CRISPR-Cas9 energy model


2018-10-26: We present a novel energy model for the CRISPR-Cas9 system by modeling the nucleotide duplex binding energy. This model account for a portion of the off-target data from NGS applications as well as perform better than machine learning models. We also provide a specificity measure for how well a gRNA is on-target versus off-target. Read the full article or visit the  webserver.

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