Center for non-coding RNA in Technology and Health (RTH)

The center aims at developing technologies, computational methods as well as experimental approaches for analysis of the mammalian genome for non-coding RNAs in relation to (inflammatory) diseases. The center will focus on developing these technologies to exploit them and the findings in relation to diabetes. The center consists of a number of national and international partners, with the core located at the Faculty for Health and Medical Sciences of University of Copenhagen.

The people in the center cover a range of expertises including computational biology, RNA bioinformatics, molecular models in diabetes, RNA biology, animal models, functional genomics and high-throughput sequence analysis.

Join us


We are always looking for motivated and talented young scientists as well as projects or colaborations within the areas of the center. Feel free to contact us with suggestions or to ask for more information.

News


For previous news, see here.

 

Events


Workshop: From Animal Genomics to Functional Analysis

2016-11-23: University of Copenhagen, Frederiksberg Campus, Grønnegårdsvej 7, building 1-04, 2nd floor library from 13:00-16:05. Speakers: Ted Kalbfleisch, Mogens Sandø Lund, Alan Archibald and Merete Fredholm

Read more.

For previous events, see here.

Recent resources


Foldalign 2.5

Webserver and Software

Foldalign 2.5: Parallel version for Foldalign for structural alignment of RNA sequences

RNAcop

Webserver and Software

RNAcop: Optimizing RNA structures by sequence extensions

RPAsuite

Software

Differential and coherent processing: Analyzing RNAseq data for pattern differences from different samples

 

Research outset


The human genome, made up of DNA, consists of three billion building blocks (nucleotides) where some regions (stretches) are complete genes. We all carry variants of the genes and some cause diseases. Here, the goal is to investigate the specific class of genes, the non-coding RNA genes, in relation to diabetes. The non-coding RNA (ncRNA) genes can be the missing components in diseases that previously have been overlooked.

Our research goal is to develop technologies for ncRNA analysis and to search for functional ncRNAs in relation to diabetes and other (inflammatory) diseases.

Read more.

Recent publications


Quality Assessment of Domesticated Animal Genome Assemblies
Seemann SE, Anthon C, Palasca O, Gorodkin J Bioinform Biol Insights. 9(Suppl 4):49-58, 2016
[ Paper ]

Foldalign 2.5: multithreaded implementation for pairwise structural RNA alignment
Sundfeld D, Havgaard JH, de Melo AC, Gorodkin J Bioinformatics. 32:1238-40, 2016
[ PubMed | Paper | Webserver | Software ]