power)	K01807	downstream	rpiA; ribose 5-phosphate isomerase A [EC:5.3.1.6]	map01100	Metabolic pathways
K01807_downstream.h1_3	Conserved sequence (low covariation and power)	K01807	downstream	rpiA; ribose 5-phosphate isomerase A [EC:5.3.1.6]	ko01100	NA
K01807_downstream.h1_3	Conserved sequence (low covariation and power)	K01807	downstream	rpiA; ribose 5-phosphate isomerase A [EC:5.3.1.6]	map01110	Biosynthesis of secondary metabolites
K01807_downstream.h1_3	Conserved sequence (low covariation and power)	K01807	downstream	rpiA; ribose 5-phosphate isomerase A [EC:5.3.1.6]	ko01110	NA
K01807_downstream.h1_3	Conserved sequence (low covariation and power)	K01807	downstream	rpiA; ribose 5-phosphate isomerase A [EC:5.3.1.6]	map01120	Microbial metabolism in diverse environments
K01807_downstream.h1_3	Conserved sequence (low covariation and power)	K01807	downstream	rpiA; ribose 5-phosphate isomerase A [EC:5.3.1.6]	ko01120	NA
K01807_downstream.h1_3	Conserved sequence (low covariation and power)	K01807	downstream	rpiA; ribose 5-phosphate isomerase A [EC:5.3.1.6]	map01200	Carbon metabolism
K01807_downstream.h1_3	Conserved sequence (low covariation and power)	K01807	downstream	rpiA; ribose 5-phosphate isomerase A [EC:5.3.1.6]	ko01200	NA
K01807_downstream.h1_3	Conserved sequence (low covariation and power)	K01807	downstream	rpiA; ribose 5-phosphate isomerase A [EC:5.3.1.6]	map01230	Biosynthesis of amino acids
K01807_downstream.h1_3	Conserved sequence (low covariation and power)	K01807	downstream	rpiA; ribose 5-phosphate isomerase A [EC:5.3.1.6]	ko01230	NA
K01807_downstream.h1_5	High covariation	K01807	downstream	rpiA; ribose 5-phosphate isomerase A [EC:5.3.1.6]	map00030	Pentose phosphate pathway
K01807_downstream.h1_5	High covariation	K01807	downstream	rpiA; ribose 5-phosphate isomerase A [EC:5.3.1.6]	ko00030	NA
K01807_downstream.h1_5	High covariation	K01807	downstream	rpiA; ribose 5-phosphate isomerase A [EC:5.3.1.6]	map00710	Carbon fixation by Calvin cycle
K01807_downstream.h1_5	High covariation	K01807	downstream	rpiA; ribose 5-phosphate isomerase A [EC:5.3.1.6]	ko00710	NA
K01807_downstream.h1_5	High covariation	K01807	downstream	rpiA; ribose 5-phosphate isomerase A [EC:5.3.1.6]	map01100	Metabolic pathways
K01807_downstream.h1_5	High covariation	K01807	downstream	rpiA; ribose 5-phosphate isomerase A [EC:5.3.1.6]	ko01100	NA
K01807_downstream.h1_5	High covariation	K01807	downstream	rpiA; ribose 5-phosphate isomerase A [EC:5.3.1.6]	map01110	Biosynthesis of secondary metabolites
K01807_downstream.h1_5	High covariation	K01807	downstream	rpiA; ribose 5-phosphate isomerase A [EC:5.3.1.6]	ko01110	NA
K01807_downstream.h1_5	High covariation	K01807	downstream	rpiA; ribose 5-phosphate isomerase A [EC:5.3.1.6]	map01120	Microbial metabolism in diverse environments
K01807_downstream.h1_5	High covariation	K01807	downstream	rpiA; ribose 5-phosphate isomerase A [EC:5.3.1.6]	ko01120	NA
K01807_downstream.h1_5	High covariation	K01807	downstream	rpiA; ribose 5-phosphate isomerase A [EC:5.3.1.6]	map01200	Carbon metabolism
K01807_downstream.h1_5	High covariation	K01807	downstream	rpiA; ribose 5-phosphate isomerase A [EC:5.3.1.6]	ko01200	NA
K01807_downstream.h1_5	High covariation	K01807	downstream	rpiA; ribose 5-phosphate isomerase A [EC:5.3.1.6]	map01230	Biosynthesis of amino acids
K01807_downstream.h1_5	High covariation	K01807	downstream	rpiA; ribose 5-phosphate isomerase A [EC:5.3.1.6]	ko01230	NA
K01870_downstream.h2_2	Conserved sequence (low covariation and power)	K01870	downstream	IARS, ileS; isoleucyl-tRNA synthetase [EC:6.1.1.5]	map00970	Aminoacyl-tRNA biosynthesis
K01870_downstream.h2_2	Conserved sequence (low covariation and power)	K01870	downstream	IARS, ileS; isoleucyl-tRNA synthetase [EC:6.1.1.5]	ko00970	NA
K01874_downstream.h1_2	High power (low covariation)	K01874	downstream	MARS, metG; methionyl-tRNA synthetase [EC:6.1.1.10]	map00450	Selenocompound metabolism
K01874_downstream.h1_2	High power (low covariation)	K01874	downstream	MARS, metG; methionyl-tRNA synthetase [EC:6.1.1.10]	ko00450	NA
K01874_downstream.h1_2	High power (low covariation)	K01874	downstream	MARS, metG; methionyl-tRNA synthetase [EC:6.1.1.10]	map00970	Aminoacyl-tRNA biosynthesis
K01874_downstream.h1_2	High power (low covariation)	K01874	downstream	MARS, metG; methionyl-tRNA synthetase [EC:6.1.1.10]	ko00970	NA
K01874_downstream.h1_2	High power (low covariation)	K01874	downstream	MARS, metG; methionyl-tRNA synthetase [EC:6.1.1.10]	map01100	Metabolic pathways
K01874_downstream.h1_2	High power (low covariation)	K01874	downstream	MARS, metG; methionyl-tRNA synthetase [EC:6.1.1.10]	ko01100	NA
K01890_downstream.h2_3	High power (low covariation)	K01890	downstream	FARSB, pheT; phenylalanyl-tRNA synthetase beta chain [EC:6.1.1.20]	map00970	Aminoacyl-tRNA biosynthesis
K01890_downstream.h2_3	High power (low covariation)	K01890	downstream	FARSB, pheT; phenylalanyl-tRNA synthetase beta chain [EC:6.1.1.20]	ko00970	NA
K01890_downstream.h2_1	High covariation	K01890	downstream	FARSB, pheT; phenylalanyl-tRNA synthetase beta chain [EC:6.1.1.20]	map00970	Aminoacyl-tRNA biosynthesis
K01890_downstream.h2_1	High covariation	K01890	downstream	FARSB, pheT; phenylalanyl-tRNA synthetase beta chain [EC:6.1.1.20]	ko00970	NA
K01895_downstream.h1_4.h2_2	Conserved sequence (low covariation and power)	K01895	downstream	ACSS1_2, acs; acetyl-CoA synthetase [EC:6.2.1.1]	map00010	Glycolysis / Gluconeogenesis
K01895_downstream.h1_4.h2_2	Conserved sequence (low covariation and power)	K01895	downstream	ACSS1_2, acs; acetyl-CoA synthetase [EC:6.2.1.1]	ko00010	NA
K01895_downstream.h1_4.h2_2	Conserved sequence (low covariation and power)	K01895	downstream	ACSS1_2, acs; acetyl-CoA synthetase [EC:6.2.1.1]	map00620	Pyruvate metabolism
K01895_downstream.h1_4.h2_2	Conserved sequence (low covariation and power)	K01895	downstream	ACSS1_2, acs; acetyl-CoA synthetase [EC:6.2.1.1]	ko00620	NA
K01895_downstream.h1_4.h2_2	Conserved sequence (low covariation and power)	K01895	downstream	ACSS1_2, acs; acetyl-CoA synthetase [EC:6.2.1.1]	map00630	Glyoxylate and dicarboxylate metabolism
K01895_downstream.h1_4.h2_2	Conserved sequence (low covariation and power)	K01895	downstream	ACSS1_2, acs; acetyl-CoA synthetase [EC:6.2.1.1]	ko00630	NA
K01895_downstream.h1_4.h2_2	Conserved sequence (low covariation and power)	K01895	downstream	ACSS1_2, acs; acetyl-CoA synthetase [EC:6.2.1.1]	map00640	Propanoate metabolism
K01895_downstream.h1_4.h2_2	Conserved sequence (low covariation and power)	K01895	downstream	ACSS1_2, acs; acetyl-CoA synthetase [EC:6.2.1.1]	ko00640	NA
K01895_downstream.h1_4.h2_2	Conserved sequence (low covariation and power)	K01895	downstream	ACSS1_2, acs; acetyl-CoA synthetase [EC:6.2.1.1]	map00680	Methane metabolism
K01895_downstream.h1_4.h2_2	Conserved sequence (low covariation and power)	K01895	downstream	ACSS1_2, acs; acetyl-CoA synthetase [EC:6.2.1.1]	ko00680	NA
K01895_downstream.h1_4.h2_2	Conserved sequence (low covariation and power)	K01895	downstream	ACSS1_2, acs; acetyl-CoA synthetase [EC:6.2.1.1]	map00720	Other carbon fixation pathways
K01895_downstream.h1_4.h2_2	Conserved sequence (low covariation and power)	K01895	downstream	ACSS1_2, acs; acetyl-CoA synthetase [EC:6.2.1.1]	ko00720	NA
K01895_downstream.h1_4.h2_2	Conserved sequence (low covariation and power)	K01895	downstream	ACSS1_2, acs; acetyl-CoA synthetase [EC:6.2.1.1]	map01100	Metabolic pathways
K01895_downstream.h1_4.h2_2	Conserved sequence (low covariation and power)	K01895	downstream	ACSS1_2, acs; acetyl-CoA synthetase [EC:6.2.1.1]	ko01100	NA
K01895_downstream.h1_4.h2_2	Conserved sequence (low covariation and power)	K01895	downstream	ACSS1_2, acs; acetyl-CoA synthetase [EC:6.2.1.1]	map01110	Biosynthesis of secondary metabolites
K01895_downstream.h1_4.h2_2	Conserved sequence (low covariation and power)	K01895	downstream	ACSS1_2, acs; acetyl-CoA synthetase [EC:6.2.1.1]	ko01110	NA
K01895_downstream.h1_4.h2_2	Conserved sequence (low covariation and power)	K01895	downstream	ACSS1_2, acs; acetyl-CoA synthetase [EC:6.2.1.1]	map01120	Microbial metabolism in diverse environments
K01895_downstream.h1_4.h2_2	Conserved sequence (low covariation and power)	K01895	downstream	ACSS1_2, acs; acetyl-CoA synthetase [EC:6.2.1.1]	ko01120	NA
K01895_downstream.h1_4.h2_2	Conserved sequence (low covariation and power)	K01895	downstream	ACSS1_2, acs; acetyl-CoA synthetase [EC:6.2.1.1]	map01200	Carbon metabolism
K01895_downstream.h1_4.h2_2	Conserved sequence (low covariation and power)	K01895	downstream	ACSS1_2, acs; acetyl-CoA synthetase [EC:6.2.1.1]	ko01200	NA
K01895_downstream.h1_2.h2_1	Conserved sequence (low covariation and power)	K01895	downstream	ACSS1_2, acs; acetyl-CoA synthetase [EC:6.2.1.1]	map00010	Glycolysis / Gluconeogenesis
K01895_downstream.h1_2.h2_1	Conserved sequence (low covariation and power)	K01895	downstream	ACSS1_2, acs; acetyl-CoA synthetase [EC:6.2.1.1]	ko00010	NA
K01895_downstream.h1_2.h2_1	Conserved sequence (low covariation and power)	K01895	downstream	ACSS1_2, acs; acetyl-CoA synthetase [EC:6.2.1.1]	map00620	Pyruvate metabolism
K01895_downstream.h1_2.h2_1	Conserved sequence (low covariation and power)	K01895	downstream	ACSS1_2, acs; acetyl-CoA synthetase [EC:6.2.1.1]	ko00620	NA
K01895_downstream.h1_2.h2_1	Conserved sequence (low covariation and power)	K01895	downstream	ACSS1_2, acs; acetyl-CoA synthetase [EC:6.2.1.1]	map00630	Glyoxylate and dicarboxylate metabolism
K01895_downstream.h1_2.h2_1	Conserved sequence (low covariation and power)	K01895	downstream	ACSS1_2, acs; acetyl-CoA synthetase [EC:6.2.1.1]	ko00630	NA
K01895_downstream.h1_2.h2_1	Conserved sequence (low covariation and power)	K01895	downstream	ACSS1_2, acs; acetyl-CoA synthetase [EC:6.2.1.1]	map00640	Propanoate metabolism
K01895_downstream.h1_2.h2_1	Conserved sequence (low covariation and power)	K01895	downstream	ACSS1_2, acs; acetyl-CoA synthetase [EC:6.2.1.1]	ko00640	NA
K01895_downstream.h1_2.h2_1	Conserved sequence (low covariation and power)	K01895	downstream	ACSS1_2, acs; acetyl-CoA synthetase [EC:6.2.1.1]	map00680	Methane metabolism
K01895_downstream.h1_2.h2_1	Conserved sequence (low covariation and power)	K01895	downstream	ACSS1_2, acs; acetyl-CoA synthetase [EC:6.2.1.1]	ko00680	NA
K01895_downstream.h1_2.h2_1	Conserved sequence (low covariation and power)	K01895	downstream	ACSS1_2, acs; acetyl-CoA synthetase [EC:6.2.1.1]	map00720	Other carbon fixation pathways
K01895_downstream.h1_2.h2_1	Conserved sequence (low covariation and power)	K01895	downstream	ACSS1_2, acs; acetyl-CoA synthetase [EC:6.2.1.1]	ko00720	NA
K01895_downstream.h1_2.h2_1	Conserved sequence (low covariation and power)	K01895	downstream	ACSS1_2, acs; acetyl-CoA synthetase [EC:6.2.1.1]	map01100	Metabolic pathways
K01895_downstream.h1_2.h2_1	Conserved sequence (low covariation and power)	K01895	downstream	ACSS1_2, acs; acetyl-CoA synthetase [EC:6.2.1.1]	ko01100	NA
K01895_downstream.h1_2.h2_1	Conserved sequence (low covariation and power)	K01895	downstream	ACSS1_2, acs; acetyl-CoA synthetase [EC:6.2.1.1]	map01110	Biosynthesis of secondary metabolites
K01895_downstream.h1_2.h2_1	Conserved sequence (low covariation and power)	K01895	downstream	ACSS1_2, acs; acetyl-CoA synthetase [EC:6.2.1.1]	ko01110	NA
K01895_downstream.h1_2.h2_1	Conserved sequence (low covariation and power)	K01895	downstream	ACSS1_2, acs; acetyl-CoA synthetase [EC:6.2.1.1]	map01120	Microbial metabolism in diverse environments
K01895_downstream.h1_2.h2_1	Conserved sequence (low covariation and power)	K01895	downstream	ACSS1_2, acs; acetyl-CoA synthetase [EC:6.2.1.1]	ko01120	NA
K01895_downstream.h1_2.h2_1	Conserved sequence (low covariation and power)	K01895	downstream	ACSS1_2, acs; acetyl-CoA synthetase [EC:6.2.1.1]	map01200	Carbon metabolism
K01895_downstream.h1_2.h2_1	Conserved sequence (low covariation and power)	K01895	downstream	ACSS1_2, acs; acetyl-CoA synthetase [EC:6.2.1.1]	ko01200	NA
K01915_downstream.h1_2	Conserved sequence (low covariation and power)	K01915	downstream	glnA, GLUL; glutamine synthetase [EC:6.3.1.2]	map00220	Arginine biosynthesis
K01915_downstream.h1_2	Conserved sequence (low covariation and power)	K01915	downstream	glnA, GLUL; glutamine synthetase [EC:6.3.1.2]	ko00220	NA
K01915_downstream.h1_2	Conserved sequence (low covariation and power)	K01915	downstream	glnA, GLUL; glutamine synthetase [EC:6.3.1.2]	map00250	Alanine, aspartate and glutamate metabolism
K01915_downstream.h1_2	Conserved sequence (low covariation and power)	K01915	downstream	glnA, GLUL; glutamine synthetase [EC:6.3.1.2]	ko00250	NA
K01915_downstream.h1_2	Conserved sequence (low covariation and power)	K01915	downstream	glnA, GLUL; glutamine synthetase [EC:6.3.1.2]	map00630	Glyoxylate and dicarboxylate metabolism
K01915_downstream.h1_2	Conserved sequence (low covariation and power)	K01915	downstream	glnA, GLUL; glutamine synthetase [EC:6.3.1.2]	ko00630	NA
K01915_downstream.h1_2	Conserved sequence (low covariation and power)	K01915	downstream	glnA, GLUL; glutamine synthetase [EC:6.3.1.2]	map00910	Nitrogen metabolism
K01915_downstream.h1_2	Conserved sequence (low covariation and power)	K01915	downstream	glnA, GLUL; glutamine synthetase [EC:6.3.1.2]	ko00910	NA
K01915_downstream.h1_2	Conserved sequence (low covariation and power)	K01915	downstream	glnA, GLUL; glutamine synthetase [EC:6.3.1.2]	map01100	Metabolic pathways
K01915_downstream.h1_2	Conserved sequence (low covariation and power)	K01915	downstream	glnA, GLUL; glutamine synthetase [EC:6.3.1.2]	ko01100	NA
K01915_downstream.h1_2	Conserved sequence (low covariation and power)	K01915	downstream	glnA, GLUL; glutamine synthetase [EC:6.3.1.2]	map01110	Biosynthesis of secondary metabolites
K01915_downstream.h1_2	Conserved sequence (low covariation and power)	K01915	downstream	glnA, GLUL; glutamine synthetase [EC:6.3.1.2]	ko01110	NA
K01915_downstream.h1_2	Conserved sequence (low covariation and power)	K01915	downstream	glnA, GLUL; glutamine synthetase [EC:6.3.1.2]	map01120	Microbial metabolism in diverse environments
K01915_downstream.h1_2	Conserved sequence (low covariation and power)	K01915	downstream	glnA, GLUL; glutamine synthetase [EC:6.3.1.2]	ko01120	NA
K01915_downstream.h1_2	Conserved sequence (low covariation and power)	K01915	downstream	glnA, GLUL; glutamine synthetase [EC:6.3.1.2]	map01230	Biosynthesis of amino acids
K01915_downstream.h1_2	Conserved sequence (low covariation and power)	K01915	downstream	glnA, GLUL; glutamine synthetase [EC:6.3.1.2]	ko01230	NA
K01915_downstream.h1_2	Conserved sequence (low covariation and power)	K01915	downstream	glnA, GLUL; glutamine synthetase [EC:6.3.1.2]	map02020	Two-component system
K01915_downstream.h1_2	Conserved sequence (low covariation and power)	K01915	downstream	glnA, GLUL; glutamine synthetase [EC:6.3.1.2]	ko02020	NA
K01915_downstream.h1_2	Conserved sequence (low covariation and power)	K01915	downstream	glnA, GLUL; glutamine synthetase [EC:6.3.1.2]	map04075	Plant hormone signal transduction
K01915_downstream.h1_2	Conserved sequence (low covariation and power)	K01915	downstream	glnA, GLUL; glutamine synthetase [EC:6.3.1.2]	ko04075	NA
K01915_downstream.h1_2	Conserved sequence (low covariation and power)	K01915	downstream	glnA, GLUL; glutamine synthetase [EC:6.3.1.2]	map04217	Necroptosis
K01915_downstream.h1_2	Conserved sequence (low covariation and power)	K01915	downstream	glnA, GLUL; glutamine synthetase [EC:6.3.1.2]	ko04217	NA
K01915_downstream.h1_2	Conserved sequence (low covariation and power)	K01915	downstream	glnA, GLUL; glutamine synthetase [EC:6.3.1.2]	map04724	Glutamatergic synapse
K01915_downstream.h1_2	Conserved sequence (low covariation and power)	K01915	downstream	glnA, GLUL; glutamine synthetase [EC:6.3.1.2]	ko04724	NA
K01915_downstream.h1_2	Conserved sequence (low covariation and power)	K01915	downstream	glnA, GLUL; glutamine synthetase [EC:6.3.1.2]	map04727	GABAergic synapse
K01915_downstream.h1_2	Conserved sequence (low covariation and power)	K01915	downstream	glnA, GLUL; glutamine synthetase [EC:6.3.1.2]	ko04727	NA
K01929_downstream.h1_1	Conserved sequence (low covariation and power)	K01929	downstream	murF; UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase [EC:6.3.2.10]	map00300	Lysine biosynthesis
K01929_downstream.h1_1	Conserved sequence (low covariation and power)	K01929	downstream	murF; UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase [EC:6.3.2.10]	ko00300	NA
K01929_downstream.h1_1	Conserved sequence (low covariation and power)	K01929	downstream	murF; UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase [EC:6.3.2.10]	map00550	Peptidoglycan biosynthesis
K01929_downstream.h1_1	Conserved sequence (low covariation and power)	K01929	downstream	murF; UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase [EC:6.3.2.10]	ko00550	NA
K01929_downstream.h1_1	Conserved sequence (low covariation and power)	K01929	downstream	murF; UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase [EC:6.3.2.10]	map01100	Metabolic pathways
K01929_downstream.h1_1	Conserved sequence (low covariation and power)	K01929	downstream	murF; UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase [EC:6.3.2.10]	ko01100	NA
K01929_downstream.h1_1	Conserved sequence (low covariation and power)	K01929	downstream	murF; UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase [EC:6.3.2.10]	map01502	Vancomycin resistance
K01929_downstream.h1_1	Conserved sequence (low covariation and power)	K01929	downstream	murF; UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase [EC:6.3.2.10]	ko01502	NA
K01961_downstream.h1_2	Conserved sequence (low covariation and power)	K01961	downstream	accC; acetyl-CoA carboxylase, biotin carboxylase subunit [EC:6.4.1.2 6.3.4.14]	map00061	Fatty acid biosynthesis
K01961_downstream.h1_2	Conserved sequence (low covariation and power)	K01961	downstream	accC; acetyl-CoA carboxylase, biotin carboxylase subunit [EC:6.4.1.2 6.3.4.14]	ko00061	NA
K01961_downstream.h1_2	Conserved sequence (low covariation and power)	K01961	downstream	accC; acetyl-CoA carboxylase, biotin carboxylase subunit [EC:6.4.1.2 6.3.4.14]	map00620	Pyruvate metabolism
K01961_downstream.h1_2	Conserved sequence (low covariation and power)	K01961	downstream	accC; acetyl-CoA carboxylase, biotin carboxylase subunit [EC:6.4.1.2 6.3.4.14]	ko00620	NA
K01961_downstream.h1_2	Conserved sequence (low covariation and power)	K01961	downstream	accC; acetyl-CoA carboxylase, biotin carboxylase subunit [EC:6.4.1.2 6.3.4.14]	map00640	Propanoate metabolism
K01961_downstream.h1_2	Conserved sequence (low covariation and power)	K01961	downstream	accC; acetyl-CoA carboxylase, biotin carboxylase subunit [EC:6.4.1.2 6.3.4.14]	ko00640	NA
K01961_downstream.h1_2	Conserved sequence (low covariation and power)	K01961	downstream	accC; acetyl-CoA carboxylase, biotin carboxylase subunit [EC:6.4.1.2 6.3.4.14]	map00720	Other carbon fixation pathways
K01961_downstream.h1_2	Conserved sequence (low covariation and power)	K01961	downstream	accC; acetyl-CoA carboxylase, biotin carboxylase subunit [EC:6.4.1.2 6.3.4.14]	ko00720	NA
K01961_downstream.h1_2	Conserved sequence (low covariation and power)	K01961	downstream	accC; acetyl-CoA carboxylase, biotin carboxylase subunit [EC:6.4.1.2 6.3.4.14]	map01100	Metabolic pathways
K01961_downstream.h1_2	Conserved sequence (low covariation and power)	K01961	downstream	accC; acetyl-CoA carboxylase, biotin carboxylase subunit [EC:6.4.1.2 6.3.4.14]	ko01100	NA
K01961_downstream.h1_2	Conserved sequence (low covariation and power)	K01961	downstream	accC; acetyl-CoA carboxylase, biotin carboxylase subunit [EC:6.4.1.2 6.3.4.14]	map01110	Biosynthesis of secondary metabolites
K01961_downstream.h1_2	Conserved sequence (low covariation and power)	K01961	downstream	accC; acetyl-CoA carboxylase, biotin carboxylase subunit [EC:6.4.1.2 6.3.4.14]	ko01110	NA
K01961_downstream.h1_2	Conserved sequence (low covariation and power)	K01961	downstream	accC; acetyl-CoA carboxylase, biotin carboxylase subunit [EC:6.4.1.2 6.3.4.14]	map01120	Microbial metabolism in diverse environments
K01961_downstream.h1_2	Conserved sequence (low covariation and power)	K01961	downstream	accC; acetyl-CoA carboxylase, biotin carboxylase subunit [EC:6.4.1.2 6.3.4.14]	ko01120	NA
K01961_downstream.h1_2	Conserved sequence (low covariation and power)	K01961	downstream	accC; acetyl-CoA carboxylase, biotin carboxylase subunit [EC:6.4.1.2 6.3.4.14]	map01200	Carbon metabolism
K01961_downstream.h1_2	Conserved sequence (low covariation and power)	K01961	downstream	accC; acetyl-CoA carboxylase, biotin carboxylase subunit [EC:6.4.1.2 6.3.4.14]	ko01200	NA
K01961_downstream.h1_2	Conserved sequence (low covariation and power)	K01961	downstream	accC; acetyl-CoA carboxylase, biotin carboxylase subunit [EC:6.4.1.2 6.3.4.14]	map01212	Fatty acid metabolism
K01961_downstream.h1_2	Conserved sequence (low covariation and power)	K01961	downstream	accC; acetyl-CoA carboxylase, biotin carboxylase subunit [EC:6.4.1.2 6.3.4.14]	ko01212	NA
K01961_downstream.h1_4.h2_4	Conserved sequence (low covariation and power)	K01961	downstream	accC; acetyl-CoA carboxylase, biotin carboxylase subunit [EC:6.4.1.2 6.3.4.14]	map00061	Fatty acid biosynthesis
K01961_downstream.h1_4.h2_4	Conserved sequence (low covariation and power)	K01961	downstream	accC; acetyl-CoA carboxylase, biotin carboxylase subunit [EC:6.4.1.2 6.3.4.14]	ko00061	NA
K01961_downstream.h1_4.h2_4	Conserved sequence (low covariation and power)	K01961	downstream	accC; acetyl-CoA carboxylase, biotin carboxylase subunit [EC:6.4.1.2 6.3.4.14]	map00620	Pyruvate metabolism
K01961_downstream.h1_4.h2_4	Conserved sequence (low covariation and power)	K01961	downstream	accC; acetyl-CoA carboxylase, biotin carboxylase subunit [EC:6.4.1.2 6.3.4.14]	ko00620	NA
K01961_downstream.h1_4.h2_4	Conserved sequence (low covariation and power)	K01961	downstream	accC; acetyl-CoA carboxylase, biotin carboxylase subunit [EC:6.4.1.2 6.3.4.14]	map00640	Propanoate metabolism
K01961_downstream.h1_4.h2_4	Conserved sequence (low covariation and power)	K01961	downstream	accC; acetyl-CoA carboxylase, biotin carboxylase subunit [EC:6.4.1.2 6.3.4.14]	ko00640	NA
K01961_downstream.h1_4.h2_4	Conserved sequence (low covariation and power)	K01961	downstream	accC; acetyl-CoA carboxylase, biotin carboxylase subunit [EC:6.4.1.2 6.3.4.14]	map00720	Other carbon fixation pathways
K01961_downstream.h1_4.h2_4	Conserved sequence (low covariation and power)	K01961	downstream	accC; acetyl-CoA carboxylase, biotin carboxylase subunit [EC:6.4.1.2 6.3.4.14]	ko00720	NA
K01961_downstream.h1_4.h2_4	Conserved sequence (low covariation and power)	K01961	downstream	accC; acetyl-CoA carboxylase, biotin carboxylase subunit [EC:6.4.1.2 6.3.4.14]	map01100	Metabolic pathways
K01961_downstream.h1_4.h2_4	Conserved sequence (low covariation and power)	K01961	downstream	accC; acetyl-CoA carboxylase, biotin carboxylase subunit [EC:6.4.1.2 6.3.4.14]	ko01100	NA
K01961_downstream.h1_4.h2_4	Conserved sequence (low covariation and power)	K01961	downstream	accC; acetyl-CoA carboxylase, biotin carboxylase subunit [EC:6.4.1.2 6.3.4.14]	map01110	Biosynthesis of secondary metabolites
K01961_downstream.h1_4.h2_4	Conserved sequence (low covariation and power)	K01961	downstream	accC; acetyl-CoA carboxylase, biotin carboxylase subunit [EC:6.4.1.2 6.3.4.14]	ko01110	NA
K01961_downstream.h1_4.h2_4	Conserved sequence (low covariation and power)	K01961	downstream	accC; acetyl-CoA carboxylase, biotin carboxylase subunit [EC:6.4.1.2 6.3.4.14]	map01120	Microbial metabolism in diverse environments
K01961_downstream.h1_4.h2_4	Conserved sequence (low covariation and power)	K01961	downstream	accC; acetyl-CoA carboxylase, biotin carboxylase subunit [EC:6.4.1.2 6.3.4.14]	ko01120	NA
K01961_downstream.h1_4.h2_4	Conserved sequence (low covariation and power)	K01961	downstream	accC; acetyl-CoA carboxylase, biotin carboxylase subunit [EC:6.4.1.2 6.3.4.14]	map01200	Carbon metabolism
K01961_downstream.h1_4.h2_4	Conserved sequence (low covariation and power)	K01961	downstream	accC; acetyl-CoA carboxylase, biotin carboxylase subunit [EC:6.4.1.2 6.3.4.14]	ko01200	NA
K01961_downstream.h1_4.h2_4	Conserved sequence (low covariation and power)	K01961	downstream	accC; acetyl-CoA carboxylase, biotin carboxylase subunit [EC:6.4.1.2 6.3.4.14]	map01212	Fatty acid metabolism
K01961_downstream.h1_4.h2_4	Conserved sequence (low covariation and power)	K01961	downstream	accC; acetyl-CoA carboxylase, biotin carboxylase subunit [EC:6.4.1.2 6.3.4.14]	ko01212	NA
K01961_downstream.h1_3	High power (low covariation)	K01961	downstream	accC; acetyl-CoA carboxylase, biotin carboxylase subunit [EC:6.4.1.2 6.3.4.14]	map00061	Fatty acid biosynthesis
K01961_downstream.h1_3	High power (low covariation)	K01961	downstream	accC; acetyl-CoA carboxylase, biotin carboxylase subunit [EC:6.4.1.2 6.3.4.14]	ko00061	NA
K01961_downstream.h1_3	High power (low covariation)	K01961	downstream	accC; acetyl-CoA carboxylase, biotin carboxylase subunit [EC:6.4.1.2 6.3.4.14]	map00620	Pyruvate metabolism
K01961_downstream.h1_3	High power (low covariation)	K01961	downstream	accC; acetyl-CoA carboxylase, biotin carboxylase subunit [EC:6.4.1.2 6.3.4.14]	ko00620	NA
K01961_downstream.h1_3	High power (low covariation)	K01961	downstream	accC; acetyl-CoA carboxylase, biotin carboxylase subunit [EC:6.4.1.2 6.3.4.14]	map00640	Propanoate metabolism
K01961_downstream.h1_3	High power (low covariation)	K01961	downstream	accC; acetyl-CoA carboxylase, biotin carboxylase subunit [EC:6.4.1.2 6.3.4.14]	ko00640	NA
K01961_downstream.h1_3	High power (low covariation)	K01961	downstream	accC; acetyl-CoA carboxylase, biotin carboxylase subunit [EC:6.4.1.2 6.3.4.14]	map00720	Other carbon fixation pathways
K01961_downstream.h1_3	High power (low covariation)	K01961	downstream	accC; acetyl-CoA carboxylase, biotin carboxylase subunit [EC:6.4.1.2 6.3.4.14]	ko00720	NA
K01961_downstream.h1_3	High power (low covariation)	K01961	downstream	accC; acetyl-CoA carboxylase, biotin carboxylase subunit [EC:6.4.1.2 6.3.4.14]	map01100	Metabolic pathways
K01961_downstream.h1_3	High power (low covariation)	K01961	downstream	accC; acetyl-CoA carboxylase, biotin carboxylase subunit [EC:6.4.1.2 6.3.4.14]	ko01100	NA
K01961_downstream.h1_3	High power (low covariation)	K01961	downstream	accC; acetyl-CoA carboxylase, biotin carboxylase subunit [EC:6.4.1.2 6.3.4.14]	map01110	Biosynthesis of secondary metabolites
K01961_downstream.h1_3	High power (low covariation)	K01961	downstream	accC; acetyl-CoA carboxylase, biotin carboxylase subunit [EC:6.4.1.2 6.3.4.14]	ko01110	NA
K01961_downstream.h1_3	High power (low covariation)	K01961	downstream	accC; acetyl-CoA carboxylase, biotin carboxylase subunit [EC:6.4.1.2 6.3.4.14]	map01120	Microbial metabolism in diverse environments
K01961_downstream.h1_3	High power (low covariation)	K01961	downstream	accC; acetyl-CoA carboxylase, biotin carboxylase subunit [EC:6.4.1.2 6.3.4.14]	ko01120	NA
K01961_downstream.h1_3	High power (low covariation)	K01961	downstream	accC; acetyl-CoA carboxylase, biotin carboxylase subunit [EC:6.4.1.2 6.3.4.14]	map01200	Carbon metabolism
K01961_downstream.h1_3	High power (low covariation)	K01961	downstream	accC; acetyl-CoA carboxylase, biotin carboxylase subunit [EC:6.4.1.2 6.3.4.14]	ko01200	NA
K01961_downstream.h1_3	High power (low covariation)	K01961	downstream	accC; acetyl-CoA carboxylase, biotin carboxylase subunit [EC:6.4.1.2 6.3.4.14]	map01212	Fatty acid metabolism
K01961_downstream.h1_3	High power (low covariation)	K01961	downstream	accC; acetyl-CoA carboxylase, biotin carboxylase subunit [EC:6.4.1.2 6.3.4.14]	ko01212	NA
K02033_downstream.h1_3	High covariation	K02033	downstream	ABC.PE.P; peptide/nickel transport system permease protein	map02024	Quorum sensing
K02033_downstream.h1_3	High covariation	K02033	downstream	ABC.PE.P; peptide/nickel transport system permease protein	ko02024	NA
K02095_downstream.h1_2.h2_3	High power (low covariation)	K02095	downstream	apcD; allophycocyanin-B	map00196	Photosynthesis - antenna proteins
K02095_downstream.h1_2.h2_3	High power (low covariation)	K02095	downstream	apcD; allophycocyanin-B	ko00196	NA
K02095_downstream.h1_2.h2_3	High power (low covariation)	K02095	downstream	apcD; allophycocyanin-B	map01100	Metabolic pathways
K02095_downstream.h1_2.h2_3	High power (low covariation)	K02095	downstream	apcD; allophycocyanin-B	ko01100	NA
K02110_downstream.h1_5	High covariation	K02110	downstream	ATPF0C, atpE; F-type H+-transporting ATPase subunit c	map00190	Oxidative phosphorylation
K02110_downstream.h1_5	High covariation	K02110	downstream	ATPF0C, atpE; F-type H+-transporting ATPase subunit c	ko00190	NA
K02110_downstream.h1_5	High covariation	K02110	downstream	ATPF0C, atpE; F-type H+-transporting ATPase subunit c	map00195	Photosynthesis
K02110_downstream.h1_5	High covariation	K02110	downstream	ATPF0C, atpE; F-type H+-transporting ATPase subunit c	ko00195	NA
K02110_downstream.h1_5	High covariation	K02110	downstream	ATPF0C, atpE; F-type H+-transporting ATPase subunit c	map01100	Metabolic pathways
K02110_downstream.h1_5	High covariation	K02110	downstream	ATPF0C, atpE; F-type H+-transporting ATPase subunit c	ko01100	NA
K02217_downstream.h2_2	Conserved sequence (low covariation and power)	K02217	downstream	ftnA, ftn; ferritin [EC:1.16.3.2]	NA	NA
K02221_downstream.h1_1	High covariation	K02221	downstream	yggT; YggT family protein	NA	NA
K02221_downstream.h2_2	High power (low covariation)	K02221	downstream	yggT; YggT family protein	NA	NA
K02221_downstream.h2_1	High power (low covariation)	K02221	downstream	yggT; YggT family protein	NA	NA
K02233_downstream.h1_4.h2_2.h1_5	Conserved sequence (low covariation and power)	K02233	downstream	E2.7.8.26, cobS, cobV; adenosylcobinamide-GDP ribazoletransferase [EC:2.7.8.26]	map00860	Porphyrin metabolism
K02233_downstream.h1_4.h2_2.h1_5	Conserved sequence (low covariation and power)	K02233	downstream	E2.7.8.26, cobS, cobV; adenosylcobinamide-GDP ribazoletransferase [EC:2.7.8.26]	ko00860	NA
K02233_downstream.h1_4.h2_2.h1_5	Conserved sequence (low covariation and power)	K02233	downstream	E2.7.8.26, cobS, cobV; adenosylcobinamide-GDP ribazoletransferase [EC:2.7.8.26]	map01100	Metabolic pathways
K02233_downstream.h1_4.h2_2.h1_5	Conserved sequence (low covariation and power)	K02233	downstream	E2.7.8.26, cobS, cobV; adenosylcobinamide-GDP ribazoletransferase [EC:2.7.8.26]	ko01100	NA
K02233_downstream.h1_4.h2_2.h1_5	Conserved sequence (low covariation and power)	K02233	downstream	E2.7.8.26, cobS, cobV; adenosylcobinamide-GDP ribazoletransferase [EC:2.7.8.26]	map01240	Biosynthesis of cofactors
K02233_downstream.h1_4.h2_2.h1_5	Conserved sequence (low covariation and power)	K02233	downstream	E2.7.8.26, cobS, cobV; adenosylcobinamide-GDP ribazoletransferase [EC:2.7.8.26]	ko01240	NA
K02294_downstream.h2_4	High power (low covariation)	K02294	downstream	crtR; beta-carotene hydroxylase [EC:1.14.13.-]	map00906	Carotenoid biosynthesis
K02294_downstream.h2_4	High power (low covariation)	K02294	downstream	crtR; beta-carotene hydroxylase [EC:1.14.13.-]	ko00906	NA
K02294_downstream.h2_4	High power (low covariation)	K02294	downstream	crtR; beta-carotene hydroxylase [EC:1.14.13.-]	map01100	Metabolic pathways
K02294_downstream.h2_4	High power (low covariation)	K02294	downstream	crtR; beta-carotene hydroxylase [EC:1.14.13.-]	ko01100	NA
K02294_downstream.h2_4	High power (low covariation)	K02294	downstream	crtR; beta-carotene hydroxylase [EC:1.14.13.-]	map01110	Biosynthesis of secondary metabolites
K02294_downstream.h2_4	High power (low covariation)	K02294	downstream	crtR; beta-carotene hydroxylase [EC:1.14.13.-]	ko01110	NA
K02313_downstream.h2_1	Conserved sequence (low covariation and power)	K02313	downstream	dnaA; chromosomal replication initiator protein	map02020	Two-component system
K02313_downstream.h2_1	Conserved sequence (low covariation and power)	K02313	downstream	dnaA; chromosomal replication initiator protein	ko02020	NA
K02313_downstream.h2_1	Conserved sequence (low covariation and power)	K02313	downstream	dnaA; chromosomal replication initiator protein	map04112	Cell cycle - Caulobacter
K02313_downstream.h2_1	Conserved sequence (low covariation and power)	K02313	downstream	dnaA; chromosomal replication initiator protein	ko04112	NA
K02337_downstream.h1_4	High covariation	K02337	downstream	dnaE; DNA polymerase III subunit alpha [EC:2.7.7.7]	map03030	DNA replication
K02337_downstream.h1_4	High covariation	K02337	downstream	dnaE; DNA polymerase III subunit alpha [EC:2.7.7.7]	ko03030	NA
K02337_downstream.h1_4	High covariation	K02337	downstream	dnaE; DNA polymerase III subunit alpha [EC:2.7.7.7]	map03430	Mismatch repair
K02337_downstream.h1_4	High covariation	K02337	downstream	dnaE; DNA polymerase III subunit alpha [EC:2.7.7.7]	ko03430	NA
K02337_downstream.h1_4	High covariation	K02337	downstream	dnaE; DNA polymerase III subunit alpha [EC:2.7.7.7]	map03440	Homologous recombination
K02337_downstream.h1_4	High covariation	K02337	downstream	dnaE; DNA polymerase III subunit alpha [EC:2.7.7.7]	ko03440	NA
K02337_downstream.h1_5	Conserved sequence (low covariation and power)	K02337	downstream	dnaE; DNA polymerase III subunit alpha [EC:2.7.7.7]	map03030	DNA replication
K02337_downstream.h1_5	Conserved sequence (low covariation and power)	K02337	downstream	dnaE; DNA polymerase III subunit alpha [EC:2.7.7.7]	ko03030	NA
K02337_downstream.h1_5	Conserved sequence (low covariation and power)	K02337	downstream	dnaE; DNA polymerase III subunit alpha [EC:2.7.7.7]	map03430	Mismatch repair
K02337_downstream.h1_5	Conserved sequence (low covariation and power)	K02337	downstream	dnaE; DNA polymerase III subunit alpha [EC:2.7.7.7]	ko03430	NA
K02337_downstream.h1_5	Conserved sequence (low covariation and power)	K02337	downstream	dnaE; DNA polymerase III subunit alpha [EC:2.7.7.7]	map03440	Homologous recombination
K02337_downstream.h1_5	Conserved sequence (low covariation and power)	K02337	downstream	dnaE; DNA polymerase III subunit alpha [EC:2.7.7.7]	ko03440	NA
K02341_downstream.h2_1.h2_2.h1_2	High power (low covariation)	K02341	downstream	holB; DNA polymerase III subunit delta' [EC:2.7.7.7]	map03030	DNA replication
K02341_downstream.h2_1.h2_2.h1_2	High power (low covariation)	K02341	downstream	holB; DNA polymerase III subunit delta' [EC:2.7.7.7]	ko03030	NA
K02341_downstream.h2_1.h2_2.h1_2	High power (low covariation)	K02341	downstream	holB; DNA polymerase III subunit delta' [EC:2.7.7.7]	map03430	Mismatch repair
K02341_downstream.h2_1.h2_2.h1_2	High power (low covariation)	K02341	downstream	holB; DNA polymerase III subunit delta' [EC:2.7.7.7]	ko03430	NA
K02341_downstream.h2_1.h2_2.h1_2	High power (low covariation)	K02341	downstream	holB; DNA polymerase III subunit delta' [EC:2.7.7.7]	map03440	Homologous recombination
K02341_downstream.h2_1.h2_2.h1_2	High power (low covariation)	K02341	downstream	holB; DNA polymerase III subunit delta' [EC:2.7.7.7]	ko03440	NA
K02356_downstream.h1_1	High covariation	K02356	downstream	efp; elongation factor P	NA	NA
K02435_downstream.h2_2.h2_4.h1_3	High power (low covariation)	K02435	downstream	gatC, GATC; aspartyl-tRNA(Asn)/glutamyl-tRNA(Gln) amidotransferase subunit C [EC:6.3.5.6 6.3.5.7]	map00970	Aminoacyl-tRNA biosynthesis
K02435_downstream.h2_2.h2_4.h1_3	High power (low covariation)	K02435	downstream	gatC, GATC; aspartyl-tRNA(Asn)/glutamyl-tRNA(Gln) amidotransferase subunit C [EC:6.3.5.6 6.3.5.7]	ko00970	NA
K02435_downstream.h2_2.h2_4.h1_3	High power (low covariation)	K02435	downstream	gatC, GATC; aspartyl-tRNA(Asn)/glutamyl-tRNA(Gln) amidotransferase subunit C [EC:6.3.5.6 6.3.5.7]	map01100	Metabolic pathways
K02435_downstream.h2_2.h2_4.h1_3	High power (low covariation)	K02435	downstream	gatC, GATC; aspartyl-tRNA(Asn)/glutamyl-tRNA(Gln) amidotransferase subunit C [EC:6.3.5.6 6.3.5.7]	ko01100	NA
K02435_downstream.h1_5.h2_1	High power (low covariation)	K02435	downstream	gatC, GATC; aspartyl-tRNA(Asn)/glutamyl-tRNA(Gln) amidotransferase subunit C [EC:6.3.5.6 6.3.5.7]	map00970	Aminoacyl-tRNA biosynthesis
K02435_downstream.h1_5.h2_1	High power (low covariation)	K02435	downstream	gatC, GATC; aspartyl-tRNA(Asn)/glutamyl-tRNA(Gln) amidotransferase subunit C [EC:6.3.5.6 6.3.5.7]	ko00970	NA
K02435_downstream.h1_5.h2_1	High power (low covariation)	K02435	downstream	gatC, GATC; aspartyl-tRNA(Asn)/glutamyl-tRNA(Gln) amidotransferase subunit C [EC:6.3.5.6 6.3.5.7]	map01100	Metabolic pathways
K02435_downstream.h1_5.h2_1	High power (low covariation)	K02435	downstream	gatC, GATC; aspartyl-tRNA(Asn)/glutamyl-tRNA(Gln) amidotransferase subunit C [EC:6.3.5.6 6.3.5.7]	ko01100	NA
K02503_downstream.h1_2	High covariation	K02503	downstream	HINT1_2, hinT, hit; histidine triad (HIT) family protein [EC:3.9.1.-]	NA	NA
K02668_downstream.h1_5	High covariation	K02668	downstream	pilS, pehS; two-component system, NtrC family, sensor histidine kinase PilS [EC:2.7.13.3]	map02020	Two-component system
K02668_downstream.h1_5	High covariation	K02668	downstream	pilS, pehS; two-component system, NtrC family, sensor histidine kinase PilS [EC:2.7.13.3]	ko02020	NA
K02700_downstream.h2_1	Conserved sequence (low covariation and power)	K02700	downstream	psaM; photosystem I subunit XII	map00195	Photosynthesis
K02700_downstream.h2_1	Conserved sequence (low covariation and power)	K02700	downstream	psaM; photosystem I subunit XII	ko00195	NA
K02700_downstream.h2_1	Conserved sequence (low covariation and power)	K02700	downstream	psaM; photosystem I subunit XII	map01100	Metabolic pathways
K02700_downstream.h2_1	Conserved sequence (low covariation and power)	K02700	downstream	psaM; photosystem I subunit XII	ko01100	NA
K02707_downstream.h1_5	High covariation	K02707	downstream	psbE; photosystem II cytochrome b559 subunit alpha	map00195	Photosynthesis
K02707_downstream.h1_5	High covariation	K02707	downstream	psbE; photosystem II cytochrome b559 subunit alpha	ko00195	NA
K02707_downstream.h1_5	High covariation	K02707	downstream	psbE; photosystem II cytochrome b559 subunit alpha	map01100	Metabolic pathways
K02707_downstream.h1_5	High covariation	K02707	downstream	psbE; photosystem II cytochrome b559 subunit alpha	ko01100	NA
K02707_downstream.h1_3	Conserved sequence (low covariation and power)	K02707	downstream	psbE; photosystem II cytochrome b559 subunit alpha	map00195	Photosynthesis
K02707_downstream.h1_3	Conserved sequence (low covariation and power)	K02707	downstream	psbE; photosystem II cytochrome b559 subunit alpha	ko00195	NA
K02707_downstream.h1_3	Conserved sequence (low covariation and power)	K02707	downstream	psbE; photosystem II cytochrome b559 subunit alpha	map01100	Metabolic pathways
K02707_downstream.h1_3	Conserved sequence (low covariation and power)	K02707	downstream	psbE; photosystem II cytochrome b559 subunit alpha	ko01100	NA
K02717_downstream.h2_1	Conserved sequence (low covariation and power)	K02717	downstream	psbP; photosystem II oxygen-evolving enhancer protein 2	map00195	Photosynthesis
K02717_downstream.h2_1	Conserved sequence (low covariation and power)	K02717	downstream	psbP; photosystem II oxygen-evolving enhancer protein 2	ko00195	NA
K02717_downstream.h2_1	Conserved sequence (low covariation and power)	K02717	downstream	psbP; photosystem II oxygen-evolving enhancer protein 2	map01100	Metabolic pathways
K02717_downstream.h2_1	Conserved sequence (low covariation and power)	K02717	downstream	psbP; photosystem II oxygen-evolving enhancer protein 2	ko01100	NA
K02835_downstream.h1_3	High power (low covariation)	K02835	downstream	prfA, MTRF1, MRF1; peptide chain release factor 1	NA	NA
K02860_downstream.h1_5	Conserved sequence (low covariation and power)	K02860	downstream	rimM; 16S rRNA processing protein RimM	NA	NA
K02860_downstream.h2_2.h2_3	Conserved sequence (low covariation and power)	K02860	downstream	rimM; 16S rRNA processing protein RimM	NA	NA
K02860_downstream.h1_1	Conserved sequence (low covariation and power)	K02860	downstream	rimM; 16S rRNA processing protein RimM	NA	NA
K02874_downstream.h2_1	High covariation	K02874	downstream	RP-L14, MRPL14, rplN; large subunit ribosomal protein L14	map03010	Ribosome
K02874_downstream.h2_1	High covariation	K02874	downstream	RP-L14, MRPL14, rplN; large subunit ribosomal protein L14	ko03010	NA
K02967_downstream.h1_1	High covariation	K02967	downstream	RP-S2, MRPS2, rpsB; small subunit ribosomal protein S2	map03010	Ribosome
K02967_downstream.h1_1	High covariation	K02967	downstream	RP-S2, MRPS2, rpsB; small subunit ribosomal protein S2	ko03010	NA
K02990_downstream.h1_2	Conserved sequence (low covariation and power)	K02990	downstream	RP-S6, MRPS6, rpsF; small subunit ribosomal protein S6	map03010	Ribosome
K02990_downstream.h1_2	Conserved sequence (low covariation and power)	K02990	downstream	RP-S6, MRPS6, rpsF; small subunit ribosomal protein S6	ko03010	NA
K03075_downstream.h2_5	Conserved sequence (low covariation and power)	K03075	downstream	secG; preprotein translocase subunit SecG	map02024	Quorum sensing
K03075_downstream.h2_5	Conserved sequence (low covariation and power)	K03075	downstream	secG; preprotein translocase subunit SecG	ko02024	NA
K03075_downstream.h2_5	Conserved sequence (low covariation and power)	K03075	downstream	secG; preprotein translocase subunit SecG	map03060	Protein export
K03075_downstream.h2_5	Conserved sequence (low covariation and power)	K03075	downstream	secG; preprotein translocase subunit SecG	ko03060	NA
K03075_downstream.h2_5	Conserved sequence (low covariation and power)	K03075	downstream	secG; preprotein translocase subunit SecG	map03070	Bacterial secretion system
K03075_downstream.h2_5	Conserved sequence (low covariation and power)	K03075	downstream	secG; preprotein translocase subunit SecG	ko03070	NA
K03075_downstream.h1_1	Conserved sequence (low covariation and power)	K03075	downstream	secG; preprotein translocase subunit SecG	map02024	Quorum sensing
K03075_downstream.h1_1	Conserved sequence (low covariation and power)	K03075	downstream	secG; preprotein translocase subunit SecG	ko02024	NA
K03075_downstream.h1_1	Conserved sequence (low covariation and power)	K03075	downstream	secG; preprotein translocase subunit SecG	map03060	Protein export
K03075_downstream.h1_1	Conserved sequence (low covariation and power)	K03075	downstream	secG; preprotein translocase subunit SecG	ko03060	NA
K03075_downstream.h1_1	Conserved sequence (low covariation and power)	K03075	downstream	secG; preprotein translocase subunit SecG	map03070	Bacterial secretion system
K03075_downstream.h1_1	Conserved sequence (low covariation and power)	K03075	downstream	secG; preprotein translocase subunit SecG	ko03070	NA
K03075_downstream.h2_2.h2_3.h2_4	Conserved sequence (low covariation and power)	K03075	downstream	secG; preprotein translocase subunit SecG	map02024	Quorum sensing
K03075_downstream.h2_2.h2_3.h2_4	Conserved sequence (low covariation and power)	K03075	downstream	secG; preprotein translocase subunit SecG	ko02024	NA
K03075_downstream.h2_2.h2_3.h2_4	Conserved sequence (low covariation and power)	K03075	downstream	secG; preprotein translocase subunit SecG	map03060	Protein export
K03075_downstream.h2_2.h2_3.h2_4	Conserved sequence (low covariation and power)	K03075	downstream	secG; preprotein translocase subunit SecG	ko03060	NA
K03075_downstream.h2_2.h2_3.h2_4	Conserved sequence (low covariation and power)	K03075	downstream	secG; preprotein translocase subunit SecG	map03070	Bacterial secretion system
K03075_downstream.h2_2.h2_3.h2_4	Conserved sequence (low covariation and power)	K03075	downstream	secG; preprotein translocase subunit SecG	ko03070	NA
K03075_downstream.h1_2.h1_3	Conserved sequence (low covariation and power)	K03075	downstream	secG; preprotein translocase subunit SecG	map02024	Quorum sensing
K03075_downstream.h1_2.h1_3	Conserved sequence (low covariation and power)	K03075	downstream	secG; preprotein translocase subunit SecG	ko02024	NA
K03075_downstream.h1_2.h1_3	Conserved sequence (low covariation and power)	K03075	downstream	secG; preprotein translocase subunit SecG	map03060	Protein export
K03075_downstream.h1_2.h1_3	Conserved sequence (low covariation and power)	K03075	downstream	secG; preprotein translocase subunit SecG	ko03060	NA
K03075_downstream.h1_2.h1_3	Conserved sequence (low covariation and power)	K03075	downstream	secG; preprotein translocase subunit SecG	map03070	Bacterial secretion system
K03075_downstream.h1_2.h1_3	Conserved sequence (low covariation and power)	K03075	downstream	secG; preprotein translocase subunit SecG	ko03070	NA
K03100_downstream.h2_2	Conserved sequence (low covariation and power)	K03100	downstream	lepB; signal peptidase I [EC:3.4.21.89]	map03060	Protein export
K03100_downstream.h2_2	Conserved sequence (low covariation and power)	K03100	downstream	lepB; signal peptidase I [EC:3.4.21.89]	ko03060	NA
K03181_downstream.h1_3.h1_5.h1_1	Conserved sequence (low covariation and power)	K03181	downstream	ubiC; chorismate lyase [EC:4.1.3.40]	map00130	Ubiquinone and other terpenoid-quinone biosynthesis
K03181_downstream.h1_3.h1_5.h1_1	Conserved sequence (low covariation and power)	K03181	downstream	ubiC; chorismate lyase [EC:4.1.3.40]	ko00130	NA
K03181_downstream.h1_3.h1_5.h1_1	Conserved sequence (low covariation and power)	K03181	downstream	ubiC; chorismate lyase [EC:4.1.3.40]	map01100	Metabolic pathways
K03181_downstream.h1_3.h1_5.h1_1	Conserved sequence (low covariation and power)	K03181	downstream	ubiC; chorismate lyase [EC:4.1.3.40]	ko01100	NA
K03181_downstream.h1_3.h1_5.h1_1	Conserved sequence (low covariation and power)	K03181	downstream	ubiC; chorismate lyase [EC:4.1.3.40]	map01110	Biosynthesis of secondary metabolites
K03181_downstream.h1_3.h1_5.h1_1	Conserved sequence (low covariation and power)	K03181	downstream	ubiC; chorismate lyase [EC:4.1.3.40]	ko01110	NA
K03181_downstream.h1_3.h1_5.h1_1	Conserved sequence (low covariation and power)	K03181	downstream	ubiC; chorismate lyase [EC:4.1.3.40]	map01240	Biosynthesis of cofactors
K03181_downstream.h1_3.h1_5.h1_1	Conserved sequence (low covariation and power)	K03181	downstream	ubiC; chorismate lyase [EC:4.1.3.40]	ko01240	NA
K03328_downstream.h1_2	High covariation	K03328	downstream	TC.PST; polysaccharide transporter, PST family	NA	NA
K03424_downstream.h2_1	High power (low covariation)	K03424	downstream	tatD; TatD DNase family protein [EC:3.1.21.-]	NA	NA
K03428_downstream.h1_3.h2_1	Conserved sequence (low covariation and power)	K03428	downstream	bchM, chlM; magnesium-protoporphyrin O-methyltransferase [EC:2.1.1.11]	map00860	Porphyrin metabolism
K03428_downstream.h1_3.h2_1	Conserved sequence (low covariation and power)	K03428	downstream	bchM, chlM; magnesium-protoporphyrin O-methyltransferase [EC:2.1.1.11]	ko00860	NA
K03428_downstream.h1_3.h2_1	Conserved sequence (low covariation and power)	K03428	downstream	bchM, chlM; magnesium-protoporphyrin O-methyltransferase [EC:2.1.1.11]	map01100	Metabolic pathways
K03428_downstream.h1_3.h2_1	Conserved sequence (low covariation and power)	K03428	downstream	bchM, chlM; magnesium-protoporphyrin O-methyltransferase [EC:2.1.1.11]	ko01100	NA
K03428_downstream.h1_3.h2_1	Conserved sequence (low covariation and power)	K03428	downstream	bchM, chlM; magnesium-protoporphyrin O-methyltransferase [EC:2.1.1.11]	map01110	Biosynthesis of secondary metabolites
K03428_downstream.h1_3.h2_1	Conserved sequence (low covariation and power)	K03428	downstream	bchM, chlM; magnesium-protoporphyrin O-methyltransferase [EC:2.1.1.11]	ko01110	NA
K03470_downstream.h2_1.h2_3	Conserved sequence (low covariation and power)	K03470	downstream	rnhB; ribonuclease HII [EC:3.1.26.4]	map03030	DNA replication
K03470_downstream.h2_1.h2_3	Conserved sequence (low covariation and power)	K03470	downstream	rnhB; ribonuclease HII [EC:3.1.26.4]	ko03030	NA
K03499_downstream.h1_5	Conserved sequence (low covariation and power)	K03499	downstream	trkA, ktrA, ktrC; trk/ktr system potassium uptake protein	NA	NA
K03499_downstream.h1_4.h2_3.h1_3	Conserved sequence (low covariation and power)	K03499	downstream	trkA, ktrA, ktrC; trk/ktr system potassium uptake protein	NA	NA
K03501_downstream.h2_2	Conserved sequence (low covariation and power)	K03501	downstream	gidB, rsmG; 16S rRNA (guanine527-N7)-methyltransferase [EC:2.1.1.170]	NA	NA
K03524_downstream.h1_4	Conserved sequence (low covariation and power)	K03524	downstream	birA; BirA family transcriptional regulator, biotin operon repressor / biotin---[acetyl-CoA-carboxylase] ligase [EC:6.3.4.15]	map00780	Biotin metabolism
K03524_downstream.h1_4	Conserved sequence (low covariation and power)	K03524	downstream	birA; BirA family transcriptional regulator, biotin operon repressor / biotin---[acetyl-CoA-carboxylase] ligase [EC:6.3.4.15]	ko00780	NA
K03524_downstream.h1_4	Conserved sequence (low covariation and power)	K03524	downstream	birA; BirA family transcriptional regulator, biotin operon repressor / biotin---[acetyl-CoA-carboxylase] ligase [EC:6.3.4.15]	map01100	Metabolic pathways
K03524_downstream.h1_4	Conserved sequence (low covariation and power)	K03524	downstream	birA; BirA family transcriptional regulator, biotin operon repressor / biotin---[acetyl-CoA-carboxylase] ligase [EC:6.3.4.15]	ko01100	NA
K03553_downstream.h2_1	Conserved sequence (low covariation and power)	K03553	downstream	recA; recombination protein RecA	map03440	Homologous recombination
K03553_downstream.h2_1	Conserved sequence (low covariation and power)	K03553	downstream	recA; recombination protein RecA	ko03440	NA
K03555_downstream.h1_3.h2_2	Conserved sequence (low covariation and power)	K03555	downstream	mutS; DNA mismatch repair protein MutS	map03430	Mismatch repair
K03555_downstream.h1_3.h2_2	Conserved sequence (low covariation and power)	K03555	downstream	mutS; DNA mismatch repair protein MutS	ko03430	NA
K03605_downstream.h1_3	Conserved sequence (low covariation and power)	K03605	downstream	hyaD, hybD; hydrogenase maturation protease [EC:3.4.23.-]	NA	NA
K03650_downstream.h1_4.h2_1	Conserved sequence (low covariation and power)	K03650	downstream	mnmE, trmE, MSS1; tRNA modification GTPase [EC:3.6.-.-]	NA	NA
K03664_downstream.h2_4	Conserved sequence (low covariation and power)	K03664	downstream	smpB; SsrA-binding protein	NA	NA
K03705_downstream.h2_1	Conserved sequence (low covariation and power)	K03705	downstream	hrcA; heat-inducible transcriptional repressor	NA	NA
K03727_downstream.h1_3.h2_4	Conserved sequence (low covariation and power)	K03727	downstream	helY; ATP-dependent RNA helicase HelY [EC:5.6.2.6]	NA	NA
K03727_downstream.h2_3	High power (low covariation)	K03727	downstream	helY; ATP-dependent RNA helicase HelY [EC:5.6.2.6]	NA	NA
K03786_downstream.h1_1	High covariation	K03786	downstream	aroQ, qutE; 3-dehydroquinate dehydratase II [EC:4.2.1.10]	map00400	Phenylalanine, tyrosine and tryptophan biosynthesis
K03786_downstream.h1_1	High covariation	K03786	downstream	aroQ, qutE; 3-dehydroquinate dehydratase II [EC:4.2.1.10]	ko00400	NA
K03786_downstream.h1_1	High covariation	K03786	downstream	aroQ, qutE; 3-dehydroquinate dehydratase II [EC:4.2.1.10]	map01100	Metabolic pathways
K03786_downstream.h1_1	High covariation	K03786	downstream	aroQ, qutE; 3-dehydroquinate dehydratase II [EC:4.2.1.10]	ko01100	NA
K03786_downstream.h1_1	High covariation	K03786	downstream	aroQ, qutE; 3-dehydroquinate dehydratase II [EC:4.2.1.10]	map01110	Biosynthesis of secondary metabolites
K03786_downstream.h1_1	High covariation	K03786	downstream	aroQ, qutE; 3-dehydroquinate dehydratase II [EC:4.2.1.10]	ko01110	NA
K03786_downstream.h1_1	High covariation	K03786	downstream	aroQ, qutE; 3-dehydroquinate dehydratase II [EC:4.2.1.10]	map01230	Biosynthesis of amino acids
K03786_downstream.h1_1	High covariation	K03786	downstream	aroQ, qutE; 3-dehydroquinate dehydratase II [EC:4.2.1.10]	ko01230	NA
K03800_downstream.h2_2	Conserved sequence (low covariation and power)	K03800	downstream	lplA, lplJ, lipL1; lipoate---protein ligase [EC:6.3.1.20]	map00785	Lipoic acid metabolism
K03800_downstream.h2_2	Conserved sequence (low covariation and power)	K03800	downstream	lplA, lplJ, lipL1; lipoate---protein ligase [EC:6.3.1.20]	ko00785	NA
K03800_downstream.h2_2	Conserved sequence (low covariation and power)	K03800	downstream	lplA, lplJ, lipL1; lipoate---protein ligase [EC:6.3.1.20]	map01100	Metabolic pathways
K03800_downstream.h2_2	Conserved sequence (low covariation and power)	K03800	downstream	lplA, lplJ, lipL1; lipoate---protein ligase [EC:6.3.1.20]	ko01100	NA
K03800_downstream.h2_2	Conserved sequence (low covariation and power)	K03800	downstream	lplA, lplJ, lipL1; lipoate---protein ligase [EC:6.3.1.20]	map01240	Biosynthesis of cofactors
K03800_downstream.h2_2	Conserved sequence (low covariation and power)	K03800	downstream	lplA, lplJ, lipL1; lipoate---protein ligase [EC:6.3.1.20]	ko01240	NA
K03800_downstream.h1_4	Conserved sequence (low covariation and power)	K03800	downstream	lplA, lplJ, lipL1; lipoate---protein ligase [EC:6.3.1.20]	map00785	Lipoic acid metabolism
K03800_downstream.h1_4	Conserved sequence (low covariation and power)	K03800	downstream	lplA, lplJ, lipL1; lipoate---protein ligase [EC:6.3.1.20]	ko00785	NA
K03800_downstream.h1_4	Conserved sequence (low covariation and power)	K03800	downstream	lplA, lplJ, lipL1; lipoate---protein ligase [EC:6.3.1.20]	map01100	Metabolic pathways
K03800_downstream.h1_4	Conserved sequence (low covariation and power)	K03800	downstream	lplA, lplJ, lipL1; lipoate---protein ligase [EC:6.3.1.20]	ko01100	NA
K03800_downstream.h1_4	Conserved sequence (low covariation and power)	K03800	downstream	lplA, lplJ, lipL1; lipoate---protein ligase [EC:6.3.1.20]	map01240	Biosynthesis of cofactors
K03800_downstream.h1_4	Conserved sequence (low covariation and power)	K03800	downstream	lplA, lplJ, lipL1; lipoate---protein ligase [EC:6.3.1.20]	ko01240	NA
K04075_downstream.h2_1	Conserved sequence (low covariation and power)	K04075	downstream	tilS, mesJ; tRNA(Ile)-lysidine synthase [EC:6.3.4.19]	NA	NA
K04485_downstream.h1_4	Conserved sequence (low covariation and power)	K04485	downstream	radA, sms; DNA repair protein RadA/Sms	NA	NA
K04485_downstream.h1_5.h2_1	Conserved sequence (low covariation and power)	K04485	downstream	radA, sms; DNA repair protein RadA/Sms	NA	NA
K04720_downstream.h1_3	High covariation	K04720	downstream	cobD; threonine-phosphate decarboxylase [EC:4.1.1.81]	map00860	Porphyrin metabolism
K04720_downstream.h1_3	High covariation	K04720	downstream	cobD; threonine-phosphate decarboxylase [EC:4.1.1.81]	ko00860	NA
K04720_downstream.h1_3	High covariation	K04720	downstream	cobD; threonine-phosphate decarboxylase [EC:4.1.1.81]	map01100	Metabolic pathways
K04720_downstream.h1_3	High covariation	K04720	downstream	cobD; threonine-phosphate decarboxylase [EC:4.1.1.81]	ko01100	NA
K05377_downstream.h1_5	Conserved sequence (low covariation and power)	K05377	downstream	cpeB, mpeB; phycoerythrin beta chain	map00196	Photosynthesis - antenna proteins
K05377_downstream.h1_5	Conserved sequence (low covariation and power)	K05377	downstream	cpeB, mpeB; phycoerythrin beta chain	ko00196	NA
K05377_downstream.h1_5	Conserved sequence (low covariation and power)	K05377	downstream	cpeB, mpeB; phycoerythrin beta chain	map01100	Metabolic pathways
K05377_downstream.h1_5	Conserved sequence (low covariation and power)	K05377	downstream	cpeB, mpeB; phycoerythrin beta chain	ko01100	NA
K06045_downstream.h2_3	Conserved sequence (low covariation and power)	K06045	downstream	shc; squalene-hopene/tetraprenyl-beta-curcumene cyclase [EC:5.4.99.17 4.2.1.129]	map00909	Sesquiterpenoid and triterpenoid biosynthesis
K06045_downstream.h2_3	Conserved sequence (low covariation and power)	K06045	downstream	shc; squalene-hopene/tetraprenyl-beta-curcumene cyclase [EC:5.4.99.17 4.2.1.129]	ko00909	NA
K06045_downstream.h2_3	Conserved sequence (low covariation and power)	K06045	downstream	shc; squalene-hopene/tetraprenyl-beta-curcumene cyclase [EC:5.4.99.17 4.2.1.129]	map01110	Biosynthesis of secondary metabolites
K06045_downstream.h2_3	Conserved sequence (low covariation and power)	K06045	downstream	shc; squalene-hopene/tetraprenyl-beta-curcumene cyclase [EC:5.4.99.17 4.2.1.129]	ko01110	NA
K06199_downstream.h2_1	Conserved sequence (low covariation and power)	K06199	downstream	crcB, FEX; fluoride exporter	NA	NA
K06381_downstream.h1_4.h2_4.h2_3	High power (low covariation)	K06381	downstream	spoIID; stage II sporulation protein D (peptidoglycan lytic transglycosylase) [EC:4.2.2.29]	NA	NA
K06442_downstream.h2_1	Conserved sequence (low covariation and power)	K06442	downstream	tlyA; 23S rRNA (cytidine1920-2'-O)/16S rRNA (cytidine1409-2'-O)-methyltransferase [EC:2.1.1.226 2.1.1.227]	NA	NA
K06864_downstream.h1_3.h2_3	Conserved sequence (low covariation and power)	K06864	downstream	larE; cysteine-dependent pyridinium-3,5-bisthiocarboxylic acid mononucleotide synthase [EC:4.4.1.37 4.4.1.45]	NA	NA
K06872_downstream.h1_5	Conserved sequence (low covariation and power)	K06872	downstream	K06872; uncharacterized protein	NA	NA
K06872_downstream.h1_3	Conserved sequence (low covariation and power)	K06872	downstream	K06872; uncharacterized protein	NA	NA
K06891_downstream.h1_3	Conserved sequence (low covariation and power)	K06891	downstream	clpS; ATP-dependent Clp protease adaptor protein ClpS	NA	NA
K06920_downstream.h1_1	High power (low covariation)	K06920	downstream	queC; 7-cyano-7-deazaguanine synthase [EC:6.3.4.20]	map00790	Folate biosynthesis
K06920_downstream.h1_1	High power (low covariation)	K06920	downstream	queC; 7-cyano-7-deazaguanine synthase [EC:6.3.4.20]	ko00790	NA
K06920_downstream.h1_1	High power (low covariation)	K06920	downstream	queC; 7-cyano-7-deazaguanine synthase [EC:6.3.4.20]	map01100	Metabolic pathways
K06920_downstream.h1_1	High power (low covariation)	K06920	downstream	queC; 7-cyano-7-deazaguanine synthase [EC:6.3.4.20]	ko01100	NA
K07007_downstream.h1_1.h1_5	High covariation	K07007	downstream	baiN; 3-dehydro-bile acid Delta4,6-reductase [EC:1.3.1.114]	map00121	Secondary bile acid biosynthesis
K07007_downstream.h1_1.h1_5	High covariation	K07007	downstream	baiN; 3-dehydro-bile acid Delta4,6-reductase [EC:1.3.1.114]	ko00121	NA
K07037_downstream.h1_5	Conserved sequence (low covariation and power)	K07037	downstream	pgpH; cyclic-di-AMP phosphodiesterase PgpH [EC:3.1.4.-]	NA	NA
K07071_downstream.h2_3	Conserved sequence (low covariation and power)	K07071	downstream	K07071; uncharacterized protein	NA	NA
K07079_downstream.h2_2	Conserved sequence (low covariation and power)	K07079	downstream	K07079; uncharacterized protein	NA	NA
K07399_downstream.h2_1.h2_3	Conserved sequence (low covariation and power)	K07399	downstream	resB, ccs1; cytochrome c biogenesis protein	NA	NA
K07399_downstream.h1_2	High covariation	K07399	downstream	resB, ccs1; cytochrome c biogenesis protein	NA	NA
K08482_downstream.h2_1.h2_3	Conserved sequence (low covariation and power)	K08482	downstream	kaiC; circadian clock protein KaiC	NA	NA
K09775_downstream.h2_1	Conserved sequence (low covariation and power)	K09775	downstream	K09775; uncharacterized protein	NA	NA
K09919_downstream.h1_3	Conserved sequence (low covariation and power)	K09919	downstream	K09919; uncharacterized protein	NA	NA
K11325_downstream.h2_1	High covariation	K11325	downstream	K11325; L-cysteine/cystine lyase	NA	NA
K12574_downstream.h1_2	Conserved sequence (low covariation and power)	K12574	downstream	rnj; ribonuclease J [EC:3.1.-.-]	map03018	RNA degradation
K12574_downstream.h1_2	Conserved sequence (low covariation and power)	K12574	downstream	rnj; ribonuclease J [EC:3.1.-.-]	ko03018	NA
K12574_downstream.h2_3	Conserved sequence (low covariation and power)	K12574	downstream	rnj; ribonuclease J [EC:3.1.-.-]	map03018	RNA degradation
K12574_downstream.h2_3	Conserved sequence (low covariation and power)	K12574	downstream	rnj; ribonuclease J [EC:3.1.-.-]	ko03018	NA
K12574_downstream.h1_4	Conserved sequence (low covariation and power)	K12574	downstream	rnj; ribonuclease J [EC:3.1.-.-]	map03018	RNA degradation
K12574_downstream.h1_4	Conserved sequence (low covariation and power)	K12574	downstream	rnj; ribonuclease J [EC:3.1.-.-]	ko03018	NA
K13005_downstream.h1_1	High covariation	K13005	downstream	rfbV, wbaV; O-antigen biosynthesis alpha-1,3-abequosyltransferase [EC:2.4.1.60]	NA	NA
K14441_downstream.h1_2	Conserved sequence (low covariation and power)	K14441	downstream	rimO; ribosomal protein S12 methylthiotransferase [EC:2.8.4.4]	NA	NA
K14441_downstream.h1_1	High covariation	K14441	downstream	rimO; ribosomal protein S12 methylthiotransferase [EC:2.8.4.4]	NA	NA
K18678_downstream.h2_4	Conserved sequence (low covariation and power)	K18678	downstream	VTE5; phytol kinase [EC:2.7.1.182]	NA	NA
K18678_downstream.h2_3	High covariation	K18678	downstream	VTE5; phytol kinase [EC:2.7.1.182]	NA	NA
K19032_downstream.h1_2	Conserved sequence (low covariation and power)	K19032	downstream	PSRP3; 30S ribosomal protein 3	map03010	Ribosome
K19032_downstream.h1_2	Conserved sequence (low covariation and power)	K19032	downstream	PSRP3; 30S ribosomal protein 3	ko03010	NA
K19294_downstream.h2_1	High covariation	K19294	downstream	algI; alginate O-acetyltransferase complex protein AlgI	map00543	Exopolysaccharide biosynthesis
K19294_downstream.h2_1	High covariation	K19294	downstream	algI; alginate O-acetyltransferase complex protein AlgI	ko00543	NA
K21703_downstream.h1_2	High power (low covariation)	K21703	downstream	cbbR, cmpR, ndhR; LysR family transcriptional regulator, low CO2-responsive transcriptional regulator	NA	NA
K21703_downstream.h2_1	High power (low covariation)	K21703	downstream	cbbR, cmpR, ndhR; LysR family transcriptional regulator, low CO2-responsive transcriptional regulator	NA	NA
K21703_downstream.h1_1.h1_3	Conserved sequence (low covariation and power)	K21703	downstream	cbbR, cmpR, ndhR; LysR family transcriptional regulator, low CO2-responsive transcriptional regulator	NA	NA