cmpA
BSGatlas-gene-581
BSGatlas
| Description | Information |
|---|---|
| Coordinates | 527912..528025 |
| Genomic Size | 114 bp |
| Name | cmpA |
| Outside Links | SubtiWiki |
| BsubCyc | |
| Strand | - |
| Type | CDS |
SubtiWiki
| Description | Information |
|---|---|
| Alternative Name | cmpA |
| Category | SW 4 Lifestyles |
| SW 4.2 Sporulation | |
| SW 4.2.1 Sporulation proteins | |
| SW 4.2.1.1 Spore coat proteins | |
| SW 4.2.1.1.8 Not yet assigned | |
| Description | cortex morphogenic protein A, checkpoint protein, orchestrates spore coat and cortex morphogenesis |
| Function | represses cortex assembly until the successful initiation of spore coat assembly |
| Locus Tag | G8J2-20 |
| Molecular weight | 4 |
| Name | cmpA |
| Product | cortex morphogenic protein A, adapter protein targeting [[protein|A25C1530DA7BB007A288E525404E9F775E219FE8]] for degradation by [[protein|ClpXP]] upon spore envelope defects |
RefSeq
| Description | Information |
|---|---|
| Alternative Locus Tag | BSU04785 |
| Description | Evidence 1a: Function from experimental evidencesin the studied strain; PubMedId: 22463703, 26387458;Product type f: factor |
| Functions | 16.1: Circulate |
| 16.3: Control | |
| 16.6: Maintain | |
| Locus Tag | BSU_04785 |
| Name | cmpA |
| Title | factor allowing degradation of SpoIVA by ClpXP |
| Type | CDS |
BsubCyc
| Description | Information |
|---|---|
| Citation | Meneghini MD Spore No More: Quality Control during Bacterial Development. Dev Cell 34(6);611-2 (2015) PUBMED: 26418292 |
| Storz G;Wolf YI;Ramamurthi KS Small proteins can no longer be ignored. Annu Rev Biochem 83;753-77 (2014) PUBMED: 24606146 | |
| Tan IS;Weiss CA;Popham DL;Ramamurthi KS A Quality-Control Mechanism Removes Unfit Cells from a Population of Sporulating Bacteria. Dev Cell 34(6);682-93 (2015) PUBMED: 26387458 | |
| Comment | CmpA acts in a spore assembly quality control pathway. If spore envelope assembly is disrupted, CmpA acts as an adaptor to the ClpXP protease, which then degrades SpoIVA, and the defective sporulating cells lyse. |CITS: [26387458]| CmpA: cortex morphogenetic protein A |CITS: [22463703]| |
| Description | cortex morphogenetic protein |
| Gene Ontology | GO:0034301 endospore formation |
| Locus Tag | G8J2-20 |
| Molecular weight | 4.754 |
| Name | cmpA |