Center for non-coding RNA in Technology and Health (RTH)
The center aims at developing technologies, computational methods as well as experimental approaches for analysis of the mammalian genome for non-coding RNAs in relation to (inflammatory) diseases. The center will focus on developing these technologies to exploit them and the findings in relation to diabetes. The center consists of a number of national and international partners, with the core located at the Faculty for Health and Medical Sciences of University of Copenhagen.
The people in the center cover a range of expertises including computational biology, RNA bioinformatics, molecular models in diabetes, RNA biology, animal models, functional genomics and high-throughput sequence analysis.
We are always looking for motivated and talented young scientists as well as projects or colaborations within the areas of the center. Feel free to contact us with suggestions or to ask for more information.
Transcriptomic landscape of lncRNAs in inflammatory bowel disease
2015-05-13: Researchers lead by Prof Flemming Pociot from RTH publish the first paper on genome-wide transcriptome profiling of human long non-coding RNAs(lncRNAs) and protein-coding genes in Inflammatory bowel disease (IBD). The identified lncRNA transcriptional signature and clinically parameters suggest a biomarker potential in IBD. See the paper here.
For previous news, see here.
PhD Defense: Christian Garde
2016-02-04: Mechanisms and functions of protein-RNA interactions. The defense will take place Thursday 4 February 2016 at 13:00, Center for Biological Sequence Analysis, DTU, Building 208, auditorium 062
Everybody is welcome. Registration is not necessary.
For previous events, see here.
Foldalign 2.5: Parallel version for Foldalign for structural alignment of RNA sequences
The human genome, made up of DNA, consists of three billion building blocks (nucleotides) where some regions (stretches) are complete genes. We all carry variants of the genes and some cause diseases. Here, the goal is to investigate the specific class of genes, the non-coding RNA genes, in relation to diabetes. The non-coding RNA (ncRNA) genes can be the missing components in diseases that previously have been overlooked.
Our research goal is to develop technologies for ncRNA analysis and to search for functional ncRNAs in relation to diabetes and other (inflammatory) diseases.
Foldalign 2.5: multithreaded implementation for pairwise structural RNA alignment
Optimizing RNA structures by sequence extensions using RNAcop