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SRPDB assists the study of the structures and functions of signal recognition particles (SRPs). SRPDB provides annotated SRP RNA and SRP protein sequences, phylogenetically ordered and aligned. Included are representative RNA secondary structure diagrams where each base pair is proven by comparative sequence analysis, information about other proteins that play a role in SRP-mediated protein transloaction, as well as structural information about components of SRP.

Recent developments: A total of 1109 SRP RNA sequences grouped as Short bacterial (537), Long bacterial (96), Archaeal (81), Protozoan (82), Fungal/Metazoan-group (80), Plant (114), and Animal (119) SRP RNAs. See Rosenblad, M.A., Larsen, N., Samuelsson, T., and Zwieb, C. (2009) Kinship in the SRP RNA family. RNA Biol. 6, 508-516. [Abstract]
Direct data submissions, questions, complaints, suggestions, etc. about SRPDB to

Christian Zwieb, Department of Biochemistry
University of Texas Health Science Center at San Antionio

For specific questions, please contact the SRPDB Associates
Ebbe Andersen, see also Biodesign
Jan Gorodkin
Niels Larsen
Magnus Alm Rosenblad
Tore Samuelsson
If your research is assisted by SRPDB, please refer to

Andersen ES, Rosenblad MA, Larsen N, Westergaard JC, Burks J, Wower IK, Wower J, Gorodkin J, Samuelsson T, and Zwieb C. (2006) The tmRDB and SRPDB Resources. Nucleic Acids Res. 34, Database issue: D163-168.

Please be sure to cite the original authors in case you fetch and use data that we only redistribute.

We gratefully acknowledge the contributions by
Florian Müller for the ERNA-3D modeling software
Ingolf Sommer for VCMD molecular dynamics software
as well as support provided by the National Institutes of Health and the Danish Technical Research Council.

Page last updated on Mar 22 2012

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