Center for non-coding RNA in Technology and Health (RTH)

The center aims at developing technologies, computational methods as well as experimental approaches for analysis of the mammalian genome for non-coding RNAs in relation to (inflammatory) diseases. The center will focus on developing these technologies to exploit them and the findings in relation to diabetes. The center consists of a number of national and international partners, with the core located at the Faculty for Health and Medical Sciences of University of Copenhagen.

The people in the center cover a range of expertises including computational biology, RNA bioinformatics, molecular models in diabetes, RNA biology, animal models, functional genomics and high-throughput sequence analysis.

Join us


We are always looking for motivated and talented young scientists as well as projects or colaborations within the areas of the center. Feel free to contact us with suggestions or to ask for more information.

News


RISearch2

RTH publishes a new RNA-RNA inter­action predic­tion method, RIsearch2, that can perform large-scale screens with an exceptional runtime. RIsearch2 together with its post-processing pipe­line is a state-of-the-art method for transcriptome-wide prediction of siRNA off-targets. Read paper here.

For previous news, see here.

 

Events


We are currently planning more seminars, stay tuned

For previous events, see here.

Recent resources


RNAscClust

Software

RNAscClust clusters RNAs taking structure conservation into account

RIsearch2

Software

Large-scale prediction of RNA-RNA interactions and siRNA off-targets

RAIN

Webserver

Searching RNA-protien interactions in STRING integrated framework

 

Research outset


The human genome, made up of DNA, consists of three billion building blocks (nucleotides) where some regions (stretches) are complete genes. We all carry variants of the genes and some cause diseases. Here, the goal is to investigate the specific class of genes, the non-coding RNA genes, in relation to diabetes. The non-coding RNA (ncRNA) genes can be the missing components in diseases that previously have been overlooked.

Our research goal is to develop technologies for ncRNA analysis and to search for functional ncRNAs in relation to diabetes and other (inflammatory) diseases.

Read more.

Recent publications


Assessing the miRNA sponge potential of RUNX1T1 in t(8;21) acute myeloid leukemia
Junge A, Zandi R, Havgaard JH, Gorodkin J, Cowland JB Gene 2017, 615:35-40
[ Paper ]

RNAscClust : clustering RNA sequences using structure conservation and graph based motifs
Miladi M, Junge A, Costa F, Seemann SE, Havgaard JH, Gorodkin J, et al. Bioinformatics 2017, e-pub
[ Paper | Software ]