Center for non-coding RNA in Technology and Health (RTH)
The center aims at developing technologies, computational methods as well as experimental approaches for analysis of the mammalian genome for non-coding RNAs in relation to (inflammatory) diseases. The center will focus on developing these technologies to exploit them and the findings in relation to diabetes. The center consists of a number of national and international partners, with the core located at the Faculty for Health and Medical Sciences of University of Copenhagen.
The people in the center cover a range of expertises including computational biology, RNA bioinformatics, molecular models in diabetes, RNA biology, animal models, functional genomics and high-throughput sequence analysis.
Join usWe are always looking for motivated and talented young scientists as well as projects or colaborations within the areas of the center. Feel free to contact us with suggestions or to ask for more information. NewsRTH contributes to the RNA annotation of the porcine genome2012-11-15: Through joint national and international collaborations RTH contributes to the annotation of the porcine genome, constituting one of the largest efforts in annotation of noncoding RNAs in a single go in a released mammalian genome sequence. For previous news, see here. |
EventsSeminar: Tales from the Cellular Underworld: mRNA Decay and Disease2013-07-04: by Lynne Maquat Lynne E. Maquat, Center for RNA Biology, University of Rochester, USA. The Seminar will take place on July 4th, 11.15am -12.00pm at University of Copenhagen, SUND/LIFE, A1-01.15 / Building 1-01, Bülowsvej 17, 1. sal, 1870 Frederiksberg C. For previous events, see here. Recent resourcesStructured RNAs in the pig genomeAnnotation of structured RNAs in the pig genome by sequence, structrure homology, RNAseq data and de novo predictions |
Research outsetThe human genome, made up of DNA, consists of three billion building blocks (nucleotides) where some regions (stretches) are complete genes. We all carry variants of the genes and some cause diseases. Here, the goal is to investigate the specific class of genes, the non-coding RNA genes, in relation to diabetes. The non-coding RNA (ncRNA) genes can be the missing components in diseases that previously have been overlooked. Our research goal is to develop technologies for ncRNA analysis and to search for functional ncRNAs in relation to diabetes and other (inflammatory) diseases. Recent publicationsThe RNAsnp web server: predicting SNP effects on local RNA secondary structure RNAsnp: efficient detection of local RNA secondary structure changes induced by SNPs |