Center for non-coding RNA in Technology and Health (RTH)

The center aims at developing technologies, computational methods as well as experimental approaches for analysis of the mammalian genome for non-coding RNAs in relation to (inflammatory) diseases. The center will focus on developing these technologies to exploit them and the findings in relation to diabetes. The center consists of a number of national and international partners, with the core located at the Faculty for Health and Medical Sciences of University of Copenhagen.

The people in the center cover a range of expertises including computational biology, RNA bioinformatics, molecular models in diabetes, RNA biology, animal models, functional genomics and high-throughput sequence analysis.

Join us

Postdoc in RNA Bioinformatics and Systems Biology

We are offering a two year Postdoc position in RNA Bioinformatics and Systems Biology to commence on 1st April 2018 or as soon as possible thereafter.

Application deadline: 24-03-2018

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Postdoc in Bioinformatics and Neurotranscriptomics

We are offering a Postdoc in Bioinformatics and Neurotranscriptomics to commence on 1st April 2018 or as soon as possible thereafter.

Application deadline: 24-03-2018

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Research Project Manager Assistant (part time)

We are looking for a new team member from 1 May 2018 or as soon as possible thereafter to provide crucial assistance to the groups Project Manager in providing the day-to-day administration and secretarial needs primarily to the large research projects, BrainStem and NextProd. The part time position is available until 31 December 2020. Application deadline: 02-04-2018


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Conserved RNA structure in the dark matter

2017-05-14: RTH researchers discover ~500,000 conserved RNA structures (CRSs) in the dark matter of the genome by using an RNA structural alignment strategy of the vertebrate genomes. The discovered CRSs locate near known genes, regulatory regions and protein binding sites. Expression studies, especially a CRS targeting CaptureSeq experiment in human fetal brain, were employed to characterize the CRSs further. Read more in the paper here.

For previous news, see here.



Seminar: RNase E endonuclease as a novel maturation enzyme of a CRISPR_Cas system and in the sRNA-mediated regulation of gene expression

2018-04-25: Wolfgang Hess, University of Freiburg, DE. The seminar will take place April 25, 15.15 - 16.00 at University of Copenhagen, SUND/SCIENCE, Building 1-04, Grønnegårdsvej 7, 1st floor library, Frederiksberg C.

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For previous events, see here.

Recent resources

Structured RNAs in the vertebrate genome

Data Resource and Supplement

Conserved RNA structures in vertebrate genomes



RNAscClust clusters RNAs taking structure conservation into account



Large-scale prediction of RNA-RNA interactions and siRNA off-targets


Research outset

The human genome, made up of DNA, consists of three billion building blocks (nucleotides) where some regions (stretches) are complete genes. We all carry variants of the genes and some cause diseases. Here, the goal is to investigate the specific class of genes, the non-coding RNA genes, in relation to diabetes. The non-coding RNA (ncRNA) genes can be the missing components in diseases that previously have been overlooked.

Our research goal is to develop technologies for ncRNA analysis and to search for functional ncRNAs in relation to diabetes and other (inflammatory) diseases.

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Recent publications

Translational co-regulation of a ligand and inhibitor by a conserved RNA element
Zaucker A, Nagorska A, Kumari P, Hecker N, Wang Y, Huang S, et al. Nucleic Acids Res. 2018 Jan 9;46(1):104-119.
[ PubMed | Paper ]

Comparative RNA Genomics
Backofen R, Gorodkin J, Hofacker IL, Stadler PF Comparative RNA Genomics In Comparative Genomics. Setubal JC, Stoye J, Stadler PF (Ed.), Methods Mol Biol. 2018;1704:363-400.
[ PubMed | Chapter ]