Center for non-coding RNA in Technology and Health (RTH)

The center aims at developing technologies, computational methods as well as experimental approaches for analysis of the mammalian genome for non-coding RNAs in relation to (inflammatory) diseases. The center will focus on developing these technologies to exploit them and the findings in relation to diabetes. The center consists of a number of national and international partners, with the core located at the Faculty for Health and Medical Sciences of University of Copenhagen.

The people in the center cover a range of expertises including computational biology, RNA bioinformatics, molecular models in diabetes, RNA biology, animal models, functional genomics and high-throughput sequence analysis.

Join us


We are always looking for motivated and talented young scientists as well as projects or colaborations within the areas of the center. Feel free to contact us with suggestions or to ask for more information.

News


RNA bioinfomatics book

2014-03-25: New book on RNA com­pu­ta­tio­nal and bio­in­for­ma­tic methods

 

List of contents and link to the publisher here.

Read more.

For previous news, see here.

 

Events


Mini Workshop: From mutations in RNA structure to 3D motifs detection

2014-06-30: Mini workshop. University of Copenhagen. From 13.00 to 14.30, Grønnegårdsvej 3; 2nd floor library. Speakers: Jermone Waldispuhl and Craig Zirbel

Read more.

cphRNA 2014 - Symposium "non-coding RNAs: from Discovery to Function"

2014-06-27: cphRNA 2014 - Symposium "non-coding RNAs: from Discovery to Function" (free),  09.15-17.05,  at festauditoriet, A1-01.01, Frederiksberg Campus, Bulowsvej 17, 1870 Frederiksberg C, Denmark. Organised by RTH and COAT.

Read more.

cphRNA 2014: Summer School in RNA Bioinformatics

RTH and COAT are co-organizing a Summer School in RNA Bioinformatics.

The event will take place on June 23rd to June 28th in the Copenhagen area. Details to follow. Program and application procedure will be made available here.

Read more.

For previous events, see here.

Recent resources


miRPD: miRNA-Protein-Disease as­so­ci­a­ti­ons

Software and Data Resource

miRNA-Disease associations inferred from Protein-dicease associations

Meta RNA Modules

Software

RNA 3D modules in structural alignments

DeepBlockAlign for RNA-seq of miRNA

Webserver

Compare RNA-seq data to a database of pre-compiled miRNA RNA-seq profiles

 

Research outset


The human genome, made up of DNA, consists of three billion building blocks (nucleotides) where some regions (stretches) are complete genes. We all carry variants of the genes and some cause diseases. Here, the goal is to investigate the specific class of genes, the non-coding RNA genes, in relation to diabetes. The non-coding RNA (ncRNA) genes can be the missing components in diseases that previously have been overlooked.

Our research goal is to develop technologies for ncRNA analysis and to search for functional ncRNAs in relation to diabetes and other (inflammatory) diseases.

Read more.

Recent publications


Transcriptome-Wide Analysis of UTRs in Non-Small Cell Lung Cancer Reveals Cancer-Related Genes with SNV- Induced Changes on RNA Secondary Structure and miRNA Target Sites
Sabarinathan R, Wenzel A, Novotny P, Tang X, Kalari KR, Gorodkin J
PLoS One. 9:e82699, 2014
[ PubMed | Paper ]

Protein-driven inference of miRNA-disease as­so­ci­a­ti­ons
Mørk S, Pletscher-Frankild S, Caro AP, Gorodkin J, Jensen LJ
Bioinformatics. 30:392-7, 2014
[ PubMed | Paper | Software | Dataresource ]