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RTH contributes to the RNA annotation of the porcine genome |
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2012 Nov 15: Through joint national and international collaborations RTH contributes to the annotation of the porcine genome, constituting one of the largest efforts in annotation of noncoding RNAs (ncRNAs) in a single go in a released mammalian genome sequence.
The annotation was conducted by searching for similarity to RNAs from other organisms taking the structural aspect of RNA into account followed by careful semi-automatic curation on selected subsets of the data. In the porcine genome the curation procedure reduced the number of candidate RNA loci from 3,601 loci to 1,976. A particularly interesting example is the class of yRNAs, part of a molecular complex involved in quality control in the cell. It is found in four closely situated copies in mammalian genomes, but in the porcine genome we found that the sequence of one of the four copies were altered to a degree were it is unlikely to be active.
Official press release for the pig genome
Press release from University of Copenhagen
Download the porcine genome paper from Nature