Conserved RNA Structures (CRSs) in the vertebrate genome
We computationally screened the genomes in the UCSC 100-species vertebrate tree for conserved RNA structures (CRSs), leveraging structure-based, rather than sequence-based, alignments. After careful correction for sequence identity and GC content, we predict ~520k human genomic regions containing CRSs.
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This is the outdated v2 of the CRSs which is for download only. Switch to the latest version 2.1.
Reference
The identification and functional annotation of RNA structures conserved in vertebrates
Seemann SE, Mirza AH, Hansen C, Bang-Berthelsen CH, Garde C, Christensen-Dalsgaard M, Torarinsson E, Yao Z, Workman CT, Pociot F, Nielsen H, Tommerup N, Ruzzo WL, Gorodkin J*
Genome Res. 2017 Aug;27(8):1371-1383. Epub 2017 May 9
[ PubMed | Paper | Dataresource | Supplement ]
Release history
The current release is 2.0. For previous versions see below.| Annotation version | GENCODE release | Release date | Comments |
| 2.0 | Release 25 | 2017-02-28 | CRS annotation in hg38 and 100-species tree. Version of the Genome Res paper. |
| 1.0 | Release 19 | 2015-09-08 | CRS annotation in hg18 and 17-species tree. |