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Weiche, B., Burk, J., Angelini, S., Schiltz, E., Thumfart, J. O., and Koch, H. G. (2008)
A Cleavable N-Terminal Membrane Anchor is Involved in Membrane Binding of the Escherichia coli SRP Receptor.
J Mol Biol 377, 761-73
van Nues, R. W., Leung, E., McDonald, J. C., Dantuluru, I., and Brown, J. D. (2008)
Roles for Srp72p in assembly, nuclear export and function of the signal recognition particle.
RNA Biol 5, [Epub ahead of print]
Hernandez Torres, J., Maldonado, M. A., and Chomilier, J. (2007)
Tandem duplications of a degenerated GTP-binding domain at the origin of GTPase receptors Toc159 and thylakoidal SRP.
Biochem Biophys Res Commun 364, 325-331
Siu, F. Y., Spanggord, R. J., and Doudna, J. A. (2007)
SRP RNA provides the physiologically essential GTPase activation function in cotranslational protein targeting.
RNA 13, 240-250
Yin, J., Iakhiaeva, E., Menichelli, E., and Zwieb, C. (2007)
Identification of the RNA binding regions of SRP68/72 and SRP72 by systematic mutagenesis of human SRP RNA.
RNA Biol 4, 154-159
Yurist, S., Dahan, I., and Eichler, J. (2007)
SRP19 is a dispensable component of the signal recognition particle in Archaea.
J Bacteriol 189, 276-279
Singh, J., Dani, H. M., Sharma, R., and Steinberg, P. (2006)
Inhibition of the biosynthesis of SRP polypeptides and secretory proteins by aflatoxin B(1) can disrupt protein targeting.
Cell Biochem Funct 24, 507-510
Focia, P. J., Gawronski-Salerno, J., Coon, J. S. t., and Freymann, D. M. (2006)
Structure of a GDP:AlF4 complex of the SRP GTPases Ffh and FtsY, and identification of a peripheral nucleotide interaction site.
J Mol Biol 360, 631-643
Romisch, K., Miller, F. W., Dobberstein, B., and High, S. (2006)
Human autoantibodies against the 54 kDa protein of the signal recognition particle block function at multiple stages,
Arthritis Res Ther 8, R39
Raine, A., Lovmar, M., Wikberg, J., and Ehrenberg, M. (2006)
Trigger factor binding to ribosomes with nascent peptide chains of varying lengths and sequences,
J Biol Chem [Epub ahead of print]
Steiner, D., Forrer, P., Stumpp, M. T., and Pluckthun, A. (2006)
Signal sequences directing cotranslational translocation expand the range of proteins amenable to phage display,
Nat Biotechnol 24, 823-831
Bloois, E. V., Haan, G. J., Gier, J. W., Oudega, B., and Luirink, J. (2006)
Distinct requirements for translocation of the N-tail and C-tail of the Escherichia coli inner membrane protein CYOA,
J Biol Chem 281, 10002-10009
Onafuwa-Nuga, A. A., Telesnitsky, A., and King, S. R. (2006)
7SL RNA, but not the 54-kd signal recognition particle protein, is an abundant component of both infectious HIV-1 and minimal virus-like particles,
RNA 12, 542-546
Eisner, G., Moser, M., Schafer, U., Beck, K., and Muller, M. (2006)
Alternate recruitment of signal recognition particle and trigger factor to the signal sequence of a growing nascent polypeptide,
J Biol Chem 281, 7172-7179
Focia, P. J., Gawronski-Salerno, J., Coon, J. S. t., and Freymann, D. M. (2006)
Structure of a GDP:AlF4 complex of the SRP GTPases Ffh and FtsY, and identification of a peripheral nucleotide interaction site,
J Mol Biol 360, 631-643
Halic, M., Gartmann, M., Schlenker, O., Mielke, T., Pool, M. R., Sinning, I., and Beckmann, R. (2006)
Signal recognition particle receptor exposes the ribosomal translocon binding site,
Science 12, 467-468
Hasler, J., and Strub, K. (2006)
Alu RNP and Alu RNA regulate translation initiation in vitro,
Nucleic Acids Res 34, 2374-2385
Zanen, G., Antelmann, H., Meima, R., Jongbloed, J. D., Kolkman, M., Hecker, M., van Dijl, J. M., and Quax, W. J. (2006)
Proteomic dissection of potential signal recognition particle dependence in protein secretion by Bacillus subtilis,
Proteomics 6, 3636-3648
Klenell, M., Morita, S., Tiemblo-Olmo, M., Muhlenbock, P., Karpinski, S., and Karpinska, B. (2005)
Involvement of the chloroplast signal recognition particle cpSRP43 in acclimation to conditions promoting photooxidative stress in Arabidopsis,
Plant Cell Physiol 46, 118-129
Kuruma, Y., Nishiyama, K. I., Shimizu, Y., Muller, M., and Ueda, T. (2005)
Development of a Minimal Cell-Free Translation System for the Synthesis of Presecretory and Integral Membrane Proteins,
Biotechnol Prog 21, 1243-1251
Spanggord, R. J., Siu, F., Ke, A., and Doudna, J. A. (2005)
RNA-mediated interaction between the peptide-binding and GTPase domains of the signal recognition particle,
Nat Struct Mol Biol 12, 1116-1122
Schaaf, A., Tintelnot, S., Baur, A., Reski, R., Gorr, G., and Decker, E. L. (2005)
Use of endogenous signal sequences for transient production and efficient secretion by moss (Physcomitrella patens) cells,
BMC Biotechnol 5, 30
Schlunzen, F., Wilson, D. N., Tian, P., Harms, J. M., McInnes, S. J., Hansen, H. A., Albrecht, R., Buerger, J., Wilbanks, S. M., and Fucini, P. (2005)
The Binding Mode of the Trigger Factor on the Ribosome: Implications for Protein Folding and SRP Interaction,
Structure (Camb) 13, 1685-1694
Halic, M., Becker, T., Frank, J., Spahn, C. M., and Beckmann, R. (2005)
Localization and dynamic behavior of ribosomal protein L30e,
Nat Struct Mol Biol 12, 467-468
Lustig, Y., Goldshmidt, H., Uliel, S., and Michaeli, S. (2005)
The Trypanosoma brucei signal recognition particle lacks the Alu-domain-binding proteins: purification and functional analysis of its binding proteins by RNAi,
J Cell Sci 118, 4551-4562
Hasona, A., Crowley, P. J., Levesque, C. M., Mair, R. W., Cvitkovitch, D. G., Bleiweis, A. S., and Brady, L. J. (2005)
Streptococcal viability and diminished stress tolerance in mutants lacking the signal recognition particle pathway or YidC2,
Proc Natl Acad Sci U S A 102, 17466-17471
Deitermann, S., Sprie, G. S., and Koch, H. G. (2005)
A dual function for SecA in the assembly of single-spanning membrane proteins in Escherichia coli,
J Biol Chem 280, 39077-39085
Buskiewicz, I., Peske, F., Wieden, H. J., Gryczynski, I., Rodnina, M. V., and Wintermeyer, W. (2005)
Conformations of the Signal Recognition Particle Protein Ffh from Escherichia coli as Determined by FRET,
J Mol Biol 351, 417-430
Buskiewicz, I., Kubarenko, A., Peske, F., Rodnina, M. V., and Wintermeyer, W. (2005)
Domain rearrangement of SRP protein Ffh upon binding 4.5S RNA and the SRP receptor FtsY,
RNA 11, 947-957
Chou, Y. T., and Gierasch, L. M. (2005)
The conformation of a signal peptide bound by Escherichia coli preprotein translocase SecA,
J Biol Chem 280, 32753-32760
Shan, S. O., and Walter, P. (2005)
Molecular Crosstalk between the Nucleotide Specificity Determinant of the SRP GTPase and the SRP Receptor,
Biochemistry 44, 6214-6222
Iakhiaeva, E., Yin, J., and Zwieb, C. (2005)
Identification of an RNA-binding Domain in Human SRP72,
J Mol Biol 345, 659-666
Shan, S. O., and Walter, P. (2005)
Co-translational protein targeting by the signal recognition particle,
FEBS Lett 579, 921-926
Singh, J., Singh, S., Dani, H. M., Sharma, R., and Steinberg, P. (2005)
Interactions of aflatoxin B1 with SRP components can disrupt protein targeting,
Cell Biochem Funct 23, 9-13
Sommerville, J., Brumwell, C. L., Politz, J. C., and Pederson, T. (2005)
Signal recognition particle assembly in relation to the function of amplified nucleoli of Xenopus oocytes,
J Cell Sci 118, 1299-1307
Hainzl, T., Huang, S., and Sauer-Eriksson, A. E. (2005)
Structural insights into SRP RNA: An induced fit mechanism for SRP assembly,
RNA 11, 1043-1050
Halic, M., and Beckmann, R. (2005)
The signal recognition particle and its interactions during protein targeting,
Curr Opin Struct Biol 15, 116-125
Houben, E. N., Zarivach, R., Oudega, B., and Luirink, J. (2005)
Early encounters of a nascent membrane protein: specificity and timing of contacts inside and outside the ribosome,
J Cell Biol
Huber, D., Boyd, D., Xia, Y., Olma, M. H., Gerstein, M., and Beckwith, J. (2005)
Use of Thioredoxin as a Reporter To Identify a Subset of Escherichia coli Signal Sequences That Promote Signal Recognition Particle-Dependent Translocation,
J Bacteriol 187, 2983-2991
Zwieb, C., Van Nues, R. W., Rosenblad, M. A., Brown, J. D., and Samuelsson, T. (2005)
A nomenclature for all signal recognition particle RNAs,
RNA 11, 7-13
Focia, P. J., Shepotinovskaya, I. V., Seidler, J. A., and Freymann, D. M. (2004)
Heterodimeric GTPase core of the SRP targeting complex,
Science 303, 373-377
Focia, P. J., Alam, H., Lu, T., Ramirez, U. D., and Freymann, D. M. (2004)
Novel protein and Mg2+ configurations in the Mg2+GDP complex of the SRP GTPase ffh,
Proteins 54, 222-230
Ferbitz, L., Maier, T., Patzelt, H., Bukau, B., Deuerling, E., and Ban, N. (2004)
Trigger factor in complex with the ribosome forms a molecular cradle for nascent proteins,
Nature 431, 590-596
Egea, P. F., Shan, S. O., Napetschnig, J., Savage, D. F., Walter, P., and Stroud, R. M. (2004)
Substrate twinning activates the signal recognition particle and its receptor,
Nature 427, 215-221
Abell, B. M., Pool, M. R., Schlenker, O., Sinning, I., and High, S. (2004)
Signal recognition particle mediates post-translational targeting in eukaryotes,
Embo J 23, 2755-2764
White, S. H., and von Heijne, G. (2004)
The machinery of membrane protein assembly,
Curr Opin Struct Biol 14, 397-404
Wild, K., Halic, M., Sinning, I., and Beckmann, R. (2004)
SRP meets the ribosome,
Nat Struct Mol Biol 11, 1049-1053
Wild, K., Rosendal, K. R., and Sinning, I. (2004)
A structural step into the SRP cycle,
Mol Microbiol 53, 357-363
Moll, R. G. (2004)
The archaeal signal recognition particle: steps toward membrane binding,
J Bioenerg Biomembr 36, 47-53
Chu, F., Shan, S. O., Moustakas, D. T., Alber, F., Egea, P. F., Stroud, R. M., Walter, P., and Burlingame, A. L. (2004)
Unraveling the interface of signal recognition particle and its receptor by using chemical cross-linking and tandem mass spectrometry,
Proc Natl Acad Sci U S A 101, 16454-16459
Yi, L., Celebi, N., Chen, M., and Dalbey, R. E. (2004)
Sec/SRP requirements and energetics of membrane insertion of subunits a, b, and c of the Escherichia coli F1F0 ATP synthase,
J Biol Chem 279, 39260-39267
Terzi, L., Pool, M. R., Dobberstein, B., and Strub, K. (2004)
Signal recognition particle Alu domain occupies a defined site at the ribosomal subunit interface upon signal sequence recognition,
Biochemistry 43, 107-117
Yin, J., Huang, Q., Pakhomova, O. P., Hinck, A. P., and Zwieb, C. (2004)
The conserved adenosine in helix 6 of signal recognition particle RNA initiates SRP assembly,
Archaea 1, 269–276
Luirink, J., and Sinning, I. (2004)
SRP-mediated protein targeting: structure and function revisited,
Biochim Biophys Acta 1694, 17-35
Tyson, G. W., Chapman, J., Hugenholtz, P., Allen, E. E., Ram, R. J., Richardson, P. M., Solovyev, V. V., Rubin, E. M., Rokhsar, D. S., and Banfield, J. F. (2004)
Community structure and metabolism through reconstruction of microbial genomes from the environment,
Nature
Dobberstein, B., and Sinning, I. (2004)
Structural biology. Surprising news from the PCC,
Science 303, 320-322
Van Nues, R. W., and Brown, J. D. (2004)
Saccharomyces SRP RNA secondary structures: A conserved S-domain and extended Alu-domain,
RNA 10, 75-89
Doudna, J. A., and Batey, R. T. (2004)
Structural Insights into the Signal Recognition Particle,
Annu Rev Biochem 73, 539-557
Yin, J., Yang, C. H., and Zwieb, C. (2004)
Two strategically placed base pairs in helix 8 of mammalian signal recognition particle RNA are crucial for the SPR19-dependent binding of protein SRP54,
Rna 10, 574-580
Halic, M., Becker, T., Pool, M. R., Spahn, C. M., Grassucci, R. A., Frank, J., and Beckmann, R. (2004)
Structure of the signal recognition particle interacting with the elongation-arrested ribosome,
Nature 427, 808-814
Horwich, A. (2004)
Cell biology: sight at the end of the tunnel,
Nature 431, 520-522
Huck, L., Scherrer, A., Terzi, L., Johnson, A. E., Bernstein, H. D., Cusack, S., Weichenrieder, O., and Strub, K. (2004)
Conserved tertiary base pairing ensures proper RNA folding and efficient assembly of the signal recognition particle Alu domain,
Nucleic Acids Res 32, 4915-4924
Rosenblad, M. A., Zwieb, C., and Samuelsson, T. (2004)
Identification and comparative analysis of components from the signal recognition particle in protozoa and fungi,
BMC Genomics 5, 5
Rosendal, K. R., Sinning, I., and Wild, K. (2004)
Crystallization of the crenarchaeal SRP core,
Acta Crystallogr Section D Biol Crystallogr 60, 140-143
Sagar, M. B., Lucast, L., and Doudna, J. A. (2004)
Conserved but nonessential interaction of SRP RNA with translation factor EF-G,
Rna 10, 772-778
Buskiewicz, I., Deuerling, E., Gu, S. Q., Jockel, J., Rodnina, M. V., Bukau, B., and Wintermeyer, W. (2004)
Trigger factor binds to ribosome-signal-recognition particle (SRP) complexes and is excluded by binding of the SRP receptor,
Proc Natl Acad Sci U S A 101, 7902-7906
Shepotinovskaya, I. V., Focia, P. J., and Freymann, D. M. (2003)
Crystallization of the GMPPCP complex of the NG domains of Thermus aquaticus Ffh and FtsY,
Acta Crystallogr D Biol Crystallogr 59, 1834-1837
Rosenblad, M. A., Gorodkin, J., Knudsen, B., Zwieb, C., and Samuelsson, T. (2003)
SRPDB: Signal Recognition Particle Database,
Nucleic Acids Res 31, 363-364
Rosendal, K. R., Wild, K., Montoya, G., and Sinning, I. (2003)
Crystal structure of the complete core of archaeal signal recognition particle and implications for interdomain communication,
Proc Natl Acad Sci U S A 100, 14701-14706
San Miguel, M., Marrington, R., Rodger, P. M., Rodger, A., and Robinson, C. (2003)
An Escherichia coli twin-arginine signal peptide switches between helical and unstructured conformations depending on the hydrophobicity of the environment,
Eur J Biochem 270, 3345-3352
Sauer-Eriksson, A. E., and Hainzl, T. (2003)
S-domain assembly of the signal recognition particle,
Curr Opin Struct Biol 13, 64-70
Koch, H. G., Moser, M., and Muller, M. (2003)
Signal recognition particle-dependent protein targeting, universal to all kingdoms of life,
Rev Physiol Biochem Pharmacol 146, 55-94
Beha, D., Deitermann, S., Muller, M., and Koch, H. G. (2003)
Export of beta-lactamase is independent of the signal recognition particle,
J Biol Chem 278, 22161-22167
Mandon, E. C., Jiang, Y., and Gilmore, R. (2003)
Dual recognition of the ribosome and the signal recognition particle by the SRP receptor during protein targeting to the endoplasmic reticulum,
J Cell Biol 162, 575-585
Schwartz, T., and Blobel, G. (2003)
Structural basis for the function of the beta subunit of the eukaryotic signal recognition particle receptor,
Cell 112, 793-803
Frasz, C., and Arvidson, C. G. (2003)
Role for both DNA and RNA in GTP Hydrolysis by the Neisseria gonorrhoeae Signal Recognition Particle Receptor,
J Bacteriol 185, 801-808
Moll, R. G. (2003)
Protein-protein, protein-RNA and protein-lipid interactions of signal-recognition particle components in the hyperthermoacidophilic archaeon Acidianus ambivalens,
Biochem J 374, 247-254
Lerner, R. S., Seiser, R. M., Zheng, T., Lager, P. J., Reedy, M. C., Keene, J. D., and Nicchitta, C. V. (2003)
Partitioning and translation of mRNAs encoding soluble proteins on membrane-bound ribosomes,
Rna 9, 1123-1137
Peterson, J. H., Woolhead, C. A., and Bernstein, H. D. (2003)
Basic amino acids in a distinct subset of signal peptides promote interaction with the signal recognition particle,
J Biol Chem 278, 46155-46162
Gu, S. Q., Peske, F., Wieden, H. J., Rodnina, M. V., and Wintermeyer, W. (2003)
The signal recognition particle binds to protein L23 at the peptide exit of the Escherichia coli ribosome,
Rna 9, 566-573
Cochrane, J. C., Batey, R. T., and Strobel, S. A. (2003)
Quantitation of free energy profiles in RNA-ligand interactions by nucleotide analog interference mapping,
Rna 9, 1282-1289
Li, Y., Cole, K., and altman, S. (2003)
The effect of a single, temperature-sensitive mutation on global gene expression in Escherichia coli,
Rna 9, 518-532
Zwieb, C. (2003)
Signal recognition particle-mediated protein targeting,
Recent Res Develop Mol Biol 1, 205-224
Liu, L., Ben-Shlomo, H., Xu, Y. X., Stern, M. Z., Goncharov, I., Zhang, Y., and Michaeli, S. (2003)
The trypanosomatid signal recognition particle consists of two RNA molecules, a 7SL RNA homologue and a novel tRNA-like molecule,
J Biol Chem 278, 18271-18280
Tyedmers, J., Lerner, M., Wiedmann, M., Volkmer, J., and Zimmermann, R. (2003)
Polypeptide-binding proteins mediate completion of co-translational protein translocation into the mammalian endoplasmic reticulum,
EMBO Rep 4, 505-510
Shepotinovskaya, I. V., and Freymann, D. M. (2002)
Conformational change of the N-domain on formation of the complex between the GTPase domains of Thermus aquaticus Ffh and FtsY,
Biochim Biophys Acta 1597,107-114
Liu, L., Liang, X. H., Uliel, S., Unger, R., Ullu, E., and Michaeli, S. (2002)
RNA interference of signal peptide-binding protein SRP54 elicits deleterious effects and protein sorting defects in trypanosomes,
J Biol Chem 277, 47348-47357
Tozik, I., Huang, Q., Zwieb, C., and Eichler, J. (2002)
Reconstitution of the signal recognition particle of the halophilic archaeon Haloferax volcanii,
Nucleic Acids Res 30, 4166-4175
Batey, R. T., and Doudna, J. A. (2002)
Structural and energetic analysis of metal ions essential to SRP signal recognition domain assembly,
Biochemistry 41, 11703-11710
Avdeeva, O. N., Myasnikov, A. G., Sergiev, P. V., Bogdanov, A. A., Brimacombe, R., and Dontsova, O. A. (2002)
Construction of the 'minimal' SRP that interacts with the translating ribosome but not with specific membrane receptors in Escherichia coli,
FEBS Lett 514, 70-73
Oubridge, C., Kuglstatter, A., Jovine, L., and Nagai, K. (2002)
Crystal structure of SRP19 in complex with the S domain of SRP RNA and its implication for the assembly of the signal recognition particle,
Mol Cell 9, 1251-1261
Pakhomova, O. N., Deep, S., Huang, Q., Zwieb, C., and Hinck, A. P. (2002)
Solution structure of protein SRP19 of Archaeoglobus fulgidus signal recognition particle,
J Mol Biol 317, 145-158
Wild, K., Weichenrieder, O., Strub, K., Sinning, I., and Cusack, S. (2002)
Towards the structure of the mammalian signal recognition particle,
Curr Opin Struct Biol 12, 72-81
Hainzl, T., Huang, S., and Sauer-Eriksson, A. E. (2002)
Structure of the SRP19 RNA complex and implications for signal recognition particle assembly,
Nature 417, 767-771
Herskovits, A. A., Shimoni, E., Minsky, A., and Bibi, E. (2002)
Accumulation of endoplasmic membranes and novel membrane-bound ribosome-signal recognition particle receptor complexes in Escherichia coli,
J Cell Biol 159, 403-410
Politz, J. C., Lewandowski, L. B., and Pederson, T. (2002)
Signal recognition particle RNA localization within the nucleolus differs from the classical sites of ribosome synthesis,
J Cell Biol 159, 411-418
Pool, M. R., Stumm, J., Fulga, T. A., Sinning, I., and Dobberstein, B. (2002)
Distinct modes of signal recognition particle interaction with the ribosome,
Science 297, 1345-1348
Kuglstatter, A., Oubridge, C., and Nagai, K. (2002)
Induced structural changes of 7SL RNA during the assembly of human signal recognition particle,
Nat Struct Biol 9, 740-744
Ramirez, U. D., Minasov, G., Focia, P. J., Stroud, R. M., Walter, P., Kuhn, P., and Freymann, D. M. (2002)
Structural basis for mobility in the 1.1 A crystal structure of the NG domain of Thermus aquaticus Ffh,
J Mol Biol 320, 783-799
Regalia, M., Rosenblad, M. A., and Samuelsson, T. (2002)
Prediction of signal recognition particle RNA genes,
Nucleic Acids Res 30, 3368-3377
Caetano-Anolles, G. (2002)
Evolved RNA secondary structure and the rooting of the universal tree of life,
J Mol Evol 54, 333-345
Rinke-Appel, J., Osswald, M., von Knoblauch, K., Mueller, F., Brimacombe, R., Sergiev, P., Avdeeva, O., Bogdanov, A., and Dontsova, O. (2002)
Crosslinking of 4.5S RNA to the Escherichia coli ribosome in the presence or absence of the protein Ffh,
RNA 8, 612-625
Brunelli, C. A., O'Connor, M., and Dahlberg, A. E. (2002)
Decreased requirement for 4.5S RNA in 16S and 23S rRNA mutants of Escherichia coli,
FEBS Lett 514, 44-48
Padmanabhan, S., and Freymann, D. M. (2001)
The conformation of bound GMPPNP suggests a mechanism for gating the active site of the SRP GTPase,
Structure 9, 859-867
Dean, K. A., von Ahsen, O., Gorlich, D., and Fried, H. M. (2001)
Signal recognition particle protein 19 is imported into the nucleus by importin 8 (RanBP8) and transportin,
J Cell Sci 114, 3479-3485
Perumal, K., Sinha, K., Henning, D., and Reddy, R. (2001)
Purification, characterization, and cloning of the cDNA of human signal recognition particle RNA 3'-adenylating enzyme,
J Biol Chem 276, 21791-21796
Yang, C. H., and Zwieb, C. (2001)
Swapping of functional domains using a chimeric monster deletion mutagenesis strategy,
Biotechniques 31, 724-728
Grosshans, H., Deinert, K., Hurt, E., and Simos, G. (2001)
Biogenesis of the signal recognition particle (SRP) involves import of SRP proteins into the nucleolus, assembly with the SRP-RNA, and Xpo1p-mediated export,
J Cell Biol 153, 745-762
Yin, J., Yang, C. H., and Zwieb, C. (2001)
Assembly of human signal recognition particle (SRP): overlap of regions required for binding of protein SRP54 and assembly control,
RNA 7, 1389-1396
Herskovits, A. A., Seluanov, A., Rajsbaum, R., ten Hagen-Jongman, C. M., Henrichs, T., Bochkareva, E. S., Phillips, G. J., Probst, F. J., Nakae, T., Ehrmann, M., Luirink, J., and Bibi, E. (2001)
Evidence for coupling of membrane targeting and function of the signal recognition particle (SRP) receptor FtsY,
EMBO Rep 2, 1040-1046
Beckmann, R., Spahn, C. M., Eswar, N., Helmers, J., Penczek, P. A., Sali, A., Frank, J., and Blobel, G. (2001)
Architecture of the protein-conducting channel associated with the translating 80S ribosome,
Cell 107, 361-372
Jagath, J. R., Matassova, N. B., de Leeuw, E., Warnecke, J. M., Lentzen, G., Rodnina, M. V., Luirink, J., and Wintermeyer, W. (2001)
Important role of the tetraloop region of 4.5S RNA in SRP binding to its receptor FtsY,
RNA 7, 293-301
Maeshima, H., Okuno, E., Aimi, T., Morinaga, T., and Itoh, T. (2001)
An archaeal protein homologous to mammalian SRP54 and bacterial Ffh recognizes a highly conserved region of SRP RNA,
FEBS Lett 507, 336-340
Keenan, R. J., Freymann, D. M., Stroud, R. M., and Walter, P. (2001)
The Signal Recognition Particle,
Annu Rev Biochem 70, 755-775
Driessen, A. J., Manting, E. H., and van der Does, C. (2001)
The structural basis of protein targeting and translocation in bacteria,
Nat Struct Biol 8, 492-498
Bhuiyan, S. H., Pakhomova, O. N., Hinck, A. P., and Zwieb, C. (2001)
Complexes with truncated RNAs from the large domain of Archaeoglobus fulgidus signal recognition particle,
FEMS Microbiol Lett 198, 105-110
Ring, G., and Eichler, J. (2001)
Characterization of inverted membrane vesicles from the halophilic archaeon Haloferax volcanii,
J Membr Biol 183, 195-204
Rose, M. A., and Weeks, K. M. (2001)
Visualizing induced fit in early assembly of the human signal recognition particle,
Nat Struct Biol 8, 515-520.
Fulga, T. A., Sinning, I., Dobberstein, B., and Pool, M. R. (2001)
SRbeta coordinates signal sequence release from SRP with ribosome binding to the translocon,
Embo J 20, 2338-2347
Gorodkin, J., Knudsen, B., Zwieb, C., and Samuelsson, T. (2001)
SRPDB (Signal Recognition Particle Database),
Nucleic Acids Research 1, 169-170
Pakhomova, O. N., Cui, Y., Zwieb, C., and Hinck, A. P. (2001)
Sequence-specific 1H, 13C and 15N signal assignments and secondary structure of archaeoglobusfulgidus SRP19,
J Biomol NMR 20, 187-188
Wild, K., Sinning, I., and Cusack, S. (2001)
Crystal structure of an early protein-RNA assembly complex of the signal recognition particle,
Science 294, 598-601
Peluso, P., Shan, S. O., Nock, S., Herschlag, D., and Walter, P. (2001)
Role of SRP RNA in the GTPase cycles of Ffh and FtsY,
Biochemistry 40, 15224-15233
Peluso, P., Herschlag, D., Nock, S., Freymann, D. M., Johnson, A. E., and Walter, P. (2000)
Role of 4.5S RNA in assembly of the bacterial signal recognition particle with its receptor,
Science 288, 1640-1643
Neumann-Haefelin, C., Schafer, U., Muller, M., and Koch, H. G. (2000)
SRP-dependent co-translational targeting and SecA-dependent translocation analyzed as individual steps in the export of a bacterial protein,
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Nucleotide-dependent binding of the GTPase domain of the signal recognition particle receptor beta-subunit to the alpha-subunit,
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Elongation arrest is a physiologically important function of signal recognition particle,
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Crystal structure of the ribonucleoprotein core of the signal recognition particle,
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Signal Recognition Particle Components in the Nucleolus,
Proc Natl Acad Sci U S A 97, 55-60
Bhuiyan, S. H., Gowda, K., Hotokezaka, H., and Zwieb, C. (2000)
Assembly of archaeal signal recognition particle from recombinant components,
Nucleic Acids Research 28, 1365-1373
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SRPrises in RNA-protein recognition,
Structure Fold Des 8, R99-104
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Charge pair interactions in a model transmembrane helix in the ER membrane,
J Mol Biol 303, 1-5
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Association of Escherichia coli ribosomes with the inner membrane requires the signal recognition particle receptor but is independent of the signal recognition particle,
Proc Natl Acad Sci U S A 97, 4621-4626.
Herskovits, A. A., Bochkareva, E. S., and Bibi, E. (2000)
New prospects in studying the bacterial signal recognition particle pathway,
Mol Microbiol 38, 927-939
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The crystal structure of the conserved GTPase of SRP54 from the archaeon Acidianus ambivalens and its comparison with related structures suggests a model for the SRP-SRP receptor complex,
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Jovine, L., Hainzl, T., Oubridge, C., Scott, W. G., Li, J., Sixma, T. K., Wonacott, A., Skarzynski, T., and Nagai, K. (2000)
Crystal structure of the ffh and EF-G binding sites in the conserved domain IV of Escherichia coli 4.5S RNA,
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Archaeal protein translocation,
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SRPDB (Signal Recognition Particle Database),
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Role of SRP19 in assembly of the archaeoglobus fulgidus signal recognition particle,
Biochemistry 39, 12862-12874
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Crystallization and preliminary X-ray analysis of the conserved domain IV of Escherichia coli 4.5S RNA. erratum,
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Structure and assembly of the Alu domain of the mammalian signal recognition particle,
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Analysis of Escherichia coli 4.5S RNA binding affinity to Ffh and EF-G,
FEMS Microbiol Lett 180, 271-277
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The ribosome regulates the GTPase of the beta-subunit of the signal recognition particle receptor,
J Cell Biol 146, 723-730
Freymann, D. M., Keenan, R. J., Stroud, R. M., and Walter, P. (1999)
Functional changes in the structure of the SRP GTPase on binding GDP and Mg2+GDP,
Nat Struct Biol 6, 793-801
Nakamura, K., Yahagi, S., Yamazaki, T., and Yamane, K. (1999)
Bacillus subtilis histone-like protein, HBsu, is an integral component of a SRP-like particle that can bind the Alu domain of small cytoplasmic RNA,
J Biol Chem 274, 13569-13576
Amin, P., Sy, D. A., Pilgrim, M. L., Parry, D. H., Nussaume, L., and Hoffman, N. E. (1999)
Arabidopsis mutants lacking the 43- and 54-kilodalton subunits of the chloroplast signal recognition particle have distinct phenotypes [In Process Citation],
Plant Physiol 121, 61-70
Moll, R., Schmidtke, S., and Schafer, G. (1999)
Domain structure, GTP-hydrolyzing activity and 7S RNA binding of Acidianus ambivalens ffh-homologous protein suggest an SRP-like complex in archaea,
Eur J Biochem 259, 441-448
Clemons, W. M., Jr., Gowda, K., Black, S. D., Zwieb, C., and Ramakrishnan, V. (1999)
Crystal Structure of the Conserved Subdomain of Human Protein SRP54M at 2.1 Å Resolution: Evidence for the Mechanism of Signal Peptide Binding,
J Mol Biol 292, 697-705
Sinha, K., Perumal, K., Chen, Y., and Reddy, R. (1999)
Post-transcriptional adenylation of signal recognition particle RNA is carried out by an enzyme different from mRNA Poly(A) polymerase [In Process Citation],
J Biol Chem 274, 30826-30831
Newitt, J. A., Ulbrandt, N. D., and Bernstein, H. D. (1999)
The structure of multiple polypeptide domains determines the signal recognition particle targeting requirement of Escherichia coli inner membrane proteins,
J Bacteriol 181, 4561-4567
Stirling, C. J. (1999)
Protein targeting to the endoplasmic reticulum in yeast. 1997 Fleming Lecture,
Microbiology 145, 991-998
Cristobal, S., Scotti, P., Luirink, J., von Heijne, G., and de Gier, J. W. (1999)
The signal recognition particle-targeting pathway does not necessarily deliver proteins to the sec-translocase in Escherichia coli,
J Biol Chem 274, 20068-20070
Dalbey, R. E., and Robinson, C. (1999)
Protein translocation into and across the bacterial plasma membrane and the plant thylakoid membrane,
Trends Biochem Sci 24, 17-22
Strub, K., Fornallaz, M., and Bui, N. (1999)
The Alu domain homolog of the yeast signal recognition particle consists of an Srp14p homodimer and a yeast-specific RNA structure,
RNA 5, 1333-1347
Tu, C. J., Schuenemann, D., and Hoffman, N. E. (1999)
Chloroplast FtsY, chloroplast signal recognition particle, and GTP are required to reconstitute the soluble phase of light-harvesting chlorophyll protein transport into thylakoid membranes,
J Biol Chem 274, 27219-27224
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Machine learning approaches for the prediction of signal peptides and other protein sorting signals,
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Signal recognition particle receptor (SRPR) is downregulated in a rat model of cyclosporin A-induced gingival overgrowth,
J Periodontal Res 34, 188-196
Gowda, K., Clemons, W. M., Jr., Zwieb, C., and Black, S. D. (1999)
Expression, purification, and crystallography of the conserved methionine-rich domain of human signal recognition particle 54 kDa protein,
Protein Sci 8, 1144-1151
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The 2 A structure of helix 6 of the human signal recognition particle RNA,
Structure Fold Des 7, 1345-1352.
Arvidson, C. G., Powers, T., Walter, P., and So, M. (1999)
Neisseria gonorrhoeae PilA is an FtsY homolog,
J Bacteriol 181, 731-739
Blatch, G. L., and Lassle, M. (1999)
The tetratricopeptide repeat: a structural motif mediating protein-protein interactions,
Bioessays 21, 932-939
Boisrame, A., Beckerich, J. M., and Gaillardin, C. (1999)
A mutation in the secretion pathway of the yeast Yarrowia lipolytica that displays synthetic lethality in combination with a mutation affecting the signal recognition particle,
Mol Gen Genet 261, 601-609
Brinkmann, H., and Philippe, H. (1999)
Archaea sister group of Bacteria? Indications from tree reconstruction artifacts in ancient phylogenies,
Mol Biol Evol 16, 817-825
Samuelsson, T., and Zwieb, N. (1999)
The Signal Recognition Particle Database (SRPDB),
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New insights into signal recognition and elongation arrest activities of the signal recognition particle,
Biol Chem 380, 135-145
Schmitz, U., Behrens, S., Freymann, D. M., Keenan, R. J., Lukavsky, P., Walter, P., and James, T. L. (1999)
Structure of the phylogenetically most conserved domain of SRP RNA,
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Structure of the most conserved internal loop in SRP RNA,
Nat Struct Biol 6, 634-638.
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SecA is not required for signal recognition particle-mediated targeting and initial membrane insertion of a nascent inner membrane protein,
J Biol Chem 274, 29883-29888
Valent, Q. A., Scotti, P. A., High, S., de Gier, J. W., von Heijne, G., Lentzen, G., Wintermeyer, W., Oudega, B., and Luirink, J. (1998)
The Escherichia coli SRP and SecB targeting pathways converge at the translocon,
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Life and death of a signal peptide,
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The Signal Recognition Particle Database (SRPDB),
Nucleic Acids Research 26, 179-180
Gowda, K., Black, S. D., Moeller, I., Sakakibara, Y., Liu, M.-C., and Zwieb, C. (1998)
Protein SRP54 of human signal recognition particle: cloning, expression, and comparative analysis of functional sites,
Gene 207, 197-207
Gribaldo, S., and Cammarano, P. (1998)
The root of the universal tree of life inferred from anciently duplicated genes encoding components of the protein-targeting machinery,
J Mol Evol 47, 508-516
Plath, K., Mothes, W., Wilkinson, B. M., Stirling, C. J., and Rapoport, T. A. (1998)
Signal sequence recognition in posttranslational protein transport across the yeast ER membrane,
Cell 94, 795-807
Matoba, S., and Ogrydziak, D. M. (1998)
Another factor besides hydrophobicity can affect signal peptide interaction with signal recognition particle,
J Biol Chem 273, 18841-18847
Beckerich, J. M., Boisrame-Baudevin, A., and Gaillardin, C. (1998)
Yarrowia lipolytica: a model organism for protein secretion studies,
Int Microbiol 1, 123-130
Jacobson, M. R., and Pederson, T. (1998)
Localization of signal recognition particle RNA in the nucleolus of mammalian cells,
Proc Natl Acad Sci U S A 95, 7981-7986
Keenan, R. J., Freymann, D. M., Walter, P., and Stroud, R. M. (1998)
Crystal structure of the signal sequence binding subunit of the signal recognition particle,
Cell 94, 181-191
Schuenemann, D., Gupta, S., Persello-Cartieaux, F., Klimyuk, V. V., Jones, J. D. G., Nussaume, L., and Hoffman, N. E. (1998)
A novel signal recognition particle targets light-harvesting proteins to the thylakoid membranes,
Proc Natl Acad Sci U S A 95, 10312-10316
Chen, Y., Sinha, K., Perumal, K., Gu, J., and Reddy, R. (1998)
Accurate 3' end processing and adenylation of human signal recognition particle RNA and alu RNA in vitro,
J Biol Chem 273, 35023-35031
Ulbrandt, N. D., Newitt, J. A., and Bernstein, H. D. (1997)
The E. coli signal recognition particle is required for the insertion of a subset of inner membrane proteins,
Cell 88, 187-196
Millman, J. S., and Andrews, D. W. (1997)
Switching the model: a concerted mechanism for GTPases in protein targeting,
Cell 89, 673-676
Freymann, D. M., Keenan, R. J., Stroud, R. M., and Walter, P. (1997)
Structure of the conserved GTPase domain of the signal recognition particle,
Nature 385, 361-364
Weichenrieder, O., Kapp, U., Cusack, S., and Strub, K. (1997)
Identification of a minimal Alu RNA folding domain that specifically binds SRP9/14,
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Moll, R., Schmidtke, S., Petersen, A., and Schafer, G. (1997)
The signal recognition particle receptor alpha subunit of the hyperthermophilic archaeon Acidianus ambivalens exhibits an intrinsic GTP-hydrolyzing activity,
Biochim Biophys Acta 1335, 218-230
Gowda, K., and Zwieb, C. (1997)
Determinants of a protein-induced RNA switch in the large domain of signal recognition particle identified by systematic site-directed mutagenesis,
Nucleic Acids Research 25, 2835-2840
Wilkinson, B. M., Regnacq, M., and Stirling, C. J. (1997)
Protein translocation across the membrane of the endoplasmic reticulum,
Journal of Membrane Biology 155, 189-197
Winzeler, E., Wheeler, R., and Shapiro, L. (1997)
Transcriptional analysis of the Caulobacter 4.5 S RNA ffs gene and the physiological basis of an ffs mutant with a Ts phenotype,
J Mol Biol 272, 665-676
Gowda, K., Chittenden, K., and Zwieb, C. (1997)
Binding site of the M-domain of human protein SRP 54 determined by systematic site directed mutagenesis of signal recognition particle RNA,
Nucleic Acids Research 25, 388-394
Montoya, G., Svennssom, C., Luirink, J., and Sinning, I. (1997)
Crystal structure of the NG domain from the signal-recognition particle receptor FtsY,
Nature 385, 365-368
Zelazny, A., Seluanov, A., Cooper, A., and Bibi, E. (1997)
The NG domain of the prokaryotic signal recognition particle receptor, FtsY, is fully functional when fused to an unrelated integral membrane polypeptide,
Proc Natl Acad Sci U S A 94, 6025-6029
Zheng, N., and Gierasch, L. M. (1997)
Domain interactions in E. coli SRP: stabilization of M domain by RNA is required for effective signal sequence modulation of NG domain,
Mol Cell 1, 79-87
Henry, K. A., Zwieb, C., and Fried, H. M. (1997)
Purification and biochemical characterization of the 19-kDa Signal Recognition Particle RNA-binding protein expressed as a hexahistidine-tagged polypeptide in Escherichia coli,
Protein Expression and Purification 9, 15-26
Zwieb, C., Gowda, K., Larsen, N. and Müller, F. (1997) Comparative modeling of the three-dimensional structure of signal recognition particle RNA ACS Symposium Series, in 682 (Leontis, N. B. S. L., J. Jr, Ed.) pp 405-413, American Chemical Society, Washington, DC.
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The signal recognition particle receptor of Escherichia coli (FtsY) has a nucleotide exchange factor built into the GTPase domain,
Proc Natl Acad Sci U S A 94, 11339-1144.
Lai, C., and Langley, C. H. (1997)
A homologue of the 19 kDa signal recognition particle protein locus in Drosophila melanogaster,
Gene 203, 59-63
Nielsen, H., Engelbrecht, J., Brunak, S., and von Heijne, G. (1997)
A neural network method for identification of prokaryotic and eukaryotic signal peptides and prediction of their cleavage sites,
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Protein translocation in the three domains of life: variations on a theme,
Cell 91, 563-56.
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Interaction of rice and human SRP19 polypeptides with signal recognition particle RNA,
Plant Mol Biol 34, 507-515
Beckmann, R., Bubeck, D., Grassucci, R., Penczek, P., Verschoor, A., Blobel, G., and Frank, J. (1997)
Alignment of conduits for the nascent polypeptide chain in the ribosome-Sec61 complex,
Science 278, 2123-2126
Ben-Shlomo, H., Levitan, A., Beja, O., and Michaeli, S. (1997)
The trypanosomatid Leptomonas collosoma 7SL RNA gene. Analysis of elements controlling its expression,
Nucleic Acids Res 25, 4977-4984
Birse, D. E., Kapp, U., Strub, K., Cusack, S., and Aberg, A. (1997)
The crystal structure of the signal recognition particle Alu RNA binding heterodimer, SRP9/14,
Embo J 16, 3757-3766
Black, S. D., Gowda, K., Chittenden, K., Walker, K. P., 3rd, and Zwieb, C. (1997)
Identification of an RNA-binding-loop in the N-terminal region of signal-recognition-particle protein SRP19,
Eur J Biochem 245, 564-572
Ronimus, R. S., and Musgrave, D. R. (1997)
Identification of a gene in the euryarchaeal Thermococcus species AN1 encoding a protein homologous to the alpha subunit of the eukaryal signal recognition particle (SRP) receptor,
Biochim Biophys Acta 1351, 1-8
Chang, D. Y., Newitt, J. A., Hsu, K., Bernstein, H. D., and Maraia, R. J. (1997)
A highly conserved nucleotide in the Alu domain of SRP RNA mediates translation arrest through high affinity binding to SRP9/14,
Nucleic Acids Res 25, 1117-1122
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Identification of prokaryotic and eukaryotic signal peptides and prediction of their cleavage sites,
Protein Eng 10, 1-6.
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A putative signal recognition particle receptor alpha subunit (SR alpha) homologue is expressed in the hyperthermophilic crenarchaeon Sulfolobus acidocaldarius,
FEMS Microbiol Lett 137, 51-56
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Signal sequences specify the targeting route to the endoplasmic reticulum membrane,
Journal of Cell Biology 134, 269-278
Andrews, D. W., and Johnson, A. E. (1996)
The translocon: more than a hole in the ER membrane?,
Trends Biochem Sci 21, 365-369
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Defining a similarity threshold for a functional protein sequence pattern: the signal peptide cleavage site,
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Regulation by the ribosome of the GTPase of the signal-recognition particle during protein targeting,
Nature 381, 248-251
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The cyanobacterial genome contains a single copy of the ffh gene encoding a homologue of the 54 kDa subunit of signal recognition particle,
Plant Molecular Biology 30, 659-665
Patel, S., and Austen, B. M. (1996)
Substitution of fifty four homologue (Ffh) in Escherichia coli with the mammalian 54-kDa protein of signal-recognition particle,
European Journal of Biochemistry 238, 760-768
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A two-step recognition of signal sequences determines the translocation efficiency of proteins,
EMBO Journal 15, 468-478
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Protein targeting. The ribosome talks back [news; comment],
Nature 381, 191-192
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Crystallization and preliminary crystallographic analysis of the signal recognition particle SRPphi14-9 fusion protein,
FEBS Letters 384, 215-218
Riedel, L., Volger, U., Luckinger, R., Putz, A., Sanger, H. L., and Wassenegger, M. (1996)
Molecular analysis of the gene family of the signal recognition particle (SRP) RNA of tomato,
Plant Molecular Biology 31, 113-125
Schmitz, U., Freymann, D. M., James, T. L., Keenan, R. J., Vinayak, R., and Walter, P. (1996)
NMR studies of the most conserved RNA domain of the mammalian signal recognition particle (SRP),
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Identification of protein synthesis elongation factor G as a 4.5 S RNA-binding protein in Escherichia coli,
Journal of Biological Chemistry 271, 13162-13168
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Assembly of a cytoplasmic membrane protein in Escherichia coli is dependent on the signal recognition particle,
FEBS Lett 399, 307-309
Larsen, N., and Zwieb, C. (1996)
The signal recognition particle database (SRPDB),
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Structure of 4.5S RNA in the signal recognition particle of Escherichia coli as studied by enzymatic and chemical probing,
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Methionine residues as endogenous antioxidants in proteins,
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Signal sequence-dependent function of the TRAM protein during early phases of protein transport across the endoplasmic reticulum membrane,
Journal of Cell Biology 134, 25-35
Doublie, S., Kapp, U., Aberg, A., Brown, K., Strub, K., and Cusack, S. (1996)
Crystallization and preliminary X-ray analysis of the 9 kDa protein of the mouse signal recognition particle and the selenomethionyl-SRP9,
FEBS Letters 384, 219-221
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The signal recognition particle receptor alpha subunit assembles co-translationally on the endoplasmic reticulum membrane during an mRNA-encoded translation pause in vitro,
EMBO Journal 15, 172-181
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Signal sequences: the same yet different,
Cell 86, 849-852
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Comparative analysis of tertiary structure elements in signal recognition particle RNA,
Folding & Design 1, 315-324
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Identification of a region of Bacillus subtilis Ffh, a homologue of mammalian SRP54 protein, that is essential for binding to small cytoplasmic RNA,
Journal of Biological Chemistry 271, 13140-13146
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The beta subunit of the signal recognition particle receptor is a transmembrane GTPase that anchors the alpha subunit, a peripheral membrane GTPase, to the endoplasmic reticulum membrane,
Journal of Cell Biology 128, 273-282
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Cooperative assembly of signal recognition particle RNA with protein SRP19,
Biochemistry 34, 11989-11997
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Macromolecular arrangement in the aminoacyl-tRNA.elongation factor Tu.GTP ternary complex. A fluorescence energy transfer study,
Biochemistry 34, 7904-7912
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The nascent-polypeptide-associated complex: having a "NAC" for fidelity in translocation [comment],
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An amino-terminal domain containing hydrophobic and hydrophilic sequences binds the signal recognition particle receptor alpha subunit to the beta subunit on the endoplasmic reticulum membrane,
Journal of Biological Chemistry 270, 15650-15657
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The functioning of the SRP receptor FtsY in protein-targeting in E. coli is correlated with its ability to bind and hydrolyse GTP,
FEBS Letters 372, 253-258
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Small cytoplasmic RNA (scRNA) gene from Clostridium perfringens can replace the gene for the Bacillus subtilis scRNA in both growth and sporulation,
Microbiology 141, 2965-2975
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The intrinsic ability of ribosomes to bind to endoplasmic reticulum membranes is regulated by signal recognition particle and nascent-polypeptide-associated complex [see comments],
Proc Natl Acad Sci U S A 92, 9435-9439
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Nascent polypeptide-associated complex protein prevents mistargeting of nascent chains to the endoplasmic reticulum [published erratum appears in Proc Natl Acad Sci U S A 1995 Aug 15;92(17):8088],
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A chloroplast homologue of the signal recognition particle subunit SRP54 is involved in the posttranslational integration of a protein into thylakoid membranes,
Proceedings of the National Academy of Sciences of U.S.A 92, 3789-3793
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Signal sequence processing in rough microsomes,
Journal of Biological Chemistry 270, 19873-19878
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Signal recognition particle (SRP), a ubiquitous initiator of protein translocation,
Eur J Biochem 228, 531-550
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The functional integration of a polytopic membrane protein of Escherichia coli is dependent on the bacterial signal-recognition particle,
European Journal of Biochemistry 233, 766-771
McNair, A., Zemzoumi, K., Lutcke, H., Guillerm, C., Boitelle, A., Capron, A., and Dissous, C. (1995)
Cloning of a signal-recognition-particle subunit of Schistosoma mansoni,
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SRP samples nascent chains for the presence of signal sequences by interacting with ribosomes at a discrete step during translation elongation,
Cell 81, 1075-1084
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Functional analysis of the ffh-trmD region of the Escherichia coli chromosome by using reverse genetics,
J Bacteriol 177, 5554-5560
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Reciprocal stimulation of GTP hydrolysis by two directly interacting GTPases,
Science 269, 1422-1424
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Characterization of the signal recognition particle (SRP) RNA population of tomato (Lycopersicon esculentum),
Plant Mol Biol 27, 669-680
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The GTPase activity of the Escherichia coli Ffh protein is important for normal growth,
Biochimica et Biophysica Acta 1267, 83-91
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EMBO J 13, 4390-4400
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Journal of Biological Chemistry 269, 20497-20502
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Cell 78, 461-471
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Molecular & Cellular Biology 14, 7839-7854
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Nucleic Acids Res 22, 1933-1947
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Journal of Cell Science 107, 903-912
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Concentrations of 4.5S RNA and Ffh protein in Escherichia coli: the stability of Ffh protein is dependent on the concentration of 4.5S RNA,
Journal of Bacteriology 176, 7148-7154
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Effect of 4.5S RNA depletion on Escherichia coli protein synthesis and secretion,
Journal of Bacteriology 176, 2502-2506
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Biophys J 67, 1534-1545
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The relationship between size of a presecretory protein and extent of signal-recognition-particle-mediated arrest of its translation,
Biochemical & Biophysical Research Communications 205, 603-611
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FEBS Letters 348, 233-238
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Mammalian and Escherichia coli signal recognition particles. [Review],
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An alternative protein targeting pathway in Escherichia coli: studies on the role of FtsY,
EMBO Journal 13, 2289-2296
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How ATP drives proteins across membranes [comment],
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Site-directed mutagenesis of signal recognition particle RNA: identification of the nucleotides in helix 8 required for interaction with protein SRP19,
European Journal of Biochemistry 222, 885-890
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Structural requirements of Bacillus subtilis small cytoplasmic RNA for cell growth, sporulation, and extracellular enzyme production,
Journal of Bacteriology 176, 157-165
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The signal recognition particle database (SRPDB),
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The Bacillus subtilis SRP54 homologue, Ffh, has an intrinsic GTPase activity and forms a ribonucleoprotein complex with small cytoplasmic RNA in vivo,
Biochemical & Biophysical Research Communications 199, 1394-1399
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Small cytoplasmic RNA of Bacillus brevis: transcriptional and phylogenetic analysis,
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The structure of the signal-binding domain of the 54 kDa subunit of signal recognition particle and its role in membrane insertion,
Biochemical Society Transactions 22, 1030-1033
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Emergence of master sequences in families of retroposons derived from 7sl RNA. [Review],
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Signal sequence recognition and targeting of ribosomes to the endoplasmic reticulum by the signal recognition particle do not require GTP,
Molecular Biology of the Cell 5, 887-897
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A stably folded presecretory protein associates with and upon unfolding translocates across the membrane of mammalian microsomes,
FEBS Letters 340, 139-144
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Genetic and biochemical analysis of the fission yeast
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Nucleic Acids Research 22, 2557-2567
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Isolation and characterization of an Arabidopsis thaliana gene for the 54 kDa subunit of the signal recognition particle,
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Discrete nascent chain lengths are required for the insertion of presecretory proteins into microsomal membranes,
Journal of Cell Biology 121, 1211-1219
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GTPase domain of the 54-kD subunit of the mammalian signal recognition particle is required for protein translocation but not for signal sequence binding,
Journal of Cell Biology 120, 1113-1121
Honda, K., Nakamura, K., Nishiguchi, M., and Yamane, K. (1993)
Cloning and characterization of a Bacillus subtilis gene encoding a homolog of the 54-kilodalton subunit of mammalian signal recognition particle and Escherichia coli Ffh,
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Assembly of the 68- and 72-kD proteins of signal recognition particle with 7S RNA,
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A GTPase cycle in initiation of protein translocation across the endoplasmic reticulum membrane. [Review],
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GTP binding and hydrolysis by the signal recognition particle during initiation of protein translocation,
Nature 366, 351-354
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Functional substitution of the signal recognition particle 54-kDa subunit by its Escherichia coli homolog,
Proc Natl Acad Sci U S A 90, 5229-5233
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Conformational behavior of Escherichia coli OmpA signal peptides in membrane mimetic environments,
Biochemistry 32, 4881-4894
Robinson, A., He, M., Westwood, O. M., and Austen, B. M. (1993)
Changes in levels of pancreatic endoplasmic reticulum proteins that function in translocation and maturation of secretory proteins in response to cholecystokinin,
Cytotechnology 11, 197-204
Selinger, D., Brennwald, P., Liao, X., and Wise, J. A. (1993)
Identification of RNA sequences and structural elements required for assembly of fission yeast SRP54 protein with signal recognition particle RNA,
Molecular & Cellular Biology 13, 1353-1362
Selinger, D., Liao, X., and Wise, J. A. (1993)
Functional interchangeability of the structurally similar tetranucleotide loops GAAA and UUCG in fission yeast signal recognition particle RNA,
Proceedings of the National Academy of Sciences of the United States of America 90, 5409-5413
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Membrane topology and biogenesis of eukaryotic signal peptidase,
Journal of Biological Chemistry 268, 5201-5208
Connolly, T., and Gilmore, R. (1993)
GTP hydrolysis by complexes of the signal recognition particle and the signal recognition particle receptor,
Journal of Cell Biology 123, 799-807
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The role of molecular chaperones in protein transport into the endoplasmic reticulum. [Review],
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Titration of protein transport activity by incremental changes in signal peptide hydrophobicity,
Biochemistry 32, 1251-1256
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SEC65 gene product is a subunit of the yeast signal recognition particle required for its integrity,
Nature 356, 532-533
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A mutant of 7SL RNA in Yarrowia lipolytica affecting the synthesis of a secreted protein,
Journal of Biological Chemistry 267, 1932-1937
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Conformity of RNAs that interact with tetranucleotide loop binding proteins,
Nucleic acids research 20, 4397-4400
Wood, H., Luirink, J., and Tollervey, D. (1992)
Evolutionary conserved nucleotides within the E. coli 4.5S RNA are required for association with P48 in vitro and for optimal function in vivo,
Nucleic Acids Research 20, 5919-5925
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Recognition of a tetranucleotide loop of signal recognition particle RNA by protein SRP19,
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A mutation in the signal recognition particle 7S RNA of the yeast Yarrowia lipolytica preferentially affects synthesis of the alkaline extracellular protease: in vivo evidence for translational arrest,
Journal of Cell Biology 116, 605-616
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Association of the halobacterial 7S RNA to the polysome correlates with expression of the membrane protein bacterioopsin,
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A protein of the endoplasmic reticulum involved early in polypeptide translocation,
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The signal recognition particle (SRP) database,
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Mechanisms that determine the transmembrane disposition of proteins,
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Fluorescence-detected assembly of the signal recognition particle: binding of the two SRP protein heterodimers to SRP RNA is noncooperative,
Biochemistry 31, 5830-5840
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PCR-assisted localization of the human SRPR gene,
Human Genetics 88, 583-585
Mitoma, J., and Ito, A. (1992)
The carboxy-terminal 10 amino acid residues of cytochrome b5 are necessary for its targeting to the endoplasmic reticulum,
EMBO Journal 11, 4197-4203
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Different positively charged amino acids have similar effects on the topology of a polytopic transmembrane protein in Escherichia coli,
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EMBO Journal 11, 1543-1551
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The 7SL RNA homologue of Trypanosoma brucei is closely related to mammalian 7SL RNA,
Molecular & Biochemical Parasitology 51, 55-64
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The signal sequence receptor, unlike the signal recognition particle receptor, is not essential for protein translocation,
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Current Opinion in Cell Biology 4, 573-580
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Signal recognition particle receptor is important for cell growth and protein secretion in Saccharomyces cerevisiae,
Molecular Biology of the Cell 3, 895-911
Okun, M. M., and Shields, D. (1992)
Translocation of preproinsulin across the endoplasmic reticulum membrane. The relationship between nascent polypeptide size and extent of signal recognition particle-mediated inhibition of protein synthesis,
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Olender, E. H., and Simon, R. D. (1992)
The intracellular targeting and membrane topology of 3-hydroxy-3-methylglutaryl-CoA reductase,
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The E. coli ffh gene is necessary for viability and efficient protein export,
Nature (London) 359, 744-746
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Protein translocation across the ER requires a functional GTP binding site in the alpha subunit of the signal recognition particle receptor,
Journal of Cell Biology 117, 493-503
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Functions of signal and signal-anchor sequences are determined by the balance between the hydrophobic segment and the N-terminal charge,
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Structural requirements for transport of preprocecropinA and related presecretory proteins into mammalian microsomes,
Journal of Biological Chemistry 267, 24328-24332
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The S. cerevisiae SEC65 gene encodes a components of yeast signal recognition particle with homology to human SRP19,
Nature (London) 356, 534-537
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Changes in 7SL RNA conformation during the signal recognition particle cycle,
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SRP-RNA sequence alignment and secondary structure,
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Photoaffinity labeling of dog pancreas microsomes with 8-azido-ATP inhibits association of nascent preprolactin with the signal sequence receptor complex,
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Probing the molecular environment of translocating polypeptide chains by cross-linking,
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The signal recognition particle in S. cerevisiae,
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SRH1 protein, the yeast homologue of the 54 kDa subunit of signal recognition particle, is involved in ER translocation of secretory proteins,
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Characterization of the rough endoplasmic reticulum ribosome-binding activity,
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Structural features that give rise to the unusual stability of RNA hairpins containing GNRA loops,
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The signal sequence interacts with the methionine-rich domain of the 54-kD protein of signal recognition particle,
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Interaction of protein SRP19 with signal recognition particle RNA lacking individual RNA-helices,
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A peptide corresponding to an export-defective mutant OmpA signal sequence with asparagine in the hydrophobic core is unable to insert into model membranes,
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Genes for 7S RNAs can replace the gene for 4.5S RNA in growth of Escherichia coli,
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A basic region neighboring the lysine-rich C-terminus of protein SRP19 is required for binding to signal recognition particle RNA,
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Binding sites of the 9- and 14-kilodalton heterodimeric protein subunit of the signal recognition particle (SRP) are contained exclusively in the Alu domain of SRP RNA and contain a sequence motif that is conserved in evolution,
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The 54-kD protein of signal recognition particle contains a methionine-rich RNA binding domain,
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Association of 7 SL RNA and an SRP-like particle with polysomes and endoplasmic reticulum in the developing sea urchin embryo,
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Genetic analysis of Schizosaccharmyces pombe 7SL RNA: A structural motif that includes a conserved tetranucleotide loop is important for function,
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Saccharomyces cerevisiae and Schizosaccharomyces pombe contain a homologue to the 54-kD subunit of the signal recognition particle that in S. cerevisiae is essential for growth,
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Diversity of 7 SL RNA from the signal recognition particle of maize endosperm,
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The most abundant small cytoplasmic RNA of Saccharomyces cerevisiae has an important function required for normal cell growth,
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Identification of an essential Schizosaccharomyces pombe RNA homologous to the 7SL component of signal recognition particle,
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Full-length prepro-alpha-factor can be translocated across the mammalian microsomal membrane only if translation has not terminated,
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Signal recognition-like particles are present in maize,
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Binding sites of the 19-kDa and 68/72-kDa signal recognition particle (SRP) proteins on SRP RNA as determined in protein-RNA 'footprinting',
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The affinity of signal recognition particle for presecretory proteins is dependent on nascent chain length,
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Evidence for an extended 7SL RNA structure in the signal recognition particle,
EMBO J 6, 3471-3477
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